Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr19 7125448 . C A CCDS12176.1:NM_000208.2:c.3104gGc>gTc_NP_000199.2:p.1035G>V Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7bw7 1 P06213 100.0 0.0 EM
 2021-04-14 GLY A:1008 NA:NA DO NA DO DO DO NA NA NA
GLY B:1008 NA:NA DO NA DO DO DO NA NA NA
7bw8 1 P06213 100.0 0.0 EM
 2021-04-14 GLY A:1008 NA:NA DO NA DO DO DO NA NA NA
GLY B:1008 NA:NA DO NA DO DO DO NA NA NA
7bwa 1 P06213 100.0 0.0 EM
 2021-04-14 GLY A:1008 NA:NA DO NA DO DO DO NA NA NA
GLY B:1008 NA:NA DO NA DO DO DO NA NA NA
7pg0 1 P06213 99.13 0.0 EM
 2022-02-02 GLY A:1023 NA:NA DO NA DO DO DO NA NA NA
GLY B:1023 NA:NA DO NA DO DO DO NA NA NA
7pg2 1 P06213 99.13 0.0 EM
 2022-02-02 GLY A:1023 NA:NA DO NA DO DO DO NA NA NA
GLY B:1023 NA:NA DO NA DO DO DO NA NA NA
7pg3 1 P06213 99.13 0.0 EM
 2022-02-02 GLY A:1023 NA:NA DO NA DO DO DO NA NA NA
GLY B:1023 NA:NA DO NA DO DO DO NA NA NA
7pg4 1 P06213 99.13 0.0 EM
 2022-02-02 GLY A:1023 NA:NA DO NA DO DO DO NA NA NA
GLY B:1023 NA:NA DO NA DO DO DO NA NA NA
6pxv 1 P06213 98.6 0.0 EM
 2019-09-04 GLY A:996 NA:NA DO NA DO DO DO NA NA NA
GLY B:996 NA:NA DO NA DO DO DO NA NA NA
6pxw 1 P06213 98.6 0.0 EM
 2019-09-04 GLY A:996 NA:NA DO NA DO DO DO NA NA NA
GLY B:996 NA:NA DO NA DO DO DO NA NA NA
4xlv 1 P06213 99.09 0.0 X-RAY
 2015-03-25 GLY A:53 A:1008 13.0 0.173 -127.0 116.3 13.0 0.173 0.0 ACP
MG
MG
HOH
 4.163
8.361
4.825
3.036
 O
O
N
N
 O2B
MG
MG
O
4ibm 1 P06213 99.67 0.0 X-RAY
 2013-08-21 GLY A:31 A:1008 3.0 0.04 E 163.8 169.0 3.0 0.04 0.0 IR1
HOH
 5.965
2.800
 O
O
 C2
O
GLY B:31 B:1008 2.0 0.027 S 165.6 -173.4 NA NA NA
1gag 1 P06213 99.35 0.0 X-RAY
 2001-01-17 GLY A:31 A:1008 8.0 0.107 E -151.6 -160.4 8.0 0.107 0.0 MG
112
HOH
 8.123
5.655
4.119
 N
C
CA
 MG
O1A
O
1ir3 1 P06213 99.35 0.0 X-RAY
 1998-01-07 GLY A:31 A:1008 0.0 0.0 S -171.8 -175.5 0.0 0.0 0.0 MG
ANP
HOH
 8.895
5.104
3.834
 N
O
N
 MG
O1A
O
1irk 1 P06213 99.35 0.0 X-RAY
 1995-02-27 GLY A:31 A:1008 1.0 0.013 S 160.6 -164.0 1.0 0.013 0.0 HOH
 2.900
 O
 O
3eta 1 P06213 100.0 0.0 X-RAY
 2009-05-26 GLY A:30 A:1008 2.0 0.027 S 173.5 170.6 2.0 0.027 0.0 351
HOH
 6.983
4.402
 O
C
 C18
O
GLY B:30 B:1008 2.0 0.027 S 174.0 166.9 NA NA NA
5hhw 1 P06213 99.35 0.0 X-RAY
 2016-04-13 GLY A:32 A:1035 0.0 0.0 S -179.1 -171.6 0.0 0.0 0.0 60O
HOH
 6.756
3.562
 O
CA
 C20
O
5e1s 1 P06213 99.35 0.0 X-RAY
 2015-10-14 GLY A:33 A:1008 2.0 0.027 S 167.4 -167.6 2.0 0.027 0.0 5JA
HOH
 6.007
2.717
 O
O
 C25
O
1rqq 1 P06213 99.35 0.0 X-RAY
 2003-12-30 GLY A:31 A:1008 6.0 0.08 E -165.5 178.3 6.0 0.08 0.0 112
HOH
 5.243
3.673
 O
N
 O1A
O
GLY B:31 B:1008 14.0 0.187 E -167.2 178.1 14.0 0.187 0.0 112
HOH
 5.413
3.088
 O
O
 O1A
O
2auh 1 P06213 99.35 0.0 X-RAY
 2005-11-01 GLY A:31 A:1008 0.0 0.0 E 171.2 -112.0 0.0 0.0 0.0 CA
 9.383
 N
 CA
2b4s 2 P06213 99.35 0.0 X-RAY
 2005-11-15 GLY B:31 B:1008 2.0 0.027 S 177.0 -179.4 2.0 0.027 0.0 HOH
 2.842
 O
 O
GLY D:31 D:1008 2.0 0.027 S 174.4 177.3 2.0 0.027 0.0 HOH
 2.838
 O
 O
3bu3 1 P06213 99.35 0.0 X-RAY
 2008-02-19 GLY A:31 A:1008 2.0 0.027 S 165.2 -177.8 2.0 0.027 0.0 HOH
 2.834
 O
 O
3bu5 1 P06213 99.35 0.0 X-RAY
 2008-02-19 GLY A:31 A:1008 34.0 0.453 360.0 120.1 34.0 0.453 0.0 MG
ATP
HOH
 9.427
4.977
3.782
 O
O
CA
 MG
O2B
O
3bu6 1 P06213 99.35 0.0 X-RAY
 2008-02-19 GLY A:31 A:1008 3.0 0.04 S 173.9 -178.2 3.0 0.04 0.0 HOH
 2.894
 O
 O
1p14 1 P06213 99.02 0.0 X-RAY
 2003-07-22 GLY A:31 A:1008 1.0 0.013 S 166.4 -169.3 1.0 0.013 0.0 HOH
 2.948
 O
 O
1i44 1 P06213 99.02 0.0 X-RAY
 2001-03-07 GLY A:31 A:1008 2.0 0.027 S 163.7 -174.5 2.0 0.027 0.0 ACP
HOH
 6.329
2.909
 N
O
 O1B
O
3ekk 1 P06213 99.02 0.0 X-RAY
 2008-12-23 GLY A:32 A:1008 3.0 0.04 S 165.0 -161.5 3.0 0.04 0.0 GS2
HOH
 6.339
2.965
 O
O
 F1
O
3ekn 1 P06213 99.02 0.0 X-RAY
 2008-12-30 GLY A:32 A:1008 1.0 0.013 S 159.5 -173.2 1.0 0.013 0.0 GS3
HOH
 6.611
2.878
 O
O
 C14
O
2z8c 1 P06213 99.67 0.0 X-RAY
 2008-08-12 GLY A:28 A:1008 6.0 0.08 S -107.2 -149.6 6.0 0.08 0.0 S91
 7.971
 O
 C5
2oj9 1 P08069 80.07 6e-177 X-RAY
 2007-05-01 GLY A:32 A:981 7.0 0.093 S 153.3 -175.8 7.0 0.093 0.0 BMI
HOH
 6.682
2.939
 O
O
 C6
O
3nw5 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 GLY A:32 A:981 4.0 0.053 S 164.9 -171.9 4.0 0.053 0.0 LGX
HOH
 6.056
3.152
 O
O
 C22
O
3nw6 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 GLY A:32 A:981 3.0 0.04 S 163.0 -168.5 3.0 0.04 0.0 LGW
HOH
 6.051
3.267
 O
O
 C22
O
3nw7 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 GLY A:32 A:981 8.0 0.107 S 162.5 -176.7 8.0 0.107 0.0 LGV
HOH
 6.796
3.076
 O
O
 C19
O
3i81 1 P08069 80.07 7e-177 X-RAY
 2009-12-22 GLY A:32 A:981 2.0 0.027 S 168.9 -176.3 2.0 0.027 0.0 EBI
HOH
 7.046
2.965
 O
O
 C27
O
3d94 1 P08069 81.06 1e-176 X-RAY
 2008-07-29 GLY A:26 A:981 5.0 0.067 S 159.2 -168.5 5.0 0.067 0.0 CA
D94
HOH
 5.746
6.289
3.465
 N
O
CA
 CA
C23
O
1jqh 1 P08069 80.53 1e-176 X-RAY
 2002-04-19 GLY A:33 A:1011 2.0 0.027 S 162.3 -177.3 2.0 0.027 0.0 ANP
HOH
 4.924
3.125
 O
O
 O2B
O
GLY B:33 B:1011 2.0 0.027 S 163.2 -177.8 NA NA NA
GLY C:33 C:1011 2.0 0.027 S 162.7 -178.6 NA NA NA
2zm3 1 P08069 80.53 1e-176 X-RAY
 2008-06-10 GLY A:33 A:1011 13.0 0.173 S 172.5 -174.8 13.0 0.173 0.0 575
HOH
 6.132
2.890
 O
O
 BR1
O
GLY B:33 B:1011 3.0 0.04 S 162.8 176.8 NA NA NA
GLY C:33 C:1011 3.0 0.04 S 172.4 -178.5 NA NA NA
GLY D:33 D:1011 16.0 0.213 S 160.6 -178.2 NA NA NA
3f5p 1 P08069 80.53 1e-176 X-RAY
 2008-12-30 GLY A:33 A:1011 8.0 0.107 E 171.3 -166.6 8.0 0.107 0.0 741
 6.924
 N
 N27
GLY B:33 B:1011 9.0 0.12 S 163.0 -175.2 NA NA NA
GLY C:33 C:1011 11.0 0.147 E -176.2 -168.8 NA NA NA
GLY D:33 D:1011 5.0 0.067 E 166.7 -169.4 NA NA NA
GLY E:33 E:1011 7.0 0.093 E 170.9 -159.6 NA NA NA
GLY F:33 F:1011 6.0 0.08 E 173.5 -157.0 NA NA NA
GLY G:33 G:1011 5.0 0.067 E 173.8 -158.1 NA NA NA
GLY H:33 H:1011 15.0 0.2 E 171.8 -160.4 NA NA NA
GLY I:33 I:1011 21.0 0.28 S 169.2 -165.0 NA NA NA
GLY J:33 J:1011 15.0 0.2 S -169.5 -164.3 NA NA NA
GLY K:33 K:1011 15.0 0.2 S 179.8 -175.2 NA NA NA
GLY L:33 M:1011 14.0 0.187 E 176.3 -167.9 NA NA NA
GLY M:33 L:1011 18.0 0.24 S 176.1 -163.7 NA NA NA
GLY N:33 R:1011 15.0 0.2 S -179.5 -164.8 NA NA NA
GLY O:33 S:1011 15.0 0.2 S 175.1 -167.8 NA NA NA
GLY P:33 T:1011 21.0 0.28 S 158.7 -169.3 NA NA NA
4d2r 1 P08069 81.06 2e-176 X-RAY
 2015-04-22 GLY A:27 A:1011 2.0 0.027 S 166.4 -173.4 2.0 0.027 0.0 DYK
HOH
 6.635
2.972
 O
O
 C23
O
1k3a 1 P08069 80.94 4e-175 X-RAY
 2001-11-28 GLY A:24 A:981 5.0 0.067 S 168.3 -179.9 5.0 0.067 0.0 ACP
HOH
 5.560
2.763
 O
O
 O1A
O
3qqu 1 P08069 80.94 6e-175 X-RAY
 2011-04-20 GLY A:26 A:1008 1.0 0.013 E 145.6 179.0 1.0 0.013 0.0 01P
HOH
 6.162
7.336
 O
N
 C10
O
GLY B:26 B:1008 2.0 0.027 S -179.1 -155.9 NA NA NA
GLY C:26 C:1008 13.0 0.173 E 145.0 161.4 NA NA NA
GLY D:26 D:1008 2.0 0.027 E 166.1 162.2 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p06213-f1 1 P06213 100.0 0.0 GLY A:1035 A:1035 7.0 0.093 E 153.5 -146.6