Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr19 7125473 . G A CCDS12176.1:NM_000208.2:c.3079Cga>Tga_NP_000199.2:p.1027R>* Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7bw7 1 P06213 100.0 0.0 EM
 2021-04-14 ARG A:1000 NA:NA DO NA DO DO DO NA NA NA
ARG B:1000 NA:NA DO NA DO DO DO NA NA NA
7bw8 1 P06213 100.0 0.0 EM
 2021-04-14 ARG A:1000 NA:NA DO NA DO DO DO NA NA NA
ARG B:1000 NA:NA DO NA DO DO DO NA NA NA
7bwa 1 P06213 100.0 0.0 EM
 2021-04-14 ARG A:1000 NA:NA DO NA DO DO DO NA NA NA
ARG B:1000 NA:NA DO NA DO DO DO NA NA NA
7pg0 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:1015 NA:NA DO NA DO DO DO NA NA NA
ARG B:1015 NA:NA DO NA DO DO DO NA NA NA
7pg2 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:1015 NA:NA DO NA DO DO DO NA NA NA
ARG B:1015 NA:NA DO NA DO DO DO NA NA NA
7pg3 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:1015 NA:NA DO NA DO DO DO NA NA NA
ARG B:1015 NA:NA DO NA DO DO DO NA NA NA
7pg4 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:1015 NA:NA DO NA DO DO DO NA NA NA
ARG B:1015 NA:NA DO NA DO DO DO NA NA NA
6pxv 1 P06213 98.6 0.0 EM
 2019-09-04 ARG A:988 NA:NA DO NA DO DO DO NA NA NA
ARG B:988 NA:NA DO NA DO DO DO NA NA NA
6pxw 1 P06213 98.6 0.0 EM
 2019-09-04 ARG A:988 NA:NA DO NA DO DO DO NA NA NA
ARG B:988 NA:NA DO NA DO DO DO NA NA NA
4xlv 1 P06213 99.09 0.0 X-RAY
 2015-03-25 ARG A:45 A:1000 163.0 0.724 E -169.8 157.8 163.0 0.724 0.0 ACP
HOH
 8.647
6.701
 O
N
 N3
O
4ibm 1 P06213 99.67 0.0 X-RAY
 2013-08-21 ARG A:23 A:1000 138.0 0.613 E -158.4 154.3 138.0 0.613 0.0 IR1
HOH
 5.151
3.123
 NH2
NH2
 C9
O
ARG B:23 B:1000 130.0 0.578 E -161.5 152.7 NA NA NA
1gag 1 P06213 99.35 0.0 X-RAY
 2001-01-17 ARG A:23 A:1000 154.0 0.684 E -161.1 166.3 154.0 0.684 0.0 112
 8.769
 O
 N3
1ir3 1 P06213 99.35 0.0 X-RAY
 1998-01-07 ARG A:23 A:1000 161.0 0.716 E -162.5 165.1 161.0 0.716 0.0 ANP
HOH
 8.673
3.273
 O
NH2
 N3
O
1irk 1 P06213 99.35 0.0 X-RAY
 1995-02-27 ARG A:23 A:1000 161.0 0.716 E -163.0 158.5 161.0 0.716 0.0 HOH
 3.640
 CB
 O
3eta 1 P06213 100.0 0.0 X-RAY
 2009-05-26 ARG A:22 A:1000 81.0 NA E -161.5 158.8 81.0 NA NA 351
 8.803
 O
 C4
ARG B:22 B:1000 148.0 0.658 E -159.6 162.3 NA NA NA
5hhw 1 P06213 99.35 0.0 X-RAY
 2016-04-13 ARG A:24 A:1027 142.0 0.631 E -158.9 164.2 142.0 0.631 0.0 60O
HOH
 8.018
3.050
 NH2
NH2
 C15
O
5e1s 1 P06213 99.35 0.0 X-RAY
 2015-10-14 ARG A:25 A:1000 144.0 0.64 E -159.9 163.5 144.0 0.64 0.0 5JA
HOH
 3.884
3.505
 NH2
NH1
 C18
O
1rqq 1 P06213 99.35 0.0 X-RAY
 2003-12-30 ARG A:23 A:1000 155.0 0.689 E -138.9 -172.4 155.0 0.689 0.0 112
 8.785
 NH2
 C2
ARG B:23 B:1000 161.0 0.716 E -139.4 -174.5 161.0 0.716 0.0 112
 9.751
 O
 O4'
2auh 1 P06213 99.35 0.0 X-RAY
 2005-11-01 ARG A:23 A:1000 141.0 0.627 E -120.2 155.6 141.0 0.627 0.0
2b4s 2 P06213 99.35 0.0 X-RAY
 2005-11-15 ARG B:23 B:1000 51.0 NA E -164.2 164.2 51.0 NA NA HOH
 8.456
 CB
 O
ARG D:23 D:1000 153.0 0.68 E -168.4 168.5 153.0 0.68 0.0 HOH
 5.087
 NH1
 O
3bu3 1 P06213 99.35 0.0 X-RAY
 2008-02-19 ARG A:23 A:1000 139.0 0.618 E -158.8 168.9 139.0 0.618 0.0 HOH
 2.518
 NH2
 O
3bu5 1 P06213 99.35 0.0 X-RAY
 2008-02-19 ARG A:23 A:1000 147.0 0.653 E -154.2 169.6 147.0 0.653 0.0 ATP
HOH
 8.124
5.193
 NH2
NH2
 N3
O
3bu6 1 P06213 99.35 0.0 X-RAY
 2008-02-19 ARG A:23 A:1000 142.0 0.631 E -159.2 165.2 142.0 0.631 0.0 HOH
 3.507
 CB
 O
1p14 1 P06213 99.02 0.0 X-RAY
 2003-07-22 ARG A:23 A:1000 137.0 0.609 E -165.0 168.6 137.0 0.609 0.0 HOH
 3.391
 NH1
 O
1i44 1 P06213 99.02 0.0 X-RAY
 2001-03-07 ARG A:23 A:1000 138.0 0.613 E -168.8 161.3 138.0 0.613 0.0 ACP
HOH
 8.090
3.042
 NH1
CD
 N3
O
3ekk 1 P06213 99.02 0.0 X-RAY
 2008-12-23 ARG A:24 A:1000 162.0 0.72 E -165.0 159.7 162.0 0.72 0.0 GS2
HOH
 6.653
3.298
 CD
NE
 C19
O
3ekn 1 P06213 99.02 0.0 X-RAY
 2008-12-30 ARG A:24 A:1000 155.0 0.689 E -167.0 159.9 155.0 0.689 0.0 HOH
 8.133
 N
 O
2z8c 1 P06213 99.67 0.0 X-RAY
 2008-08-12 ARG A:20 A:1000 146.0 0.649 E -153.4 173.5 146.0 0.649 0.0 S91
 4.931
 NH2
 C20
2oj9 1 P08069 80.07 6e-177 X-RAY
 2007-05-01 ARG A:24 A:973 177.0 0.787 E -150.9 166.6 177.0 0.787 0.0 BMI
HOH
 9.082
3.453
 O
CG
 C16
O
3nw5 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 ARG A:24 A:973 144.0 0.64 E -93.8 148.9 144.0 0.64 0.0 LGX
HOH
 8.885
4.604
 O
NH2
 C2
O
3nw6 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 ARG A:24 A:973 142.0 0.631 E -82.3 146.6 142.0 0.631 0.0 LGW
HOH
 8.593
2.629
 O
NH2
 C23
O
3nw7 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 ARG A:24 A:973 157.0 0.698 E -67.6 150.9 157.0 0.698 0.0 LGV
HOH
 8.735
3.231
 O
NH2
 C3
O
3i81 1 P08069 80.07 7e-177 X-RAY
 2009-12-22 ARG A:24 A:973 140.0 0.622 E -77.9 149.8 140.0 0.622 0.0 EBI
HOH
 8.728
3.253
 O
NE
 C27
O
3d94 1 P08069 81.06 1e-176 X-RAY
 2008-07-29 ARG A:18 A:973 152.0 0.676 E -82.0 150.1 152.0 0.676 0.0 D94
HOH
 8.185
3.309
 NH2
NH2
 C1
O
1jqh 1 P08069 80.53 1e-176 X-RAY
 2002-04-19 ARG A:25 A:1003 137.0 0.609 E -152.3 163.7 137.0 0.609 0.0 ANP
HOH
 9.011
5.886
 O
N
 O4'
O
ARG B:25 B:1003 138.0 0.613 E -149.6 162.2 NA NA NA
ARG C:25 C:1003 135.0 0.6 E -142.6 158.2 NA NA NA
2zm3 1 P08069 80.53 1e-176 X-RAY
 2008-06-10 ARG A:25 A:1003 136.0 0.604 E -174.2 163.0 136.0 0.604 0.0 575
HOH
 4.566
3.396
 NH2
NH1
 C1
O
ARG B:25 B:1003 154.0 0.684 E -152.4 169.3 NA NA NA
ARG C:25 C:1003 142.0 0.631 E -71.1 154.4 NA NA NA
ARG D:25 D:1003 138.0 0.613 E -142.2 163.6 NA NA NA
3f5p 1 P08069 80.53 1e-176 X-RAY
 2008-12-30 ARG A:25 A:1003 151.0 0.671 E -120.3 158.1 151.0 0.671 0.0 741
 4.677
 NH1
 C36
ARG B:25 B:1003 138.0 0.613 E -125.0 144.4 NA NA NA
ARG C:25 C:1003 143.0 0.636 E -150.2 141.7 NA NA NA
ARG D:25 D:1003 143.0 0.636 E -140.4 146.0 NA NA NA
ARG E:25 E:1003 145.0 0.644 E -136.6 149.9 NA NA NA
ARG F:25 F:1003 150.0 0.667 E -132.7 149.8 NA NA NA
ARG G:25 G:1003 157.0 0.698 E -149.1 141.1 NA NA NA
ARG H:25 H:1003 151.0 0.671 E -156.3 142.1 NA NA NA
ARG I:25 I:1003 128.0 0.569 E -119.1 160.2 NA NA NA
ARG J:25 J:1003 151.0 0.671 E -138.2 156.3 NA NA NA
ARG K:25 K:1003 146.0 0.649 E -97.6 151.8 NA NA NA
ARG L:25 M:1003 148.0 0.658 E -133.3 145.4 NA NA NA
ARG M:25 L:1003 138.0 0.613 E -108.6 143.9 NA NA NA
ARG N:25 R:1003 154.0 0.684 E -136.7 144.6 NA NA NA
ARG O:25 S:1003 140.0 0.622 E -118.5 153.6 NA NA NA
ARG P:25 T:1003 156.0 0.693 E -135.3 143.2 NA NA NA
4d2r 1 P08069 81.06 2e-176 X-RAY
 2015-04-22 ARG A:19 A:1003 64.0 NA E -72.3 130.0 64.0 NA NA DYK
HOH
 6.319
6.948
 CG
N
 C12
O
1k3a 1 P08069 80.94 4e-175 X-RAY
 2001-11-28 ARG A:16 A:973 141.0 0.627 E -160.8 168.1 141.0 0.627 0.0 ACP
HOH
 8.203
2.796
 NH2
NH2
 N3
O
3qqu 1 P08069 80.94 6e-175 X-RAY
 2011-04-20 ARG A:18 A:1000 190.0 0.844 E 160.5 139.3 190.0 0.844 0.0 01P
HOH
 8.590
4.347
 O
CD
 C16
O
ARG B:18 B:1000 198.0 0.88 E -173.7 161.8 NA NA NA
ARG C:18 C:1000 73.0 NA S -57.3 168.4 NA NA NA
ARG D:18 D:1000 62.0 NA S -103.1 165.1 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p06213-f1 1 P06213 100.0 0.0 ARG A:1027 A:1027 138.0 0.613 E -138.1 158.1