Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr19 | 7184444 | . | C | A | CCDS12176.1:NM_000208.2:c.857tGc>tTc_NP_000199.2:p.286C>F | Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 7bw7 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | CYS | A:259 | A:259 | 13.0 | 0.096 | H | -63.8 | -30.8 | 13.0 | 0.096 | 0.0 | ||||||
| CYS | B:259 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7bw8 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | CYS | A:259 | A:259 | 8.0 | 0.059 | H | -58.1 | -31.1 | 8.0 | 0.059 | 0.0 | ||||||
| CYS | B:259 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7bwa | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | CYS | A:259 | A:259 | 1.0 | 0.007 | H | -62.5 | -43.5 | 1.0 | 0.007 | 0.0 | ||||||
| CYS | B:259 | C:259 | 1.0 | 0.007 | H | -62.5 | -43.5 | NA | NA | NA | |||||||||||||
| 7pg0 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | CYS | A:286 | A:259 | 0.0 | 0.0 | H | -62.5 | -52.9 | 0.0 | 0.0 | 0.0 | ||||||
| CYS | B:286 | B:259 | 0.0 | 0.0 | H | -68.5 | -37.6 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 7pg2 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | CYS | A:286 | A:259 | 0.0 | 0.0 | H | -65.1 | -48.6 | 0.0 | 0.0 | 0.0 | ||||||
| CYS | B:286 | B:259 | 0.0 | 0.0 | H | -68.3 | -38.6 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 7pg3 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | CYS | A:286 | A:259 | 1.0 | 0.007 | H | -62.7 | -52.4 | 1.0 | 0.007 | 0.0 | ||||||
| CYS | B:286 | B:259 | 0.0 | 0.0 | H | -61.9 | -51.8 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 7pg4 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | CYS | A:286 | A:259 | 0.0 | 0.0 | H | -62.3 | -58.7 | 0.0 | 0.0 | 0.0 | ||||||
| CYS | B:286 | B:259 | 1.0 | 0.007 | H | -59.4 | -27.6 | 1.0 | 0.007 | 0.0 | |||||||||||||
| 6pxv | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | CYS | A:259 | A:259 | 0.0 | 0.0 | H | -67.8 | -29.2 | 0.0 | 0.0 | 0.0 | ||||||
| CYS | B:259 | C:259 | 0.0 | 0.0 | H | -67.8 | -29.2 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6pxw | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | CYS | A:259 | A:259 | 1.0 | 0.007 | H | -67.8 | -29.2 | 1.0 | 0.007 | 0.0 | ||||||
| CYS | B:259 | B:259 | 0.0 | 0.0 | H | -67.8 | -29.2 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6ce7 | 1 | P06213 | 99.89 | 0.0 |
EM |
2018-03-14 | CYS | A:259 | B:259 | 0.0 | 0.0 | H | -84.3 | -33.9 | 0.0 | 0.0 | 0.0 | ||||||
| CYS | B:259 | A:259 | 4.0 | 0.03 | H | -63.1 | -30.8 | 4.0 | 0.03 | 0.0 | |||||||||||||
| 6ce9 | 1 | P06213 | 98.6 | 0.0 |
EM |
2018-03-14 | CYS | A:259 | A:259 | 1.0 | 0.007 | H | -66.6 | -22.9 | 1.0 | 0.007 | 0.0 |
NAG FUC |
7.175 9.066 |
N N |
O5 C5 |
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| CYS | B:259 | B:259 | 2.0 | 0.015 | H | -66.6 | -22.9 | 2.0 | 0.015 | 0.0 |
NAG FUC |
7.195 9.029 |
N N |
O5 C5 |
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| 6ceb | 1 | P06213 | 98.6 | 0.0 |
EM |
2018-03-14 | CYS | A:259 | A:259 | 2.0 | 0.015 | H | -67.5 | -22.6 | 2.0 | 0.015 | 0.0 |
NAG FUC |
7.311 9.246 |
N N |
O5 O5 |
||
| CYS | B:259 | B:259 | 3.0 | 0.022 | H | -64.0 | -26.5 | 3.0 | 0.022 | 0.0 |
NAG FUC |
6.925 8.973 |
N N |
O5 O5 |
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| 6hn4 | 1 | P06213,P03069 | 95.7 | 0.0 |
EM |
2018-11-21 | CYS | A:259 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| CYS | B:259 | F:259 | 0.0 | 0.0 | H | -63.2 | -35.1 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6hn5 | 3 | P06213,P03069 | 95.7 | 0.0 |
EM |
2018-11-21 | CYS | C:259 | E:259 | 2.0 | 0.015 | H | -73.3 | -37.0 | 2.0 | 0.015 | 0.0 |
NAG |
7.396 |
N |
C1 |
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| CYS | D:259 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 4zxb | 5 | P06213 | 95.48 | 0.0 |
X-RAY |
2016-02-24 | CYS | E:259 | E:259 | 0.0 | 0.0 | H | -65.1 | -34.4 | 0.0 | 0.0 | 0.0 |
NAG NAG FUC |
7.181 9.876 8.437 |
N N N |
O5 C8 C6 |
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| 6sof | 1 | P06213 | 100.0 | 0.0 |
EM |
2019-11-13 | CYS | A:259 | A:259 | 2.0 | 0.015 | H | -53.2 | -36.4 | 2.0 | 0.015 | 0.0 | ||||||
| CYS | C:259 | C:259 | 4.0 | 0.03 | H | -59.4 | -42.7 | 4.0 | 0.03 | 0.0 | |||||||||||||
| 7qid | 1 | P06213 | 100.0 | 0.0 |
EM |
2022-02-02 | CYS | A:259 | A:259 | 4.0 | 0.03 | H | -63.5 | -39.7 | 4.0 | 0.03 | 0.0 | ||||||
| CYS | C:259 | C:259 | 0.0 | 0.0 | T | -118.1 | -46.5 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 5kqv | 5 | P06213 | 99.83 | 0.0 |
X-RAY |
2017-07-19 | CYS | E:259 | E:259 | 0.0 | 0.0 | H | -60.4 | -37.6 | 0.0 | 0.0 | 0.0 | ||||||
| CYS | F:259 | F:259 | 0.0 | 0.0 | H | -60.6 | -37.7 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 2hr7 | 1 | P06213 | 99.59 | 0.0 |
X-RAY |
2006-08-15 | CYS | A:259 | A:259 | 0.0 | 0.0 | H | -62.0 | -36.3 | 0.0 | 0.0 | 0.0 |
NAG FUC SO4 HOH |
7.490 9.827 8.055 6.394 |
N N N N |
C1 C6 O3 O |
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| CYS | B:259 | B:259 | 0.0 | 0.0 | H | -55.4 | -41.4 | 0.0 | 0.0 | 0.0 |
NAG NAG FUC HOH |
7.456 9.405 8.148 6.371 |
N N N N |
O5 C8 C6 O |
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| 4oga | 5 | P06213 | 99.68 | 0.0 |
X-RAY |
2014-08-27 | CYS | E:259 | E:259 | 0.0 | 0.0 | H | -63.6 | -35.3 | 0.0 | 0.0 | 0.0 |
NAG FUC |
7.409 8.448 |
N N |
C1 C6 |
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| 4xss | 2 | P06213 | 99.68 | 0.0 |
X-RAY |
2015-06-10 | CYS | B:259 | E:259 | 0.0 | 0.0 | H | -62.5 | -36.7 | 0.0 | 0.0 | 0.0 |
NAG NAG FUC |
6.990 9.392 9.248 |
N N N |
O5 C8 C1 |
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| 4xst | 1 | P06213 | 99.68 | 0.0 |
X-RAY |
2015-06-10 | CYS | A:259 | E:259 | 0.0 | 0.0 | H | -63.3 | -35.2 | 0.0 | 0.0 | 0.0 |
NAG FUC |
7.223 8.886 |
N N |
O5 C1 |
||
| 5j3h | 4 | P06213 | 99.68 | 0.0 |
X-RAY |
2016-06-15 | CYS | D:259 | E:259 | 0.0 | 0.0 | H | -61.2 | -38.1 | 0.0 | 0.0 | 0.0 |
NAG NAG FUC |
7.239 9.641 9.118 |
N N N |
O5 C8 O5 |
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| 6vep | 5 | P06213 | 99.68 | 0.0 |
X-RAY |
2020-06-03 | CYS | E:259 | E:259 | 0.0 | 0.0 | H | -62.3 | -37.3 | 0.0 | 0.0 | 0.0 |
NAG NAG FUC |
7.179 9.407 8.300 |
N N N |
O5 C8 C6 |
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| CYS | K:259 | K:259 | 0.0 | 0.0 | H | -63.2 | -37.0 | NA | NA | NA | |||||||||||||
| CYS | Q:259 | Q:259 | 0.0 | 0.0 | H | -62.3 | -37.4 | NA | NA | NA | |||||||||||||
| CYS | W:259 | W:259 | 0.0 | 0.0 | H | -62.7 | -37.9 | NA | NA | NA | |||||||||||||
| 6veq | 3 | P06213 | 99.68 | 0.0 |
X-RAY |
2020-06-03 | CYS | C:259 | E:259 | 0.0 | 0.0 | H | -65.1 | -20.6 | 0.0 | 0.0 | 0.0 |
NAG FUC |
7.313 8.633 |
N N |
O5 C6 |
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| CYS | G:259 | K:259 | 0.0 | 0.0 | H | -64.9 | -20.5 | NA | NA | NA | |||||||||||||
| 7kd6 | 4 | P06213 | 99.68 | 0.0 |
X-RAY |
2021-10-13 | CYS | D:259 | E:259 | 0.0 | 0.0 | H | -62.9 | -42.1 | 0.0 | 0.0 | 0.0 |
NAG NAG FUC HOH |
7.274 8.775 7.858 6.596 |
N N N N |
O5 C8 C6 O |
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| CYS | I:259 | K:259 | 0.0 | 0.0 | H | -61.6 | -41.7 | NA | NA | NA | |||||||||||||
| CYS | N:259 | Q:259 | 0.0 | 0.0 | H | -62.7 | -41.7 | NA | NA | NA | |||||||||||||
| CYS | S:259 | W:259 | 7.0 | 0.052 | H | -60.2 | -43.4 | NA | NA | NA | |||||||||||||
| 3w11 | 5 | P06213 | 99.68 | 0.0 |
X-RAY |
2013-01-09 | CYS | E:259 | E:259 | 0.0 | 0.0 | H | -60.4 | -37.2 | 0.0 | 0.0 | 0.0 |
NAG |
7.089 |
N |
C1 |
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| 3w12 | 1 | P06213 | 99.68 | 0.0 |
X-RAY |
2013-01-09 | CYS | A:259 | E:259 | 0.0 | 0.0 | H | -58.8 | -41.7 | 0.0 | 0.0 | 0.0 |
NAG |
6.861 |
N |
O5 |
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| 3w13 | 1 | P06213 | 99.68 | 0.0 |
X-RAY |
2013-01-09 | CYS | A:259 | E:259 | 0.0 | 0.0 | H | -56.2 | -44.9 | 0.0 | 0.0 | 0.0 |
NAG |
7.109 |
N |
C1 |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p06213-f1 | 1 | P06213 | 100.0 | 0.0 | CYS | A:286 | A:286 | 0.0 | 0.0 | H | -64.3 | -38.3 | |