Variant
Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr19 | 7184495 | . | G | A | CCDS12176.1:NM_000208.2:c.806cCg>cTg_NP_000199.2:p.269P>L | Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA. |
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PDB
Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
7bw7 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | PRO | A:242 | A:242 | 92.0 | 0.634 | -69.0 | 168.0 | 92.0 | 0.634 | 0.0 | |||||||
PRO | B:242 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
7bw8 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | PRO | A:242 | A:242 | 87.0 | 0.6 | -68.0 | 162.8 | 87.0 | 0.6 | 0.0 | |||||||
PRO | B:242 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
7bwa | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | PRO | A:242 | A:242 | 59.0 | 0.407 | -68.6 | 152.7 | 59.0 | 0.407 | 0.0 | |||||||
PRO | B:242 | C:242 | 57.0 | 0.393 | -68.6 | 152.7 | NA | NA | NA | ||||||||||||||
7pg0 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | PRO | A:269 | A:242 | 56.0 | 0.386 | -64.7 | 161.4 | 56.0 | 0.386 | 0.0 | |||||||
PRO | B:269 | B:242 | 59.0 | 0.407 | -57.8 | 143.8 | 59.0 | 0.407 | 0.0 | ||||||||||||||
7pg2 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | PRO | A:269 | A:242 | 69.0 | 0.476 | -60.7 | 153.9 | 69.0 | 0.476 | 0.0 | |||||||
PRO | B:269 | B:242 | 69.0 | 0.476 | -67.6 | 166.4 | 69.0 | 0.476 | 0.0 | ||||||||||||||
7pg3 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | PRO | A:269 | A:242 | 64.0 | 0.441 | -49.4 | 156.4 | 64.0 | 0.441 | 0.0 | |||||||
PRO | B:269 | B:242 | 61.0 | 0.421 | -76.5 | 126.7 | 61.0 | 0.421 | 0.0 | ||||||||||||||
7pg4 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | PRO | A:269 | A:242 | 70.0 | 0.483 | -48.1 | 133.4 | 70.0 | 0.483 | 0.0 | |||||||
PRO | B:269 | B:242 | 56.0 | 0.386 | -85.7 | 149.2 | 56.0 | 0.386 | 0.0 | ||||||||||||||
6pxv | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | PRO | A:242 | A:242 | 56.0 | 0.386 | -77.5 | 156.9 | 56.0 | 0.386 | 0.0 | |||||||
PRO | B:242 | C:242 | 56.0 | 0.386 | -77.5 | 156.9 | 56.0 | 0.386 | 0.0 | ||||||||||||||
6pxw | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | PRO | A:242 | A:242 | 55.0 | 0.379 | -77.5 | 156.9 | 55.0 | 0.379 | 0.0 | |||||||
PRO | B:242 | B:242 | 56.0 | 0.386 | -77.5 | 156.9 | 56.0 | 0.386 | 0.0 | ||||||||||||||
6ce7 | 1 | P06213 | 99.89 | 0.0 |
EM |
2018-03-14 | PRO | A:242 | B:242 | 62.0 | 0.428 | -87.4 | 168.1 | 62.0 | 0.428 | 0.0 | |||||||
PRO | B:242 | A:242 | 56.0 | 0.386 | -62.8 | 144.2 | 56.0 | 0.386 | 0.0 | ||||||||||||||
6ce9 | 1 | P06213 | 98.6 | 0.0 |
EM |
2018-03-14 | PRO | A:242 | A:242 | 62.0 | 0.428 | -73.0 | 155.3 | 62.0 | 0.428 | 0.0 | |||||||
PRO | B:242 | B:242 | 63.0 | 0.434 | -73.0 | 155.3 | 63.0 | 0.434 | 0.0 | ||||||||||||||
6ceb | 1 | P06213 | 98.6 | 0.0 |
EM |
2018-03-14 | PRO | A:242 | A:242 | 59.0 | 0.407 | -71.4 | 156.2 | 59.0 | 0.407 | 0.0 | |||||||
PRO | B:242 | B:242 | 54.0 | 0.372 | -71.2 | 155.1 | 54.0 | 0.372 | 0.0 | ||||||||||||||
6hn4 | 1 | P06213,P03069 | 95.7 | 0.0 |
EM |
2018-11-21 | PRO | A:242 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
PRO | B:242 | F:242 | 60.0 | 0.414 | -79.1 | 154.4 | 60.0 | 0.414 | 0.0 | ||||||||||||||
6hn5 | 3 | P06213,P03069 | 95.7 | 0.0 |
EM |
2018-11-21 | PRO | C:242 | E:242 | 76.0 | 0.524 | -65.6 | 149.0 | 76.0 | 0.524 | 0.0 | |||||||
PRO | D:242 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
4zxb | 5 | P06213 | 95.48 | 0.0 |
X-RAY |
2016-02-24 | PRO | E:242 | E:242 | 54.0 | 0.372 | -78.2 | 153.6 | 5.0 | 0.034 | 0.338 |
B:P01837:0.09 A:U5LP42:0.269 |
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6sof | 1 | P06213 | 100.0 | 0.0 |
EM |
2019-11-13 | PRO | A:242 | A:242 | 84.0 | 0.579 | -66.7 | 168.2 | 84.0 | 0.579 | 0.0 | |||||||
PRO | C:242 | C:242 | 56.0 | 0.386 | -73.7 | 147.4 | 56.0 | 0.386 | 0.0 | ||||||||||||||
7qid | 1 | P06213 | 100.0 | 0.0 |
EM |
2022-02-02 | PRO | A:242 | A:242 | 102.0 | 0.703 | -66.0 | 164.9 | 102.0 | 0.703 | 0.0 | |||||||
PRO | C:242 | C:242 | 44.0 | 0.303 | -73.7 | 156.7 | 44.0 | 0.303 | 0.0 | ||||||||||||||
5kqv | 5 | P06213 | 99.83 | 0.0 |
X-RAY |
2017-07-19 | PRO | E:242 | E:242 | 52.0 | 0.359 | -79.1 | 161.8 | 52.0 | 0.359 | 0.0 | |||||||
PRO | F:242 | F:242 | 52.0 | 0.359 | -79.6 | 162.0 | 52.0 | 0.359 | 0.0 | ||||||||||||||
2hr7 | 1 | P06213 | 99.59 | 0.0 |
X-RAY |
2006-08-15 | PRO | A:242 | A:242 | 55.0 | 0.379 | -87.3 | 167.3 | 55.0 | 0.379 | 0.0 |
FUC GOL HOH |
9.131 5.596 5.138 |
O N O |
C6 O1 O |
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PRO | B:242 | B:242 | 52.0 | 0.359 | -70.7 | 152.5 | 52.0 | 0.359 | 0.0 |
HOH |
5.046 |
O |
O |
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4oga | 5 | P06213 | 99.68 | 0.0 |
X-RAY |
2014-08-27 | PRO | E:242 | E:242 | 53.0 | 0.366 | -85.6 | 159.7 | 5.0 | 0.034 | 0.332 |
C:None:0.255 D:None:0.076 |
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4xss | 2 | P06213 | 99.68 | 0.0 |
X-RAY |
2015-06-10 | PRO | B:242 | E:242 | 53.0 | 0.366 | -83.8 | 165.1 | 53.0 | 0.366 | 0.0 | |||||||
4xst | 1 | P06213 | 99.68 | 0.0 |
X-RAY |
2015-06-10 | PRO | A:242 | E:242 | 53.0 | 0.366 | -85.4 | 162.4 | 53.0 | 0.366 | 0.0 |
NAG |
9.954 |
O |
O7 |
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5j3h | 4 | P06213 | 99.68 | 0.0 |
X-RAY |
2016-06-15 | PRO | D:242 | E:242 | 53.0 | 0.366 | -82.0 | 155.1 | 4.0 | 0.028 | 0.338 |
B:None:0.262 C:None:0.097 |
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6vep | 5 | P06213 | 99.68 | 0.0 |
X-RAY |
2020-06-03 | PRO | E:242 | E:242 | 56.0 | 0.386 | -79.0 | 155.3 | 6.0 | 0.041 | 0.345 |
D:None:0.09 C:None:0.262 |
HOH |
9.666 |
CD |
O |
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PRO | K:242 | K:242 | 57.0 | 0.393 | -79.2 | 156.3 | NA | NA | NA | ||||||||||||||
PRO | Q:242 | Q:242 | 57.0 | 0.393 | -80.9 | 155.8 | NA | NA | NA | ||||||||||||||
PRO | W:242 | W:242 | 56.0 | 0.386 | -79.7 | 156.6 | NA | NA | NA | ||||||||||||||
6veq | 3 | P06213 | 99.68 | 0.0 |
X-RAY |
2020-06-03 | PRO | C:242 | E:242 | 59.0 | 0.407 | -77.7 | 160.2 | 3.0 | 0.021 | 0.386 |
E:None:0.29 F:None:0.138 |
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PRO | G:242 | K:242 | 58.0 | 0.4 | -78.0 | 159.8 | NA | NA | NA | ||||||||||||||
7kd6 | 4 | P06213 | 99.68 | 0.0 |
X-RAY |
2021-10-13 | PRO | D:242 | E:242 | 57.0 | 0.393 | -82.4 | 151.8 | 7.0 | 0.048 | 0.345 |
B:None:0.262 C:None:0.09 |
HOH |
8.361 |
O |
O |
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PRO | I:242 | K:242 | 58.0 | 0.4 | -81.9 | 153.3 | NA | NA | NA | ||||||||||||||
PRO | N:242 | Q:242 | 54.0 | 0.372 | -84.4 | 155.6 | NA | NA | NA | ||||||||||||||
PRO | S:242 | W:242 | 57.0 | 0.393 | -81.9 | 153.2 | NA | NA | NA | ||||||||||||||
3w11 | 5 | P06213 | 99.68 | 0.0 |
X-RAY |
2013-01-09 | PRO | E:242 | E:242 | 56.0 | 0.386 | -80.5 | 156.6 | 4.0 | 0.028 | 0.358 |
D:None:0.097 C:None:0.276 |
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3w12 | 1 | P06213 | 99.68 | 0.0 |
X-RAY |
2013-01-09 | PRO | A:242 | E:242 | 65.0 | 0.448 | -80.9 | 152.5 | 3.0 | 0.021 | 0.427 |
B:None:0.317 C:None:0.145 |
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3w13 | 1 | P06213 | 99.68 | 0.0 |
X-RAY |
2013-01-09 | PRO | A:242 | E:242 | 65.0 | 0.448 | -84.6 | 151.3 | 3.0 | 0.021 | 0.427 |
B:None:0.317 C:None:0.152 |
AlphaFold DB
Entity | Residue | Monomer | View | ||||||||||
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ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
af-p06213-f1 | 1 | P06213 | 100.0 | 0.0 | PRO | A:269 | A:269 | 55.0 | 0.379 | -66.5 | 145.0 |