Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr19 | 7184522 | . | A | C | CCDS12176.1:NM_000208.2:c.779cTg>cGg_NP_000199.2:p.260L>R | Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 7bw7 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | LEU | A:233 | A:233 | 40.0 | 0.235 | -158.8 | 107.8 | 40.0 | 0.235 | 0.0 | |||||||
| LEU | B:233 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7bw8 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | LEU | A:233 | A:233 | 34.0 | 0.2 | S | -149.0 | 94.3 | 34.0 | 0.2 | 0.0 | ||||||
| LEU | B:233 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7bwa | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | LEU | A:233 | A:233 | 16.0 | 0.094 | E | -153.3 | 124.4 | 16.0 | 0.094 | 0.0 | ||||||
| LEU | B:233 | C:233 | 17.0 | 0.1 | E | -153.3 | 124.4 | NA | NA | NA | |||||||||||||
| 7pg0 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | LEU | A:260 | A:233 | 12.0 | 0.071 | E | -167.3 | 136.5 | 12.0 | 0.071 | 0.0 | ||||||
| LEU | B:260 | B:233 | 9.0 | 0.053 | B | -163.7 | 140.3 | 9.0 | 0.053 | 0.0 | |||||||||||||
| 7pg2 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | LEU | A:260 | A:233 | 27.0 | 0.159 | E | -155.7 | 140.7 | 27.0 | 0.159 | 0.0 | ||||||
| LEU | B:260 | B:233 | 13.0 | 0.076 | B | -165.6 | 136.6 | 13.0 | 0.076 | 0.0 | |||||||||||||
| 7pg3 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | LEU | A:260 | A:233 | 13.0 | 0.076 | E | -169.0 | 142.2 | 13.0 | 0.076 | 0.0 | ||||||
| LEU | B:260 | B:233 | 30.0 | 0.176 | E | -165.4 | 132.5 | 30.0 | 0.176 | 0.0 | |||||||||||||
| 7pg4 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | LEU | A:260 | A:233 | 25.0 | 0.147 | B | -149.2 | 116.9 | 25.0 | 0.147 | 0.0 | ||||||
| LEU | B:260 | B:233 | 3.0 | 0.018 | -130.7 | 110.3 | 3.0 | 0.018 | 0.0 | ||||||||||||||
| 6pxv | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | LEU | A:233 | A:233 | 5.0 | 0.029 | E | -157.1 | 107.8 | 5.0 | 0.029 | 0.0 | ||||||
| LEU | B:233 | C:233 | 6.0 | 0.035 | E | -157.1 | 107.9 | 6.0 | 0.035 | 0.0 | |||||||||||||
| 6pxw | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | LEU | A:233 | A:233 | 5.0 | 0.029 | E | -157.2 | 107.8 | 5.0 | 0.029 | 0.0 | ||||||
| LEU | B:233 | B:233 | 6.0 | 0.035 | E | -157.1 | 107.9 | 6.0 | 0.035 | 0.0 | |||||||||||||
| 6ce7 | 1 | P06213 | 99.89 | 0.0 |
EM |
2018-03-14 | LEU | A:233 | B:233 | 21.0 | 0.124 | -159.7 | 128.1 | 21.0 | 0.124 | 0.0 | |||||||
| LEU | B:233 | A:233 | 8.0 | 0.047 | -145.2 | 117.7 | 8.0 | 0.047 | 0.0 | ||||||||||||||
| 6ce9 | 1 | P06213 | 98.6 | 0.0 |
EM |
2018-03-14 | LEU | A:233 | A:233 | 15.0 | 0.088 | E | -147.9 | 92.6 | 15.0 | 0.088 | 0.0 |
NAG FUC |
8.725 7.020 |
CD1 CD1 |
O6 O3 |
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| LEU | B:233 | B:233 | 15.0 | 0.088 | E | -147.9 | 92.6 | 15.0 | 0.088 | 0.0 |
NAG FUC |
8.722 6.887 |
CD1 CD1 |
O6 O3 |
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| 6ceb | 1 | P06213 | 98.6 | 0.0 |
EM |
2018-03-14 | LEU | A:233 | A:233 | 10.0 | 0.059 | -149.7 | 93.9 | 10.0 | 0.059 | 0.0 |
NAG FUC |
8.792 7.022 |
CD1 CD1 |
O6 O3 |
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| LEU | B:233 | B:233 | 10.0 | 0.059 | E | -153.8 | 100.6 | 10.0 | 0.059 | 0.0 |
NAG FUC |
8.315 6.292 |
CD1 CD1 |
O6 O3 |
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| 6hn4 | 1 | P06213,P03069 | 95.7 | 0.0 |
EM |
2018-11-21 | LEU | A:233 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| LEU | B:233 | F:233 | 20.0 | 0.118 | E | -154.4 | 131.0 | 20.0 | 0.118 | 0.0 | |||||||||||||
| 6hn5 | 3 | P06213,P03069 | 95.7 | 0.0 |
EM |
2018-11-21 | LEU | C:233 | E:233 | 24.0 | 0.141 | -150.1 | 124.3 | 24.0 | 0.141 | 0.0 |
NAG |
8.114 |
CD1 |
O6 |
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| LEU | D:233 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 4zxb | 5 | P06213 | 95.48 | 0.0 |
X-RAY |
2016-02-24 | LEU | E:233 | E:233 | 17.0 | 0.1 | E | -153.5 | 132.1 | 7.0 | 0.041 | 0.059 |
A:U5LP42:0.059 |
NAG FUC |
8.582 6.474 |
CD1 CD1 |
O6 O3 |
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| 6sof | 1 | P06213 | 100.0 | 0.0 |
EM |
2019-11-13 | LEU | A:233 | A:233 | 45.0 | 0.265 | E | -161.4 | 113.4 | 45.0 | 0.265 | 0.0 | ||||||
| LEU | C:233 | C:233 | 34.0 | 0.2 | B | -165.7 | 123.2 | 34.0 | 0.2 | 0.0 | |||||||||||||
| 7qid | 1 | P06213 | 100.0 | 0.0 |
EM |
2022-02-02 | LEU | A:233 | A:233 | 48.0 | 0.282 | E | -139.3 | 117.6 | 48.0 | 0.282 | 0.0 | ||||||
| LEU | C:233 | C:233 | 5.0 | 0.029 | E | -161.2 | 124.9 | 5.0 | 0.029 | 0.0 | |||||||||||||
| 5kqv | 5 | P06213 | 99.83 | 0.0 |
X-RAY |
2017-07-19 | LEU | E:233 | E:233 | 21.0 | 0.124 | E | -150.8 | 129.2 | 21.0 | 0.124 | 0.0 | ||||||
| LEU | F:233 | F:233 | 23.0 | 0.135 | E | -150.6 | 128.4 | 23.0 | 0.135 | 0.0 | |||||||||||||
| 2hr7 | 1 | P06213 | 99.59 | 0.0 |
X-RAY |
2006-08-15 | LEU | A:233 | A:233 | 24.0 | 0.141 | E | -151.7 | 131.8 | 24.0 | 0.141 | 0.0 |
NAG FUC GOL GOL HOH |
7.798 3.765 8.129 6.838 3.582 |
CD1 CD1 CD2 N CD1 |
O6 O4 O2 C1 O |
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| LEU | B:233 | B:233 | 29.0 | 0.171 | E | -146.0 | 122.9 | 29.0 | 0.171 | 0.0 |
NAG FUC GOL HOH |
8.700 6.875 6.365 3.095 |
CD1 CD1 O O |
O5 C4 C2 O |
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| 4oga | 5 | P06213 | 99.68 | 0.0 |
X-RAY |
2014-08-27 | LEU | E:233 | E:233 | 17.0 | 0.1 | E | -152.8 | 131.2 | 8.0 | 0.047 | 0.053 |
C:None:0.053 |
NAG FUC |
8.515 5.829 |
CD1 CD1 |
O5 C6 |
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| 4xss | 2 | P06213 | 99.68 | 0.0 |
X-RAY |
2015-06-10 | LEU | B:233 | E:233 | 27.0 | 0.159 | -139.5 | 114.3 | 27.0 | 0.159 | 0.0 |
NAG FUC |
8.565 7.134 |
CD1 C |
O7 C4 |
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| 4xst | 1 | P06213 | 99.68 | 0.0 |
X-RAY |
2015-06-10 | LEU | A:233 | E:233 | 22.0 | 0.129 | E | -150.9 | 129.0 | 22.0 | 0.129 | 0.0 |
NAG FUC |
7.872 5.563 |
CD1 CD1 |
O7 O4 |
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| 5j3h | 4 | P06213 | 99.68 | 0.0 |
X-RAY |
2016-06-15 | LEU | D:233 | E:233 | 14.0 | 0.082 | E | -151.0 | 129.7 | 6.0 | 0.035 | 0.047 |
B:None:0.047 |
NAG FUC |
8.588 6.559 |
CD1 CD1 |
O6 C6 |
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| 6vep | 5 | P06213 | 99.68 | 0.0 |
X-RAY |
2020-06-03 | LEU | E:233 | E:233 | 16.0 | 0.094 | E | -159.9 | 132.4 | 6.0 | 0.035 | 0.059 |
C:None:0.059 |
NAG FUC HOH |
8.494 6.567 4.010 |
CD1 CD1 CA |
O6 C4 O |
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| LEU | K:233 | K:233 | 15.0 | 0.088 | E | -160.2 | 134.2 | NA | NA | NA | |||||||||||||
| LEU | Q:233 | Q:233 | 15.0 | 0.088 | E | -160.4 | 132.8 | NA | NA | NA | |||||||||||||
| LEU | W:233 | W:233 | 17.0 | 0.1 | E | -160.3 | 132.1 | NA | NA | NA | |||||||||||||
| 6veq | 3 | P06213 | 99.68 | 0.0 |
X-RAY |
2020-06-03 | LEU | C:233 | E:233 | 11.0 | 0.065 | E | -152.9 | 125.3 | 5.0 | 0.029 | 0.036 |
E:None:0.035 |
NAG FUC |
8.857 6.267 |
CD1 CD1 |
O6 C6 |
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| LEU | G:233 | K:233 | 13.0 | 0.076 | E | -152.6 | 125.1 | NA | NA | NA | |||||||||||||
| 7kd6 | 4 | P06213 | 99.68 | 0.0 |
X-RAY |
2021-10-13 | LEU | D:233 | E:233 | 18.0 | 0.106 | E | -148.4 | 131.4 | 5.0 | 0.029 | 0.077 |
B:None:0.076 |
NAG FUC HOH |
8.722 6.454 6.697 |
CD1 CD1 CD1 |
O6 C4 O |
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| LEU | I:233 | K:233 | 17.0 | 0.1 | E | -154.0 | 133.8 | NA | NA | NA | |||||||||||||
| LEU | N:233 | Q:233 | 14.0 | 0.082 | E | -150.7 | 132.0 | NA | NA | NA | |||||||||||||
| LEU | S:233 | W:233 | 15.0 | 0.088 | E | -152.6 | 133.7 | NA | NA | NA | |||||||||||||
| 3w11 | 5 | P06213 | 99.68 | 0.0 |
X-RAY |
2013-01-09 | LEU | E:233 | E:233 | 14.0 | 0.082 | E | -154.9 | 133.4 | 5.0 | 0.029 | 0.053 |
C:None:0.053 |
NAG NAG |
8.028 8.217 |
CG C |
O6 C8 |
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| 3w12 | 1 | P06213 | 99.68 | 0.0 |
X-RAY |
2013-01-09 | LEU | A:233 | E:233 | 17.0 | 0.1 | E | -154.7 | 133.7 | 3.0 | 0.018 | 0.082 |
B:None:0.082 |
NAG NAG |
8.243 7.372 |
CG C |
O6 C8 |
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| 3w13 | 1 | P06213 | 99.68 | 0.0 |
X-RAY |
2013-01-09 | LEU | A:233 | E:233 | 16.0 | 0.094 | E | -156.5 | 133.9 | 4.0 | 0.024 | 0.07 |
B:None:0.071 |
NAG NAG |
8.134 7.354 |
CG C |
O6 C8 |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p06213-f1 | 1 | P06213 | 100.0 | 0.0 | LEU | A:260 | A:260 | 19.0 | 0.112 | E | -144.8 | 125.1 | |