Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr19 7184594 . T A CCDS12176.1:NM_000208.2:c.707cAc>cTc_NP_000199.2:p.236H>L Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7bw7 1 P06213 100.0 0.0 EM
 2021-04-14 HIS A:209 A:209 58.0 0.297 -50.9 110.4 58.0 0.297 0.0
HIS B:209 NA:NA DO NA DO DO DO NA NA NA
7bw8 1 P06213 100.0 0.0 EM
 2021-04-14 HIS A:209 A:209 26.0 0.133 -61.4 123.8 26.0 0.133 0.0
HIS B:209 NA:NA DO NA DO DO DO NA NA NA
7bwa 1 P06213 100.0 0.0 EM
 2021-04-14 HIS A:209 A:209 46.0 0.236 -57.5 135.5 46.0 0.236 0.0
HIS B:209 C:209 47.0 0.241 -57.4 135.5 NA NA NA
7pg0 1 P06213 99.13 0.0 EM
 2022-02-02 HIS A:236 A:209 54.0 0.277 -66.5 141.2 54.0 0.277 0.0
HIS B:236 B:209 107.0 0.549 -69.8 179.0 107.0 0.549 0.0
7pg2 1 P06213 99.13 0.0 EM
 2022-02-02 HIS A:236 A:209 51.0 0.262 -56.7 161.3 51.0 0.262 0.0
HIS B:236 B:209 48.0 0.246 -67.2 171.4 48.0 0.246 0.0
7pg3 1 P06213 99.13 0.0 EM
 2022-02-02 HIS A:236 A:209 50.0 0.256 -58.5 150.6 50.0 0.256 0.0
HIS B:236 B:209 62.0 0.318 -71.3 179.9 62.0 0.318 0.0
7pg4 1 P06213 99.13 0.0 EM
 2022-02-02 HIS A:236 A:209 53.0 0.272 -59.2 150.6 53.0 0.272 0.0
HIS B:236 B:209 37.0 0.19 S -94.6 -58.5 37.0 0.19 0.0
6pxv 1 P06213 98.6 0.0 EM
 2019-09-04 HIS A:209 A:209 45.0 0.231 -64.5 158.6 45.0 0.231 0.0
HIS B:209 C:209 43.0 0.221 -64.6 158.6 43.0 0.221 0.0
6pxw 1 P06213 98.6 0.0 EM
 2019-09-04 HIS A:209 A:209 45.0 0.231 -64.5 158.6 45.0 0.231 0.0
HIS B:209 B:209 44.0 0.226 -64.5 158.6 44.0 0.226 0.0
6ce7 1 P06213 99.89 0.0 EM
 2018-03-14 HIS A:209 B:209 50.0 0.256 -72.3 168.2 50.0 0.256 0.0
HIS B:209 A:209 38.0 0.195 -76.3 156.6 38.0 0.195 0.0
6ce9 1 P06213 98.6 0.0 EM
 2018-03-14 HIS A:209 A:209 38.0 0.195 -71.8 156.3 38.0 0.195 0.0
HIS B:209 B:209 38.0 0.195 -71.8 156.3 38.0 0.195 0.0
6ceb 1 P06213 98.6 0.0 EM
 2018-03-14 HIS A:209 A:209 40.0 0.205 -71.4 157.4 40.0 0.205 0.0
HIS B:209 B:209 37.0 0.19 -73.6 155.2 37.0 0.19 0.0 NAG
 9.939
 O
 O6
6hn4 1 P06213,P03069 95.7 0.0 EM
 2018-11-21 HIS A:209 NA:NA DO NA DO DO DO NA NA NA
HIS B:209 F:209 40.0 0.205 -61.4 152.1 40.0 0.205 0.0 NAG
 9.777
 O
 O6
6hn5 3 P06213,P03069 95.7 0.0 EM
 2018-11-21 HIS C:209 E:209 47.0 0.241 -60.7 140.5 47.0 0.241 0.0
HIS D:209 NA:NA DO NA DO DO DO NA NA NA
4zxb 5 P06213 95.48 0.0 X-RAY
 2016-02-24 HIS E:209 E:209 38.0 0.195 -62.2 151.5 29.0 0.149 0.046 A:U5LP42:0.046
6sof 1 P06213 100.0 0.0 EM
 2019-11-13 HIS A:209 A:209 48.0 0.246 -61.8 151.9 48.0 0.246 0.0
HIS C:209 C:209 70.0 0.359 -57.0 156.1 70.0 0.359 0.0
7qid 1 P06213 100.0 0.0 EM
 2022-02-02 HIS A:209 A:209 102.0 0.523 -115.6 -177.5 102.0 0.523 0.0
HIS C:209 C:209 49.0 0.251 -57.9 154.9 49.0 0.251 0.0
5kqv 5 P06213 99.83 0.0 X-RAY
 2017-07-19 HIS E:209 E:209 40.0 0.205 -62.6 150.5 40.0 0.205 0.0
HIS F:209 F:209 42.0 0.215 -62.7 150.6 42.0 0.215 0.0
2hr7 1 P06213 99.59 0.0 X-RAY
 2006-08-15 HIS A:209 A:209 45.0 0.231 -59.5 152.8 45.0 0.231 0.0 NAG
GOL
GOL
GOL
HOH
 9.962
6.062
6.098
8.117
2.946
 O
N
CE1
CB
NE2
 C6
O1
O3
O3
O
HIS B:209 B:209 38.0 0.195 -60.6 149.6 38.0 0.195 0.0 NAG
SO4
GOL
HOH
 9.284
6.314
7.722
2.927
 O
NE2
CB
N
 O6
O1
O3
O
4oga 5 P06213 99.68 0.0 X-RAY
 2014-08-27 HIS E:209 E:209 45.0 0.231 -61.6 149.3 44.0 0.226 0.005 C:None:0.005
4xss 2 P06213 99.68 0.0 X-RAY
 2015-06-10 HIS B:209 E:209 38.0 0.195 -60.7 151.2 38.0 0.195 0.0
4xst 1 P06213 99.68 0.0 X-RAY
 2015-06-10 HIS A:209 E:209 43.0 0.221 -60.2 149.3 43.0 0.221 0.0 NAG
 9.218
 O
 O6
5j3h 4 P06213 99.68 0.0 X-RAY
 2016-06-15 HIS D:209 E:209 39.0 0.2 -59.0 149.8 33.0 0.169 0.031 B:None:0.031
6vep 5 P06213 99.68 0.0 X-RAY
 2020-06-03 HIS E:209 E:209 43.0 0.221 -61.4 149.7 43.0 0.221 0.0 NAG
HOH
 9.316
9.792
 O
N
 O6
O
HIS K:209 K:209 42.0 0.215 -62.2 149.8 NA NA NA
HIS Q:209 Q:209 42.0 0.215 -61.3 149.5 NA NA NA
HIS W:209 W:209 43.0 0.221 -61.9 149.1 NA NA NA
6veq 3 P06213 99.68 0.0 X-RAY
 2020-06-03 HIS C:209 E:209 39.0 0.2 -64.6 154.0 36.0 0.185 0.015 E:None:0.015
 NAG
 9.404
 O
 O6
HIS G:209 K:209 40.0 0.205 -63.4 153.9 NA NA NA
7kd6 4 P06213 99.68 0.0 X-RAY
 2021-10-13 HIS D:209 E:209 41.0 0.21 -52.9 145.8 41.0 0.21 0.0 SO4
NAG
HOH
 4.075
9.487
2.864
 NE2
O
N
 O2
O6
O
HIS I:209 K:209 40.0 0.205 -55.6 148.4 NA NA NA
HIS N:209 Q:209 40.0 0.205 -57.0 145.9 NA NA NA
HIS S:209 W:209 42.0 0.215 -58.0 148.1 NA NA NA
3w11 5 P06213 99.68 0.0 X-RAY
 2013-01-09 HIS E:209 E:209 51.0 0.262 -59.1 147.3 51.0 0.262 0.0
3w12 1 P06213 99.68 0.0 X-RAY
 2013-01-09 HIS A:209 E:209 50.0 0.256 -62.4 146.1 50.0 0.256 0.0
3w13 1 P06213 99.68 0.0 X-RAY
 2013-01-09 HIS A:209 E:209 54.0 0.277 -60.9 146.6 54.0 0.277 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p06213-f1 1 P06213 100.0 0.0 HIS A:236 A:236 37.0 0.19 -58.1 151.5