Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr19 | 7267376 | . | G | A | CCDS12176.1:NM_000208.2:c.632aCt>aTt_NP_000199.2:p.211T>I | Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 7bw7 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | THR | A:184 | A:184 | 4.0 | 0.029 | -150.2 | 165.4 | 4.0 | 0.029 | 0.0 | |||||||
| THR | B:184 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7bw8 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | THR | A:184 | A:184 | 22.0 | 0.157 | -142.0 | -175.8 | 22.0 | 0.157 | 0.0 | |||||||
| THR | B:184 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7bwa | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | THR | A:184 | A:184 | 1.0 | 0.007 | S | -106.9 | 161.7 | 1.0 | 0.007 | 0.0 | ||||||
| THR | B:184 | C:184 | 1.0 | 0.007 | S | -106.9 | 161.7 | NA | NA | NA | |||||||||||||
| 7pg0 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | THR | A:211 | A:184 | 4.0 | 0.029 | S | -115.7 | 154.2 | 4.0 | 0.029 | 0.0 | ||||||
| THR | B:211 | B:184 | 0.0 | 0.0 | E | -161.3 | 169.8 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 7pg2 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | THR | A:211 | A:184 | 13.0 | 0.093 | B | -156.9 | 167.2 | 13.0 | 0.093 | 0.0 | ||||||
| THR | B:211 | B:184 | 0.0 | 0.0 | E | -155.2 | 165.3 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 7pg3 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | THR | A:211 | A:184 | 9.0 | 0.064 | E | -151.5 | 147.4 | 9.0 | 0.064 | 0.0 | ||||||
| THR | B:211 | B:184 | 0.0 | 0.0 | E | -124.9 | -178.0 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 7pg4 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | THR | A:211 | A:184 | 4.0 | 0.029 | S | -95.8 | -110.9 | 4.0 | 0.029 | 0.0 | ||||||
| THR | B:211 | B:184 | 0.0 | 0.0 | E | -142.5 | 157.5 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6pxv | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | THR | A:184 | A:184 | 0.0 | 0.0 | S | -119.3 | -169.0 | 0.0 | 0.0 | 0.0 | ||||||
| THR | B:184 | C:184 | 0.0 | 0.0 | S | -119.3 | -169.0 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6pxw | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | THR | A:184 | A:184 | 0.0 | 0.0 | S | -119.3 | -169.0 | 0.0 | 0.0 | 0.0 | ||||||
| THR | B:184 | B:184 | 0.0 | 0.0 | S | -119.3 | -169.0 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6ce7 | 1 | P06213 | 99.89 | 0.0 |
EM |
2018-03-14 | THR | A:184 | B:184 | 13.0 | 0.093 | S | -123.9 | -167.6 | 13.0 | 0.093 | 0.0 | ||||||
| THR | B:184 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6ce9 | 1 | P06213 | 98.6 | 0.0 |
EM |
2018-03-14 | THR | A:184 | A:184 | 2.0 | 0.014 | S | -103.4 | -175.1 | 2.0 | 0.014 | 0.0 | ||||||
| THR | B:184 | B:184 | 2.0 | 0.014 | S | -103.4 | -175.0 | 2.0 | 0.014 | 0.0 | |||||||||||||
| 6ceb | 1 | P06213 | 98.6 | 0.0 |
EM |
2018-03-14 | THR | A:184 | A:184 | 1.0 | 0.007 | S | -114.2 | -173.1 | 1.0 | 0.007 | 0.0 | ||||||
| THR | B:184 | B:184 | 0.0 | 0.0 | S | -114.0 | -171.6 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6hn4 | 1 | P06213,P03069 | 95.7 | 0.0 |
EM |
2018-11-21 | THR | A:184 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| THR | B:184 | F:184 | 0.0 | 0.0 | S | -146.1 | 178.5 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6hn5 | 3 | P06213,P03069 | 95.7 | 0.0 |
EM |
2018-11-21 | THR | C:184 | E:184 | 2.0 | 0.014 | S | -122.6 | -167.1 | 2.0 | 0.014 | 0.0 | ||||||
| THR | D:184 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 4zxb | 5 | P06213 | 95.48 | 0.0 |
X-RAY |
2016-02-24 | THR | E:184 | E:184 | 0.0 | 0.0 | E | -146.0 | 178.1 | 0.0 | 0.0 | 0.0 | ||||||
| 6sof | 1 | P06213 | 100.0 | 0.0 |
EM |
2019-11-13 | THR | A:184 | A:184 | 0.0 | 0.0 | S | -120.4 | -176.0 | 0.0 | 0.0 | 0.0 | ||||||
| THR | C:184 | C:184 | 2.0 | 0.014 | S | -135.8 | -168.0 | 2.0 | 0.014 | 0.0 | |||||||||||||
| 7qid | 1 | P06213 | 100.0 | 0.0 |
EM |
2022-02-02 | THR | A:184 | A:184 | 2.0 | 0.014 | S | -166.8 | 178.4 | 2.0 | 0.014 | 0.0 | ||||||
| THR | C:184 | C:184 | 3.0 | 0.021 | E | -139.4 | -167.1 | 3.0 | 0.021 | 0.0 | |||||||||||||
| 5kqv | 5 | P06213 | 99.83 | 0.0 |
X-RAY |
2017-07-19 | THR | E:184 | E:184 | 1.0 | 0.007 | E | -146.4 | 178.7 | 1.0 | 0.007 | 0.0 | ||||||
| THR | F:184 | F:184 | 1.0 | 0.007 | E | -146.0 | 178.2 | 1.0 | 0.007 | 0.0 | |||||||||||||
| 2hr7 | 1 | P06213 | 99.59 | 0.0 |
X-RAY |
2006-08-15 | THR | A:184 | A:184 | 0.0 | 0.0 | E | -146.8 | 176.8 | 0.0 | 0.0 | 0.0 |
SO4 GOL GOL HOH |
7.743 9.017 7.232 2.911 |
O CG2 CB OG1 |
O2 O1 C3 O |
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| THR | B:184 | B:184 | 0.0 | 0.0 | S | -144.4 | 178.7 | 0.0 | 0.0 | 0.0 |
HOH |
3.541 |
CB |
O |
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| 4oga | 5 | P06213 | 99.68 | 0.0 |
X-RAY |
2014-08-27 | THR | E:184 | E:184 | 1.0 | 0.007 | E | -147.3 | 176.7 | 1.0 | 0.007 | 0.0 | ||||||
| 4xss | 2 | P06213 | 99.68 | 0.0 |
X-RAY |
2015-06-10 | THR | B:184 | E:184 | 0.0 | 0.0 | E | -146.9 | 176.4 | 0.0 | 0.0 | 0.0 | ||||||
| 4xst | 1 | P06213 | 99.68 | 0.0 |
X-RAY |
2015-06-10 | THR | A:184 | E:184 | 0.0 | 0.0 | E | -146.4 | 176.6 | 0.0 | 0.0 | 0.0 | ||||||
| 5j3h | 4 | P06213 | 99.68 | 0.0 |
X-RAY |
2016-06-15 | THR | D:184 | E:184 | 0.0 | 0.0 | E | -146.4 | 178.8 | 0.0 | 0.0 | 0.0 | ||||||
| 6vep | 5 | P06213 | 99.68 | 0.0 |
X-RAY |
2020-06-03 | THR | E:184 | E:184 | 0.0 | 0.0 | S | -142.9 | -177.9 | 0.0 | 0.0 | 0.0 | ||||||
| THR | K:184 | K:184 | 0.0 | 0.0 | S | -144.7 | 177.4 | NA | NA | NA | |||||||||||||
| THR | Q:184 | Q:184 | 0.0 | 0.0 | S | -145.8 | 178.5 | NA | NA | NA | |||||||||||||
| THR | W:184 | W:184 | 0.0 | 0.0 | E | -154.8 | 170.0 | NA | NA | NA | |||||||||||||
| 6veq | 3 | P06213 | 99.68 | 0.0 |
X-RAY |
2020-06-03 | THR | C:184 | E:184 | 0.0 | 0.0 | E | -120.3 | -169.2 | 0.0 | 0.0 | 0.0 | ||||||
| THR | G:184 | K:184 | 0.0 | 0.0 | E | -119.8 | -169.4 | NA | NA | NA | |||||||||||||
| 7kd6 | 4 | P06213 | 99.68 | 0.0 |
X-RAY |
2021-10-13 | THR | D:184 | E:184 | 0.0 | 0.0 | E | -141.9 | 177.2 | 0.0 | 0.0 | 0.0 |
HOH |
9.024 |
CG2 |
O |
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| THR | I:184 | K:184 | 1.0 | 0.007 | E | -138.0 | 180.0 | NA | NA | NA | |||||||||||||
| THR | N:184 | Q:184 | 0.0 | 0.0 | E | -140.1 | 178.7 | NA | NA | NA | |||||||||||||
| THR | S:184 | W:184 | 1.0 | 0.007 | S | -136.3 | -177.4 | NA | NA | NA | |||||||||||||
| 3w11 | 5 | P06213 | 99.68 | 0.0 |
X-RAY |
2013-01-09 | THR | E:184 | E:184 | 0.0 | 0.0 | E | -146.5 | 174.7 | 0.0 | 0.0 | 0.0 | ||||||
| 3w12 | 1 | P06213 | 99.68 | 0.0 |
X-RAY |
2013-01-09 | THR | A:184 | E:184 | 0.0 | 0.0 | E | -132.8 | 173.7 | 0.0 | 0.0 | 0.0 | ||||||
| 3w13 | 1 | P06213 | 99.68 | 0.0 |
X-RAY |
2013-01-09 | THR | A:184 | E:184 | 0.0 | 0.0 | E | -131.8 | 173.3 | 0.0 | 0.0 | 0.0 | ||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p06213-f1 | 1 | P06213 | 100.0 | 0.0 | THR | A:211 | A:211 | 0.0 | 0.0 | E | -154.2 | 170.6 | |