Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr19 7267529 . C A CCDS12176.1:NM_000208.2:c.479tGg>tTg_NP_000199.2:p.160W>L Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7bw7 1 P06213 100.0 0.0 EM
 2021-04-14 TRP A:133 A:133 37.0 0.145 -93.9 -0.7 37.0 0.145 0.0
TRP B:133 NA:NA DO NA DO DO DO NA NA NA
7bw8 1 P06213 100.0 0.0 EM
 2021-04-14 TRP A:133 A:133 37.0 0.145 -101.9 0.7 37.0 0.145 0.0
TRP B:133 NA:NA DO NA DO DO DO NA NA NA
7bwa 1 P06213 100.0 0.0 EM
 2021-04-14 TRP A:133 A:133 66.0 0.259 -132.9 -10.2 66.0 0.259 0.0
TRP B:133 C:133 64.0 0.251 -132.9 -10.2 NA NA NA
7pg0 1 P06213 99.13 0.0 EM
 2022-02-02 TRP A:160 A:133 72.0 0.282 H -52.5 -33.2 72.0 0.282 0.0
TRP B:160 B:133 44.0 0.173 G -86.4 -2.6 44.0 0.173 0.0
7pg2 1 P06213 99.13 0.0 EM
 2022-02-02 TRP A:160 A:133 49.0 0.192 H -54.6 -39.0 49.0 0.192 0.0
TRP B:160 B:133 36.0 0.141 -134.2 30.8 36.0 0.141 0.0
7pg3 1 P06213 99.13 0.0 EM
 2022-02-02 TRP A:160 A:133 41.0 0.161 H -44.2 -40.3 41.0 0.161 0.0
TRP B:160 B:133 23.0 0.09 T -94.1 66.4 23.0 0.09 0.0
7pg4 1 P06213 99.13 0.0 EM
 2022-02-02 TRP A:160 A:133 104.0 0.408 H -53.2 -33.4 104.0 0.408 0.0
TRP B:160 B:133 27.0 0.106 H -65.1 -19.5 27.0 0.106 0.0
6pxv 1 P06213 98.6 0.0 EM
 2019-09-04 TRP A:133 A:133 23.0 0.09 G -75.2 -22.4 23.0 0.09 0.0
TRP B:133 C:133 23.0 0.09 G -75.2 -22.5 23.0 0.09 0.0
6pxw 1 P06213 98.6 0.0 EM
 2019-09-04 TRP A:133 A:133 23.0 0.09 G -75.1 -22.5 23.0 0.09 0.0
TRP B:133 B:133 23.0 0.09 G -75.2 -22.5 23.0 0.09 0.0
6ce7 1 P06213 99.89 0.0 EM
 2018-03-14 TRP A:133 B:133 8.0 0.031 G -77.6 -19.0 8.0 0.031 0.0
TRP B:133 A:133 85.0 0.333 S -99.5 -38.9 85.0 0.333 0.0
6ce9 1 P06213 98.6 0.0 EM
 2018-03-14 TRP A:133 A:133 31.0 0.122 G -72.2 -25.0 31.0 0.122 0.0 NAG
 5.544
 O
 C8
TRP B:133 B:133 32.0 0.125 G -72.2 -25.1 32.0 0.125 0.0 NAG
 5.520
 O
 C8
6ceb 1 P06213 98.6 0.0 EM
 2018-03-14 TRP A:133 A:133 33.0 0.129 S -80.1 -21.3 33.0 0.129 0.0 NAG
 5.297
 O
 C8
TRP B:133 B:133 34.0 0.133 S -77.0 -22.7 34.0 0.133 0.0 NAG
 5.438
 O
 C8
6hn4 1 P06213,P03069 95.7 0.0 EM
 2018-11-21 TRP A:133 NA:NA DO NA DO DO DO NA NA NA
TRP B:133 F:133 22.0 0.086 G -68.0 -21.4 22.0 0.086 0.0 NAG
 5.924
 O
 O7
6hn5 3 P06213,P03069 95.7 0.0 EM
 2018-11-21 TRP C:133 E:133 21.0 0.082 G -63.7 -21.9 21.0 0.082 0.0 NAG
 5.902
 O
 O7
TRP D:133 NA:NA DO NA DO DO DO NA NA NA
4zxb 5 P06213 95.48 0.0 X-RAY
 2016-02-24 TRP E:133 E:133 19.0 0.075 G -68.2 -20.9 19.0 0.075 0.0 NAG
 5.169
 O
 C8
6sof 1 P06213 100.0 0.0 EM
 2019-11-13 TRP A:133 A:133 40.0 0.157 -89.7 -8.8 40.0 0.157 0.0
TRP C:133 C:133 54.0 0.212 S -122.3 -31.9 54.0 0.212 0.0
7qid 1 P06213 100.0 0.0 EM
 2022-02-02 TRP A:133 A:133 35.0 0.137 -136.2 -22.4 35.0 0.137 0.0
TRP C:133 C:133 95.0 0.373 S -99.0 -58.2 95.0 0.373 0.0
5kqv 5 P06213 99.83 0.0 X-RAY
 2017-07-19 TRP E:133 E:133 21.0 0.082 G -69.3 -21.1 21.0 0.082 0.0
TRP F:133 F:133 21.0 0.082 G -68.7 -22.0 21.0 0.082 0.0
2hr7 1 P06213 99.59 0.0 X-RAY
 2006-08-15 TRP A:133 A:133 24.0 0.094 G -68.1 -22.6 24.0 0.094 0.0 NAG
GOL
HOH
 5.206
6.793
2.701
 O
O
NE1
 C8
O2
O
TRP B:133 B:133 20.0 0.078 G -71.3 -20.2 20.0 0.078 0.0 NAG
HOH
 5.204
2.873
 O
NE1
 C8
O
4oga 5 P06213 99.68 0.0 X-RAY
 2014-08-27 TRP E:133 E:133 23.0 0.09 G -69.2 -21.4 23.0 0.09 0.0 NAG
 5.184
 O
 C8
4xss 2 P06213 99.68 0.0 X-RAY
 2015-06-10 TRP B:133 E:133 19.0 0.075 G -68.1 -21.4 19.0 0.075 0.0 NAG
 5.420
 O
 C8
4xst 1 P06213 99.68 0.0 X-RAY
 2015-06-10 TRP A:133 E:133 20.0 0.078 G -68.8 -21.4 20.0 0.078 0.0 NAG
 5.327
 O
 C8
5j3h 4 P06213 99.68 0.0 X-RAY
 2016-06-15 TRP D:133 E:133 19.0 0.075 G -67.1 -22.4 19.0 0.075 0.0 NAG
 5.156
 O
 C8
6vep 5 P06213 99.68 0.0 X-RAY
 2020-06-03 TRP E:133 E:133 17.0 0.067 G -64.0 -22.4 17.0 0.067 0.0 NAG
HOH
 5.649
7.187
 O
O
 C8
O
TRP K:133 K:133 19.0 0.075 G -63.4 -22.7 NA NA NA
TRP Q:133 Q:133 19.0 0.075 G -65.0 -21.4 NA NA NA
TRP W:133 W:133 17.0 0.067 G -62.9 -22.6 NA NA NA
6veq 3 P06213 99.68 0.0 X-RAY
 2020-06-03 TRP C:133 E:133 18.0 0.071 G -67.3 -16.7 18.0 0.071 0.0 NAG
 5.413
 O
 O7
TRP G:133 K:133 23.0 0.09 G -67.9 -16.5 NA NA NA
7kd6 4 P06213 99.68 0.0 X-RAY
 2021-10-13 TRP D:133 E:133 18.0 0.071 G -69.3 -20.7 18.0 0.071 0.0 NAG
HOH
 5.059
7.634
 O
O
 C8
O
TRP I:133 K:133 18.0 0.071 G -66.3 -21.0 NA NA NA
TRP N:133 Q:133 17.0 0.067 G -66.9 -22.6 NA NA NA
TRP S:133 W:133 18.0 0.071 G -66.8 -21.5 NA NA NA
3w11 5 P06213 99.68 0.0 X-RAY
 2013-01-09 TRP E:133 E:133 23.0 0.09 G -72.1 -15.7 23.0 0.09 0.0 NAG
 5.185
 O
 C8
3w12 1 P06213 99.68 0.0 X-RAY
 2013-01-09 TRP A:133 E:133 28.0 0.11 G -71.1 -25.2 28.0 0.11 0.0 NAG
 5.184
 O
 C8
3w13 1 P06213 99.68 0.0 X-RAY
 2013-01-09 TRP A:133 E:133 23.0 0.09 G -70.5 -27.5 23.0 0.09 0.0 NAG
 5.114
 O
 C8

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p06213-f1 1 P06213 100.0 0.0 TRP A:160 A:160 21.0 0.082 G -61.3 -24.7