Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr19 7267566 . T A CCDS12176.1:NM_000208.2:c.442Aag>Tag_NP_000199.2:p.148K>* Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7bw7 1 P06213 100.0 0.0 EM
 2021-04-14 LYS A:121 A:121 73.0 0.365 E 55.9 60.7 37.0 0.185 0.18 C:P01308+A6XGL2:0.04
B:P06213:0.145
LYS B:121 NA:NA DO NA DO DO DO NA NA NA
7bw8 1 P06213 100.0 0.0 EM
 2021-04-14 LYS A:121 A:121 86.0 0.43 S 57.1 47.6 75.0 0.375 0.055 C:P01308+A6XGL2:0.015
B:P06213:0.035
LYS B:121 NA:NA DO NA DO DO DO NA NA NA
7bwa 1 P06213 100.0 0.0 EM
 2021-04-14 LYS A:121 A:121 83.0 0.415 E 63.7 37.1 83.0 0.415 0.0
LYS B:121 C:121 83.0 0.415 E 63.8 37.1 NA NA NA
7pg0 1 P06213 99.13 0.0 EM
 2022-02-02 LYS A:148 A:121 66.0 0.33 58.9 51.1 52.0 0.26 0.07 B:P06213:0.07
LYS B:148 B:121 66.0 0.33 S 52.8 44.9 31.0 0.155 0.175 F:P01308:0.175
7pg2 1 P06213 99.13 0.0 EM
 2022-02-02 LYS A:148 A:121 89.0 0.445 S 59.2 59.0 47.0 0.235 0.21 D:P01308:0.13
B:P06213:0.135
LYS B:148 B:121 101.0 0.505 S 57.5 29.3 57.0 0.285 0.22 F:P01308:0.22
7pg3 1 P06213 99.13 0.0 EM
 2022-02-02 LYS A:148 A:121 111.0 0.555 S 57.2 42.6 64.0 0.32 0.235 D:P01308:0.11
B:P06213:0.125
LYS B:148 B:121 95.0 0.475 S 53.5 44.7 70.0 0.35 0.125 F:P01308:0.125
7pg4 1 P06213 99.13 0.0 EM
 2022-02-02 LYS A:148 A:121 79.0 0.395 S 64.6 45.3 63.0 0.315 0.08 B:P06213:0.08
LYS B:148 B:121 100.0 0.5 S 57.2 61.6 100.0 0.5 0.0
6pxv 1 P06213 98.6 0.0 EM
 2019-09-04 LYS A:121 A:121 90.0 0.45 E 61.0 44.5 51.0 0.255 0.195 C:A6XGL2:0.01
B:P06213:0.185
LYS B:121 C:121 89.0 0.445 E 61.0 44.6 52.0 0.26 0.185 A:P06213:0.185
D:A6XGL2:0.005
6pxw 1 P06213 98.6 0.0 EM
 2019-09-04 LYS A:121 A:121 89.0 0.445 E 61.0 44.6 52.0 0.26 0.185 C:A6XGL2:0.005
B:P06213:0.18
LYS B:121 B:121 86.0 0.43 E 61.0 44.6 51.0 0.255 0.175 A:P06213:0.175
6ce7 1 P06213 99.89 0.0 EM
 2018-03-14 LYS A:121 B:121 94.0 0.47 S 63.2 26.4 94.0 0.47 0.0
LYS B:121 A:121 81.0 0.405 S 66.6 16.9 58.0 0.29 0.115 E:P06213:0.055
A:P06213:0.06
6ce9 1 P06213 98.6 0.0 EM
 2018-03-14 LYS A:121 A:121 96.0 0.48 E 62.9 43.5 39.0 0.195 0.285 G:P01318:0.06
H:P06213:0.1
B:P06213:0.215
LYS B:121 B:121 98.0 0.49 E 62.9 43.5 43.0 0.215 0.275 A:P06213:0.2
C:P06213:0.11
E:P01318:0.05
6ceb 1 P06213 98.6 0.0 EM
 2018-03-14 LYS A:121 A:121 95.0 0.475 E 62.4 41.2 40.0 0.2 0.275 G:P01318:0.03
H:P06213:0.105
B:P06213:0.19
LYS B:121 B:121 95.0 0.475 E 62.2 42.5 40.0 0.2 0.275 E:P01318:0.045
A:P06213:0.205
C:P06213:0.105
6hn4 1 P06213,P03069 95.7 0.0 EM
 2018-11-21 LYS A:121 NA:NA DO NA DO DO DO NA NA NA
LYS B:121 F:121 93.0 0.465 62.0 49.0 92.0 0.46 0.005 A:P06213+P03069:0.005
6hn5 3 P06213,P03069 95.7 0.0 EM
 2018-11-21 LYS C:121 E:121 86.0 0.43 E 55.0 32.1 38.0 0.19 0.24 B:P01308:0.07
D:P06213+P03069:0.22
LYS D:121 NA:NA DO NA DO DO DO NA NA NA
4zxb 5 P06213 95.48 0.0 X-RAY
 2016-02-24 LYS E:121 E:121 94.0 0.47 61.6 48.4 68.0 0.34 0.13 E:P06213:0.13
6sof 1 P06213 100.0 0.0 EM
 2019-11-13 LYS A:121 A:121 82.0 0.41 60.9 55.5 53.0 0.265 0.145 H:P01308:0.055
C:P06213:0.085
LYS C:121 C:121 101.0 0.505 S 49.2 55.1 76.0 0.38 0.125 A:P06213:0.125
7qid 1 P06213 100.0 0.0 EM
 2022-02-02 LYS A:121 A:121 87.0 0.435 S 55.9 41.3 46.0 0.23 0.205 C:P06213:0.2
F:P01308:0.005
LYS C:121 C:121 75.0 0.375 57.9 65.4 75.0 0.375 0.0
5kqv 5 P06213 99.83 0.0 X-RAY
 2017-07-19 LYS E:121 E:121 88.0 0.44 60.6 48.0 42.0 0.21 0.23 B:P01317:0.05
I:None:0.145
F:P06213:0.1
LYS F:121 F:121 84.0 0.42 60.9 47.0 40.0 0.2 0.22 E:P06213:0.09
H:P01317:0.02
C:None:0.16
2hr7 1 P06213 99.59 0.0 X-RAY
 2006-08-15 LYS A:121 A:121 87.0 0.435 E 63.8 48.1 78.0 0.39 0.045 B:P06213:0.045
 P33
GOL
GOL
GOL
SO4
HOH
 9.747
3.448
5.448
7.634
6.013
2.690
 CB
CD
C
O
CE
O
 O1
O3
O2
O1
O2
O
LYS B:121 B:121 77.0 0.385 61.3 46.6 56.0 0.28 0.105 A:P06213:0.105
 NAG
P33
HOH
 5.807
8.615
2.747
 NZ
CD
O
 C8
C8
O
4oga 5 P06213 99.68 0.0 X-RAY
 2014-08-27 LYS E:121 E:121 83.0 0.415 E 60.6 48.2 69.0 0.345 0.07 B:P01308:0.02
F:P06213:0.055
4xss 2 P06213 99.68 0.0 X-RAY
 2015-06-10 LYS B:121 E:121 85.0 0.425 E 60.4 48.4 61.0 0.305 0.12 C:None:0.1
A:P05019:0.04
4xst 1 P06213 99.68 0.0 X-RAY
 2015-06-10 LYS A:121 E:121 85.0 0.425 E 59.2 51.8 78.0 0.39 0.035 B:P15127:0.035
5j3h 4 P06213 99.68 0.0 X-RAY
 2016-06-15 LYS D:121 E:121 80.0 0.4 61.8 45.9 65.0 0.325 0.075 A:None:0.075
6vep 5 P06213 99.68 0.0 X-RAY
 2020-06-03 LYS E:121 E:121 84.0 0.42 S 62.4 40.4 50.0 0.25 0.17 F:P06213:0.105
B:P01308:0.1
LYS K:121 K:121 83.0 0.415 S 62.3 40.3 NA NA NA
LYS Q:121 Q:121 85.0 0.425 63.1 41.0 NA NA NA
LYS W:121 W:121 84.0 0.42 62.0 40.8 NA NA NA
6veq 3 P06213 99.68 0.0 X-RAY
 2020-06-03 LYS C:121 E:121 90.0 0.45 S 59.0 39.6 63.0 0.315 0.135 D:P06213:0.135
 SO4
 7.669
 NZ
 O2
LYS G:121 K:121 87.0 0.435 S 59.6 40.5 NA NA NA
7kd6 4 P06213 99.68 0.0 X-RAY
 2021-10-13 LYS D:121 E:121 85.0 0.425 S 57.1 45.1 50.0 0.25 0.175 E:None:0.105
A:None:0.11
 HOH
 9.832
 CD
 O
LYS I:121 K:121 83.0 0.415 S 56.6 45.7 NA NA NA
LYS N:121 Q:121 86.0 0.43 S 57.7 43.3 NA NA NA
LYS S:121 W:121 95.0 0.475 E 56.0 43.0 NA NA NA
3w11 5 P06213 99.68 0.0 X-RAY
 2013-01-09 LYS E:121 E:121 94.0 0.47 E 58.8 48.4 74.0 0.37 0.1 B:P01308:0.02
F:P06213:0.085
3w12 1 P06213 99.68 0.0 X-RAY
 2013-01-09 LYS A:121 E:121 92.0 0.46 S 60.0 44.0 73.0 0.365 0.095 F:P06213:0.085
E:P01308:0.015
3w13 1 P06213 99.68 0.0 X-RAY
 2013-01-09 LYS A:121 E:121 89.0 0.445 E 58.6 41.6 69.0 0.345 0.1 E:P01308:0.01
F:P06213:0.09

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p06213-f1 1 P06213 100.0 0.0 LYS A:148 A:148 65.0 0.325 60.8 41.6