Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr2 204735377 . T A CCDS2362.1:NM_005214.4:c.178Tat>Aat_NP_005205.2:p.60Y>N Homo sapiens cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant 1, mRNA.
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3osk 1 P16410 98.44 1e-90 X-RAY
 2010-12-08 TYR A:25 A:25 2.0 0.009 E -111.3 158.9 2.0 0.009 0.0 GOL
HOH
 5.706
3.902
 CD1
O
 O2
O
TYR B:25 B:25 4.0 0.017 E -117.6 147.1 4.0 0.017 0.0 HOH
 4.704
 C
 O
5xj3 3 P16410 100.0 1e-90 X-RAY
 2018-04-25 TYR C:26 C:60 5.0 0.022 E -139.1 148.1 NA NA NA
TYR F:26 F:60 4.0 0.017 E -133.8 152.2 NA NA NA
TYR I:26 I:60 4.0 0.017 E -135.4 145.6 NA NA NA
TYR L:26 L:60 3.0 0.013 E -135.0 152.1 NA NA NA
1i85 2 P16410 100.0 2e-90 X-RAY
 2001-04-04 TYR C:25 C:25 6.0 0.026 E -119.5 170.1 6.0 0.026 0.0
TYR D:25 D:25 14.0 0.061 E -121.5 158.8 14.0 0.061 0.0
5ggv 3 P16410 100.0 2e-90 X-RAY
 2016-11-09 TYR C:25 Y:25 14.0 0.061 E -143.5 146.5 14.0 0.061 0.0 HOH
 4.012
 CA
 O
7elx 3 P16410 100.0 2e-90 X-RAY
 2021-06-30 TYR E:25 c:25 5.0 0.022 E -128.7 147.7 NA NA NA
TYR F:25 C:25 6.0 0.026 E -127.8 151.2 6.0 0.026 0.0 HOH
 7.990
 CA
 O
1i8l 2 P16410 99.21 9e-90 X-RAY
 2001-04-04 TYR C:25 C:25 5.0 0.022 E -115.2 158.0 5.0 0.022 0.0
TYR D:25 D:25 17.0 0.074 E -131.8 158.3 NA NA NA
2x44 1 P16410 97.66 1e-89 X-RAY
 2010-04-07 TYR A:26 D:25 18.0 0.078 E -152.8 158.2 18.0 0.078 0.0 HOH
 8.032
 CB
 O
1ah1 1 P16410 100.0 1e-89 NMR
 1998-04-15 TYR A:24 A:23 12.0 0.052 -140.1 176.4 12.0 0.052 0.0
6rqm 2 P16410 100.0 1e-89 X-RAY
 2020-07-08 TYR B:24 A:25 17.0 0.074 E -126.5 139.7 17.0 0.074 0.0
3bx7 1 P16410 100.0 5e-89 X-RAY
 2009-01-20 TYR A:23 C:25 7.0 0.03 -149.8 -169.1 7.0 0.03 0.0 HOH
 3.055
 OH
 O
6xy2 1 P16410 100.0 6e-88 X-RAY
 2020-12-09 TYR A:23 A:25 14.0 0.061 E -127.3 151.9 14.0 0.061 0.0
6rpj 1 P16410 100.0 2e-85 X-RAY
 2020-07-08 TYR A:24 A:25 6.0 0.026 E -140.3 139.6 NA NA NA
TYR C:24 C:25 9.0 0.039 E -139.0 139.2 NA NA NA
TYR E:24 E:25 12.0 0.052 E -139.0 135.4 NA NA NA
TYR G:24 G:25 12.0 0.052 E -140.7 137.9 12.0 0.052 0.0 NAG
 9.398
 CA
 C8
7dv4 1 P16410 100.0 1e-83 X-RAY
 2022-01-12 TYR A:25 A:25 0.0 0.0 E -147.5 154.9 0.0 0.0 0.0
TYR C:25 C:25 5.0 0.022 E -142.9 167.0 NA NA NA
TYR E:25 E:25 9.0 0.039 E -136.2 165.8 NA NA NA
TYR G:25 G:25 36.0 0.157 -122.9 360.0 36.0 0.157 0.0
5tru 3 P16410 100.0 2e-83 X-RAY
 2017-05-10 TYR E:24 c:25 28.0 0.122 E -135.7 152.3 NA NA NA
TYR F:24 C:25 19.0 0.083 E -134.4 150.3 19.0 0.083 0.0
6rp8 3 P16410 100.0 2e-83 X-RAY
 2020-07-08 TYR E:24 C:25 19.0 0.083 E -151.0 134.7 NA NA NA
TYR F:24 c:25 9.0 0.039 E -150.0 142.3 9.0 0.039 0.0
4kkn 1 Q28090 80.65 3e-70 X-RAY
 2013-06-12 TYR A:30 A:58 16.0 0.07 E -128.9 147.5 16.0 0.07 0.0 HOH
 3.696
 CA
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p16410-f1 1 P16410 100.0 2e-168 TYR A:60 A:60 4.0 0.017 E -120.9 137.7