Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr2 29006821 . G A CCDS33169.1:NM_002709.2:c.569aGa>aAa_NP_002700.1:p.190R>K Homo sapiens protein phosphatase 1 catalytic subunit beta (PPP1CB), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1s70 1 P62140 100.0 0.0 X-RAY
 2004-06-22 ARG A:193 A:191 52.0 0.231 S -161.9 134.4 52.0 0.231 0.0 HOH
 2.911
 O
 O
1fjm 1 P08129 88.79 0.0 X-RAY
 1996-06-20 ARG A:191 A:191 45.0 0.2 S -126.9 151.5 45.0 0.2 0.0 HOH
 2.974
 NH1
 O
ARG B:191 B:191 48.0 0.213 S -123.8 156.1 NA NA NA
4g9j 1 P62136 88.79 0.0 X-RAY
 2012-09-19 ARG A:192 A:191 46.0 0.204 S -103.5 153.5 46.0 0.204 0.0 HOH
 8.480
 N
 O
ARG B:192 B:191 40.0 0.178 S -132.9 147.6 NA NA NA
6g0i 1 P62136 88.79 0.0 X-RAY
 2018-11-21 ARG A:192 A:191 39.0 0.173 S -127.5 152.0 39.0 0.173 0.0 HOH
 2.998
 NH2
 O
6g0j 1 P62136 88.79 0.0 X-RAY
 2018-11-21 ARG A:192 A:191 43.0 0.191 S -121.5 151.0 43.0 0.191 0.0 HOH
 2.898
 NE
 O
3egg 1 P62136 89.26 0.0 X-RAY
 2010-03-23 ARG A:190 A:191 40.0 0.178 S -118.7 151.5 40.0 0.178 0.0 GOL
HOH
 8.864
3.441
 NH2
NH2
 C1
O
ARG B:190 B:191 41.0 0.182 S -120.5 152.4 NA NA NA
3egh 1 P62136 89.26 0.0 X-RAY
 2010-03-23 ARG A:190 A:191 37.0 0.164 S -116.0 154.2 37.0 0.164 0.0 GOL
HOH
 9.975
3.013
 NH2
NH1
 C2
O
ARG B:190 B:191 40.0 0.178 S -116.1 149.8 NA NA NA
3hvq 1 P62136 89.26 0.0 X-RAY
 2010-03-23 ARG A:190 A:191 43.0 0.191 S -123.3 155.5 43.0 0.191 0.0 HOH
 3.139
 N
 O
ARG B:190 B:191 40.0 0.178 S -113.7 153.8 39.0 0.173 0.005 C:O35867:0.004
 HOH
 2.911
 NH1
 O
6ghm 1 P62136 89.26 0.0 X-RAY
 2019-02-27 ARG A:190 A:191 48.0 0.213 S -125.3 153.6 48.0 0.213 0.0 EDO
HOH
 9.297
2.933
 NH2
NE
 O1
O
ARG B:190 B:191 45.0 0.2 S -118.3 155.5 NA NA NA
6dcx 1 P62136 88.79 0.0 X-RAY
 2019-05-15 ARG A:200 A:191 40.0 0.178 S -117.3 153.0 40.0 0.178 0.0
ARG B:200 B:191 40.0 0.178 S -118.2 151.0 NA NA NA
6zk6 1 P62136 88.48 0.0 X-RAY
 2020-11-18 ARG A:192 A:191 42.0 0.187 S -119.6 153.6 42.0 0.187 0.0 HOH
 2.894
 NE
 O
5zqv 1 P62137 89.23 0.0 X-RAY
 2019-03-13 ARG A:191 A:191 42.0 0.187 S -97.3 152.1 42.0 0.187 0.0
ARG B:191 B:191 45.0 0.2 S -109.8 150.5 NA NA NA
ARG C:191 C:191 33.0 0.147 S -81.1 153.2 33.0 0.147 0.0
ARG D:191 D:191 37.0 0.164 S -116.4 154.6 NA NA NA
4v0u 2 P63087 89.06 0.0 X-RAY
 2015-03-25 ARG D:191 D:191 48.0 0.213 S -117.9 154.4 NA NA NA
ARG F:191 F:191 47.0 0.209 S -118.0 154.3 NA NA NA
ARG H:191 H:191 48.0 0.213 S -117.9 154.3 NA NA NA
ARG J:191 J:191 49.0 0.218 S -118.0 154.3 49.0 0.218 0.0
ARG N:191 N:191 47.0 0.209 S -117.8 154.2 NA NA NA
1it6 1 P36873 89.06 0.0 X-RAY
 2002-05-22 ARG A:191 A:191 49.0 0.218 S -116.3 154.2 49.0 0.218 0.0 HOH
 3.121
 NH1
 O
ARG B:191 B:191 50.0 0.222 S -113.2 148.8 NA NA NA
1jk7 1 P36873 89.06 0.0 X-RAY
 2001-08-15 ARG A:191 A:191 48.0 0.213 S -125.9 151.5 48.0 0.213 0.0 HOH
 2.869
 NE
 O
2bcd 1 P36873 89.06 0.0 X-RAY
 2006-01-17 ARG A:191 A:191 48.0 0.213 S -113.9 151.7 48.0 0.213 0.0 HOH
 3.492
 NH1
 O
2bdx 1 P36873 89.06 0.0 X-RAY
 2006-01-17 ARG A:191 A:191 50.0 0.222 S -119.0 145.6 50.0 0.222 0.0 HOH
 3.199
 NH1
 O
4ut2 1 P36873 89.06 0.0 X-RAY
 2015-07-22 ARG A:191 A:191 29.0 0.129 S -118.9 150.0 29.0 0.129 0.0 HOH
 3.032
 N
 O
ARG B:191 B:191 30.0 0.133 S -118.8 149.1 NA NA NA
4ut3 1 P36873 89.06 0.0 X-RAY
 2015-07-22 ARG A:191 A:191 33.0 0.147 S -118.1 150.2 33.0 0.147 0.0 HOH
 2.986
 NE
 O
4ut3 2 P36873 89.06 0.0 X-RAY
 2015-07-22 ARG B:191 B:191 31.0 0.138 S -118.6 152.1 NA NA NA
2o8a 1 P63088 89.52 0.0 X-RAY
 2007-07-17 ARG A:197 A:191 47.0 0.209 S -122.6 153.9 47.0 0.209 0.0 HOH
 2.772
 NE
 O
ARG C:197 B:191 48.0 0.213 S -117.4 151.1 NA NA NA
2o8g 1 P63088 89.52 0.0 X-RAY
 2007-07-17 ARG A:197 A:191 45.0 0.2 S -128.5 153.4 45.0 0.2 0.0 HOH
 2.880
 NE
 O
ARG C:197 B:191 45.0 0.2 S -121.1 152.3 NA NA NA
6zej 1 P62136,Q4VY12 86.42 0.0 X-RAY
 2020-09-30 ARG A:190 D:190 34.0 0.151 S -117.3 154.0 34.0 0.151 0.0 HOH
 2.218
 H
 O
ARG B:190 A:190 31.0 0.138 S -117.2 154.7 NA NA NA
ARG C:190 F:190 30.0 0.133 S -117.1 155.0 NA NA NA
ARG D:190 I:190 31.0 0.138 S -112.7 155.3 NA NA NA
ARG E:190 L:190 31.0 0.138 S -114.5 153.1 NA NA NA
ARG F:190 O:190 33.0 0.147 S -118.7 151.7 NA NA NA
3v4y 1 P62136 92.05 0.0 X-RAY
 2012-10-31 ARG A:190 A:191 52.0 0.231 S -122.1 151.2 45.0 0.2 0.031 B:Q12972:0.031
 GOL
HOH
 7.469
2.052
 HH22
H
 H12
O
ARG C:190 C:191 54.0 0.24 S -127.5 152.5 NA NA NA
ARG E:190 E:191 50.0 0.222 S -126.3 149.6 NA NA NA
ARG G:190 G:191 45.0 0.2 S -128.8 146.2 NA NA NA
6zeh 1 P62136,Q13813 92.28 0.0 X-RAY
 2020-09-30 ARG A:190 A:191 46.0 0.204 S -117.2 155.3 31.0 0.138 0.066 B:Q4VY12:0.067
 HOH
 2.214
 HH12
 O
ARG C:190 B:191 40.0 0.178 S -121.0 153.2 NA NA NA
6obn 1 P62136 92.0 0.0 X-RAY
 2019-09-18 ARG A:196 A:191 52.0 0.231 S -123.1 148.9 52.0 0.231 0.0 CL
MPD
HOH
 2.947
7.549
3.037
 NE
O
NH1
 CL
C1
O
ARG B:196 B:191 53.0 0.236 S -125.5 148.9 NA NA NA
6obp 1 P62136 92.0 0.0 X-RAY
 2019-09-18 ARG A:196 A:191 50.0 0.222 S -116.0 152.2 50.0 0.222 0.0 HOH
 2.568
 NH1
 O
3n5u 1 P62136 92.0 0.0 X-RAY
 2010-08-11 ARG A:191 A:191 40.0 0.178 S -111.1 153.2 40.0 0.178 0.0
ARG B:191 B:191 42.0 0.187 S -110.9 153.5 42.0 0.187 0.0
6zeg 1 P62136,Q9UQB8 92.28 0.0 X-RAY
 2020-09-30 ARG A:190 A:191 42.0 0.187 S -111.6 153.3 29.0 0.129 0.058 B:Q4VY12:0.058
 EDO
HOH
 1.755
2.183
 HE
HH12
 HO1
O
ARG C:190 B:191 39.0 0.173 S -119.5 151.5 NA NA NA
6zei 1 P62136,Q9UQB8 92.28 0.0 X-RAY
 2020-09-30 ARG A:190 A:191 45.0 0.2 S -117.6 153.3 31.0 0.138 0.062 B:Q4VY12:0.062
 HOH
 2.026
 H
 O
ARG C:190 B:191 40.0 0.178 S -123.1 150.7 NA NA NA
3e7a 1 P62136 92.57 0.0 X-RAY
 2008-11-04 ARG A:190 A:191 40.0 0.178 S -122.8 152.2 40.0 0.178 0.0 GOL
HOH
 8.515
2.905
 NH2
NE
 O2
O
ARG B:190 B:191 44.0 0.196 S -124.5 152.3 NA NA NA
3e7b 1 P62136 92.57 0.0 X-RAY
 2008-11-04 ARG A:190 A:191 44.0 0.196 S -125.4 154.1 44.0 0.196 0.0 GOL
AZI
HOH
 8.937
3.096
2.844
 NH2
N
O
 O2
N3
O
ARG B:190 B:191 42.0 0.187 S -123.8 153.1 NA NA NA
4mov 1 P62136 92.57 0.0 X-RAY
 2014-03-26 ARG A:190 A:191 41.0 0.182 S -123.5 152.3 41.0 0.182 0.0 HOH
 2.885
 O
 O
ARG B:190 B:191 41.0 0.182 S -122.4 153.5 NA NA NA
4moy 1 P62136 92.57 0.0 X-RAY
 2014-03-26 ARG A:190 A:191 44.0 0.196 S -115.4 148.9 44.0 0.196 0.0 GOL
HOH
 9.261
2.758
 NH2
N
 O2
O
4mp0 1 P62136 92.57 0.0 X-RAY
 2014-03-26 ARG A:190 A:191 42.0 0.187 S -120.0 149.5 42.0 0.187 0.0 GOL
HOH
 9.239
2.853
 NH2
O
 O3
O
ARG B:190 C:191 45.0 0.2 S -120.4 149.3 NA NA NA
4xpn 1 P62136 92.57 0.0 X-RAY
 2015-07-01 ARG A:190 A:191 41.0 0.182 S -124.1 153.4 41.0 0.182 0.0 GOL
HOH
 9.303
3.155
 NH2
N
 O2
O
ARG C:190 C:191 43.0 0.191 S -123.9 152.3 NA NA NA
5ioh 1 P62136 92.57 0.0 X-RAY
 2016-10-05 ARG A:190 A:191 46.0 0.204 S -116.3 151.4 46.0 0.204 0.0 HOH
 2.853
 NE
 O
ARG C:190 C:191 51.0 0.227 S -115.5 151.4 NA NA NA
6alz 1 P62136 92.57 0.0 X-RAY
 2017-11-29 ARG A:190 A:191 43.0 0.191 S -127.5 148.9 43.0 0.191 0.0 DMS
HOH
 9.020
3.026
 NH2
NH1
 C2
O
ARG B:190 B:191 42.0 0.187 S -128.1 149.0 NA NA NA
6czo 1 P62136 92.57 0.0 X-RAY
 2019-01-23 ARG A:190 A:191 41.0 0.182 S -115.2 150.7 41.0 0.182 0.0 HOH
 3.078
 NH1
 O
ARG C:190 C:191 48.0 0.213 S -107.8 153.5 NA NA NA
6dno 1 P62136 92.57 0.0 X-RAY
 2019-01-23 ARG A:190 A:191 47.0 0.209 S -122.2 152.2 47.0 0.209 0.0 HOH
 2.853
 N
 O
6zee 1 P62136 92.57 0.0 X-RAY
 2020-09-30 ARG A:190 P:191 50.0 0.222 S -119.9 152.8 34.0 0.151 0.071 G:Q4VY12:0.071
 EDO
HOH
 8.663
2.091
 HG3
H
 HO1
O
ARG B:190 Q:191 50.0 0.222 S -123.6 151.1 34.0 0.151 0.071 L:Q4VY12:0.071
 HOH
 1.994
 H
 O
ARG C:190 B:191 41.0 0.182 S -117.9 151.1 29.0 0.129 0.053 I:Q4VY12:0.053
 HOH
 2.024
 H
 O
ARG D:190 A:191 47.0 0.209 S -112.8 152.6 31.0 0.138 0.071 J:Q4VY12:0.071
 16P
EDO
EDO
HOH
 1.672
3.098
8.469
2.360
 HH21
HH21
HH22
HH12
 H62
HO1
HO2
O
ARG E:190 I:191 42.0 0.187 S -114.5 153.9 30.0 0.133 0.054 K:Q4VY12:0.053
 HOH
 2.045
 HH12
 O
ARG F:190 K:191 48.0 0.213 S -114.8 154.1 34.0 0.151 0.062 H:Q4VY12:0.062
 EDO
GOL
HOH
 7.702
1.749
2.126
 HH22
HE
HH12
 HO2
H32
O
6zef 1 P62136 92.57 0.0 X-RAY
 2020-09-30 ARG A:190 A:191 39.0 0.173 S -118.4 156.8 38.0 0.169 0.004 C:Q4VY12:0.004
 EDO
EDO
CL
HOH
 7.816
7.641
2.217
2.226
 HH22
HH22
HE
HH12
 HO2
H22
CL
O
ARG B:190 B:191 42.0 0.187 S -117.9 155.7 NA NA NA
5inb 1 P36873 92.57 0.0 X-RAY
 2016-10-05 ARG A:188 A:191 43.0 0.191 S -120.4 153.7 43.0 0.191 0.0 GOL
HOH
 9.311
2.971
 NH2
O
 O3
O
5j28 1 P36873 92.57 0.0 X-RAY
 2016-10-05 ARG A:188 A:191 40.0 0.178 S -122.7 151.6 40.0 0.178 0.0 HOH
 2.918
 NH1
 O
ARG B:188 B:191 44.0 0.196 S -118.3 154.6 NA NA NA
6obr 1 P62136 92.23 0.0 X-RAY
 2019-09-18 ARG A:190 A:191 41.0 0.182 S -128.2 151.6 41.0 0.182 0.0 HOH
 2.729
 O
 O
ARG B:190 B:191 40.0 0.178 S -129.1 151.7 NA NA NA
6obq 1 P62136 92.23 0.0 X-RAY
 2019-09-18 ARG A:190 A:191 49.0 0.218 S -128.2 150.1 49.0 0.218 0.0 HOH
 2.828
 O
 O
ARG B:190 B:191 40.0 0.178 S -127.9 148.9 NA NA NA
6obs 1 P62136 92.23 0.0 X-RAY
 2019-09-18 ARG A:190 A:191 47.0 0.209 S -128.1 150.5 47.0 0.209 0.0 HOH
 2.964
 NE
 O
ARG B:190 B:191 48.0 0.213 S -127.7 149.9 NA NA NA
6obu 1 P62136 92.23 0.0 X-RAY
 2019-09-18 ARG A:190 A:191 48.0 0.213 S -126.5 150.0 48.0 0.213 0.0 GOL
HOH
 9.074
2.974
 NH2
NE
 C1
O
ARG B:190 B:191 41.0 0.182 S -126.6 149.1 NA NA NA
5zt0 1 P62137 92.52 0.0 X-RAY
 2019-03-13 ARG A:185 A:191 31.0 0.138 S -127.4 146.7 31.0 0.138 0.0
ARG B:185 B:191 34.0 0.151 S -130.4 147.8 NA NA NA
ARG C:185 C:191 34.0 0.151 S -134.3 146.8 NA NA NA
ARG D:185 D:191 33.0 0.147 S -129.7 146.0 NA NA NA
ARG E:185 E:191 33.0 0.147 S -132.4 148.4 NA NA NA
ARG F:185 F:191 37.0 0.164 S -133.4 144.7 NA NA NA
4v0v 1 P63087 92.52 0.0 X-RAY
 2015-03-25 ARG A:186 A:191 45.0 0.2 S -115.8 152.7 45.0 0.2 0.0 HOH
 2.861
 O
 O
ARG C:186 C:191 49.0 0.218 S -115.1 149.2 NA NA NA
4v0w 1 P63087 92.52 0.0 X-RAY
 2015-03-25 ARG A:186 A:191 44.0 0.196 S -120.9 151.5 44.0 0.196 0.0 HOH
 2.713
 O
 O
ARG C:186 C:191 41.0 0.182 S -121.1 151.6 NA NA NA
4v0x 1 P63087 92.52 0.0 X-RAY
 2015-03-25 ARG A:186 A:191 47.0 0.209 S -122.0 152.1 47.0 0.209 0.0 HOH
 2.181
 HH12
 O
7nzm 2 P62139 92.52 0.0 EM
 2021-09-29 ARG B:185 B:191 61.0 0.271 S -123.6 151.7 61.0 0.271 0.0
1u32 1 P36873 90.78 0.0 X-RAY
 2004-08-17 ARG A:186 A:191 48.0 0.213 S -126.0 153.5 48.0 0.213 0.0 HOH
 2.913
 NE
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p62140-f1 1 P62140 100.0 0.0 ARG A:190 A:190 40.0 0.178 S -116.3 146.6
af-p62136-f1 1 P62136 88.79 0.0 ARG A:191 A:191 40.0 0.178 S -115.6 146.9
af-p36873-f1 1 P36873 89.06 0.0 ARG A:191 A:191 40.0 0.178 S -117.1 147.8