Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr2 29016739 . A C CCDS33169.1:NM_002709.2:c.755gAt>gCt_NP_002700.1:p.252D>A Homo sapiens protein phosphatase 1 catalytic subunit beta (PPP1CB), transcript variant 1, mRNA.
pdb_id: 
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label_seq_id: 
label_comp_id: 
auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1s70 1 P62140 100.0 0.0 X-RAY
 2004-06-22 ASP A:255 A:253 92.0 0.613 B -102.0 23.9 72.0 0.48 0.133 B:Q90624:0.133
 HOH
 2.773
 OD2
 O
1fjm 1 P08129 88.79 0.0 X-RAY
 1996-06-20 ASP A:253 A:253 91.0 0.607 T -91.6 3.1 91.0 0.607 0.0 HOH
 2.802
 N
 O
ASP B:253 B:253 103.0 0.687 T -91.9 3.2 NA NA NA
4g9j 1 P62136 88.79 0.0 X-RAY
 2012-09-19 ASP A:254 A:253 79.0 0.527 T 72.1 -11.4 79.0 0.527 0.0 HOH
 6.617
 OD2
 O
ASP B:254 B:253 79.0 0.527 T -107.7 7.4 NA NA NA
6g0i 1 P62136 88.79 0.0 X-RAY
 2018-11-21 ASP A:254 A:253 98.0 0.653 T -94.0 4.1 98.0 0.653 0.0 HOH
 3.316
 OD2
 O
6g0j 1 P62136 88.79 0.0 X-RAY
 2018-11-21 ASP A:254 A:253 99.0 0.66 T -94.3 6.3 99.0 0.66 0.0 HOH
 2.570
 OD1
 O
3egg 1 P62136 89.26 0.0 X-RAY
 2010-03-23 ASP A:252 A:253 90.0 0.6 T -93.7 2.5 90.0 0.6 0.0 HOH
 2.759
 N
 O
ASP B:252 B:253 97.0 0.647 T -87.5 -4.6 NA NA NA
3egh 1 P62136 89.26 0.0 X-RAY
 2010-03-23 ASP A:252 A:253 97.0 0.647 T -92.7 -3.2 97.0 0.647 0.0 HOH
 2.682
 N
 O
ASP B:252 B:253 97.0 0.647 T -86.7 -5.4 NA NA NA
3hvq 1 P62136 89.26 0.0 X-RAY
 2010-03-23 ASP A:252 A:253 91.0 0.607 T -95.8 4.3 89.0 0.593 0.014 C:O35867:0.013
 HOH
 2.927
 N
 O
ASP B:252 B:253 74.0 0.493 T -96.9 5.5 74.0 0.493 0.0 HOH
 2.805
 N
 O
6ghm 1 P62136 89.26 0.0 X-RAY
 2019-02-27 ASP A:252 A:253 91.0 0.607 T -96.0 13.7 87.0 0.58 0.027 D:Q13625:0.027
 EDO
GOL
HOH
 9.557
3.282
2.782
 N
OD2
N
 O2
O2
O
ASP B:252 B:253 99.0 0.66 T -91.5 6.4 NA NA NA
6dcx 1 P62136 88.79 0.0 X-RAY
 2019-05-15 ASP A:262 A:253 94.0 0.627 T -87.4 -1.2 81.0 0.54 0.087 D:Q8WUF5:0.087
ASP B:262 B:253 93.0 0.62 T -88.1 -1.1 NA NA NA
6zk6 1 P62136 88.48 0.0 X-RAY
 2020-11-18 ASP A:254 A:253 108.0 0.72 T -94.7 6.2 108.0 0.72 0.0 HOH
 2.729
 O
 O
5zqv 1 P62137 89.23 0.0 X-RAY
 2019-03-13 ASP A:253 A:253 71.0 0.473 T -92.9 13.1 71.0 0.473 0.0
ASP B:253 B:253 75.0 0.5 T -89.0 17.3 NA NA NA
ASP C:253 C:253 87.0 0.58 T -95.9 9.7 87.0 0.58 0.0
ASP D:253 D:253 72.0 0.48 T -89.1 12.8 NA NA NA
4v0u 2 P63087 89.06 0.0 X-RAY
 2015-03-25 ASP D:253 D:253 71.0 0.473 T -103.8 10.9 NA NA NA
ASP F:253 F:253 70.0 0.467 T -103.9 11.0 NA NA NA
ASP H:253 H:253 70.0 0.467 T -103.9 11.0 NA NA NA
ASP J:253 J:253 69.0 0.46 T -104.0 10.9 69.0 0.46 0.0
ASP N:253 N:253 71.0 0.473 T -103.9 11.0 NA NA NA
1it6 1 P36873 89.06 0.0 X-RAY
 2002-05-22 ASP A:253 A:253 104.0 0.693 T -100.0 10.9 104.0 0.693 0.0 HOH
 2.898
 N
 O
ASP B:253 B:253 103.0 0.687 T -89.0 0.8 NA NA NA
1jk7 1 P36873 89.06 0.0 X-RAY
 2001-08-15 ASP A:253 A:253 89.0 0.593 T -98.2 8.2 89.0 0.593 0.0 BME
HOH
 8.783
2.663
 OD2
OD2
 C1
O
2bcd 1 P36873 89.06 0.0 X-RAY
 2006-01-17 ASP A:253 A:253 93.0 0.62 T -100.2 8.1 93.0 0.62 0.0 MN
MN
HOH
 9.433
6.424
2.945
 OD2
N
N
 MN
MN
O
2bdx 1 P36873 89.06 0.0 X-RAY
 2006-01-17 ASP A:253 A:253 95.0 0.633 T -88.9 -0.5 95.0 0.633 0.0 HOH
 9.748
 O
 O
4ut2 1 P36873 89.06 0.0 X-RAY
 2015-07-22 ASP A:253 A:253 102.0 0.68 T -91.0 6.7 102.0 0.68 0.0 HOH
 2.785
 O
 O
ASP B:253 B:253 102.0 0.68 T -91.0 6.6 NA NA NA
4ut3 1 P36873 89.06 0.0 X-RAY
 2015-07-22 ASP A:253 A:253 99.0 0.66 T -96.2 5.2 99.0 0.66 0.0 HOH
 2.811
 O
 O
4ut3 2 P36873 89.06 0.0 X-RAY
 2015-07-22 ASP B:253 B:253 99.0 0.66 T -96.2 3.5 NA NA NA
2o8a 1 P63088 89.52 0.0 X-RAY
 2007-07-17 ASP A:259 A:253 116.0 0.773 E -98.6 14.5 116.0 0.773 0.0 HOH
 2.646
 N
 O
ASP C:259 B:253 116.0 0.773 T -97.9 13.0 NA NA NA
2o8g 1 P63088 89.52 0.0 X-RAY
 2007-07-17 ASP A:259 A:253 111.0 0.74 E -102.9 14.1 107.0 0.713 0.027 B:Q9DCL8:0.027
 HOH
 2.760
 N
 O
ASP C:259 B:253 116.0 0.773 T -99.1 12.6 NA NA NA
6zej 1 P62136,Q4VY12 86.42 0.0 X-RAY
 2020-09-30 ASP A:252 D:252 64.0 0.427 T -100.8 15.0 64.0 0.427 0.0 HOH
 4.662
 H
 O
ASP B:252 A:252 68.0 0.453 T -98.9 13.6 NA NA NA
ASP C:252 F:252 84.0 0.56 T -93.3 12.5 NA NA NA
ASP D:252 I:252 64.0 0.427 T -99.2 16.8 NA NA NA
ASP E:252 L:252 63.0 0.42 T -100.5 12.7 NA NA NA
ASP F:252 O:252 61.0 0.407 T -94.1 12.2 NA NA NA
3v4y 1 P62136 92.05 0.0 X-RAY
 2012-10-31 ASP A:252 A:253 81.0 0.54 E -96.0 12.8 81.0 0.54 0.0 HOH
 2.087
 H
 O
ASP C:252 C:253 79.0 0.527 T -94.3 10.0 NA NA NA
ASP E:252 E:253 79.0 0.527 E -96.0 12.3 NA NA NA
ASP G:252 G:253 84.0 0.56 T -96.0 6.3 NA NA NA
6zeh 1 P62136,Q13813 92.28 0.0 X-RAY
 2020-09-30 ASP A:252 A:253 83.0 0.553 T -92.3 5.4 83.0 0.553 0.0 HOH
 2.082
 H
 O
ASP C:252 B:253 96.0 0.64 T -93.6 7.2 NA NA NA
6obn 1 P62136 92.0 0.0 X-RAY
 2019-09-18 ASP A:258 A:253 78.0 0.52 T -93.1 18.2 78.0 0.52 0.0 PO4
 8.291
 O
 O3
ASP B:258 B:253 95.0 0.633 T -93.1 16.1 NA NA NA
6obp 1 P62136 92.0 0.0 X-RAY
 2019-09-18 ASP A:258 A:253 98.0 0.653 T -83.2 12.8 98.0 0.653 0.0
3n5u 1 P62136 92.0 0.0 X-RAY
 2010-08-11 ASP A:253 A:253 94.0 0.627 T -93.2 -8.8 94.0 0.627 0.0
ASP B:253 B:253 94.0 0.627 S -92.6 -10.1 94.0 0.627 0.0
6zeg 1 P62136,Q9UQB8 92.28 0.0 X-RAY
 2020-09-30 ASP A:252 A:253 79.0 0.527 T -90.4 2.2 79.0 0.527 0.0 HOH
 2.036
 H
 O
ASP C:252 B:253 80.0 0.533 T -93.7 8.4 NA NA NA
6zei 1 P62136,Q9UQB8 92.28 0.0 X-RAY
 2020-09-30 ASP A:252 A:253 69.0 0.46 T -93.0 4.2 69.0 0.46 0.0 GOL
HOH
 7.889
2.054
 H
H
 H11
O
ASP C:252 B:253 82.0 0.547 T -93.0 7.1 NA NA NA
3e7a 1 P62136 92.57 0.0 X-RAY
 2008-11-04 ASP A:252 A:253 86.0 0.573 T -88.0 0.8 86.0 0.573 0.0 IOD
IOD
HOH
 9.097
6.138
2.787
 OD2
N
OD2
 I
I
O
ASP B:252 B:253 89.0 0.593 T -89.7 -1.4 NA NA NA
3e7b 1 P62136 92.57 0.0 X-RAY
 2008-11-04 ASP A:252 A:253 91.0 0.607 T -89.5 2.3 91.0 0.607 0.0 AZI
AZI
HOH
 9.966
5.932
2.613
 OD2
N
OD1
 N1
N2
O
ASP B:252 B:253 95.0 0.633 T -86.7 -1.5 NA NA NA
4mov 1 P62136 92.57 0.0 X-RAY
 2014-03-26 ASP A:252 A:253 94.0 0.627 T -90.4 0.5 94.0 0.627 0.0 HOH
 2.743
 OD1
 O
ASP B:252 B:253 94.0 0.627 T -88.9 1.9 NA NA NA
4moy 1 P62136 92.57 0.0 X-RAY
 2014-03-26 ASP A:252 A:253 90.0 0.6 T -91.0 6.2 85.0 0.567 0.033 B:O55000:0.033
 HOH
 2.768
 N
 O
4mp0 1 P62136 92.57 0.0 X-RAY
 2014-03-26 ASP A:252 A:253 89.0 0.593 T -99.2 9.7 81.0 0.54 0.053 C:O55000:0.053
 HOH
 2.855
 N
 O
ASP B:252 C:253 91.0 0.607 T -98.7 9.1 NA NA NA
4xpn 1 P62136 92.57 0.0 X-RAY
 2015-07-01 ASP A:252 A:253 70.0 0.467 T -102.4 14.0 70.0 0.467 0.0 HOH
 3.011
 N
 O
ASP C:252 C:253 68.0 0.453 T -105.0 13.4 NA NA NA
5ioh 1 P62136 92.57 0.0 X-RAY
 2016-10-05 ASP A:252 A:253 110.0 0.733 T -88.1 4.0 110.0 0.733 0.0 HOH
 6.198
 OD2
 O
ASP C:252 C:253 106.0 0.707 T -89.1 4.0 NA NA NA
6alz 1 P62136 92.57 0.0 X-RAY
 2017-11-29 ASP A:252 A:253 93.0 0.62 T -89.6 4.4 93.0 0.62 0.0 CL
HOH
 9.880
2.472
 O
OD1
 CL
O
ASP B:252 B:253 93.0 0.62 T -88.7 5.3 NA NA NA
6czo 1 P62136 92.57 0.0 X-RAY
 2019-01-23 ASP A:252 A:253 104.0 0.693 T -100.0 9.7 104.0 0.693 0.0 HOH
 9.790
 N
 O
ASP C:252 C:253 95.0 0.633 T -98.0 16.6 NA NA NA
6dno 1 P62136 92.57 0.0 X-RAY
 2019-01-23 ASP A:252 A:253 88.0 0.587 T -93.7 4.4 88.0 0.587 0.0 HOH
 2.806
 N
 O
6zee 1 P62136 92.57 0.0 X-RAY
 2020-09-30 ASP A:252 P:253 73.0 0.487 T -90.7 7.1 73.0 0.487 0.0 HOH
 1.769
 H
 O
ASP B:252 Q:253 71.0 0.473 T -84.5 5.9 71.0 0.473 0.0 EDO
EDO
HOH
 8.372
9.656
9.660
 H
OD2
OD1
 HO2
HO1
O
ASP C:252 B:253 72.0 0.48 T -93.1 4.0 72.0 0.48 0.0 EDO
EDO
HOH
 8.045
9.585
2.502
 H
OD2
OD1
 H22
O2
O
ASP D:252 A:253 63.0 0.42 T -91.0 16.6 56.0 0.373 0.047 B:P62136:0.047
 EDO
HOH
 9.370
1.991
 OD2
H
 O1
O
ASP E:252 I:253 82.0 0.547 T -95.1 11.1 71.0 0.473 0.074 A:P62136:0.073
 EDO
EDO
HOH
 8.122
8.371
4.800
 OD2
H
H
 O1
HO1
O
ASP F:252 K:253 68.0 0.453 T -94.3 10.5 68.0 0.453 0.0 HOH
 3.466
 OD1
 O
6zef 1 P62136 92.57 0.0 X-RAY
 2020-09-30 ASP A:252 A:253 77.0 0.513 T -94.9 6.2 77.0 0.513 0.0 HOH
 1.993
 H
 O
ASP B:252 B:253 88.0 0.587 T -96.6 4.6 NA NA NA
5inb 1 P36873 92.57 0.0 X-RAY
 2016-10-05 ASP A:250 A:253 98.0 0.653 T -95.4 7.3 98.0 0.653 0.0 GOL
HOH
 9.055
2.853
 N
N
 O3
O
5j28 1 P36873 92.57 0.0 X-RAY
 2016-10-05 ASP A:250 A:253 96.0 0.64 T -91.0 11.1 96.0 0.64 0.0 HOH
 2.715
 OD2
 O
ASP B:250 B:253 102.0 0.68 T -99.9 20.3 NA NA NA
6obr 1 P62136 92.23 0.0 X-RAY
 2019-09-18 ASP A:252 A:253 101.0 0.673 T -89.1 1.3 101.0 0.673 0.0 HOH
 2.807
 O
 O
ASP B:252 B:253 91.0 0.607 T -89.3 0.5 NA NA NA
6obq 1 P62136 92.23 0.0 X-RAY
 2019-09-18 ASP A:252 A:253 98.0 0.653 T -87.3 2.2 98.0 0.653 0.0 HOH
 2.433
 OD1
 O
ASP B:252 B:253 94.0 0.627 T -86.1 0.8 NA NA NA
6obs 1 P62136 92.23 0.0 X-RAY
 2019-09-18 ASP A:252 A:253 93.0 0.62 T -88.6 3.3 93.0 0.62 0.0 HOH
 2.733
 O
 O
ASP B:252 B:253 91.0 0.607 T -89.3 1.5 NA NA NA
6obu 1 P62136 92.23 0.0 X-RAY
 2019-09-18 ASP A:252 A:253 94.0 0.627 T -84.2 0.5 94.0 0.627 0.0 GOL
HOH
 8.944
2.923
 OD2
O
 O3
O
ASP B:252 B:253 95.0 0.633 T -84.3 -0.2 NA NA NA
5zt0 1 P62137 92.52 0.0 X-RAY
 2019-03-13 ASP A:247 A:253 78.0 0.52 S -83.4 0.3 78.0 0.52 0.0
ASP B:247 B:253 77.0 0.513 T -88.2 -3.3 NA NA NA
ASP C:247 C:253 81.0 0.54 T -84.6 -0.5 NA NA NA
ASP D:247 D:253 79.0 0.527 S -89.3 -1.1 NA NA NA
ASP E:247 E:253 75.0 0.5 T -91.9 3.5 NA NA NA
ASP F:247 F:253 72.0 0.48 T -97.3 6.7 NA NA NA
4v0v 1 P63087 92.52 0.0 X-RAY
 2015-03-25 ASP A:248 A:253 79.0 0.527 T -102.8 12.8 79.0 0.527 0.0 HOH
 2.966
 N
 O
ASP C:248 C:253 75.0 0.5 T -105.7 12.8 NA NA NA
4v0w 1 P63087 92.52 0.0 X-RAY
 2015-03-25 ASP A:248 A:253 68.0 0.453 T -103.2 10.7 68.0 0.453 0.0 HOH
 2.864
 N
 O
ASP C:248 C:253 86.0 0.573 T -104.2 12.7 NA NA NA
4v0x 1 P63087 92.52 0.0 X-RAY
 2015-03-25 ASP A:248 A:253 87.0 0.58 T -99.7 0.6 83.0 0.553 0.027 B:Q5SWA1:0.027
 HOH
 1.646
 H
 O
7nzm 2 P62139 92.52 0.0 EM
 2021-09-29 ASP B:247 B:253 99.0 0.66 T -89.7 0.6 99.0 0.66 0.0
1u32 1 P36873 90.78 0.0 X-RAY
 2004-08-17 ASP A:248 A:253 82.0 0.547 T -94.6 13.7 82.0 0.547 0.0 HOH
 3.327
 OD2
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p62140-f1 1 P62140 100.0 0.0 ASP A:252 A:252 93.0 0.62 T -88.4 7.5
af-p62136-f1 1 P62136 88.79 0.0 ASP A:253 A:253 87.0 0.58 T -88.0 8.1
af-p36873-f1 1 P36873 89.06 0.0 ASP A:253 A:253 87.0 0.58 T -88.9 8.2