Variant
Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr2 | 113588064 | . | A | C | CCDS2102.1:NM_000576.2:c.684ttT>ttG_NP_000567.1:p.228F>L | Homo sapiens interleukin 1 beta (IL1B), mRNA. |
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PDB
Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
5mvz | 3 | B5BUQ8 | 98.09 | 6e-111 |
X-RAY |
2017-02-15 | PHE | C:136 | U:112 | 0.0 | 0.0 | E | -121.2 | 121.0 | 0.0 | 0.0 | 0.0 |
HOH |
2.566 |
N |
O |
||
PHE | F:136 | V:112 | 4.0 | 0.019 | E | -119.0 | 129.1 | NA | NA | NA | |||||||||||||
7chy | 3 | P01584 | 100.0 | 4e-110 |
X-RAY |
2021-01-13 | PHE | C:116 | I:228 | 1.0 | 0.005 | -146.5 | 83.4 | 1.0 | 0.005 | 0.0 |
HOH |
8.703 |
CD2 |
O |
|||
7chz | 3 | P01584 | 100.0 | 4e-110 |
X-RAY |
2021-01-13 | PHE | C:116 | I:229 | 1.0 | 0.005 | E | -129.7 | 100.0 | 1.0 | 0.005 | 0.0 |
HOH |
2.923 |
N |
O |
||
1i1b | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
1990-01-15 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -116.9 | 105.8 | 0.0 | 0.0 | 0.0 |
HOH |
2.858 |
N |
O |
||
1iob | 1 | P01584 | 100.0 | 4e-110 |
NMR X-RAY |
1996-08-17 | PHE | A:112 | A:112 | 1.0 | 0.005 | E | -118.3 | 103.6 | 1.0 | 0.005 | 0.0 |
HOH |
2.951 |
N |
O |
||
1itb | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
1998-02-04 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -125.5 | 98.6 | 0.0 | 0.0 | 0.0 |
HOH |
1.890 |
H |
O |
||
2i1b | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
1990-04-15 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -121.1 | 102.4 | 0.0 | 0.0 | 0.0 |
HOH |
2.779 |
N |
O |
||
2nvh | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2006-12-12 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -117.5 | 94.0 | 0.0 | 0.0 | 0.0 |
HOH |
2.842 |
N |
O |
||
4i1b | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
1990-04-15 | PHE | A:112 | A:112 | 1.0 | 0.005 | E | -114.1 | 100.6 | 1.0 | 0.005 | 0.0 |
HOH |
2.828 |
N |
O |
||
5bvp | 2 | P01584 | 100.0 | 4e-110 |
X-RAY |
2015-09-02 | PHE | B:112 | I:112 | 0.0 | 0.0 | E | -117.9 | 99.6 | 0.0 | 0.0 | 0.0 |
HOH |
2.703 |
N |
O |
||
5i1b | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
1992-01-15 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -123.5 | 107.3 | 0.0 | 0.0 | 0.0 |
HOH |
2.862 |
N |
O |
||
5r7w | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -122.7 | 100.6 | 0.0 | 0.0 | 0.0 |
HOH |
2.842 |
N |
O |
||
5r85 | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -121.4 | 100.5 | 0.0 | 0.0 | 0.0 |
HOH |
2.824 |
N |
O |
||
5r86 | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -121.8 | 100.3 | 0.0 | 0.0 | 0.0 |
GT4 HOH |
8.233 2.821 |
CZ N |
C6 O |
||
5r87 | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -120.3 | 99.8 | 0.0 | 0.0 | 0.0 |
K0G HOH |
7.335 2.833 |
CZ N |
C2 O |
||
5r88 | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -121.5 | 100.0 | 0.0 | 0.0 | 0.0 |
HOH |
2.832 |
N |
O |
||
5r89 | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -120.1 | 97.0 | 0.0 | 0.0 | 0.0 |
HOH |
2.780 |
N |
O |
||
5r8a | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -124.3 | 96.7 | 0.0 | 0.0 | 0.0 |
HOH |
2.844 |
N |
O |
||
5r8b | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -121.6 | 97.8 | 0.0 | 0.0 | 0.0 |
K34 K34 HOH |
8.443 8.131 2.859 |
CZ CZ N |
S S O |
||
5r8c | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -121.7 | 99.1 | 0.0 | 0.0 | 0.0 |
HOH |
2.835 |
N |
O |
||
5r8d | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -121.0 | 100.3 | 0.0 | 0.0 | 0.0 |
HOH |
2.841 |
N |
O |
||
5r8e | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -121.6 | 99.4 | 0.0 | 0.0 | 0.0 |
HOH |
2.865 |
N |
O |
||
5r8f | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -121.7 | 99.7 | 0.0 | 0.0 | 0.0 |
HOH |
2.849 |
N |
O |
||
5r8g | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -123.7 | 100.0 | 0.0 | 0.0 | 0.0 |
HOH |
2.803 |
N |
O |
||
5r8h | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -120.4 | 99.8 | 0.0 | 0.0 | 0.0 |
HOH |
2.844 |
N |
O |
||
5r8i | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -121.7 | 98.7 | 0.0 | 0.0 | 0.0 |
HOH |
2.846 |
N |
O |
||
5r8j | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -120.3 | 99.0 | 0.0 | 0.0 | 0.0 |
HOH |
2.821 |
N |
O |
||
5r8k | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -121.6 | 97.7 | 0.0 | 0.0 | 0.0 |
HOH |
2.821 |
N |
O |
||
5r8l | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -118.9 | 100.9 | 0.0 | 0.0 | 0.0 |
HOH |
2.844 |
N |
O |
||
5r8m | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -122.2 | 101.3 | 0.0 | 0.0 | 0.0 |
HOH |
2.816 |
N |
O |
||
5r8n | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -121.7 | 98.2 | 0.0 | 0.0 | 0.0 |
HOH |
2.838 |
N |
O |
||
5r8o | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -121.0 | 98.9 | 0.0 | 0.0 | 0.0 |
HOH |
2.858 |
N |
O |
||
5r8p | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -120.2 | 98.4 | 0.0 | 0.0 | 0.0 |
HOH |
2.862 |
N |
O |
||
5r8q | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-04-22 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -124.2 | 98.9 | 0.0 | 0.0 | 0.0 |
HOH |
2.816 |
N |
O |
||
6y8i | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-06-17 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -122.3 | 98.7 | 0.0 | 0.0 | 0.0 |
OGE HOH |
8.016 2.806 |
CZ N |
C6 O |
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6y8m | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
2020-03-18 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -117.5 | 97.7 | 0.0 | 0.0 | 0.0 |
SX2 SX2 HOH |
7.957 8.004 2.686 |
CZ CZ N |
C9 O2 O |
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9ilb | 1 | P01584 | 100.0 | 4e-110 |
X-RAY |
1999-01-06 | PHE | A:112 | A:112 | 1.0 | 0.005 | E | -121.7 | 109.1 | 1.0 | 0.005 | 0.0 |
HOH |
2.714 |
N |
O |
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4g6j | 1 | P01584 | 100.0 | 6e-110 |
X-RAY |
2012-12-19 | PHE | A:113 | A:112 | 1.0 | 0.005 | E | -125.2 | 96.6 | 1.0 | 0.005 | 0.0 |
HOH |
2.804 |
N |
O |
||
3o4o | 1 | P01584 | 100.0 | 8e-110 |
X-RAY |
2010-09-01 | PHE | A:117 | A:112 | 0.0 | 0.0 | E | -132.6 | 97.7 | 0.0 | 0.0 | 0.0 | ||||||
4dep | 1 | P01584 | 100.0 | 8e-110 |
X-RAY |
2012-03-21 | PHE | A:117 | A:112 | 2.0 | 0.01 | E | -109.5 | 113.3 | 2.0 | 0.01 | 0.0 | ||||||
PHE | D:117 | D:112 | 1.0 | 0.005 | E | -105.4 | 105.7 | NA | NA | NA | |||||||||||||
1twm | 1 | P01584 | 99.35 | 9e-110 |
X-RAY |
2004-12-07 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -123.5 | 105.3 | 0.0 | 0.0 | 0.0 |
HOH |
2.776 |
N |
O |
||
1twe | 1 | P01584 | 99.35 | 9e-110 |
X-RAY |
2004-12-07 | PHE | A:112 | A:112 | 1.0 | 0.005 | E | -121.6 | 103.7 | 1.0 | 0.005 | 0.0 |
HOH |
2.755 |
N |
O |
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1t4q | 1 | P01584 | 99.35 | 3e-109 |
X-RAY |
2004-12-07 | PHE | A:112 | A:112 | 1.0 | 0.005 | E | -122.0 | 105.6 | 1.0 | 0.005 | 0.0 |
HOH |
2.760 |
N |
O |
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1too | 1 | P01584 | 99.35 | 3e-109 |
X-RAY |
2004-12-07 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -118.4 | 104.3 | 0.0 | 0.0 | 0.0 |
HOH |
2.764 |
N |
O |
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1s0l | 1 | P01584 | 99.35 | 3e-109 |
X-RAY |
2004-03-30 | PHE | A:112 | A:112 | 1.0 | 0.005 | E | -117.6 | 107.6 | 1.0 | 0.005 | 0.0 |
HOH |
2.779 |
N |
O |
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21bi | 1 | P01584 | 99.35 | 4e-109 |
X-RAY |
1992-04-15 | PHE | A:112 | A:112 | 1.0 | 0.005 | E | -116.6 | 98.5 | 1.0 | 0.005 | 0.0 | ||||||
41bi | 1 | P01584 | 99.35 | 4e-109 |
X-RAY |
1992-04-15 | PHE | A:112 | A:112 | 1.0 | 0.005 | E | -115.9 | 98.1 | 1.0 | 0.005 | 0.0 | ||||||
31bi | 1 | P01584 | 99.35 | 6e-109 |
X-RAY |
1992-04-15 | PHE | A:112 | A:112 | 1.0 | 0.005 | E | -125.6 | 99.5 | 1.0 | 0.005 | 0.0 | ||||||
1hib | 1 | P01584 | 99.35 | 7e-109 |
X-RAY |
1994-01-31 | PHE | A:112 | A:112 | 0.0 | 0.0 | E | -130.1 | 107.8 | 0.0 | 0.0 | 0.0 |
HOH |
2.899 |
N |
O |
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1tp0 | 1 | P01584 | 98.04 | 2e-108 |
X-RAY |
2005-02-08 | PHE | A:112 | A:112 | 1.0 | 0.005 | E | -119.4 | 103.0 | 1.0 | 0.005 | 0.0 |
HOH |
2.940 |
N |
O |
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4g6m | 1 | P01584 | 100.0 | 6e-108 |
X-RAY |
2012-12-19 | PHE | A:111 | A:112 | 1.0 | 0.005 | E | -121.4 | 100.4 | 1.0 | 0.005 | 0.0 |
HOH |
2.880 |
N |
O |
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1l2h | 1 | P01584 | 98.69 | 1e-107 |
X-RAY |
2003-02-04 | PHE | A:112 | A:112 | 1.0 | 0.005 | E | -124.1 | 101.9 | 1.0 | 0.005 | 0.0 |
HOH |
2.750 |
N |
O |
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3ltq | 1 | P01584 | 90.0 | 4e-105 |
X-RAY |
2011-02-16 | PHE | A:130 | A:112 | 0.0 | 0.0 | E | -119.9 | 98.7 | 0.0 | 0.0 | 0.0 |
HOH |
2.942 |
N |
O |
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3pok | 1 | P01584 | 90.36 | 5e-102 |
X-RAY |
2011-01-19 | PHE | A:126 | A:125 | 0.0 | 0.0 | E | -122.8 | 104.5 | 0.0 | 0.0 | 0.0 |
HOH |
2.791 |
N |
O |
AlphaFold DB
Entity | Residue | Monomer | View | ||||||||||
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ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
af-p01584-f1 | 1 | P01584 | 100.0 | 0.0 | PHE | A:228 | A:228 | 0.0 | 0.0 | E | -123.8 | 93.3 |