Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr2 204735525 . G A CCDS2362.1:NM_005214.4:c.326gGa>gAa_NP_005205.2:p.109G>E Homo sapiens cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant 1, mRNA.
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3osk 1 P16410 98.44 1e-90 X-RAY
 2010-12-08 GLY A:74 A:74 59.0 0.787 T 54.6 -126.7 59.0 0.787 0.0 HOH
 3.202
 N
 O
GLY B:74 B:74 37.0 0.493 S 88.1 -142.3 37.0 0.493 0.0 NAG
HOH
 9.028
9.190
 N
N
 C1
O
5xj3 3 P16410 100.0 1e-90 X-RAY
 2018-04-25 GLY C:75 C:109 43.0 0.573 T 58.7 -121.1 NA NA NA
GLY F:75 F:109 41.0 0.547 T 61.8 -120.3 NA NA NA
GLY I:75 I:109 44.0 0.587 T 59.5 -122.9 NA NA NA
GLY L:75 L:109 46.0 0.613 T 59.7 -120.8 NA NA NA
1i85 2 P16410 100.0 2e-90 X-RAY
 2001-04-04 GLY C:74 C:74 25.0 0.333 S 61.0 122.6 25.0 0.333 0.0
GLY D:74 D:74 25.0 0.333 S 65.1 132.8 25.0 0.333 0.0
5ggv 3 P16410 100.0 2e-90 X-RAY
 2016-11-09 GLY C:74 Y:74 53.0 0.707 S 65.4 -136.5 53.0 0.707 0.0 HOH
 4.799
 O
 O
7elx 3 P16410 100.0 2e-90 X-RAY
 2021-06-30 GLY E:74 c:74 44.0 0.587 T 57.7 -127.4 NA NA NA
GLY F:74 C:74 45.0 0.6 T 57.9 -129.9 45.0 0.6 0.0
1i8l 2 P16410 99.21 9e-90 X-RAY
 2001-04-04 GLY C:74 C:74 40.0 0.533 S 61.1 -136.9 40.0 0.533 0.0
GLY D:74 D:74 59.0 0.787 T 45.2 -133.2 NA NA NA
2x44 1 P16410 97.66 1e-89 X-RAY
 2010-04-07 GLY A:75 D:74 37.0 0.493 S 76.1 -123.9 37.0 0.493 0.0
1ah1 1 P16410 100.0 1e-89 NMR
 1998-04-15 GLY A:73 A:74 51.0 0.68 T 53.5 -124.0 51.0 0.68 0.0 FUC
 9.598
 H
 HO3
6rqm 2 P16410 100.0 1e-89 X-RAY
 2020-07-08 GLY B:73 A:74 66.0 0.88 S -40.6 -63.7 66.0 0.88 0.0
3bx7 1 P16410 100.0 5e-89 X-RAY
 2009-01-20 GLY A:72 C:74 41.0 0.547 T 55.4 -127.2 41.0 0.547 0.0 HOH
 2.550
 O
 O
6xy2 1 P16410 100.0 6e-88 X-RAY
 2020-12-09 GLY A:72 A:74 49.0 0.653 S 74.6 -108.7 49.0 0.653 0.0
6rpj 1 P16410 100.0 2e-85 X-RAY
 2020-07-08 GLY A:73 A:74 50.0 0.667 S 76.3 -103.7 NA NA NA
GLY C:73 C:74 55.0 0.733 S 74.4 -104.0 NA NA NA
GLY E:73 E:74 53.0 0.707 S 71.5 -115.6 NA NA NA
GLY G:73 G:74 51.0 0.68 S 73.0 -116.3 51.0 0.68 0.0
7dv4 1 P16410 100.0 1e-83 X-RAY
 2022-01-12 GLY A:74 A:74 48.0 0.64 S 72.5 -107.9 48.0 0.64 0.0
GLY C:74 C:74 19.0 0.253 S 76.2 -83.0 NA NA NA
GLY E:74 E:74 37.0 0.493 S 77.1 -100.3 NA NA NA
GLY G:74 G:74 53.0 0.707 S 67.2 -90.7 53.0 0.707 0.0
5tru 3 P16410 100.0 2e-83 X-RAY
 2017-05-10 GLY E:73 c:74 69.0 0.92 T 59.8 -105.7 NA NA NA
GLY F:73 C:74 52.0 0.693 S 78.2 -136.1 52.0 0.693 0.0
6rp8 3 P16410 100.0 2e-83 X-RAY
 2020-07-08 GLY E:73 C:74 60.0 0.8 T 67.6 -130.4 NA NA NA
GLY F:73 c:74 40.0 0.533 T 67.5 -130.6 40.0 0.533 0.0
4kkn 1 Q28090 80.65 3e-70 X-RAY
 2013-06-12 GLY A:79 A:107 22.0 0.293 T 59.2 -117.8 22.0 0.293 0.0 NAG
HOH
 6.311
4.258
 N
N
 C8
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p16410-f1 1 P16410 100.0 2e-168 GLY A:109 A:109 39.0 0.52 T 61.3 -125.3