Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr2 204735580 . C A CCDS2362.1:NM_005214.4:c.381taC>taA_NP_005205.2:p.127Y>* Homo sapiens cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant 1, mRNA.
pdb_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3osk 1 P16410 98.44 1e-90 X-RAY
 2010-12-08 TYR A:92 A:92 6.0 0.026 E -118.5 114.2 6.0 0.026 0.0 HOH
 5.929
 N
 O
TYR B:92 B:92 6.0 0.026 E -110.4 117.3 6.0 0.026 0.0 HOH
 2.761
 OH
 O
5xj3 3 P16410 100.0 1e-90 X-RAY
 2018-04-25 TYR C:93 C:127 0.0 0.0 E -116.9 116.5 NA NA NA
TYR F:93 F:127 1.0 0.004 E -116.2 115.3 NA NA NA
TYR I:93 I:127 0.0 0.0 E -118.0 111.2 NA NA NA
TYR L:93 L:127 0.0 0.0 E -119.0 115.2 NA NA NA
1i85 2 P16410 100.0 2e-90 X-RAY
 2001-04-04 TYR C:92 C:92 3.0 0.013 E -85.6 99.9 3.0 0.013 0.0
TYR D:92 D:92 5.0 0.022 E -91.1 101.4 5.0 0.022 0.0
5ggv 3 P16410 100.0 2e-90 X-RAY
 2016-11-09 TYR C:92 Y:92 4.0 0.017 E -110.4 117.8 4.0 0.017 0.0 HOH
 3.757
 OH
 O
7elx 3 P16410 100.0 2e-90 X-RAY
 2021-06-30 TYR E:92 c:92 14.0 0.061 E -111.9 114.1 NA NA NA
TYR F:92 C:92 6.0 0.026 E -111.6 114.2 6.0 0.026 0.0 HOH
 5.589
 CE1
 O
1i8l 2 P16410 99.21 9e-90 X-RAY
 2001-04-04 TYR C:92 C:92 5.0 0.022 E -106.5 93.8 5.0 0.022 0.0
TYR D:92 D:92 7.0 0.03 E -110.1 99.2 NA NA NA
2x44 1 P16410 97.66 1e-89 X-RAY
 2010-04-07 TYR A:93 D:92 43.0 0.187 E -108.6 114.6 8.0 0.035 0.152 A:P16410:0.152
 HOH
 2.692
 OH
 O
1ah1 1 P16410 100.0 1e-89 NMR
 1998-04-15 TYR A:91 A:92 10.0 0.043 E -124.5 125.3 10.0 0.043 0.0 NAG
 7.921
 O
 H82
6rqm 2 P16410 100.0 1e-89 X-RAY
 2020-07-08 TYR B:91 A:92 2.0 0.009 E -116.1 116.0 2.0 0.009 0.0
3bx7 1 P16410 100.0 5e-89 X-RAY
 2009-01-20 TYR A:90 C:92 4.0 0.017 E -98.2 107.0 4.0 0.017 0.0 HOH
 3.045
 OH
 O
6xy2 1 P16410 100.0 6e-88 X-RAY
 2020-12-09 TYR A:90 A:92 3.0 0.013 E -102.6 93.6 3.0 0.013 0.0
6rpj 1 P16410 100.0 2e-85 X-RAY
 2020-07-08 TYR A:91 A:92 3.0 0.013 E -94.1 88.6 NA NA NA
TYR C:91 C:92 3.0 0.013 E -95.1 90.0 NA NA NA
TYR E:91 E:92 3.0 0.013 E -97.1 90.3 NA NA NA
TYR G:91 G:92 3.0 0.013 E -96.7 88.0 0.0 0.0 0.013 H:None:0.013
 HOH
 8.682
 CE2
 O
7dv4 1 P16410 100.0 1e-83 X-RAY
 2022-01-12 TYR A:92 A:92 4.0 0.017 E -104.8 113.7 4.0 0.017 0.0 HOH
 7.086
 O
 O
TYR C:92 C:92 11.0 0.048 E -86.4 107.8 NA NA NA
TYR E:92 E:92 4.0 0.017 E -113.3 113.8 NA NA NA
TYR G:92 G:92 4.0 0.017 E -114.2 106.9 4.0 0.017 0.0
5tru 3 P16410 100.0 2e-83 X-RAY
 2017-05-10 TYR E:91 c:92 4.0 0.017 E -109.3 101.8 NA NA NA
TYR F:91 C:92 8.0 0.035 E -109.8 109.0 8.0 0.035 0.0
6rp8 3 P16410 100.0 2e-83 X-RAY
 2020-07-08 TYR E:91 C:92 5.0 0.022 E -107.7 115.8 NA NA NA
TYR F:91 c:92 39.0 0.17 E -104.5 114.6 39.0 0.17 0.0
4kkn 1 Q28090 80.65 3e-70 X-RAY
 2013-06-12 TYR A:97 A:125 7.0 0.03 E -112.5 113.2 7.0 0.03 0.0 HOH
 5.893
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p16410-f1 1 P16410 100.0 2e-168 TYR A:127 A:127 4.0 0.017 E -109.5 113.4