Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr2 204735649 . T A CCDS2362.1:NM_005214.4:c.450taT>taA_NP_005205.2:p.150Y>* Homo sapiens cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant 1, mRNA.
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3osk 1 P16410 98.44 1e-90 X-RAY
 2010-12-08 TYR A:115 A:115 117.0 0.509 E -92.4 128.8 41.0 0.178 0.331 B:P16410:0.33
 HOH
 2.608
 OH
 O
TYR B:115 B:115 112.0 0.487 E -94.6 132.3 40.0 0.174 0.313 A:P16410:0.313
 HOH
 2.437
 OH
 O
5xj3 3 P16410 100.0 1e-90 X-RAY
 2018-04-25 TYR C:116 C:150 110.0 0.478 E -107.7 128.9 NA NA NA
TYR F:116 F:150 108.0 0.47 E -105.3 131.0 NA NA NA
TYR I:116 I:150 108.0 0.47 E -106.3 128.4 NA NA NA
TYR L:116 L:150 111.0 0.483 E -105.4 131.1 NA NA NA
1i85 2 P16410 100.0 2e-90 X-RAY
 2001-04-04 TYR C:115 C:115 125.0 0.543 E -81.5 117.4 46.0 0.2 0.343 D:P16410:0.343
TYR D:115 D:115 122.0 0.53 E -96.9 111.9 45.0 0.196 0.334 C:P16410:0.335
5ggv 3 P16410 100.0 2e-90 X-RAY
 2016-11-09 TYR C:115 Y:115 117.0 0.509 E -104.4 135.5 117.0 0.509 0.0 HOH
 2.643
 OH
 O
7elx 3 P16410 100.0 2e-90 X-RAY
 2021-06-30 TYR E:115 c:115 127.0 0.552 E -102.6 125.7 NA NA NA
TYR F:115 C:115 115.0 0.5 E -101.0 126.2 115.0 0.5 0.0 HOH
 6.953
 C
 O
1i8l 2 P16410 99.21 9e-90 X-RAY
 2001-04-04 TYR C:115 C:115 122.0 0.53 E -105.0 119.7 122.0 0.53 0.0
TYR D:115 D:115 130.0 0.565 E -102.2 124.4 NA NA NA
2x44 1 P16410 97.66 1e-89 X-RAY
 2010-04-07 TYR A:116 D:115 199.0 0.865 -103.8 126.2 117.0 0.509 0.356 A:P16410:0.357
 HOH
 3.316
 OH
 O
1ah1 1 P16410 100.0 1e-89 NMR
 1998-04-15 TYR A:114 A:116 114.0 0.496 E -101.4 147.2 114.0 0.496 0.0
6rqm 2 P16410 100.0 1e-89 X-RAY
 2020-07-08 TYR B:114 A:115 187.0 0.813 -110.3 126.1 187.0 0.813 0.0
3bx7 1 P16410 100.0 5e-89 X-RAY
 2009-01-20 TYR A:113 C:115 119.0 0.517 E -99.5 129.2 43.0 0.187 0.33 A:P16410:0.33
 HOH
 2.590
 OH
 O
6xy2 1 P16410 100.0 6e-88 X-RAY
 2020-12-09 TYR A:113 A:115 120.0 0.522 E -110.1 146.6 120.0 0.522 0.0
6rpj 1 P16410 100.0 2e-85 X-RAY
 2020-07-08 TYR A:114 A:115 113.0 0.491 E -96.8 131.3 NA NA NA
TYR C:114 C:115 114.0 0.496 E -95.0 131.3 NA NA NA
TYR E:114 E:115 114.0 0.496 E -95.8 130.0 NA NA NA
TYR G:114 G:115 114.0 0.496 E -97.7 129.7 114.0 0.496 0.0
7dv4 1 P16410 100.0 1e-83 X-RAY
 2022-01-12 TYR A:115 A:115 114.0 0.496 E -93.4 118.2 114.0 0.496 0.0 HOH
 7.643
 O
 O
TYR C:115 C:115 95.0 0.413 E -107.9 123.0 NA NA NA
TYR E:115 E:115 109.0 0.474 E -92.4 106.1 NA NA NA
TYR G:115 G:115 110.0 0.478 E -101.4 137.3 110.0 0.478 0.0
5tru 3 P16410 100.0 2e-83 X-RAY
 2017-05-10 TYR E:114 c:115 108.0 0.47 E -107.7 122.8 NA NA NA
TYR F:114 C:115 125.0 0.543 E -110.2 130.0 125.0 0.543 0.0
6rp8 3 P16410 100.0 2e-83 X-RAY
 2020-07-08 TYR E:114 C:115 127.0 0.552 E -93.3 130.9 NA NA NA
TYR F:114 c:115 136.0 0.591 E -95.3 133.2 136.0 0.591 0.0
4kkn 1 Q28090 80.65 3e-70 X-RAY
 2013-06-12 TYR A:120 A:148 115.0 0.5 E -97.4 135.4 115.0 0.5 0.0 HOH
 5.050
 C
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p16410-f1 1 P16410 100.0 2e-168 TYR A:150 A:150 115.0 0.5 E -99.6 125.0