Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr2 27015053 . G A CCDS1729.1:NM_001809.3:c.155cGa>cAa_NP_001800.1:p.52R>Q Homo sapiens centromere protein A (CENPA), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3an2 1 P49450 100.0 2e-98 X-RAY
 2011-07-20 ARG A:55 A:52 117.0 0.52 T -150.9 11.8 98.0 0.436 0.084 G:P04908:0.084
ARG E:55 E:52 163.0 0.724 H -81.6 20.6 144.0 0.64 0.084 C:P04908:0.084
3wtp 1 P49450 100.0 2e-98 X-RAY
 2014-12-03 ARG A:55 A:52 155.0 0.689 H -54.8 -44.6 129.0 0.573 0.116 G:P04908:0.116
 DT
DA
DT
DT
DC
DC
 8.243
6.241
6.077
8.661
6.389
5.060
 NH1
NH1
NH1
CB
CD
CD
 O3'
O3'
OP1
O3'
O3'
OP1
6l49 1 P49450 100.0 2e-98 EM
 2019-12-04 ARG A:55 A:52 154.0 0.684 H -97.9 12.5 142.0 0.631 0.053 G:P04908:0.053
 DT
DG
DT
 9.610
7.334
5.482
 NH2
NH2
NH1
 O3'
O5'
OP1
ARG E:55 E:52 171.0 0.76 H -82.2 7.4 147.0 0.653 0.107 C:P04908:0.107
 DG
 9.400
 NH2
 OP1
7d20 1 P49450 100.0 2e-98 EM
 2021-02-10 ARG A:55 A:52 136.0 0.604 H -63.6 -34.5 127.0 0.564 0.04 D:P04908:0.04
 DA
DT
DC
 6.721
4.750
6.240
 NH2
NH1
NH1
 O3'
OP1
OP1
ARG B:55 E:52 126.0 0.56 H -61.2 -30.1 117.0 0.52 0.04 G:P04908:0.04
 DG
DT
DA
 7.324
5.013
5.331
 NH2
NH2
NH2
 O3'
OP1
OP2
3r45 1 P49450 100.0 2e-98 X-RAY
 2011-04-06 ARG A:68 NA:NA DO NA DO DO DO NA NA NA
3nqu 1 P49450 100.0 2e-98 X-RAY
 2010-08-25 ARG A:52 NA:NA DO NA DO DO DO NA NA NA
6c0w 1 P49450 100.0 2e-98 EM
 2018-01-17 ARG A:52 A:52 136.0 0.604 H -71.9 -6.0 115.0 0.511 0.093 G:Q93077:0.093
 DT
DC
DG
DT
DA
 9.943
9.111
6.837
4.912
6.442
 NH2
NH2
NH2
NH2
NH1
 C4'
OP1
O3'
OP1
OP1
ARG E:52 E:52 147.0 0.653 H -69.1 -32.9 134.0 0.596 0.057 C:Q93077:0.058
 DA
DA
DT
DC
DT
 8.665
5.741
4.660
9.867
9.007
 NH1
NH1
CD
CD
NH2
 O3'
O3'
OP1
OP2
OP1
6se0 1 P49450 100.0 2e-98 EM
 2019-08-14 ARG A:52 A:52 118.0 0.524 H -75.0 -26.4 112.0 0.498 0.026 G:Q6FI13:0.027
 DA
DT
DC
DG
DT
DA
DT
 9.758
8.358
9.197
7.027
3.557
2.798
9.564
 NH2
NH2
NH1
NH2
NH2
NH2
NH2
 O3'
C5'
OP1
O3'
O3'
OP1
OP2
ARG E:52 E:52 166.0 0.738 H -69.6 -29.7 154.0 0.684 0.054 C:Q6FI13:0.053
 DA
DT
DC
DT
DC
DT
 9.407
7.311
6.325
9.003
7.417
8.540
 NH1
NH1
CD
NH1
NH1
NH1
 O3'
O3'
OP1
O3'
C5'
OP1
6se6 1 P49450 100.0 2e-98 EM
 2019-08-14 ARG A:52 A:52 159.0 0.707 H -69.6 -25.3 130.0 0.578 0.129 G:Q6FI13:0.129
 DC
DG
DT
DA
 8.693
9.379
7.201
8.093
 NH2
NH2
CD
CD
 OP1
O3'
OP1
OP1
ARG E:52 E:52 154.0 0.684 H -67.5 -26.1 139.0 0.618 0.066 C:Q6FI13:0.067
 DA
DT
DC
DC
DT
 9.237
7.617
7.925
9.067
7.197
 NH2
CD
CD
NH2
NH2
 O3'
OP1
OP1
O3'
OP1
6see 1 P49450 100.0 2e-98 EM
 2019-08-14 ARG A:52 A:52 154.0 0.684 H -65.1 -37.8 142.0 0.631 0.053 G:Q6FI13:0.053
 DA
DT
DC
DT
 7.420
5.824
6.656
9.006
 NH2
NH2
NH1
NH2
 O3'
OP1
OP1
OP1
ARG E:52 E:52 116.0 0.516 H -64.6 -30.4 116.0 0.516 0.0 DG
DT
DA
 8.440
6.103
5.690
 NH1
NH1
NH1
 O3'
OP1
OP1
6sef 1 P49450 100.0 2e-98 EM
 2019-08-14 ARG A:52 A:52 146.0 0.649 H -64.1 -42.1 137.0 0.609 0.04 G:Q6FI13:0.04
 DT
DC
DG
DT
DA
 9.557
7.382
9.082
6.994
6.714
 NH2
NH2
NH2
NH2
NH2
 C5'
OP1
O3'
OP1
OP1
ARG E:52 E:52 164.0 0.729 H -64.6 -40.8 136.0 0.604 0.125 C:Q6FI13:0.124
 DA
DT
DC
DT
 8.941
6.813
9.000
8.243
 CD
CD
CD
NH1
 O3'
OP1
OP1
OP1
6seg 1 P49450 100.0 2e-98 EM
 2019-08-14 ARG A:52 A:52 162.0 0.72 H -68.5 -26.4 147.0 0.653 0.067 G:Q6FI13:0.067
 DT
DC
DG
DG
DT
DA
 9.476
8.554
9.805
9.578
7.194
6.271
 NH2
NH1
NH1
CB
CG
NH2
 O5'
OP1
OP2
O3'
OP1
OP1
ARG E:52 E:52 174.0 0.773 H -72.9 -35.0 163.0 0.724 0.049 C:Q6FI13:0.049
 DA
DT
DC
DC
DT
 9.688
7.319
6.890
8.788
7.026
 NH2
CB
NH2
NH2
NH2
 O3'
OP1
OP1
O3'
OP1
6tem 1 P49450 100.0 2e-98 EM
 2020-04-08 ARG A:52 A:52 146.0 0.649 H -69.7 -32.5 137.0 0.609 0.04 G:Q6AZJ8:0.04
ARG E:52 E:52 153.0 0.68 H -75.4 -22.3 142.0 0.631 0.049 C:Q6AZJ8:0.049
 DA
DT
DC
DC
DT
 7.800
5.331
7.398
9.566
8.346
 CD
CD
NH1
NH1
NH2
 O3'
OP1
OP1
O3'
OP1
6buz 1 P49450 100.0 3e-98 EM
 2017-12-20 ARG A:72 A:52 154.0 0.684 H -70.2 -23.4 135.0 0.6 0.084 G:P04908:0.084
 DT
DC
DC
DG
DT
DA
 9.222
8.438
8.511
6.858
5.709
9.569
 NH2
NH2
NH2
NH2
NH2
NH1
 O3'
OP1
OP2
O3'
OP1
OP2
ARG E:72 E:52 154.0 0.684 H -70.2 -23.4 137.0 0.609 0.075 C:P04908:0.076
 DA
DT
DC
DC
DT
 8.105
5.724
5.849
9.670
7.995
 NH2
NH2
NH1
NH1
NH2
 O3'
OP1
OP1
O5'
OP1
6e0c 1 P49450 100.0 3e-98 EM
 2019-05-22 ARG A:70 A:52 153.0 0.68 H -70.2 -31.7 118.0 0.524 0.156 G:P04908:0.156
 DG
DT
DA
DT
DC
 7.451
5.623
8.802
9.639
8.865
 NH1
CD
CD
NH1
NH1
 O3'
OP1
OP2
O3'
OP1
ARG E:70 E:52 156.0 0.693 H -70.0 -32.9 128.0 0.569 0.124 C:P04908:0.124
 DC
DT
DA
DT
DC
 9.577
9.110
7.511
5.870
8.722
 NH1
NH1
NH1
NH1
CD
 O3'
OP1
O3'
OP1
OP1
6e0p 1 P49450 100.0 3e-98 EM
 2019-05-22 ARG A:70 A:52 160.0 0.711 H -71.6 -28.2 128.0 0.569 0.142 G:P04908:0.142
 DA
DT
DC
DT
DT
 8.694
6.491
8.213
8.606
7.484
 NH1
CB
NH1
NH1
NH1
 O3'
OP1
OP1
O3'
OP1
ARG E:70 E:52 159.0 0.707 H -71.5 -28.2 126.0 0.56 0.147 C:P04908:0.147
 DC
DT
DA
DA
DG
 8.744
7.873
8.556
6.456
8.652
 NH1
NH1
NH1
CB
NH1
 O3'
OP1
O3'
OP1
OP1
6o1d 1 P49450 100.0 3e-98 EM
 2019-05-22 ARG A:70 A:52 152.0 0.676 H -72.5 -37.4 122.0 0.542 0.134 G:P04908:0.133
 DA
DT
DC
DT
DT
 8.921
6.953
8.338
8.082
7.285
 NH1
CB
NH1
NH1
NH1
 O3'
OP1
OP1
O3'
OP1
ARG E:70 E:52 157.0 0.698 H -71.3 -35.0 127.0 0.564 0.134 C:P04908:0.133
 DC
DT
DA
DA
DG
 8.119
6.366
9.192
7.294
8.565
 NH1
NH1
NH1
CB
NH1
 O3'
OP1
O3'
OP1
OP1
6muo 1 P49450 100.0 3e-70 EM
 2019-07-24 ARG A:15 A:52 159.0 0.707 H -72.8 -18.2 141.0 0.627 0.08 G:Q93077:0.08
 DA
DA
 8.165
8.982
 NH1
CD
 OP1
OP2
ARG E:15 E:52 147.0 0.653 H -73.2 -14.6 116.0 0.516 0.137 C:Q93077:0.138
 DT
DA
 9.184
7.218
 NH1
NH1
 O3'
OP1
6mup 1 P49450 100.0 3e-70 EM
 2019-07-24 ARG A:15 A:52 145.0 0.644 H -76.5 -8.8 128.0 0.569 0.075 G:Q93077:0.076
 DG
DA
DA
 9.423
7.087
7.179
 NH2
NH2
NH1
 O3'
OP1
OP1
ARG E:15 E:52 151.0 0.671 H -77.3 -22.6 136.0 0.604 0.067 C:Q93077:0.067
 DT
DA
DT
 8.595
6.449
9.265
 NH1
NH1
CD
 O3'
OP1
OP2

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p49450-f1 1 P49450 100.0 9e-99 ARG A:52 A:52 163.0 0.724 H -61.9 -36.4