Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr2 | 27015667 | . | A | C | CCDS1729.1:NM_001809.3:c.254aAt>aCt_NP_001800.1:p.85N>T | Homo sapiens centromere protein A (CENPA), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 3an2 | 1 | P49450 | 100.0 | 2e-98 |
X-RAY |
2011-07-20 | ASN | A:88 | A:85 | 148.0 | 0.925 | -65.4 | 138.3 | 84.0 | 0.525 | 0.4 |
B:B2R4R0:0.4 |
DA DT DT DC DT DA DA DT DT DC |
7.657 7.308 3.695 3.042 7.263 9.224 8.013 4.384 3.849 3.334 |
ND2 ND2 CB OD1 OD1 ND2 ND2 ND2 ND2 ND2 |
C2 O2 O3' C5' P C2 N3 O3' O5' OP1 |
||
| ASN | E:88 | E:85 | 152.0 | 0.95 | -154.4 | 132.9 | 98.0 | 0.613 | 0.337 |
F:B2R4R0:0.338 |
DA DA DT DT DC DA DT DT DC DT |
8.729 8.820 4.916 4.872 5.725 9.260 8.089 4.085 3.796 6.850 |
OD1 OD1 OD1 OD1 CB OD1 OD1 CB ND2 ND2 |
C2 N3 O3' O5' OP1 C2 O2 O3' C5' P |
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| 3wtp | 1 | P49450 | 100.0 | 2e-98 |
X-RAY |
2014-12-03 | ASN | A:88 | A:85 | 145.0 | 0.906 | -83.4 | 163.2 | 90.0 | 0.562 | 0.344 |
B:P62805:0.344 |
DC DT DC DC DA DG DA DG DC DA |
9.543 7.530 4.411 3.157 6.546 7.834 8.092 4.648 3.892 6.078 |
ND2 ND2 CG CA OD1 ND2 ND2 ND2 ND2 ND2 |
O2 O2 O3' OP1 OP1 N2 N3 O3' C5' OP1 |
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| 6l49 | 1 | P49450 | 100.0 | 2e-98 |
EM |
2019-12-04 | ASN | A:88 | A:85 | 144.0 | 0.9 | -84.9 | 134.8 | 92.0 | 0.575 | 0.325 |
B:P62805:0.325 |
DA DG DC DA DT DA DG DA |
8.161 3.660 3.303 6.697 8.473 4.528 3.430 5.788 |
CB CB CA OD1 ND2 ND2 ND2 ND2 |
O3' O3' OP1 P O2 N3 C5' OP1 |
||
| ASN | E:88 | E:85 | 143.0 | 0.894 | -143.8 | 124.5 | 83.0 | 0.519 | 0.375 |
F:P62805:0.375 |
DA DG DG DG DG DC DT DT DG |
9.444 8.313 5.884 6.175 6.594 6.187 3.401 3.005 7.868 |
OD1 OD1 ND2 CB CB ND2 ND2 OD1 OD1 |
C2 N2 N2 C5' OP1 O3' C5' OP1 P |
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| 7d20 | 1 | P49450 | 100.0 | 2e-98 |
EM |
2021-02-10 | ASN | A:88 | A:85 | 155.0 | 0.969 | -74.7 | 92.6 | 105.0 | 0.656 | 0.313 |
F:P62805:0.312 |
DA DG DG DG DG DC DC DT DT DG |
9.063 7.333 4.730 3.638 5.387 9.711 7.767 3.540 3.372 7.179 |
ND2 ND2 ND2 ND2 ND2 ND2 O CB CA OD1 |
C2 N2 O3' C5' OP1 O2 O3' O3' OP1 OP1 |
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| ASN | B:88 | E:85 | 155.0 | 0.969 | -55.2 | 151.5 | 104.0 | 0.65 | 0.319 |
C:P62805:0.319 |
DT DA DG DC DA DT DA DG DA |
8.970 7.737 3.980 3.612 7.313 8.251 5.038 3.709 5.974 |
ND2 ND2 CB CA OD1 ND2 ND2 ND2 CB |
O2 N3 O3' OP1 P O2 O3' C5' OP1 |
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| 3r45 | 1 | P49450 | 100.0 | 2e-98 |
X-RAY |
2011-04-06 | ASN | A:101 | A:85 | 161.0 | 1.0 | -79.4 | 161.6 | 35.0 | 0.219 | 0.781 |
C:Q8NCD3:0.55 B:P62805:0.281 |
SO4 SO4 HOH |
6.743 7.455 2.560 |
CB O OD1 |
O1 O1 O |
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| 3nqu | 1 | P49450 | 100.0 | 2e-98 |
X-RAY |
2010-08-25 | ASN | A:85 | A:85 | 159.0 | 0.994 | -101.2 | 151.6 | 106.0 | 0.662 | 0.332 |
B:P62805:0.331 |
SO4 HOH |
6.459 3.996 |
ND2 C |
O4 O |
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| 6c0w | 1 | P49450 | 100.0 | 2e-98 |
EM |
2018-01-17 | ASN | A:85 | A:85 | 147.0 | 0.919 | -137.0 | 94.7 | 85.0 | 0.531 | 0.388 |
B:P62805:0.319 K:Q96H22:0.069 |
DA DG DC DA DT DA DG DA |
8.467 4.169 3.371 6.635 9.275 4.672 3.366 6.512 |
O CB OD1 OD1 ND2 ND2 ND2 ND2 |
O3' O3' C5' OP1 O2 O3' C5' OP1 |
||
| ASN | E:85 | E:85 | 150.0 | 0.938 | -68.5 | 142.8 | 83.0 | 0.519 | 0.419 |
F:P62805:0.419 |
DG DG DG DG DA DC DC DT DT DG |
7.335 7.033 5.786 5.063 9.779 8.819 6.228 2.795 2.880 9.090 |
ND2 ND2 ND2 ND2 ND2 ND2 ND2 OD1 OD1 OD1 |
N2 N2 C4' OP1 P O2 O3' O3' OP1 OP2 |
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| 6se0 | 1 | P49450 | 100.0 | 2e-98 |
EM |
2019-08-14 | ASN | A:85 | A:85 | 148.0 | 0.925 | -90.4 | 160.3 | 104.0 | 0.65 | 0.275 |
B:P62805:0.275 |
DT DA DG DC DA DC DT DA DG DA |
9.016 7.671 3.947 3.300 6.536 9.406 7.665 5.590 4.720 6.630 |
ND2 ND2 CB C OD1 ND2 ND2 ND2 ND2 CB |
O2 N3 O3' OP1 OP1 O2 O2 O3' C5' OP1 |
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| ASN | E:85 | E:85 | 140.0 | 0.875 | -90.9 | 158.8 | 92.0 | 0.575 | 0.3 |
F:P62805:0.3 |
DA DG DG DG DG DC DC DT DT DG |
8.641 6.785 5.263 4.422 6.224 9.132 7.630 4.012 3.304 6.543 |
ND2 ND2 ND2 ND2 CB ND2 ND2 CB C OD1 |
C2 N2 O3' C5' OP1 O2 O2 O3' OP1 OP1 |
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| 6se6 | 1 | P49450 | 100.0 | 2e-98 |
EM |
2019-08-14 | ASN | A:85 | A:85 | 154.0 | 0.963 | -95.8 | 164.9 | 108.0 | 0.675 | 0.288 |
B:P62805:0.287 |
DA DG DC DA DT DA DG DA |
8.147 3.730 3.359 6.743 8.769 5.040 3.887 6.356 |
CB CB OD1 OD1 ND2 ND2 ND2 ND2 |
O3' O3' C5' OP1 O2 O3' C5' OP1 |
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| ASN | E:85 | E:85 | 144.0 | 0.9 | -92.8 | 166.0 | 94.0 | 0.588 | 0.312 |
F:P62805:0.312 |
DG DG DG DG DC DT DT DG |
8.086 5.279 4.201 6.462 8.097 3.888 3.457 6.805 |
ND2 ND2 ND2 ND2 CB CB OD1 OD1 |
N2 O3' C5' OP1 O3' O3' C5' P |
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| 6see | 1 | P49450 | 100.0 | 2e-98 |
EM |
2019-08-14 | ASN | A:85 | A:85 | 136.0 | 0.85 | -88.7 | 151.4 | 89.0 | 0.556 | 0.294 |
B:P62805:0.294 |
DA DG DG DG DG DC DC DT DT DG |
8.875 6.881 6.118 5.244 7.221 9.755 7.426 3.241 3.219 7.224 |
ND2 ND2 ND2 ND2 CB ND2 ND2 ND2 CA OD1 |
C2 N2 O3' C5' OP1 O2 O2 O3' OP1 P |
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| ASN | E:85 | E:85 | 147.0 | 0.919 | -92.6 | 153.4 | 104.0 | 0.65 | 0.269 |
F:P62805:0.269 |
DT DA DG DC DA DC DT DA DG DA |
9.847 8.088 3.662 3.265 6.744 9.735 8.026 5.743 4.772 6.835 |
ND2 ND2 CB CA OD1 ND2 ND2 ND2 ND2 CB |
O2 N3 O3' OP1 OP1 O2 O2 O3' C5' OP1 |
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| 6sef | 1 | P49450 | 100.0 | 2e-98 |
EM |
2019-08-14 | ASN | A:85 | A:85 | 155.0 | 0.969 | -92.2 | 165.0 | 107.0 | 0.669 | 0.3 |
B:P62805:0.3 |
DT DA DG DC DA DT DA DG DA |
9.585 7.795 3.676 3.307 6.979 8.745 5.188 3.704 5.971 |
ND2 CB CB CA OD1 ND2 ND2 ND2 ND2 |
O2 O3' O3' OP1 OP1 O2 O3' C5' OP1 |
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| ASN | E:85 | E:85 | 147.0 | 0.919 | -102.4 | 153.9 | 93.0 | 0.581 | 0.338 |
F:P62805:0.338 |
DG DG DG DG DC DT DT DG |
7.858 5.026 4.547 5.845 8.448 3.806 3.325 6.717 |
ND2 ND2 ND2 ND2 ND2 CB CA OD1 |
N2 O3' C5' OP1 O2 O3' OP1 P |
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| 6seg | 1 | P49450 | 100.0 | 2e-98 |
EM |
2019-08-14 | ASN | A:85 | A:85 | 161.0 | 1.0 | -91.2 | 151.7 | 102.0 | 0.637 | 0.363 |
B:P62805:0.369 |
DT DA DG DC DA DT DA DG DA |
9.344 8.020 3.931 3.627 7.491 8.075 5.053 4.038 6.250 |
ND2 ND2 CB CA OD1 ND2 ND2 ND2 CB |
O2 N3 O3' OP1 OP1 O2 O3' C5' OP1 |
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| ASN | E:85 | E:85 | 152.0 | 0.95 | -89.2 | 150.4 | 98.0 | 0.613 | 0.337 |
F:P62805:0.338 |
DA DG DG DG DG DC DC DT DT DG |
9.096 7.073 5.379 4.409 6.491 9.445 7.646 3.748 3.399 7.429 |
ND2 ND2 ND2 ND2 CB ND2 ND2 CB CA OD1 |
C2 N2 O3' C5' OP1 O2 O2 O3' OP1 OP1 |
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| 6tem | 1 | P49450 | 100.0 | 2e-98 |
EM |
2020-04-08 | ASN | A:85 | A:85 | 156.0 | 0.975 | -127.2 | 103.5 | 92.0 | 0.575 | 0.4 |
B:P62799:0.4 |
DA DG DC DA DT DA DG DA |
8.563 3.845 3.762 7.118 9.794 4.990 3.629 5.655 |
CB CB CA ND2 OD1 OD1 OD1 OD1 |
O3' O3' OP1 OP1 O2 O3' C5' OP1 |
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| ASN | E:85 | E:85 | 148.0 | 0.925 | -132.9 | 140.9 | 83.0 | 0.519 | 0.406 |
F:P62799:0.406 |
DG DG DG DG DC DC DT DT DG |
8.028 5.119 3.455 5.158 9.687 8.166 3.999 3.257 8.089 |
ND2 ND2 ND2 OD1 ND2 ND2 CB CB CB |
N2 O3' OP1 OP1 O2 O3' O3' OP1 OP2 |
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| 6buz | 1 | P49450 | 100.0 | 3e-98 |
EM |
2017-12-20 | ASN | A:105 | A:85 | 153.0 | 0.956 | -72.4 | 152.2 | 94.0 | 0.588 | 0.368 |
B:P62805:0.369 |
DT DA DG DC DA DT DA DG DA |
9.590 7.594 4.189 3.227 7.302 8.316 5.213 3.697 5.613 |
ND2 CB CB OD1 OD1 ND2 ND2 ND2 ND2 |
O2 O3' O3' C5' P O2 O3' C5' OP1 |
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| ASN | E:105 | E:85 | 151.0 | 0.944 | -72.4 | 152.1 | 91.0 | 0.569 | 0.375 |
F:P62805:0.375 |
DA DG DG DG DG DC DC DT DT DG |
9.995 7.684 5.302 3.393 5.273 9.825 7.907 3.898 3.361 7.011 |
OD1 ND2 ND2 ND2 ND2 ND2 CB CB CA OD1 |
C2 N2 O3' C5' OP1 O2 O3' O3' OP1 P |
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| 6e0c | 1 | P49450 | 100.0 | 3e-98 |
EM |
2019-05-22 | ASN | A:103 | A:85 | 146.0 | 0.912 | -82.0 | 159.9 | 93.0 | 0.581 | 0.331 |
B:P62805:0.331 |
DC DT DA DG DA DT DA DG DC DA |
9.947 7.999 5.344 4.164 6.096 9.104 7.547 3.945 3.390 6.931 |
ND2 ND2 ND2 ND2 CB ND2 ND2 CG CA OD1 |
O2 O2 O3' C5' OP1 O2 N3 O3' OP1 OP1 |
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| ASN | E:103 | E:85 | 153.0 | 0.956 | -85.1 | 158.5 | 99.0 | 0.619 | 0.337 |
F:P62805:0.338 |
DC DC DT DT DG DA DG DG DG DG |
9.148 7.455 3.859 3.378 7.248 9.133 7.046 5.188 4.131 5.961 |
ND2 ND2 CB CA OD1 ND2 ND2 ND2 ND2 CB |
O2 O2 O3' OP1 OP1 C2 N2 O3' C5' OP1 |
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| 6e0p | 1 | P49450 | 100.0 | 3e-98 |
EM |
2019-05-22 | ASN | A:103 | A:85 | 157.0 | 0.981 | -91.0 | 163.1 | 98.0 | 0.613 | 0.368 |
B:P62805:0.369 |
DA DG DA DA DT DT DC DT DT DT |
9.877 7.898 4.826 3.357 5.661 9.609 8.147 3.754 3.314 7.003 |
ND2 ND2 ND2 ND2 ND2 ND2 CB CB CA OD1 |
C2 N2 O3' C5' OP1 O2 O3' O3' OP1 OP1 |
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| ASN | E:103 | E:85 | 156.0 | 0.975 | -91.0 | 163.1 | 97.0 | 0.606 | 0.369 |
F:P62805:0.369 |
DC DT DC DC DA DG DA DG DC DA |
9.767 8.071 3.962 3.309 6.895 8.767 8.882 4.714 3.501 4.985 |
ND2 CB CB OD1 OD1 ND2 ND2 ND2 ND2 ND2 |
O2 O3' O3' C5' OP1 N2 N3 O3' C5' OP1 |
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| 6o1d | 1 | P49450 | 100.0 | 3e-98 |
EM |
2019-05-22 | ASN | A:103 | A:85 | 157.0 | 0.981 | -87.5 | 142.9 | 96.0 | 0.6 | 0.381 |
B:P62805:0.381 |
DG DA DA DT DC DT DT DT |
8.489 5.425 3.665 6.247 8.460 3.878 3.249 6.580 |
ND2 ND2 ND2 ND2 CB CB CA OD1 |
N2 O3' C5' OP1 O3' O3' OP1 OP1 |
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| ASN | E:103 | E:85 | 155.0 | 0.969 | -86.2 | 148.1 | 90.0 | 0.562 | 0.407 |
F:P62805:0.406 |
DT DC DC DA DG DA DG DC DA |
8.009 4.046 3.422 7.408 8.889 9.044 4.924 3.569 5.337 |
ND2 CB CA OD1 ND2 ND2 ND2 ND2 ND2 |
O2 O3' OP1 OP1 N2 N3 O3' C5' OP1 |
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| 6muo | 1 | P49450 | 100.0 | 3e-70 |
EM |
2019-07-24 | ASN | A:48 | A:85 | 146.0 | 0.912 | -130.1 | 132.2 | 91.0 | 0.569 | 0.343 |
B:P62805:0.344 |
DC DT DC DC DA DG DA DG DC DA |
9.185 7.159 2.805 2.963 7.848 9.331 8.320 5.999 4.393 6.283 |
ND2 ND2 OD1 OD1 OD1 ND2 ND2 ND2 ND2 CB |
O2 O3' O3' OP1 P N2 N3 O3' C5' OP1 |
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| ASN | E:48 | E:85 | 148.0 | 0.925 | -149.7 | 127.2 | 95.0 | 0.594 | 0.331 |
F:P62805:0.331 |
DA DG DA DA DT DT DC DT DT DT |
9.427 6.810 6.350 4.689 6.574 9.077 6.763 2.840 2.837 7.790 |
ND2 ND2 ND2 ND2 CB ND2 ND2 OD1 OD1 OD1 |
C2 N2 O3' C5' OP1 O2 O3' O3' OP1 OP2 |
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| 6mup | 1 | P49450 | 100.0 | 3e-70 |
EM |
2019-07-24 | ASN | A:48 | A:85 | 156.0 | 0.975 | -77.8 | 129.3 | 88.0 | 0.55 | 0.425 |
B:P62805:0.338 M:Q96H22:0.087 |
DT DC DC DA DA DG DC DA |
8.010 3.675 3.334 6.879 9.143 4.684 3.495 6.354 |
CB CB CA OD1 ND2 ND2 ND2 ND2 |
O3' O3' OP1 OP1 N3 O3' C5' OP1 |
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| ASN | E:48 | E:85 | 152.0 | 0.95 | -68.3 | 147.1 | 96.0 | 0.6 | 0.35 |
F:P62805:0.344 |
DG DA DA DT DC DT DT DT |
8.599 4.825 3.423 6.064 7.937 3.798 3.381 6.821 |
ND2 ND2 ND2 ND2 CB CB OD1 OD1 |
N2 O3' C5' OP1 O3' O3' C5' P |
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| 3nqj | 1 | P49450 | 100.0 | 1e-53 |
X-RAY |
2010-08-25 | ASN | A:27 | A:85 | 143.0 | 0.894 | -137.7 | 168.5 | 83.0 | 0.519 | 0.375 |
B:P62805:0.375 |
HOH |
3.472 |
CB |
O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p49450-f1 | 1 | P49450 | 100.0 | 9e-99 | ASN | A:85 | A:85 | 163.0 | 1.0 | -76.5 | 124.2 | ||