Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr2 29016804 . G A CCDS33169.1:NM_002709.2:c.820Gag>Aag_NP_002700.1:p.274E>K Homo sapiens protein phosphatase 1 catalytic subunit beta (PPP1CB), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1s70 1 P62140 100.0 0.0 X-RAY
 2004-06-22 GLU A:277 A:275 152.0 0.8 T -77.3 -59.0 152.0 0.8 0.0 HOH
 5.045
 CG
 O
1fjm 1 P08129 88.79 0.0 X-RAY
 1996-06-20 GLU A:275 A:275 179.0 0.942 S -74.9 -21.6 131.0 0.689 0.253 C:NOR00109:0.253
 HOH
 7.639
 OE1
 O
GLU B:275 B:275 178.0 0.937 S -74.4 -19.5 NA NA NA
4g9j 1 P62136 88.79 0.0 X-RAY
 2012-09-19 GLU A:276 A:275 167.0 0.879 S -86.4 -66.9 167.0 0.879 0.0 HOH
 7.195
 O
 O
GLU B:276 B:275 158.0 0.832 T 165.0 -41.8 NA NA NA
6g0i 1 P62136 88.79 0.0 X-RAY
 2018-11-21 GLU A:276 A:275 77.0 NA T -83.9 -38.6 77.0 NA NA HOH
 7.965
 N
 O
6g0j 1 P62136 88.79 0.0 X-RAY
 2018-11-21 GLU A:276 A:275 76.0 NA T -98.6 -15.0 76.0 NA NA HOH
 7.363
 O
 O
3egg 1 P62136 89.26 0.0 X-RAY
 2010-03-23 GLU A:274 A:275 151.0 0.795 T -120.2 -2.2 137.0 0.721 0.074 C:O35274:0.074
 HOH
 2.747
 O
 O
GLU B:274 B:275 147.0 0.774 T -110.5 -17.1 NA NA NA
3egh 1 P62136 89.26 0.0 X-RAY
 2010-03-23 GLU A:274 A:275 151.0 0.795 T -124.3 -8.4 113.0 0.595 0.2 C:O35274:0.095
E:NOR00279:0.1
 HOH
 5.197
 OE2
 O
GLU B:274 B:275 154.0 0.811 T -108.2 -7.0 NA NA NA
3hvq 1 P62136 89.26 0.0 X-RAY
 2010-03-23 GLU A:274 A:275 150.0 0.789 T -118.0 -7.4 130.0 0.684 0.105 C:O35867:0.105
 HOH
 4.710
 OE2
 O
GLU B:274 B:275 149.0 0.784 T -111.2 -11.4 146.0 0.768 0.016 D:O35867:0.016
 HOH
 3.587
 OE2
 O
6ghm 1 P62136 89.26 0.0 X-RAY
 2019-02-27 GLU A:274 A:275 82.0 NA T -98.7 -32.3 82.0 NA NA HOH
 8.156
 C
 O
GLU B:274 B:275 83.0 NA T -84.1 -49.4 NA NA NA
6dcx 1 P62136 88.79 0.0 X-RAY
 2019-05-15 GLU A:284 A:275 153.0 0.805 T -109.0 -15.6 153.0 0.805 0.0
GLU B:284 B:275 153.0 0.805 T -109.5 -14.7 NA NA NA
6zk6 1 P62136 88.48 0.0 X-RAY
 2020-11-18 GLU A:276 A:275 73.0 NA T -88.9 -31.9 73.0 NA NA HOH
 3.797
 O
 O
5zqv 1 P62137 89.23 0.0 X-RAY
 2019-03-13 GLU A:275 A:275 163.0 0.858 T -89.9 -2.3 163.0 0.858 0.0 FLC
 9.407
 OE1
 OB2
GLU B:275 B:275 161.0 0.847 T -96.8 -37.7 NA NA NA
GLU C:275 C:275 160.0 0.842 S -110.8 4.8 160.0 0.842 0.0
GLU D:275 D:275 148.0 0.779 T -67.4 -29.0 NA NA NA
4v0u 2 P63087 89.06 0.0 X-RAY
 2015-03-25 GLU D:275 D:275 145.0 0.763 T -132.5 -41.9 NA NA NA
GLU F:275 F:275 145.0 0.763 T -132.5 -42.1 NA NA NA
GLU H:275 H:275 146.0 0.768 T -132.3 -41.9 NA NA NA
GLU J:275 J:275 146.0 0.768 T -132.6 -41.9 146.0 0.768 0.0
GLU N:275 N:275 147.0 0.774 T -132.4 -42.0 NA NA NA
1it6 1 P36873 89.06 0.0 X-RAY
 2002-05-22 GLU A:275 A:275 135.0 0.711 T -114.8 -46.6 135.0 0.711 0.0 CYU
HOH
 6.084
7.334
 OE1
N
 C43
O
GLU B:275 B:275 134.0 0.705 T -134.9 -39.2 NA NA NA
1jk7 1 P36873 89.06 0.0 X-RAY
 2001-08-15 GLU A:275 A:275 162.0 0.853 T -128.1 -8.3 162.0 0.853 0.0 OKA
HOH
 3.285
4.506
 OE1
OE1
 C43
O
2bcd 1 P36873 89.06 0.0 X-RAY
 2006-01-17 GLU A:275 A:275 149.0 0.784 T -118.6 -41.6 118.0 0.621 0.163 B:NOR00825:0.163
 MN
HOH
 8.149
5.320
 O
OE2
 MN
O
2bdx 1 P36873 89.06 0.0 X-RAY
 2006-01-17 GLU A:275 A:275 174.0 0.916 T -114.8 -37.1 150.0 0.789 0.127 B:NOR00106:0.126
 HOH
 8.072
 N
 O
4ut2 1 P36873 89.06 0.0 X-RAY
 2015-07-22 GLU A:275 A:275 152.0 0.8 T -111.0 -49.3 152.0 0.8 0.0 HOH
 6.104
 N
 O
GLU B:275 B:275 151.0 0.795 T -111.1 -49.1 NA NA NA
4ut3 1 P36873 89.06 0.0 X-RAY
 2015-07-22 GLU A:275 A:275 156.0 0.821 T -95.0 -49.2 156.0 0.821 0.0 HOH
 2.638
 OE2
 O
4ut3 2 P36873 89.06 0.0 X-RAY
 2015-07-22 GLU B:275 B:275 149.0 0.784 T -95.0 -49.2 NA NA NA
2o8a 1 P63088 89.52 0.0 X-RAY
 2007-07-17 GLU A:281 A:275 153.0 0.805 T -122.2 -14.7 106.0 0.558 0.247 B:Q9DCL8:0.247
 HOH
 2.806
 OE2
 O
GLU C:281 B:275 147.0 0.774 T -119.4 -12.6 NA NA NA
2o8g 1 P63088 89.52 0.0 X-RAY
 2007-07-17 GLU A:281 A:275 149.0 0.784 T -115.1 -23.9 107.0 0.563 0.221 B:Q9DCL8:0.221
 HOH
 2.544
 OE2
 O
GLU C:281 B:275 142.0 0.747 T -117.6 -13.1 NA NA NA
6zej 1 P62136,Q4VY12 86.42 0.0 X-RAY
 2020-09-30 GLU A:274 D:274 104.0 0.547 T -118.2 -8.5 104.0 0.547 0.0 HOH
 7.283
 H
 O
GLU B:274 A:274 103.0 0.542 T -114.3 -8.5 NA NA NA
GLU C:274 F:274 104.0 0.547 T -120.3 -5.4 NA NA NA
GLU D:274 I:274 112.0 0.589 T -112.9 -12.6 NA NA NA
GLU E:274 L:274 111.0 0.584 T -113.8 -12.6 NA NA NA
GLU F:274 O:274 107.0 0.563 T -115.3 -7.4 NA NA NA
3v4y 1 P62136 92.05 0.0 X-RAY
 2012-10-31 GLU A:274 A:275 141.0 0.742 T -111.8 -29.1 141.0 0.742 0.0 HOH
 2.797
 OE1
 O
GLU C:274 C:275 137.0 0.721 T -89.1 -39.3 NA NA NA
GLU E:274 E:275 125.0 0.658 T -78.4 -40.8 NA NA NA
GLU G:274 G:275 136.0 0.716 T -93.4 -32.5 NA NA NA
6zeh 1 P62136,Q13813 92.28 0.0 X-RAY
 2020-09-30 GLU A:274 A:275 136.0 0.716 T -117.8 -15.3 84.0 0.442 0.274 B:Q4VY12:0.274
 HOH
 3.450
 HG3
 O
GLU C:274 B:275 136.0 0.716 T -117.4 -16.1 NA NA NA
6obn 1 P62136 92.0 0.0 X-RAY
 2019-09-18 GLU A:280 A:275 192.0 1.0 T -71.3 -24.5 161.0 0.847 0.153 C:Q15435:0.163
 HOH
 6.971
 N
 O
GLU B:280 B:275 173.0 0.911 T -66.5 -27.4 NA NA NA
6obp 1 P62136 92.0 0.0 X-RAY
 2019-09-18 GLU A:280 A:275 193.0 1.0 S -95.4 -4.1 116.0 0.611 0.389 B:Q15435:0.405
3n5u 1 P62136 92.0 0.0 X-RAY
 2010-08-11 GLU A:275 A:275 151.0 0.795 S -119.0 25.1 151.0 0.795 0.0
GLU B:275 B:275 150.0 0.789 S -119.2 25.2 150.0 0.789 0.0
6zeg 1 P62136,Q9UQB8 92.28 0.0 X-RAY
 2020-09-30 GLU A:274 A:275 114.0 0.6 T -121.8 -15.8 60.0 0.316 0.284 B:Q4VY12:0.284
 HOH
 3.063
 HA
 O
GLU C:274 B:275 138.0 0.726 T -120.3 -13.0 NA NA NA
6zei 1 P62136,Q9UQB8 92.28 0.0 X-RAY
 2020-09-30 GLU A:274 A:275 128.0 0.674 T -117.7 -7.6 84.0 0.442 0.232 B:Q4VY12:0.232
 HOH
 2.533
 OE1
 O
GLU C:274 B:275 136.0 0.716 T -113.0 -10.3 NA NA NA
3e7a 1 P62136 92.57 0.0 X-RAY
 2008-11-04 GLU A:274 A:275 124.0 NA T -112.7 -14.5 99.0 NA NA C:NOR00279:NA
 IOD
HOH
 6.797
3.802
 O
N
 I
O
GLU B:274 B:275 119.0 NA T -105.5 -47.0 NA NA NA
3e7b 1 P62136 92.57 0.0 X-RAY
 2008-11-04 GLU A:274 A:275 76.0 NA T -113.6 -25.4 76.0 NA NA E7B
AZI
HOH
 7.179
7.275
3.821
 CB
O
N
 C41
N1
O
GLU B:274 B:275 72.0 NA T -112.0 -9.2 NA NA NA
4mov 1 P62136 92.57 0.0 X-RAY
 2014-03-26 GLU A:274 A:275 73.0 NA T -105.4 -14.3 73.0 NA NA HOH
 4.283
 N
 O
GLU B:274 B:275 72.0 NA T -102.4 -15.5 NA NA NA
4moy 1 P62136 92.57 0.0 X-RAY
 2014-03-26 GLU A:274 A:275 148.0 0.779 T -110.5 -4.5 120.0 0.632 0.147 B:O55000:0.147
 HOH
 4.065
 N
 O
4mp0 1 P62136 92.57 0.0 X-RAY
 2014-03-26 GLU A:274 A:275 151.0 0.795 T -114.0 -15.6 113.0 0.595 0.2 C:O55000:0.2
 HOH
 6.358
 OE2
 O
GLU B:274 C:275 149.0 0.784 T -111.9 -16.0 NA NA NA
4xpn 1 P62136 92.57 0.0 X-RAY
 2015-07-01 GLU A:274 A:275 76.0 NA T -110.3 -29.9 76.0 NA NA HOH
 4.291
 C
 O
GLU C:274 C:275 138.0 0.726 T -115.8 -30.4 NA NA NA
5ioh 1 P62136 92.57 0.0 X-RAY
 2016-10-05 GLU A:274 A:275 71.0 NA S -127.2 2.5 71.0 NA NA HOH
 3.746
 O
 O
GLU C:274 C:275 68.0 NA S -126.8 2.2 NA NA NA
6alz 1 P62136 92.57 0.0 X-RAY
 2017-11-29 GLU A:274 A:275 73.0 NA T -93.0 -42.4 73.0 NA NA BKM
HOH
 7.518
4.655
 CB
O
 C39
O
GLU B:274 B:275 77.0 NA T -93.6 -52.7 NA NA NA
6czo 1 P62136 92.57 0.0 X-RAY
 2019-01-23 GLU A:274 A:275 161.0 0.847 T -101.8 -20.8 161.0 0.847 0.0
GLU C:274 C:275 85.0 NA T -98.3 -38.4 NA NA NA
6dno 1 P62136 92.57 0.0 X-RAY
 2019-01-23 GLU A:274 A:275 176.0 0.926 S -84.1 -24.5 128.0 0.674 0.252 C:None:0.253
 HOH
 2.588
 OE2
 O
6zee 1 P62136 92.57 0.0 X-RAY
 2020-09-30 GLU A:274 P:275 75.0 NA T -100.7 -28.5 75.0 NA NA EDO
HOH
 4.566
7.259
 N
H
 H22
O
GLU B:274 Q:275 155.0 0.816 T -111.6 -11.3 116.0 0.611 0.205 L:Q4VY12:0.205
 HOH
 3.857
 HG3
 O
GLU C:274 B:275 153.0 0.805 T -110.9 -27.2 114.0 0.6 0.205 I:Q4VY12:0.205
 EDO
EDO
HOH
 5.681
9.976
3.680
 OE1
OE2
O
 HO2
O2
O
GLU D:274 A:275 150.0 0.789 T -109.1 -25.9 106.0 0.558 0.231 J:Q4VY12:0.232
 EDO
HOH
 7.843
5.034
 OE1
N
 H21
O
GLU E:274 I:275 152.0 0.8 T -110.2 -25.7 109.0 0.574 0.226 K:Q4VY12:0.226
 HOH
 5.107
 N
 O
GLU F:274 K:275 154.0 0.811 T -115.5 -21.9 111.0 0.584 0.227 H:Q4VY12:0.226
 HOH
 4.887
 N
 O
6zef 1 P62136 92.57 0.0 X-RAY
 2020-09-30 GLU A:274 A:275 152.0 0.8 T -110.3 -18.4 111.0 0.584 0.216 C:Q4VY12:0.216
 MN
HOH
 9.428
4.891
 OE1
OE2
 MN
O
GLU B:274 B:275 153.0 0.805 T -111.5 -14.7 NA NA NA
5inb 1 P36873 92.57 0.0 X-RAY
 2016-10-05 GLU A:272 A:275 126.0 0.663 T -114.0 -27.4 126.0 0.663 0.0 MLI
HOH
 8.275
4.068
 OE1
OE2
 O9
O
5j28 1 P36873 92.57 0.0 X-RAY
 2016-10-05 GLU A:272 A:275 128.0 0.674 T -111.5 -16.6 128.0 0.674 0.0 MLI
HOH
 8.117
4.507
 OE1
OE2
 O9
O
GLU B:272 B:275 125.0 0.658 T -112.1 -31.9 NA NA NA
6obr 1 P62136 92.23 0.0 X-RAY
 2019-09-18 GLU A:274 A:275 91.0 NA S -67.8 -79.8 79.0 NA NA C:None:NA
 HOH
 9.739
 N
 O
GLU B:274 B:275 94.0 NA S -66.6 -78.0 NA NA NA
6obq 1 P62136 92.23 0.0 X-RAY
 2019-09-18 GLU A:274 A:275 176.0 0.926 S -95.5 -18.4 134.0 0.705 0.221 C:None:0.221
 HOH
 8.387
 OE1
 O
GLU B:274 B:275 175.0 0.921 S -94.1 -21.0 NA NA NA
6obs 1 P62136 92.23 0.0 X-RAY
 2019-09-18 GLU A:274 A:275 89.0 NA S -108.2 45.5 89.0 NA NA HOH
 7.965
 O
 O
GLU B:274 B:275 94.0 NA S -116.3 81.9 NA NA NA
6obu 1 P62136 92.23 0.0 X-RAY
 2019-09-18 GLU A:274 A:275 92.0 NA S -79.4 -25.5 75.0 NA NA C:None:NA
 HOH
 6.964
 CB
 O
GLU B:274 B:275 92.0 NA S -78.8 -26.6 NA NA NA
5zt0 1 P62137 92.52 0.0 X-RAY
 2019-03-13 GLU A:269 A:275 148.0 0.779 S -128.2 20.1 148.0 0.779 0.0
GLU B:269 B:275 151.0 0.795 S -133.3 19.6 NA NA NA
GLU C:269 C:275 156.0 0.821 S -133.3 19.8 NA NA NA
GLU D:269 D:275 148.0 0.779 S -137.4 20.3 NA NA NA
GLU E:269 E:275 152.0 0.8 S -125.4 17.4 NA NA NA
GLU F:269 F:275 155.0 0.816 S -134.0 22.3 NA NA NA
4v0v 1 P63087 92.52 0.0 X-RAY
 2015-03-25 GLU A:270 A:275 146.0 0.768 T -114.8 -40.2 146.0 0.768 0.0 HOH
 3.548
 O
 O
GLU C:270 C:275 150.0 0.789 S -137.3 9.9 NA NA NA
4v0w 1 P63087 92.52 0.0 X-RAY
 2015-03-25 GLU A:270 A:275 154.0 0.811 T -124.3 -34.4 154.0 0.811 0.0 HOH
 2.833
 OE1
 O
GLU C:270 C:275 139.0 0.732 T -116.3 -19.7 NA NA NA
4v0x 1 P63087 92.52 0.0 X-RAY
 2015-03-25 GLU A:270 A:275 159.0 0.837 T -92.6 -3.9 157.0 0.826 0.011 B:Q5SWA1:0.011
 HOH
 7.044
 H
 O
7nzm 2 P62139 92.52 0.0 EM
 2021-09-29 GLU B:269 B:275 77.0 NA T -105.8 -14.8 70.0 NA NA A:P05198:NA
1u32 1 P36873 90.78 0.0 X-RAY
 2004-08-17 VAL A:270 A:275 125.0 0.806 T -98.0 -47.9 125.0 0.806 0.0 OKA
HOH
 4.186
8.053
 CG2
N
 C43
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p62140-f1 1 P62140 100.0 0.0 GLU A:274 A:274 119.0 0.626 T -112.9 -24.5
af-p62136-f1 1 P62136 88.79 0.0 GLU A:275 A:275 150.0 0.789 T -108.6 -30.6
af-p36873-f1 1 P36873 89.06 0.0 GLU A:275 A:275 162.0 0.853 T -109.2 -30.6