Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr2 | 37596849 | . | T | A | CCDS1790.1:NM_012413.3:c.745Ttg>Atg_NP_036545.1:p.249L>M | Homo sapiens glutaminyl-peptide cyclotransferase (QPCT), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 4ywy | 1 | Q16769 | 99.45 | 0.0 |
X-RAY |
2015-08-05 | LEU | A:249 | A:249 | 4.0 | 0.024 | S | 70.3 | 41.5 | 4.0 | 0.024 | 0.0 |
ZN PBD HOH |
4.761 3.739 2.855 |
CD2 CD2 O |
ZN CAD O |
||
| LEU | B:249 | B:249 | 4.0 | 0.024 | S | 64.6 | 44.0 | NA | NA | NA | |||||||||||||
| LEU | C:249 | C:249 | 3.0 | 0.018 | S | 58.6 | 44.5 | NA | NA | NA | |||||||||||||
| 2afm | 1 | Q16769 | 100.0 | 0.0 |
X-RAY |
2005-08-23 | LEU | A:217 | A:249 | 3.0 | 0.018 | S | 58.4 | 43.0 | 3.0 | 0.018 | 0.0 |
ZN SO4 HOH |
4.540 9.019 2.753 |
CD2 CD2 O |
ZN O4 O |
||
| LEU | B:217 | B:249 | 4.0 | 0.024 | S | 58.2 | 45.3 | NA | NA | NA | |||||||||||||
| 2afo | 1 | Q16769 | 100.0 | 0.0 |
X-RAY |
2005-08-23 | LEU | A:217 | A:249 | 4.0 | 0.024 | S | 54.1 | 43.3 | 4.0 | 0.024 | 0.0 |
ZN SO4 HOH |
4.513 9.143 2.743 |
CD2 CD2 O |
ZN O4 O |
||
| LEU | B:217 | B:249 | 4.0 | 0.024 | S | 56.5 | 41.9 | NA | NA | NA | |||||||||||||
| 2afw | 1 | Q16769 | 100.0 | 0.0 |
X-RAY |
2005-08-23 | LEU | A:217 | A:249 | 0.0 | 0.0 | S | 60.1 | 43.3 | 0.0 | 0.0 | 0.0 |
ZN SO4 AHN HOH |
4.588 9.547 3.591 2.779 |
CD2 CD2 CD2 O |
ZN O4 CE1 O |
||
| LEU | B:217 | B:249 | 1.0 | 0.006 | S | 57.9 | 45.7 | NA | NA | NA | |||||||||||||
| 2afx | 1 | Q16769 | 100.0 | 0.0 |
X-RAY |
2005-08-23 | LEU | A:217 | A:249 | 4.0 | 0.024 | S | 56.4 | 46.2 | 4.0 | 0.024 | 0.0 |
ZN SO4 1BN HOH |
4.655 9.227 3.677 2.766 |
CD2 CD2 CD2 O |
ZN O4 C2 O |
||
| LEU | B:217 | B:249 | 4.0 | 0.024 | S | 57.1 | 46.4 | NA | NA | NA | |||||||||||||
| 2afz | 1 | Q16769 | 100.0 | 0.0 |
X-RAY |
2005-08-23 | LEU | A:217 | A:249 | 3.0 | 0.018 | S | 57.3 | 43.1 | 3.0 | 0.018 | 0.0 |
ZN SO4 NVI HOH |
4.644 9.163 3.732 2.785 |
CD2 CD2 CD2 O |
ZN O4 C2 O |
||
| LEU | B:217 | B:249 | 3.0 | 0.018 | S | 56.8 | 46.0 | NA | NA | NA | |||||||||||||
| 3pbb | 1 | Q16769 | 100.0 | 0.0 |
X-RAY |
2011-02-02 | LEU | A:217 | A:249 | 4.0 | 0.024 | S | 64.5 | 45.8 | 4.0 | 0.024 | 0.0 |
PBD ZN HOH |
3.929 4.684 2.595 |
CD2 CD2 O |
CAD ZN O |
||
| LEU | B:217 | B:249 | 4.0 | 0.024 | S | 68.6 | 40.0 | NA | NA | NA | |||||||||||||
| 2zef | 1 | Q16769 | 99.7 | 0.0 |
X-RAY |
2008-04-22 | LEU | A:217 | A:249 | 3.0 | 0.018 | S | 58.3 | 41.9 | 3.0 | 0.018 | 0.0 |
ZN SO4 HOH |
4.561 9.136 2.743 |
CD2 CD2 O |
ZN O4 O |
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| LEU | B:217 | B:249 | 3.0 | 0.018 | S | 58.8 | 44.8 | NA | NA | NA | |||||||||||||
| 2zed | 1 | Q16769 | 99.7 | 0.0 |
X-RAY |
2008-04-22 | LEU | A:217 | A:249 | 3.0 | 0.018 | S | 58.3 | 42.3 | 3.0 | 0.018 | 0.0 |
ZN SO4 HOH |
4.613 9.090 2.747 |
CD2 CD2 O |
ZN O4 O |
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| LEU | B:217 | B:249 | 3.0 | 0.018 | S | 57.1 | 41.1 | NA | NA | NA | |||||||||||||
| 2afu | 1 | Q16769 | 99.7 | 0.0 |
X-RAY |
2005-08-23 | LEU | A:217 | A:249 | 1.0 | 0.006 | S | 52.9 | 49.4 | 1.0 | 0.006 | 0.0 |
ZN BGT HOH |
4.686 3.826 2.862 |
CD2 CD1 O |
ZN CB O |
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| LEU | B:217 | B:249 | 1.0 | 0.006 | S | 57.6 | 49.1 | NA | NA | NA | |||||||||||||
| 2zeh | 1 | Q16769 | 99.7 | 0.0 |
X-RAY |
2008-04-22 | LEU | A:217 | A:249 | 3.0 | 0.018 | S | 58.9 | 41.6 | 3.0 | 0.018 | 0.0 |
ZN SO4 HOH |
4.773 9.190 2.756 |
CD2 CD2 O |
ZN O4 O |
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| LEU | B:217 | B:249 | 4.0 | 0.024 | S | 58.2 | 41.7 | NA | NA | NA | |||||||||||||
| 2zeo | 1 | Q16769 | 99.7 | 0.0 |
X-RAY |
2008-04-22 | LEU | A:217 | A:249 | 2.0 | 0.012 | S | 59.9 | 43.2 | 2.0 | 0.012 | 0.0 |
ZN SO4 HOH |
4.714 9.218 2.762 |
CD2 CD2 O |
ZN O4 O |
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| LEU | B:217 | B:249 | 3.0 | 0.018 | S | 60.5 | 44.0 | NA | NA | NA | |||||||||||||
| 2zee | 1 | Q16769 | 99.7 | 0.0 |
X-RAY |
2008-04-22 | LEU | A:217 | A:249 | 4.0 | 0.024 | S | 58.5 | 41.2 | 4.0 | 0.024 | 0.0 |
ZN SO4 HOH |
4.548 9.048 2.796 |
CD2 CD2 O |
ZN O4 O |
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| LEU | B:217 | B:249 | 5.0 | 0.029 | S | 56.8 | 38.4 | NA | NA | NA | |||||||||||||
| 3pbe | 1 | Q16769 | 99.7 | 0.0 |
X-RAY |
2011-02-02 | LEU | A:217 | A:249 | 3.0 | 0.018 | S | 60.9 | 39.9 | 3.0 | 0.018 | 0.0 |
ZN SO4 HOH |
4.480 8.942 2.720 |
CD2 CD2 O |
ZN O4 O |
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| LEU | B:217 | B:249 | 3.0 | 0.018 | S | 63.6 | 38.0 | NA | NA | NA | |||||||||||||
| 2zem | 1 | Q16769 | 99.7 | 0.0 |
X-RAY |
2008-04-22 | LEU | A:217 | A:249 | 1.0 | 0.006 | S | 56.7 | 45.2 | 1.0 | 0.006 | 0.0 |
ZN SO4 HOH |
4.783 9.334 2.587 |
CD2 CD1 O |
ZN O4 O |
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| LEU | B:217 | B:249 | 2.0 | 0.012 | S | 58.9 | 44.3 | NA | NA | NA | |||||||||||||
| 2zen | 1 | Q16769 | 99.7 | 0.0 |
X-RAY |
2008-04-22 | LEU | A:217 | A:249 | 4.0 | 0.024 | S | 57.3 | 41.1 | 4.0 | 0.024 | 0.0 |
ZN SO4 HOH |
4.843 9.307 2.702 |
CD2 CD2 O |
ZN O4 O |
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| LEU | B:217 | B:249 | 4.0 | 0.024 | S | 54.8 | 42.8 | NA | NA | NA | |||||||||||||
| 2zel | 1 | Q16769 | 99.7 | 0.0 |
X-RAY |
2008-04-22 | LEU | A:217 | A:249 | 7.0 | 0.041 | S | 56.4 | 40.6 | 7.0 | 0.041 | 0.0 |
ZN SO4 HOH |
4.767 9.266 2.714 |
CD2 CD2 O |
ZN O4 O |
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| LEU | B:217 | B:249 | 6.0 | 0.035 | S | 54.2 | 39.2 | NA | NA | NA | |||||||||||||
| 2zeg | 1 | Q16769 | 99.7 | 0.0 |
X-RAY |
2008-04-22 | LEU | A:217 | A:249 | 4.0 | 0.024 | S | 56.9 | 41.7 | 4.0 | 0.024 | 0.0 |
ZN SO4 IMD HOH |
4.717 9.404 3.804 2.713 |
CD2 CD2 CD2 O |
ZN O4 C5 O |
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| LEU | B:217 | B:249 | 4.0 | 0.024 | S | 56.0 | 44.8 | NA | NA | NA | |||||||||||||
| 2zep | 1 | Q16769 | 99.7 | 0.0 |
X-RAY |
2008-04-22 | LEU | A:217 | A:249 | 4.0 | 0.024 | S | 58.0 | 42.3 | 4.0 | 0.024 | 0.0 |
ZN SO4 HOH |
4.471 9.018 2.790 |
CD2 CD2 O |
ZN O4 O |
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| LEU | B:217 | B:249 | 5.0 | 0.029 | S | 58.8 | 36.4 | NA | NA | NA | |||||||||||||
| 7cm0 | 1 | Q16769 | 100.0 | 0.0 |
X-RAY |
2021-12-22 | LEU | A:215 | A:249 | 3.0 | 0.018 | S | 59.2 | 56.2 | 3.0 | 0.018 | 0.0 |
G5R ZN HOH |
4.102 5.123 4.527 |
CD1 CD2 CD2 |
C21 ZN O |
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| LEU | B:215 | B:249 | 3.0 | 0.018 | S | 63.6 | 58.2 | NA | NA | NA | |||||||||||||
| LEU | C:215 | C:249 | 5.0 | 0.029 | S | 63.3 | 56.9 | NA | NA | NA | |||||||||||||
| LEU | D:215 | D:249 | 3.0 | 0.018 | S | 60.6 | 59.2 | NA | NA | NA | |||||||||||||
| 2afs | 1 | Q16769 | 99.7 | 0.0 |
X-RAY |
2005-08-23 | LEU | A:217 | A:249 | 4.0 | 0.024 | S | 52.8 | 46.4 | 4.0 | 0.024 | 0.0 |
ZN SO4 HOH |
4.607 9.235 2.671 |
CD2 CD2 O |
ZN O4 O |
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| LEU | B:217 | B:249 | 3.0 | 0.018 | S | 59.7 | 40.3 | NA | NA | NA | |||||||||||||
| 6yi1 | 1 | Q16769 | 100.0 | 0.0 |
X-RAY |
2020-07-01 | LEU | A:217 | A:249 | 2.0 | 0.012 | S | 61.0 | 44.5 | 2.0 | 0.012 | 0.0 |
ZN ORT PHE 66N HOH |
4.348 3.901 7.186 8.250 2.692 |
CD2 CD2 CD1 CD1 O |
ZN N1 N C35 O |
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| LEU | B:217 | B:249 | 4.0 | 0.024 | S | 61.4 | 41.7 | NA | NA | NA | |||||||||||||
| 6yjy | 1 | Q16769 | 100.0 | 0.0 |
X-RAY |
2020-07-01 | LEU | A:217 | A:249 | 3.0 | 0.018 | S | 61.1 | 42.9 | 3.0 | 0.018 | 0.0 |
SO4 ZN PCA LEU TYR HOH |
9.164 4.614 4.014 6.606 7.039 2.767 |
CD1 CD2 CD1 CD1 CD1 O |
O1 ZN CG N CE2 O |
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| LEU | B:217 | B:249 | 1.0 | 0.006 | S | 59.9 | 44.2 | NA | NA | NA | |||||||||||||
| 4yu9 | 1 | Q16769 | 99.39 | 0.0 |
X-RAY |
2015-08-05 | LEU | A:217 | A:249 | 4.0 | 0.024 | S | 69.9 | 40.4 | 4.0 | 0.024 | 0.0 |
ZN HOH |
4.657 2.825 |
CD2 O |
ZN O |
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| LEU | B:217 | B:249 | 4.0 | 0.024 | S | 69.0 | 41.9 | NA | NA | NA | |||||||||||||
| LEU | C:217 | C:249 | 4.0 | 0.024 | S | 59.3 | 38.5 | NA | NA | NA | |||||||||||||
| 6gbx | 1 | Q16769 | 99.39 | 0.0 |
X-RAY |
2018-09-19 | LEU | A:217 | A:249 | 5.0 | 0.029 | S | 60.3 | 44.3 | 5.0 | 0.029 | 0.0 |
ZN S77 EDO HOH |
4.640 3.935 7.003 2.809 |
CD2 CD2 CD1 O |
ZN C13 O1 O |
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| LEU | B:217 | B:249 | 7.0 | 0.041 | S | 60.7 | 43.4 | NA | NA | NA | |||||||||||||
| LEU | C:217 | C:249 | 5.0 | 0.029 | S | 61.4 | 45.5 | NA | NA | NA | |||||||||||||
| 7d8e | 1 | Q16769 | 99.39 | 0.0 |
X-RAY |
2021-12-08 | LEU | A:217 | A:249 | 4.0 | 0.024 | S | 60.5 | 45.3 | 4.0 | 0.024 | 0.0 |
ZN EDO GYO HOH |
4.692 6.867 3.565 2.755 |
CD2 CD1 CD2 O |
ZN O2 C04 O |
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| LEU | B:217 | B:249 | 4.0 | 0.024 | S | 58.7 | 43.1 | NA | NA | NA | |||||||||||||
| LEU | C:217 | C:249 | 4.0 | 0.024 | S | 61.2 | 42.3 | NA | NA | NA | |||||||||||||
| 7coz | 1 | Q16769 | 99.39 | 0.0 |
X-RAY |
2021-01-13 | LEU | A:215 | A:249 | 3.0 | 0.018 | S | 60.4 | 48.3 | 3.0 | 0.018 | 0.0 |
ZN Q39 EDO HOH |
4.651 3.807 6.824 2.762 |
CD2 CD2 CD1 O |
ZN N1 O2 O |
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| LEU | B:215 | B:249 | 4.0 | 0.024 | S | 63.1 | 48.2 | NA | NA | NA | |||||||||||||
| LEU | C:215 | C:249 | 3.0 | 0.018 | S | 61.4 | 46.6 | NA | NA | NA | |||||||||||||
| 7cp0 | 1 | Q16769 | 99.39 | 0.0 |
X-RAY |
2021-01-13 | LEU | A:215 | A:249 | 4.0 | 0.024 | S | 64.4 | 43.5 | 4.0 | 0.024 | 0.0 |
ZN EDO EDO HOH |
4.752 6.924 9.600 2.796 |
CD2 CD1 CD2 O |
ZN O2 O2 O |
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| LEU | B:215 | B:249 | 4.0 | 0.024 | S | 62.9 | 45.0 | NA | NA | NA | |||||||||||||
| LEU | C:215 | C:249 | 4.0 | 0.024 | S | 64.1 | 43.5 | NA | NA | NA | |||||||||||||
| 3si0 | 1 | Q16769 | 100.0 | 0.0 |
X-RAY |
2011-06-29 | LEU | A:218 | A:249 | 2.0 | 0.012 | S | 57.6 | 44.0 | 2.0 | 0.012 | 0.0 |
ZN IMD HOH |
4.617 3.677 2.947 |
CD2 CD2 O |
ZN C4 O |
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| 3si2 | 1 | B2RX76 | 86.24 | 0.0 |
X-RAY |
2011-06-29 | LEU | A:215 | A:250 | 1.0 | 0.006 | S | 61.2 | 53.0 | 1.0 | 0.006 | 0.0 |
ZN PBD HOH |
4.889 3.841 2.643 |
CD2 CD2 O |
ZN CAD O |
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| 3si1 | 1 | Q9CYK2 | 85.93 | 0.0 |
X-RAY |
2011-06-29 | LEU | A:215 | A:250 | 3.0 | 0.018 | S | 40.3 | 41.3 | 3.0 | 0.018 | 0.0 |
ZN HOH |
5.052 4.128 |
CD2 CD2 |
ZN O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q16769-f1 | 1 | Q16769 | 100.0 | 0.0 | LEU | A:249 | A:249 | 3.0 | 0.018 | S | 50.2 | 36.2 | |