Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr20 10280005 . A C CCDS13109.1:NM_003081.3:c.497gAt>gCt_NP_003072.2:p.166D>A Homo sapiens synaptosome associated protein 25kDa (SNAP25), transcript variant 1, mRNA.
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6mdm 2 P60881 100.0 2e-149 EM
 2018-09-19 ASP G:169 H:166 94.0 0.627 H -72.4 -39.0 46.0 0.307 0.32 J:P54921:0.32
6mdn 2 P60881 100.0 2e-149 EM
 2018-09-19 ASP G:169 H:166 65.0 0.433 H -73.2 -48.9 40.0 0.267 0.166 J:P54921:0.167
6mdo 2 P60881 100.0 2e-149 EM
 2018-09-19 ASP G:169 NA:NA DO NA DO DO DO NA NA NA
6mdp 2 P60881 100.0 2e-149 EM
 2018-09-19 ASP G:169 NA:NA DO NA DO DO DO NA NA NA
3j97 5 ? 98.48 1e-141 EM
 2015-01-28 ASP M:160 M:166 89.0 0.593 H -37.2 -69.3 61.0 0.407 0.186 I:P54921:0.153
J:P54921:0.04
3j96 5 ? 98.4 3e-134 EM
 2015-01-28 ASP M:150 M:166 74.0 0.493 H -59.3 -51.9 56.0 0.373 0.12 J:P54921:0.12
3j98 5 ? 98.4 3e-134 EM
 2015-01-28 ASP M:150 M:166 68.0 0.453 H -63.3 -38.4 49.0 0.327 0.126 J:P54921:0.127
3j99 5 ? 98.4 3e-134 EM
 2015-01-28 ASP M:150 M:166 69.0 0.46 H -63.4 -38.3 50.0 0.333 0.127 J:P54921:0.127
1sfc 4 P60881 100.0 1e-56 X-RAY
 1998-10-28 ASP D:47 D:166 111.0 0.74 H -60.9 -44.4 96.0 0.64 0.1 C:P60881:0.1
 SR
 9.996
 O
 SR
ASP H:47 H:166 98.0 0.653 H -51.2 -52.8 NA NA NA
ASP L:47 L:166 103.0 0.687 H -59.5 -49.6 NA NA NA
6ip1 4 P60881 100.0 2e-52 EM
 2019-04-24 ASP D:43 D:166 82.0 0.547 H -67.0 -34.5 37.0 0.247 0.3 C:P60881:0.053
F:A5D7S0:0.28
2n1t 4 P60880 100.0 6e-47 NMR
 2015-06-03 ASP D:36 D:166 100.0 0.667 H -60.1 -47.9 90.0 0.6 0.067 C:P60880:0.067
1n7s 4 P60881 100.0 9e-39 X-RAY
 2002-12-27 ASP D:28 D:166 92.0 0.613 H -65.7 -41.7 80.0 0.533 0.08 C:P60881:0.08
 HOH
 2.618
 OD1
 O
5kj7 4 P60881 100.0 1e-38 X-RAY
 2016-10-19 ASP D:26 D:166 110.0 0.733 H -57.3 -41.8 60.0 0.4 0.333 E:P21707:0.333
C:P60881:0.053
ASP J:26 J:166 86.0 0.573 H -57.3 -42.3 NA NA NA
5kj8 4 P60881 100.0 1e-38 X-RAY
 2016-10-19 ASP D:26 D:166 114.0 0.76 H -57.0 -43.1 65.0 0.433 0.327 E:P21707:0.327
C:P60881:0.047
ASP J:26 J:166 91.0 0.607 H -56.8 -42.7 NA NA NA
6wvw 4 P60881 100.0 1e-38 X-RAY
 2021-03-17 ASP D:26 D:166 85.0 0.567 H -58.9 -42.7 70.0 0.467 0.1 C:P60881:0.1
 HOH
 2.476
 OD2
 O
ASP H:26 H:166 81.0 0.54 H -59.2 -43.0 NA NA NA
3hd7 4 P60881 100.0 1e-38 X-RAY
 2009-07-14 ASP D:30 D:166 84.0 0.56 H -74.8 -48.1 75.0 0.5 0.06 C:P60881:0.06
ASP H:30 H:166 89.0 0.593 H -68.1 -49.7 NA NA NA
3ipd 4 P60881 100.0 1e-38 X-RAY
 2009-09-01 ASP D:30 D:166 101.0 0.673 H -47.2 -45.9 98.0 0.653 0.02 C:P60881:0.02
ASP H:30 H:166 100.0 0.667 H -47.4 -45.5 NA NA NA
5ccg 4 P60881 100.0 1e-38 X-RAY
 2015-08-12 ASP D:27 D:166 110.0 0.733 H -58.0 -41.8 60.0 0.4 0.333 E:P21707:0.333
C:P60881:0.053
ASP J:27 J:166 84.0 0.56 H -57.5 -42.5 NA NA NA
5cch 4 P60881 100.0 1e-38 X-RAY
 2015-08-12 ASP D:27 D:166 77.0 0.513 H -56.5 -43.8 33.0 0.22 0.293 E:P21707:0.287
C:P60881:0.08
5cci 4 P60881 100.0 1e-38 X-RAY
 2015-08-12 ASP D:27 D:166 86.0 0.573 H -56.6 -48.0 41.0 0.273 0.3 E:P21707:0.293
C:P60881:0.073
5w5c 4 P60881 100.0 1e-38 X-RAY
 2017-08-23 ASP D:27 D:166 115.0 0.767 H -60.4 -48.2 95.0 0.633 0.134 F:P21707:0.027
C:P60881:0.107
 GOL
HOH
 8.204
2.612
 N
OD2
 O3
O
5w5d 4 P60881 100.0 1e-38 X-RAY
 2017-08-23 ASP D:27 D:166 97.0 0.647 H -57.0 -51.0 80.0 0.533 0.114 F:P21707:0.013
C:P60881:0.1
 HOH
 2.374
 OD1
 O
6mti 6 P60881 100.0 1e-38 EM
 2019-04-24 ASP J:27 D:166 88.0 0.587 H -56.6 -48.0 48.0 0.32 0.267 I:P60881:0.067
C:P21707:0.247
ASP N:27 H:166 88.0 0.587 H -56.7 -47.9 35.0 0.233 0.354 B:P21707:0.333
M:P60881:0.067
ASP R:27 L:166 86.0 0.573 H -56.5 -48.1 76.0 0.507 0.066 Q:P60881:0.067
ASP V:27 P:166 87.0 0.58 H -56.6 -47.9 35.0 0.233 0.347 D:P21707:0.307
U:P60881:0.08
ASP Z:27 T:166 85.0 0.567 H -56.7 -47.9 46.0 0.307 0.26 E:P21707:0.24
Y:P60881:0.073
ASP DA:27 X:166 89.0 0.593 H -56.6 -47.9 78.0 0.52 0.073 CA:P60881:0.073
1urq 4 P13795 98.44 2e-38 X-RAY
 2004-08-26 ASP D:31 D:165 86.0 0.573 H -65.9 -36.5 67.0 0.447 0.126 C:P13795:0.127
 HOH
 2.560
 OD1
 O
5low 3 P60881 100.0 6e-38 X-RAY
 2017-06-21 ASP E:45 E:166 110.0 0.733 H -66.5 -31.1 80.0 0.533 0.2 A:P47709:0.12
D:P60881:0.087
 HOH
 9.442
 N
 O
ASP G:45 G:166 108.0 0.72 H -65.2 -24.1 104.0 0.693 0.027 F:P60881:0.027
 HOH
 4.992
 N
 O
ASP L:45 L:166 96.0 0.64 H -59.6 -42.7 NA NA NA
ASP N:45 N:166 105.0 0.7 H -63.2 -34.9 NA NA NA
3rk2 4 P60880 100.0 8e-38 X-RAY
 2011-07-27 ASP D:28 D:166 83.0 0.553 H -53.1 -44.7 65.0 0.433 0.12 C:P60880:0.12
 HOH
 7.192
 O
 O
ASP H:28 H:166 79.0 0.527 H -57.2 -48.6 NA NA NA
3rk3 4 P60880 100.0 8e-38 X-RAY
 2011-07-27 ASP D:28 D:166 95.0 0.633 H -64.8 -55.2 87.0 0.58 0.053 C:P60880:0.053
3rl0 4 P60880 100.0 8e-38 X-RAY
 2011-07-27 ASP D:28 D:166 111.0 0.74 H -58.5 -45.4 94.0 0.627 0.113 C:P60880:0.113
ASP H:28 H:166 111.0 0.74 H -59.1 -45.3 NA NA NA
ASP L:28 L:166 110.0 0.733 H -60.8 -44.4 NA NA NA
ASP P:28 P:166 112.0 0.747 H -60.1 -45.1 NA NA NA
ASP T:28 T:166 111.0 0.74 H -58.8 -45.0 NA NA NA
ASP X:28 X:166 113.0 0.753 H -59.0 -45.4 NA NA NA
ASP BA:28 b:166 113.0 0.753 H -60.2 -44.2 NA NA NA
ASP FA:28 f:166 113.0 0.753 H -60.1 -44.9 NA NA NA
5lob 3 P60881 100.0 1e-37 X-RAY
 2017-06-21 ASP E:59 E:166 108.0 0.72 H -68.5 -24.9 97.0 0.647 0.073 D:P60881:0.073
 SO4
 6.178
 CB
 O2
ASP G:59 G:166 93.0 0.62 H -75.0 -22.3 76.0 0.507 0.113 B:P47709:0.04
F:P60881:0.073
 SO4
 8.056
 OD2
 O2
1kil 4 P60880 100.0 1e-37 X-RAY
 2002-03-13 ASP D:28 D:166 90.0 0.6 H -66.7 -47.2 69.0 0.46 0.14 C:P60880:0.14
 HOH
 2.994
 OD1
 O
1xtg 2 P60880 100.0 3e-35 X-RAY
 2004-12-21 ASP B:21 B:166 119.0 0.793 H -111.9 -26.8 47.0 0.313 0.48 A:33321098:0.48
 HOH
 3.057
 O
 O
3zur 1 P10845,P60880 98.41 9e-34 X-RAY
 2011-12-07 ASP A:472 NA:NA DO NA DO DO DO NA NA NA
ASP B:472 NA:NA DO NA DO DO DO NA NA NA
6jlh 2 P60880 100.0 1.0 X-RAY
 2020-03-11 ASP B:13 B:13 75.0 0.5 H -66.0 -43.2 75.0 0.5 0.0 HOH
 7.344
 O
 O
ASP D:13 D:13 101.0 0.673 H -65.0 -44.6 101.0 0.673 0.0 HOH
 4.785
 CB
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p60880-f1 1 P60880 95.63 1e-143 ASP A:166 A:166 90.0 0.6 H -63.3 -46.4