Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr20 39728723 . C A CCDS13312.1:NM_003286.2:c.1003Ctg>Atg_NP_003277.1:p.335L>M Homo sapiens topoisomerase (DNA) I (TOP1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1k4s 4 P11387 100.0 0.0 X-RAY
 2002-12-04 LEU D:162 A:335 54.0 0.318 H -51.3 -63.3 54.0 0.318 0.0 5IU
5IU
DC
 9.729
7.309
8.426
 CD2
CD2
CD2
 O3'
OP1
OP2
1k4t 4 P11387 100.0 0.0 X-RAY
 2002-12-04 LEU D:162 A:335 42.0 0.247 H -68.6 -37.6 42.0 0.247 0.0 DT
HOH
 9.382
6.236
 CG
O
 OP2
O
1sc7 4 P11387 100.0 0.0 X-RAY
 2005-04-19 LEU D:162 A:335 48.0 0.282 H -64.7 -36.1 48.0 0.282 0.0 DT
DT
M38
 7.899
6.394
9.523
 CD2
CD2
CD2
 O3'
OP2
O19
1t8i 4 P11387 100.0 0.0 X-RAY
 2005-05-31 LEU D:162 A:335 48.0 0.282 H -65.8 -25.3 48.0 0.282 0.0 DT
 8.791
 CD2
 OP2
1tl8 4 P11387 100.0 0.0 X-RAY
 2005-06-21 LEU D:162 A:335 47.0 0.276 H -52.3 -25.3 47.0 0.276 0.0 DT
DT
 9.711
8.363
 CG
CD2
 O3'
OP2
1seu 4 P11387 99.83 0.0 X-RAY
 2005-04-19 LEU D:162 A:335 61.0 0.359 H -72.1 -24.2 61.0 0.359 0.0 DT
DT
 8.639
7.110
 CD2
CD2
 C3'
OP2
1a31 3 P11387 100.0 0.0 X-RAY
 1998-08-28 LEU C:161 A:335 39.0 0.229 H -66.0 -36.3 39.0 0.229 0.0 DA
5IU
5IU
DC
HOH
 9.868
7.612
5.336
8.019
2.977
 CB
CD2
CD2
CD2
CD2
 OP1
O3'
OP1
OP2
O
1r49 3 P11387 99.66 0.0 X-RAY
 2003-12-16 LEU C:162 A:335 34.0 0.2 H -64.6 -48.0 34.0 0.2 0.0 DA
DT
DT
DC
 9.351
7.148
4.810
7.913
 CD2
CD2
CD2
CD2
 OP1
O3'
OP1
OP2
1a35 3 P11387 99.83 0.0 X-RAY
 1998-08-28 LEU C:161 A:335 48.0 0.282 H -61.2 -44.1 48.0 0.282 0.0 DA
BRU
BRU
DC
HOH
 9.212
8.220
5.921
8.910
4.400
 CB
CD2
CD2
CD2
CD2
 OP1
O3'
OP1
OP2
O
1a36 3 P11387 99.83 0.0 X-RAY
 1998-08-12 LEU C:161 A:335 59.0 0.347 H -66.7 -36.0 59.0 0.347 0.0 DT
DT
DC
HOH
 8.707
6.383
9.159
6.228
 CD2
CD2
CD1
O
 O3'
OP1
OP2
O
1rrj 3 P11387 99.82 0.0 X-RAY
 2004-07-06 LEU C:135 A:335 44.0 0.259 H -74.2 -31.2 44.0 0.259 0.0 DT
HOH
 9.188
3.627
 CG
CB
 OP2
O
1lpq 3 P11387 99.82 0.0 X-RAY
 2002-08-16 LEU C:134 A:335 52.0 0.306 H -70.6 -4.1 52.0 0.306 0.0 DT
DT
DC
HOH
 7.892
5.867
9.584
9.094
 CD2
CD2
CD1
CD1
 O3'
OP1
OP2
O
1nh3 4 P11387 100.0 0.0 X-RAY
 2003-03-04 LEU D:133 A:335 24.0 NA H -47.2 -30.3 24.0 NA NA DU
DC
 9.052
9.531
 CA
CA
 O5'
OP2
1ej9 3 P11387 99.64 0.0 X-RAY
 2000-08-03 LEU C:133 A:335 53.0 0.312 H -59.1 -45.6 53.0 0.312 0.0 DT
DT
DC
HOH
 8.931
6.560
9.568
4.368
 CD2
CD2
CD1
N
 O3'
OP1
OP2
O
1rr8 3 P11387 99.64 0.0 X-RAY
 2004-07-06 LEU C:135 C:335 56.0 0.329 H -70.8 -28.5 56.0 0.329 0.0 DT
HOH
 8.724
3.654
 CD2
CD2
 OP2
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p11387-f1 1 P11387 100.0 0.0 LEU A:335 A:335 53.0 0.312 H -67.1 -36.6