Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr20 39729937 . G A CCDS13312.1:NM_003286.2:c.1252Gag>Aag_NP_003277.1:p.418E>K Homo sapiens topoisomerase (DNA) I (TOP1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1k4s 4 P11387 100.0 0.0 X-RAY
 2002-12-04 GLU D:245 A:418 18.0 0.095 -67.8 150.1 18.0 0.095 0.0 DG
DA
DC
DA
DA
DA
DG
 8.950
9.864
9.673
7.424
5.055
7.868
8.590
 N
OE2
OE2
CG
CG
OE2
OE2
 OP2
N6
N4
O3'
OP2
OP2
O6
1k4t 4 P11387 100.0 0.0 X-RAY
 2002-12-04 GLU D:245 A:418 31.0 0.163 -87.1 136.5 31.0 0.163 0.0 DG
DC
DA
DA
DG
TTC
TTG
HOH
 8.665
9.221
6.859
7.008
8.703
9.350
9.083
4.214
 N
OE2
OE2
OE2
OE2
OE2
OE2
OE2
 OP2
N4
C2'
OP2
O6
O26
O26
O
1sc7 4 P11387 100.0 0.0 X-RAY
 2005-04-19 GLU D:245 A:418 28.0 0.147 -90.1 135.7 28.0 0.147 0.0 DG
DA
DC
DT
DC
DA
DA
DG
M38
 9.090
9.431
8.597
9.877
9.736
6.657
6.223
8.086
8.900
 N
OE2
OE2
OE2
OE1
OE2
OE2
OE2
OE2
 OP2
N6
N4
O4
O3'
C8
N7
O6
C15
1t8i 4 P11387 100.0 0.0 X-RAY
 2005-05-31 GLU D:245 A:418 23.0 0.121 -80.7 151.8 23.0 0.121 0.0 DG
DC
DA
DA
DG
EHD
 8.510
9.786
7.672
7.971
9.198
9.716
 N
OE2
OE1
OE2
OE2
CG
 OP2
N4
OP2
OP2
O6
C2
1tl8 4 P11387 100.0 0.0 X-RAY
 2005-06-21 GLU D:245 A:418 21.0 0.111 -78.3 163.6 21.0 0.111 0.0 DG
DC
DA
DA
DG
AI3
 8.474
9.872
7.665
7.622
8.874
8.115
 N
CG
OE2
OE2
OE2
CG
 OP2
N4
C2'
OP2
O6
C39
1seu 4 P11387 99.83 0.0 X-RAY
 2005-04-19 GLU D:245 A:418 15.0 0.079 -105.1 134.3 15.0 0.079 0.0 DG
DA
DC
DC
DA
DA
DG
SA3
 9.248
9.948
9.749
9.282
7.093
7.588
8.983
8.613
 N
OE2
OE2
OE1
OE1
OE2
OE2
CG
 OP2
N6
N4
C2'
OP2
OP2
O6
O1
1a31 3 P11387 100.0 0.0 X-RAY
 1998-08-28 GLU C:244 A:418 9.0 0.047 -71.3 135.8 9.0 0.047 0.0 DG
DA
DA
DA
HOH
 9.262
7.200
4.819
7.120
2.467
 N
OE2
OE2
OE2
OE2
 OP2
O3'
OP2
OP2
O
1r49 3 P11387 99.66 0.0 X-RAY
 2003-12-16 GLU C:245 A:418 15.0 0.079 -86.7 136.2 15.0 0.079 0.0 DG
DA
DC
DT
DA
DA
DG
 9.052
9.868
9.745
7.599
5.162
7.053
9.741
 N
OE1
OE1
OE2
OE2
OE2
OE1
 OP2
N6
N4
O3'
OP2
OP2
O6
1a35 3 P11387 99.83 0.0 X-RAY
 1998-08-28 GLU C:244 A:418 8.0 0.042 -80.0 132.4 8.0 0.042 0.0 DA
DG
BRU
DA
DA
HOH
 9.984
9.253
7.302
4.898
7.640
2.769
 O
N
CG
CG
OE2
OE2
 OP2
OP2
O3'
OP2
OP2
O
1a36 3 P11387 99.83 0.0 X-RAY
 1998-08-12 GLU C:244 A:418 13.0 0.068 -80.5 127.9 13.0 0.068 0.0 DG
DT
DA
DA
HOH
 9.454
6.850
4.411
7.112
7.134
 N
OE2
OE2
OE2
C
 OP2
O3'
OP2
OP2
O
1rrj 3 P11387 99.82 0.0 X-RAY
 2004-07-06 GLU C:218 A:418 31.0 0.163 -92.1 142.5 31.0 0.163 0.0 DG
DA
DC
DA
DA
DG
TTG
TTC
HOH
 8.684
9.801
9.211
7.020
6.988
8.591
9.658
9.643
3.252
 N
OE2
OE2
OE2
OE2
OE2
CG
CG
OE1
 OP2
N6
N4
C2'
OP2
O6
O26
O26
O
1lpq 3 P11387 99.82 0.0 X-RAY
 2002-08-16 GLU C:217 A:418 24.0 0.126 -70.9 128.0 24.0 0.126 0.0 DG
DA
DC
DC
DA
DA
DG
HOH
 9.246
9.657
9.031
5.537
3.110
6.449
8.427
4.717
 N
OE1
OE1
OE2
OE2
OE2
OE1
C
 OP2
N6
N4
O3'
OP2
OP2
O6
O
1nh3 4 P11387 100.0 0.0 X-RAY
 2003-03-04 GLU D:216 A:418 10.0 0.053 -87.0 125.8 10.0 0.053 0.0 DG
CAR
DA
DA
DG
HOH
 8.538
7.104
4.981
7.180
9.707
3.717
 N
OE2
OE2
OE2
OE2
OE2
 OP2
O3'
OP1
OP2
O6
O
1ej9 3 P11387 99.64 0.0 X-RAY
 2000-08-03 GLU C:216 A:418 7.0 0.037 E -67.9 120.3 7.0 0.037 0.0 DG
DT
DG
DA
HOH
 9.488
6.367
3.982
7.926
3.718
 N
CG
CG
OE1
CG
 OP2
O3'
OP2
OP2
O
1rr8 3 P11387 99.64 0.0 X-RAY
 2004-07-06 GLU C:218 C:418 28.0 0.147 -92.5 150.6 28.0 0.147 0.0 DG
DA
DC
DA
DA
DG
TTG
TTC
HOH
 9.023
9.962
9.140
7.359
7.342
8.756
9.423
9.391
3.195
 N
OE2
OE2
OE2
OE2
OE2
CG
CG
OE1
 OP2
N6
N4
C2'
N7
O6
O26
O26
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p11387-f1 1 P11387 100.0 0.0 GLU A:418 A:418 17.0 0.089 -84.0 150.7