Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr20 39741467 . A C CCDS13312.1:NM_003286.2:c.1354Aaa>Caa_NP_003277.1:p.452K>Q Homo sapiens topoisomerase (DNA) I (TOP1), mRNA.
pdb_id: 
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label_seq_id: 
label_comp_id: 
auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1k4s 4 P11387 100.0 0.0 X-RAY
 2002-12-04 LYS D:279 A:452 142.0 0.71 T -82.2 -67.5 142.0 0.71 0.0
1k4t 4 P11387 100.0 0.0 X-RAY
 2002-12-04 LYS D:279 A:452 169.0 0.845 T -75.9 3.8 169.0 0.845 0.0 HOH
 9.203
 N
 O
1sc7 4 P11387 100.0 0.0 X-RAY
 2005-04-19 LYS D:279 A:452 175.0 0.875 T -78.0 -7.3 175.0 0.875 0.0
1t8i 4 P11387 100.0 0.0 X-RAY
 2005-05-31 LYS D:279 A:452 173.0 0.865 T -66.9 -9.5 173.0 0.865 0.0
1tl8 4 P11387 100.0 0.0 X-RAY
 2005-06-21 LYS D:279 A:452 163.0 0.815 H -55.8 -27.9 163.0 0.815 0.0
1seu 4 P11387 99.83 0.0 X-RAY
 2005-04-19 LYS D:279 A:452 166.0 0.83 T -69.5 -12.2 166.0 0.83 0.0
1a31 3 P11387 100.0 0.0 X-RAY
 1998-08-28 LYS C:278 A:452 168.0 0.84 H -65.3 -48.6 168.0 0.84 0.0 HOH
 4.562
 CD
 O
1r49 3 P11387 99.66 0.0 X-RAY
 2003-12-16 LYS C:279 A:452 154.0 0.77 H -70.5 -66.8 154.0 0.77 0.0 HOH
 9.233
 NZ
 O
1a35 3 P11387 99.83 0.0 X-RAY
 1998-08-28 LYS C:278 A:452 153.0 0.765 H -78.1 -34.5 153.0 0.765 0.0 HOH
 2.824
 O
 O
1a36 3 P11387 99.83 0.0 X-RAY
 1998-08-12 LYS C:278 A:452 175.0 0.875 H -70.5 -35.4 175.0 0.875 0.0 HOH
 3.078
 NZ
 O
1rrj 3 P11387 99.82 0.0 X-RAY
 2004-07-06 LYS C:252 A:452 168.0 0.84 T -77.3 -5.7 168.0 0.84 0.0 HOH
 3.150
 NZ
 O
1lpq 3 P11387 99.82 0.0 X-RAY
 2002-08-16 LYS C:251 A:452 158.0 0.79 T -96.3 -68.6 158.0 0.79 0.0
1nh3 4 P11387 100.0 0.0 X-RAY
 2003-03-04 LYS D:250 A:452 68.0 NA T -82.2 -39.7 68.0 NA NA HOH
 4.986
 N
 O
1ej9 3 P11387 99.64 0.0 X-RAY
 2000-08-03 LYS C:250 A:452 170.0 0.85 T -68.0 -9.5 170.0 0.85 0.0 HOH
 2.493
 NZ
 O
1rr8 3 P11387 99.64 0.0 X-RAY
 2004-07-06 LYS C:252 C:452 166.0 0.83 T -93.5 28.4 166.0 0.83 0.0 HOH
 3.273
 NZ
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p11387-f1 1 P11387 100.0 0.0 LYS A:452 A:452 190.0 0.95 H -75.8 -24.7