Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr20 39741497 . C A CCDS13312.1:NM_003286.2:c.1384Cga>Aga_NP_003277.1:p.462R>R Homo sapiens topoisomerase (DNA) I (TOP1), mRNA.
pdb_id: 
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label_seq_id: 
label_comp_id: 
auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1k4s 4 P11387 100.0 0.0 X-RAY
 2002-12-04 ARG D:289 A:462 38.0 NA H -58.9 -43.9 38.0 NA NA
1k4t 4 P11387 100.0 0.0 X-RAY
 2002-12-04 ARG D:289 A:462 130.0 0.578 H -65.3 -40.4 130.0 0.578 0.0 HOH
 8.040
 NH1
 O
1sc7 4 P11387 100.0 0.0 X-RAY
 2005-04-19 ARG D:289 A:462 117.0 0.52 H -72.8 -30.1 117.0 0.52 0.0
1t8i 4 P11387 100.0 0.0 X-RAY
 2005-05-31 ARG D:289 A:462 137.0 0.609 H -73.9 -58.5 137.0 0.609 0.0
1tl8 4 P11387 100.0 0.0 X-RAY
 2005-06-21 ARG D:289 A:462 155.0 0.689 H -65.9 -35.3 155.0 0.689 0.0
1seu 4 P11387 99.83 0.0 X-RAY
 2005-04-19 ARG D:289 A:462 115.0 0.511 T -70.2 -41.5 115.0 0.511 0.0
1a31 3 P11387 100.0 0.0 X-RAY
 1998-08-28 ARG C:288 A:462 91.0 0.404 H -73.6 -17.4 91.0 0.404 0.0 HOH
 3.317
 O
 O
1r49 3 P11387 99.66 0.0 X-RAY
 2003-12-16 ARG C:289 A:462 101.0 0.449 T -81.1 -21.4 101.0 0.449 0.0 HOH
 8.774
 CD
 O
1a35 3 P11387 99.83 0.0 X-RAY
 1998-08-28 ARG C:288 A:462 90.0 0.4 H -63.0 -25.3 90.0 0.4 0.0 HOH
 2.891
 CD
 O
1a36 3 P11387 99.83 0.0 X-RAY
 1998-08-12 ARG C:288 A:462 38.0 NA H -71.9 -27.9 38.0 NA NA
1rrj 3 P11387 99.82 0.0 X-RAY
 2004-07-06 ARG C:262 A:462 127.0 0.564 H -70.9 -36.4 127.0 0.564 0.0 HOH
 2.864
 NH1
 O
1lpq 3 P11387 99.82 0.0 X-RAY
 2002-08-16 ARG C:261 A:462 122.0 0.542 H -65.9 -46.3 122.0 0.542 0.0
1nh3 4 P11387 100.0 0.0 X-RAY
 2003-03-04 ARG D:260 A:462 39.0 NA H -62.8 -30.8 39.0 NA NA HOH
 8.802
 CB
 O
1ej9 3 P11387 99.64 0.0 X-RAY
 2000-08-03 ARG C:260 A:462 94.0 0.418 H -54.2 -39.4 94.0 0.418 0.0 HOH
 2.764
 NE
 O
1rr8 3 P11387 99.64 0.0 X-RAY
 2004-07-06 ARG C:262 C:462 120.0 0.533 H -73.7 -29.5 120.0 0.533 0.0 HOH
 6.339
 NE
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p11387-f1 1 P11387 100.0 0.0 ARG A:462 A:462 98.0 0.436 H -68.5 -31.4