Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr20 39741518 . G A CCDS13312.1:NM_003286.2:c.1405Gag>Aag_NP_003277.1:p.469E>K Homo sapiens topoisomerase (DNA) I (TOP1), mRNA.
pdb_id: 
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auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1k4s 4 P11387 100.0 0.0 X-RAY
 2002-12-04 GLU D:296 A:469 142.0 0.747 S -75.2 120.9 142.0 0.747 0.0
1k4t 4 P11387 100.0 0.0 X-RAY
 2002-12-04 GLU D:296 A:469 102.0 0.537 S -92.8 133.4 102.0 0.537 0.0 HOH
 3.551
 CG
 O
1sc7 4 P11387 100.0 0.0 X-RAY
 2005-04-19 GLU D:296 A:469 126.0 0.663 -97.7 139.1 126.0 0.663 0.0
1t8i 4 P11387 100.0 0.0 X-RAY
 2005-05-31 GLU D:296 A:469 107.0 0.563 -88.3 143.2 107.0 0.563 0.0
1tl8 4 P11387 100.0 0.0 X-RAY
 2005-06-21 GLU D:296 A:469 111.0 0.584 S -89.2 129.7 111.0 0.584 0.0
1seu 4 P11387 99.83 0.0 X-RAY
 2005-04-19 GLU D:296 A:469 109.0 0.574 S -69.1 156.9 109.0 0.574 0.0
1a31 3 P11387 100.0 0.0 X-RAY
 1998-08-28 GLU C:295 A:469 117.0 0.616 -151.3 93.5 117.0 0.616 0.0 HOH
 2.901
 CG
 O
1r49 3 P11387 99.66 0.0 X-RAY
 2003-12-16 GLU C:296 A:469 118.0 0.621 S -146.6 143.4 118.0 0.621 0.0
1a35 3 P11387 99.83 0.0 X-RAY
 1998-08-28 GLU C:295 A:469 40.0 NA -130.6 120.1 40.0 NA NA HOH
 4.273
 C
 O
1a36 3 P11387 99.83 0.0 X-RAY
 1998-08-12 GLU C:295 A:469 124.0 0.653 -122.6 115.4 124.0 0.653 0.0 HOH
 3.050
 CG
 O
1rrj 3 P11387 99.82 0.0 X-RAY
 2004-07-06 GLU C:269 A:469 92.0 0.484 S -93.6 139.5 92.0 0.484 0.0 HOH
 3.957
 CG
 O
1lpq 3 P11387 99.82 0.0 X-RAY
 2002-08-16 GLU C:268 A:469 124.0 0.653 S -69.6 131.1 124.0 0.653 0.0
1nh3 4 P11387 100.0 0.0 X-RAY
 2003-03-04 GLU D:267 A:469 123.0 0.647 S -120.5 152.9 123.0 0.647 0.0 HOH
 5.630
 N
 O
1ej9 3 P11387 99.64 0.0 X-RAY
 2000-08-03 GLU C:267 A:469 116.0 0.611 S -69.8 116.8 116.0 0.611 0.0 HOH
 6.688
 OE2
 O
1rr8 3 P11387 99.64 0.0 X-RAY
 2004-07-06 GLU C:269 C:469 118.0 0.621 -87.5 137.5 118.0 0.621 0.0 HOH
 6.592
 OE1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p11387-f1 1 P11387 100.0 0.0 GLU A:469 A:469 121.0 0.637 -89.0 124.7