Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr20 39741525 . A C CCDS13312.1:NM_003286.2:c.1412aAa>aCa_NP_003277.1:p.471K>T Homo sapiens topoisomerase (DNA) I (TOP1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1k4s 4 P11387 100.0 0.0 X-RAY
 2002-12-04 LYS D:298 A:471 43.0 NA H -43.0 -41.8 43.0 NA NA
1k4t 4 P11387 100.0 0.0 X-RAY
 2002-12-04 LYS D:298 A:471 94.0 0.47 H -52.0 -38.9 94.0 0.47 0.0 HOH
 3.326
 CD
 O
1sc7 4 P11387 100.0 0.0 X-RAY
 2005-04-19 LYS D:298 A:471 75.0 0.375 H -68.8 -39.4 75.0 0.375 0.0 DA
 8.365
 NZ
 OP2
1t8i 4 P11387 100.0 0.0 X-RAY
 2005-05-31 LYS D:298 A:471 98.0 0.49 H -60.2 -31.5 98.0 0.49 0.0
1tl8 4 P11387 100.0 0.0 X-RAY
 2005-06-21 LYS D:298 A:471 72.0 0.36 H -64.9 -23.0 72.0 0.36 0.0
1seu 4 P11387 99.83 0.0 X-RAY
 2005-04-19 LYS D:298 A:471 89.0 0.445 H -60.3 -38.2 89.0 0.445 0.0
1a31 3 P11387 100.0 0.0 X-RAY
 1998-08-28 LYS C:297 A:471 40.0 NA H -51.3 -63.6 40.0 NA NA HOH
 3.346
 CB
 O
1r49 3 P11387 99.66 0.0 X-RAY
 2003-12-16 LYS C:298 A:471 82.0 0.41 H -41.3 -45.4 82.0 0.41 0.0 DA
DA
 6.657
6.889
 NZ
NZ
 C3'
OP2
1a35 3 P11387 99.83 0.0 X-RAY
 1998-08-28 LYS C:297 A:471 105.0 0.525 H -53.9 -50.9 105.0 0.525 0.0 DA
DA
HOH
 9.389
9.307
2.786
 NZ
NZ
CG
 O5'
OP2
O
1a36 3 P11387 99.83 0.0 X-RAY
 1998-08-12 LYS C:297 A:471 31.0 NA H -65.6 -29.5 31.0 NA NA HOH
 3.233
 CB
 O
1rrj 3 P11387 99.82 0.0 X-RAY
 2004-07-06 LYS C:271 A:471 92.0 0.46 H -60.1 -34.4 92.0 0.46 0.0 HOH
 3.391
 CD
 O
1lpq 3 P11387 99.82 0.0 X-RAY
 2002-08-16 LYS C:270 A:471 35.0 NA S -57.5 -179.7 35.0 NA NA
1nh3 4 P11387 100.0 0.0 X-RAY
 2003-03-04 LYS D:269 A:471 35.0 NA H -48.5 -21.6 35.0 NA NA HOH
 8.543
 N
 O
1ej9 3 P11387 99.64 0.0 X-RAY
 2000-08-03 LYS C:269 A:471 93.0 0.465 H -53.3 -49.9 93.0 0.465 0.0 DA
HOH
 8.583
3.549
 NZ
CD
 OP2
O
1rr8 3 P11387 99.64 0.0 X-RAY
 2004-07-06 LYS C:271 C:471 125.0 0.625 H -63.2 -28.9 125.0 0.625 0.0 HOH
 5.698
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p11387-f1 1 P11387 100.0 0.0 LYS A:471 A:471 93.0 0.465 H -58.6 -39.3