Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr20 39742794 . G A CCDS13312.1:NM_003286.2:c.1637cGa>cAa_NP_003277.1:p.546R>Q Homo sapiens topoisomerase (DNA) I (TOP1), mRNA.
pdb_id: 
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label_comp_id: 
auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1k4s 4 P11387 100.0 0.0 X-RAY
 2002-12-04 ARG D:373 A:546 40.0 NA H -55.5 -46.4 40.0 NA NA
1k4t 4 P11387 100.0 0.0 X-RAY
 2002-12-04 ARG D:373 A:546 113.0 0.502 H -60.2 -30.5 113.0 0.502 0.0 HOH
 3.129
 NE
 O
1sc7 4 P11387 100.0 0.0 X-RAY
 2005-04-19 ARG D:373 A:546 94.0 0.418 H -74.8 -23.1 94.0 0.418 0.0
1t8i 4 P11387 100.0 0.0 X-RAY
 2005-05-31 ARG D:373 A:546 117.0 0.52 H -62.2 -39.7 117.0 0.52 0.0
1tl8 4 P11387 100.0 0.0 X-RAY
 2005-06-21 ARG D:373 A:546 108.0 0.48 H -59.3 -51.4 108.0 0.48 0.0
1seu 4 P11387 99.83 0.0 X-RAY
 2005-04-19 ARG D:373 A:546 114.0 0.507 H -66.7 -6.8 114.0 0.507 0.0
1a31 3 P11387 100.0 0.0 X-RAY
 1998-08-28 ARG C:372 A:546 148.0 0.658 H -55.3 -30.1 148.0 0.658 0.0 HOH
 2.826
 NH2
 O
1r49 3 P11387 99.66 0.0 X-RAY
 2003-12-16 ARG C:373 A:546 118.0 0.524 H -58.9 -40.9 118.0 0.524 0.0
1a35 3 P11387 99.83 0.0 X-RAY
 1998-08-28 ARG C:372 A:546 53.0 NA H -54.9 -39.0 53.0 NA NA HOH
 2.798
 N
 O
1a36 3 P11387 99.83 0.0 X-RAY
 1998-08-12 ARG C:372 A:546 42.0 NA H -60.4 -34.7 42.0 NA NA
1rrj 3 P11387 99.82 0.0 X-RAY
 2004-07-06 ARG C:346 A:546 120.0 0.533 H -66.8 -29.6 120.0 0.533 0.0 HOH
 2.735
 NE
 O
1lpq 3 P11387 99.82 0.0 X-RAY
 2002-08-16 ARG C:345 A:546 50.0 NA H -61.5 -28.0 50.0 NA NA
1nh3 4 P11387 100.0 0.0 X-RAY
 2003-03-04 ARG D:344 A:546 41.0 NA H -48.9 -38.5 41.0 NA NA HOH
 5.842
 N
 O
1ej9 3 P11387 99.64 0.0 X-RAY
 2000-08-03 ARG C:344 A:546 27.0 NA H -58.6 -49.2 27.0 NA NA HOH
 7.467
 O
 O
1rr8 3 P11387 99.64 0.0 X-RAY
 2004-07-06 ARG C:346 C:546 115.0 0.511 H -70.6 -29.4 115.0 0.511 0.0 HOH
 8.049
 NE
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p11387-f1 1 P11387 100.0 0.0 ARG A:546 A:546 145.0 0.644 H -69.0 -36.0