Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr21 42609453 . C A CCDS13668.1:NM_012105.4:c.415Cgc>Agc_NP_036237.2:p.139R>S Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6uj0 1 Q9Y5Z0 99.78 0.0 X-RAY
 2020-10-07 ARG A:139 A:77 183.0 0.813 E -135.1 118.7 183.0 0.813 0.0 HOH
 3.037
 NE
 O
ARG B:139 B:77 136.0 0.604 E -133.0 123.1 NA NA NA
6uj1 1 Q9Y5Z0 99.78 0.0 X-RAY
 2020-10-07 ARG A:139 A:77 171.0 0.76 E -143.0 139.3 171.0 0.76 0.0
ARG B:139 B:77 165.0 0.733 E -136.2 149.8 NA NA NA
3zkm 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 ARG A:65 A:77 129.0 0.573 E -131.1 128.1 129.0 0.573 0.0 SO4
HOH
 6.375
4.614
 NH2
CB
 O3
O
ARG B:65 B:77 131.0 0.582 E -138.5 130.5 NA NA NA
3zkn 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 ARG A:65 A:77 127.0 0.564 E -132.5 122.0 NA NA NA
ARG B:65 B:77 128.0 0.569 E -133.0 126.7 128.0 0.569 0.0 SO4
HOH
 6.060
6.022
 NH2
O
 O4
O
3zkq 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 ARG A:65 A:77 152.0 0.676 E -135.1 134.1 71.0 0.316 0.36 B:None:0.36
 HOH
 3.356
 NE
 O
3zks 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 ARG A:65 A:77 151.0 0.671 E -136.3 131.5 73.0 0.324 0.347 B:None:0.347
 HOH
 3.580
 CG
 O
4bel 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 ARG A:65 A:77 149.0 0.662 E -130.9 128.5 69.0 0.307 0.355 C:None:0.356
 HOH
 3.467
 NE
 O
ARG B:65 B:77 154.0 0.684 E -140.5 145.9 NA NA NA
4bfb 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 ARG A:65 A:77 149.0 0.662 E -146.9 120.1 68.0 0.302 0.36 C:None:0.36
 HOH
 3.545
 CG
 O
ARG B:65 B:77 157.0 0.698 E -141.2 140.0 NA NA NA
6jsz 1 Q9Y5Z0 100.0 0.0 X-RAY
 2019-08-28 ARG A:65 A:77 152.0 0.676 E -137.4 128.0 72.0 0.32 0.356 B:None:0.356
 HOH
 2.847
 NH2
 O
7d5b 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-03-31 ARG A:65 A:77 151.0 0.671 E -131.6 132.8 74.0 0.329 0.342 B:None:0.342
 HOH
 3.063
 NH2
 O
7d5u 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-03-31 ARG A:65 A:77 153.0 0.68 E -138.6 121.3 75.0 0.333 0.347 B:None:0.347
 HOH
 3.210
 NE
 O
7n4n 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-10-06 ARG A:65 A:77 148.0 0.658 E -136.7 135.0 73.0 0.324 0.334 B:None:0.333
 EDO
HOH
 5.958
2.735
 HH21
HE
 HO2
O
3zkg 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 ARG A:65 A:77 142.0 0.631 E -131.8 127.4 142.0 0.631 0.0 HOH
 3.380
 CA
 O
ARG B:65 B:77 130.0 0.578 E -131.2 133.5 NA NA NA
3zki 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 ARG A:65 A:77 144.0 0.64 E -130.1 127.2 144.0 0.64 0.0 HOH
 3.084
 NH2
 O
ARG B:65 B:77 137.0 0.609 E -147.8 124.1 NA NA NA
3zkx 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 ARG A:65 A:77 158.0 0.702 E -130.6 137.6 80.0 0.356 0.346 B:None:0.347
 HOH
 3.434
 NH2
 O
3zl7 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 ARG A:65 A:77 151.0 0.671 E -124.1 112.9 151.0 0.671 0.0 HOH
 6.188
 C
 O
3zlq 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-01 ARG A:65 A:77 155.0 0.689 E -125.3 140.6 74.0 0.329 0.36 C:None:0.36
 HOH
 3.255
 NH2
 O
ARG B:65 B:77 154.0 0.684 E -129.1 140.3 79.0 0.351 0.333 D:None:0.333
 HOH
 3.343
 NH1
 O
2ewy 1 Q9Y5Z0 100.0 0.0 X-RAY
 2006-11-07 ARG A:62 A:77 155.0 0.689 E -125.8 135.6 155.0 0.689 0.0 HOH
 7.837
 O
 O
ARG B:62 B:77 150.0 0.667 E -125.8 135.6 NA NA NA
ARG C:62 C:77 151.0 0.671 E -125.8 135.6 NA NA NA
ARG D:62 D:77 154.0 0.684 E -125.8 135.6 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9y5z0-f1 1 Q9Y5Z0 100.0 0.0 ARG A:139 A:139 154.0 0.684 E -133.7 116.0