Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr21 42617980 . G A CCDS13668.1:NM_012105.4:c.974cGc>cAc_NP_036237.2:p.325R>H Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6uj0 1 Q9Y5Z0 99.78 0.0 X-RAY
 2020-10-07 ARG A:325 A:263 177.0 0.787 H -66.9 -48.5 177.0 0.787 0.0 HOH
 4.368
 NH1
 O
ARG B:325 B:263 184.0 0.818 H -71.0 -29.9 NA NA NA
6uj1 1 Q9Y5Z0 99.78 0.0 X-RAY
 2020-10-07 ARG A:325 A:263 212.0 0.942 H -62.4 -37.0 212.0 0.942 0.0
ARG B:325 B:263 178.0 0.791 H -58.9 -15.7 NA NA NA
3zkm 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 ARG A:251 A:263 174.0 0.773 H -69.4 -32.9 151.0 0.671 0.102 F:None:0.102
 HOH
 2.646
 NH1
 O
ARG B:251 B:263 168.0 0.747 H -72.8 -31.8 NA NA NA
3zkn 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 ARG A:251 A:263 173.0 0.769 H -69.5 -39.1 NA NA NA
ARG B:251 B:263 173.0 0.769 H -67.1 -34.8 149.0 0.662 0.107 D:None:0.107
 HOH
 3.021
 NH1
 O
3zkq 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 ARG A:251 A:263 200.0 0.889 H -64.4 -36.5 200.0 0.889 0.0 HOH
 3.414
 NH2
 O
3zks 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 ARG A:251 A:263 180.0 0.8 H -58.1 -32.0 180.0 0.8 0.0 HOH
 3.025
 NH2
 O
4bel 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 ARG A:251 A:263 153.0 0.68 H -68.4 -28.7 153.0 0.68 0.0 HOH
 4.671
 NH1
 O
ARG B:251 B:263 184.0 0.818 H -66.3 -15.7 NA NA NA
4bfb 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 ARG A:251 A:263 223.0 0.991 T -72.6 25.9 223.0 0.991 0.0
ARG B:251 B:263 179.0 0.796 H -55.3 -38.3 NA NA NA
6jsz 1 Q9Y5Z0 100.0 0.0 X-RAY
 2019-08-28 ARG A:251 A:263 193.0 0.858 H -62.3 -45.9 193.0 0.858 0.0 HOH
 3.759
 CB
 O
7d5b 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-03-31 ARG A:251 A:263 103.0 NA H -67.6 -42.7 103.0 NA NA HOH
 3.807
 CB
 O
7d5u 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-03-31 ARG A:251 A:263 174.0 0.773 H -71.4 -51.2 174.0 0.773 0.0 HOH
 3.576
 CB
 O
7n4n 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-10-06 ARG A:251 A:263 208.0 0.924 H -65.6 -38.9 208.0 0.924 0.0 HOH
 2.440
 HD2
 O
3zkg 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 ARG A:251 A:263 178.0 0.791 H -65.6 -31.7 178.0 0.791 0.0 HOH
 2.816
 O
 O
ARG B:251 B:263 196.0 0.871 T -69.2 3.2 NA NA NA
3zki 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 ARG A:251 A:263 176.0 0.782 H -70.5 -31.2 176.0 0.782 0.0 HOH
 3.450
 NH1
 O
ARG B:251 B:263 169.0 0.751 H -43.1 -29.2 NA NA NA
3zkx 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 ARG A:251 A:263 142.0 0.631 H -62.5 -42.2 142.0 0.631 0.0 HOH
 2.947
 NH2
 O
3zl7 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 ARG A:251 A:263 231.0 1.0 H -71.0 -24.5 231.0 1.0 0.0 HOH
 8.777
 N
 O
3zlq 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-01 ARG A:251 A:263 163.0 0.724 H -68.9 -59.0 163.0 0.724 0.0
ARG B:251 B:263 151.0 0.671 H -51.8 -46.4 151.0 0.671 0.0
2ewy 1 Q9Y5Z0 100.0 0.0 X-RAY
 2006-11-07 ARG A:248 A:263 186.0 0.827 H -41.5 -40.9 186.0 0.827 0.0 HOH
 6.876
 C
 O
ARG B:248 B:263 187.0 0.831 H -41.5 -40.8 NA NA NA
ARG C:248 C:263 185.0 0.822 H -41.4 -40.9 NA NA NA
ARG D:248 D:263 182.0 0.809 H -41.5 -40.8 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9y5z0-f1 1 Q9Y5Z0 100.0 0.0 ARG A:325 A:325 152.0 0.676 H -67.0 -35.3