Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr21 | 42622731 | . | C | A | CCDS13668.1:NM_012105.4:c.1037aCg>aAg_NP_036237.2:p.346T>K | Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6uj0 | 1 | Q9Y5Z0 | 99.78 | 0.0 |
X-RAY |
2020-10-07 | THR | A:346 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| THR | B:346 | B:284 | 41.0 | 0.293 | E | -66.2 | 143.6 | NA | NA | NA | |||||||||||||
| 6uj1 | 1 | Q9Y5Z0 | 99.78 | 0.0 |
X-RAY |
2020-10-07 | THR | A:346 | A:284 | 75.0 | 0.536 | E | -58.7 | 150.0 | 75.0 | 0.536 | 0.0 | ||||||
| THR | B:346 | B:284 | 97.0 | 0.693 | -55.5 | 106.8 | NA | NA | NA | ||||||||||||||
| 3zkm | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | THR | A:272 | A:284 | 72.0 | 0.514 | E | -112.6 | 174.7 | 72.0 | 0.514 | 0.0 |
DMS HOH |
6.349 2.794 |
N N |
O O |
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| THR | B:272 | B:284 | 78.0 | 0.557 | E | -113.0 | 172.3 | NA | NA | NA | |||||||||||||
| 3zkn | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | THR | A:272 | A:284 | 72.0 | 0.514 | E | -116.9 | 179.4 | NA | NA | NA | ||||||
| THR | B:272 | B:284 | 76.0 | 0.543 | E | -113.1 | 174.8 | 76.0 | 0.543 | 0.0 |
DMS HOH |
6.348 3.337 |
N N |
C2 O |
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| 3zkq | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | THR | A:272 | A:284 | 63.0 | 0.45 | E | -58.1 | 138.2 | 63.0 | 0.45 | 0.0 |
HOH |
8.905 |
C |
O |
||
| 3zks | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | THR | A:272 | A:284 | 131.0 | 0.936 | -72.8 | 360.0 | 131.0 | 0.936 | 0.0 |
HOH |
5.835 |
CG2 |
O |
|||
| 4bel | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | THR | A:272 | A:284 | 199.0 | 1.0 | 59.5 | 360.0 | 199.0 | 1.0 | 0.0 | |||||||
| THR | B:272 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 4bfb | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | THR | A:272 | A:284 | 67.0 | 0.479 | E | -78.9 | 147.7 | 67.0 | 0.479 | 0.0 |
HOH |
3.869 |
O |
O |
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| THR | B:272 | B:284 | 69.0 | 0.493 | E | -62.7 | 150.1 | NA | NA | NA | |||||||||||||
| 6jsz | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2019-08-28 | THR | A:272 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 7d5b | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2021-03-31 | THR | A:272 | A:284 | 141.0 | 1.0 | -108.8 | 134.3 | 141.0 | 1.0 | 0.0 | |||||||
| 7d5u | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2021-03-31 | THR | A:272 | A:284 | 82.0 | 0.586 | E | -50.5 | 120.6 | 82.0 | 0.586 | 0.0 | ||||||
| 7n4n | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2021-10-06 | THR | A:272 | A:284 | 138.0 | 0.986 | -60.8 | 360.0 | 138.0 | 0.986 | 0.0 |
HOH |
8.574 |
H |
O |
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| 3zkg | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | THR | A:272 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| THR | B:272 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3zki | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | THR | A:272 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| THR | B:272 | B:284 | 167.0 | 1.0 | -133.0 | 360.0 | NA | NA | NA | ||||||||||||||
| 3zkx | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | THR | A:272 | A:284 | 53.0 | 0.379 | -98.8 | 174.0 | 30.0 | 0.214 | 0.165 |
C:None:0.164 |
HOH |
2.817 |
N |
O |
||
| 3zl7 | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | THR | A:272 | A:284 | 118.0 | 0.843 | S | -61.8 | 150.6 | 118.0 | 0.843 | 0.0 |
HOH |
7.521 |
N |
O |
||
| 3zlq | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-01 | THR | A:272 | A:284 | 54.0 | 0.386 | E | -70.5 | 168.9 | 54.0 | 0.386 | 0.0 |
HOH |
5.956 |
N |
O |
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| THR | B:272 | B:284 | 54.0 | 0.386 | E | -66.2 | 151.8 | 54.0 | 0.386 | 0.0 |
HOH |
5.964 |
CG2 |
O |
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| 2ewy | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2006-11-07 | THR | A:269 | A:284 | 93.0 | 0.664 | -98.5 | -2.6 | 93.0 | 0.664 | 0.0 |
HOH |
2.938 |
O |
O |
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| THR | B:269 | B:284 | 92.0 | 0.657 | -98.5 | -2.6 | NA | NA | NA | ||||||||||||||
| THR | C:269 | C:284 | 92.0 | 0.657 | -98.6 | -2.6 | NA | NA | NA | ||||||||||||||
| THR | D:269 | D:284 | 91.0 | 0.65 | -98.6 | -2.6 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9y5z0-f1 | 1 | Q9Y5Z0 | 100.0 | 0.0 | THR | A:346 | A:346 | 53.0 | 0.379 | E | -100.1 | 165.5 | |