Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr21 42609471 . G A CCDS13668.1:NM_012105.4:c.433Gtc>Atc_NP_036237.2:p.145V>I Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6uj0 1 Q9Y5Z0 99.78 0.0 X-RAY
 2020-10-07 VAL A:145 A:83 10.0 0.065 E -149.6 144.5 10.0 0.065 0.0 HOH
 3.593
 CA
 O
VAL B:145 B:83 8.0 0.052 E -139.6 142.6 NA NA NA
6uj1 1 Q9Y5Z0 99.78 0.0 X-RAY
 2020-10-07 VAL A:145 A:83 10.0 0.065 E -146.9 147.2 10.0 0.065 0.0
VAL B:145 B:83 15.0 0.097 E -149.8 141.5 NA NA NA
3zkm 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 VAL A:71 A:83 5.0 0.032 E -162.2 145.0 5.0 0.032 0.0 HOH
 3.452
 CG2
 O
VAL B:71 B:83 5.0 0.032 E -162.2 142.4 NA NA NA
3zkn 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 VAL A:71 A:83 3.0 0.019 E -153.2 141.5 NA NA NA
VAL B:71 B:83 3.0 0.019 E -156.6 143.6 3.0 0.019 0.0 HOH
 3.583
 CA
 O
3zkq 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 VAL A:71 A:83 5.0 0.032 E -142.9 139.0 5.0 0.032 0.0 HOH
 3.273
 C
 O
3zks 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 VAL A:71 A:83 7.0 0.045 E -137.1 137.2 7.0 0.045 0.0 HOH
 3.171
 CG2
 O
4bel 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 VAL A:71 A:83 8.0 0.052 E -144.5 137.4 8.0 0.052 0.0 HOH
 3.433
 C
 O
VAL B:71 B:83 8.0 0.052 E -150.0 135.9 NA NA NA
4bfb 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 VAL A:71 A:83 5.0 0.032 E -131.4 141.6 5.0 0.032 0.0 HOH
 3.550
 CA
 O
VAL B:71 B:83 9.0 0.058 E -145.8 148.9 NA NA NA
6jsz 1 Q9Y5Z0 100.0 0.0 X-RAY
 2019-08-28 VAL A:71 A:83 4.0 0.026 E -135.8 142.1 4.0 0.026 0.0 HOH
 3.675
 CG2
 O
7d5b 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-03-31 VAL A:71 A:83 7.0 0.045 E -139.8 138.2 7.0 0.045 0.0 HOH
 3.503
 CA
 O
7d5u 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-03-31 VAL A:71 A:83 2.0 0.013 E -121.7 146.8 2.0 0.013 0.0 GX6
HOH
 8.786
5.974
 CG2
CG1
 C17
O
7n4n 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-10-06 VAL A:71 A:83 7.0 0.045 E -141.7 140.1 7.0 0.045 0.0 HOH
 2.664
 HA
 O
3zkg 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 VAL A:71 A:83 8.0 0.052 E -146.2 143.3 8.0 0.052 0.0 HOH
 3.740
 CA
 O
VAL B:71 B:83 4.0 0.026 E -135.7 136.7 NA NA NA
3zki 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 VAL A:71 A:83 5.0 0.032 E -143.9 135.5 5.0 0.032 0.0 HOH
 3.758
 C
 O
VAL B:71 B:83 8.0 0.052 E -133.5 142.0 NA NA NA
3zkx 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 VAL A:71 A:83 11.0 0.071 E -155.5 139.9 11.0 0.071 0.0 HOH
 5.430
 N
 O
3zl7 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 VAL A:71 A:83 14.0 0.09 E -132.7 146.4 14.0 0.09 0.0 HOH
 9.836
 N
 O
3zlq 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-01 VAL A:71 A:83 8.0 0.052 E -143.0 145.9 8.0 0.052 0.0 HOH
 3.268
 C
 O
VAL B:71 B:83 7.0 0.045 E -122.1 147.0 7.0 0.045 0.0 HOH
 5.977
 CG1
 O
2ewy 1 Q9Y5Z0 100.0 0.0 X-RAY
 2006-11-07 VAL A:68 A:83 7.0 0.045 E -143.7 149.9 7.0 0.045 0.0 HOH
 5.723
 CG1
 O
VAL B:68 B:83 7.0 0.045 E -143.7 149.9 NA NA NA
VAL C:68 C:83 9.0 0.058 E -143.7 149.9 NA NA NA
VAL D:68 D:83 6.0 0.039 E -143.6 149.9 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9y5z0-f1 1 Q9Y5Z0 100.0 0.0 VAL A:145 A:145 7.0 0.045 E -135.7 140.4