Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr21 | 42613806 | . | G | A | CCDS13668.1:NM_012105.4:c.679Gtt>Att_NP_036237.2:p.227V>I | Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6uj0 | 1 | Q9Y5Z0 | 99.78 | 0.0 |
X-RAY |
2020-10-07 | VAL | A:227 | A:165 | 12.0 | 0.077 | E | -149.2 | 144.5 | 12.0 | 0.077 | 0.0 |
HOH |
3.253 |
CG2 |
O |
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| VAL | B:227 | B:165 | 13.0 | 0.084 | E | -147.5 | 143.3 | NA | NA | NA | |||||||||||||
| 6uj1 | 1 | Q9Y5Z0 | 99.78 | 0.0 |
X-RAY |
2020-10-07 | VAL | A:227 | A:165 | 14.0 | 0.09 | E | -158.3 | 131.8 | 14.0 | 0.09 | 0.0 | ||||||
| VAL | B:227 | B:165 | 15.0 | 0.097 | E | -135.2 | 148.1 | NA | NA | NA | |||||||||||||
| 3zkm | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | VAL | A:153 | A:165 | 17.0 | 0.11 | E | -146.2 | 145.2 | 17.0 | 0.11 | 0.0 |
HOH |
3.543 |
CG2 |
O |
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| VAL | B:153 | B:165 | 18.0 | 0.116 | E | -144.9 | 144.0 | NA | NA | NA | |||||||||||||
| 3zkn | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | VAL | A:153 | A:165 | 17.0 | 0.11 | E | -146.2 | 138.8 | NA | NA | NA | ||||||
| VAL | B:153 | B:165 | 17.0 | 0.11 | E | -147.7 | 135.1 | 17.0 | 0.11 | 0.0 |
HOH |
3.422 |
CG2 |
O |
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| 3zkq | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | VAL | A:153 | A:165 | 15.0 | 0.097 | -153.4 | 139.7 | 15.0 | 0.097 | 0.0 |
HOH |
3.298 |
CG2 |
O |
|||
| 3zks | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | VAL | A:153 | A:165 | 15.0 | 0.097 | E | -141.1 | 142.4 | 15.0 | 0.097 | 0.0 |
HOH |
3.307 |
CG2 |
O |
||
| 4bel | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | VAL | A:153 | A:165 | 14.0 | 0.09 | -150.9 | 140.7 | 14.0 | 0.09 | 0.0 |
HOH |
3.269 |
CG2 |
O |
|||
| VAL | B:153 | B:165 | 16.0 | 0.103 | -150.9 | 136.8 | NA | NA | NA | ||||||||||||||
| 4bfb | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | VAL | A:153 | A:165 | 13.0 | 0.084 | -153.0 | 137.4 | 13.0 | 0.084 | 0.0 |
HOH |
5.244 |
CG2 |
O |
|||
| VAL | B:153 | B:165 | 16.0 | 0.103 | E | -160.9 | 137.3 | NA | NA | NA | |||||||||||||
| 6jsz | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2019-08-28 | VAL | A:153 | A:165 | 16.0 | 0.103 | -156.2 | 135.1 | 16.0 | 0.103 | 0.0 |
HOH |
3.368 |
CG2 |
O |
|||
| 7d5b | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2021-03-31 | VAL | A:153 | A:165 | 15.0 | 0.097 | -153.8 | 140.2 | 15.0 | 0.097 | 0.0 |
HOH |
3.244 |
CG2 |
O |
|||
| 7d5u | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2021-03-31 | VAL | A:153 | A:165 | 16.0 | 0.103 | -160.7 | 144.4 | 16.0 | 0.103 | 0.0 |
HOH |
3.696 |
CG2 |
O |
|||
| 7n4n | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2021-10-06 | VAL | A:153 | A:165 | 16.0 | 0.103 | -149.0 | 139.4 | 16.0 | 0.103 | 0.0 |
HOH |
2.712 |
HG22 |
O |
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| 3zkg | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | VAL | A:153 | A:165 | 13.0 | 0.084 | E | -151.7 | 145.7 | 13.0 | 0.084 | 0.0 |
HOH |
3.374 |
CG2 |
O |
||
| VAL | B:153 | B:165 | 13.0 | 0.084 | E | -151.9 | 145.3 | NA | NA | NA | |||||||||||||
| 3zki | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | VAL | A:153 | A:165 | 13.0 | 0.084 | -142.6 | 138.7 | 13.0 | 0.084 | 0.0 |
HOH |
3.350 |
CG2 |
O |
|||
| VAL | B:153 | B:165 | 13.0 | 0.084 | E | -149.0 | 138.6 | NA | NA | NA | |||||||||||||
| 3zkx | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | VAL | A:153 | A:165 | 16.0 | 0.103 | E | -143.3 | 146.6 | 16.0 | 0.103 | 0.0 |
HOH |
5.404 |
CG2 |
O |
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| 3zl7 | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | VAL | A:153 | A:165 | 12.0 | 0.077 | E | -141.2 | 133.8 | 12.0 | 0.077 | 0.0 |
HOH |
5.803 |
N |
O |
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| 3zlq | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-01 | VAL | A:153 | A:165 | 14.0 | 0.09 | -146.9 | 139.6 | 14.0 | 0.09 | 0.0 |
HOH |
4.162 |
CG1 |
O |
|||
| VAL | B:153 | B:165 | 14.0 | 0.09 | E | -147.9 | 141.1 | 14.0 | 0.09 | 0.0 |
HOH |
3.255 |
CG1 |
O |
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| 2ewy | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2006-11-07 | VAL | A:150 | A:165 | 15.0 | 0.097 | -147.9 | 157.3 | 15.0 | 0.097 | 0.0 |
HOH |
7.071 |
N |
O |
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| VAL | B:150 | B:165 | 15.0 | 0.097 | -147.9 | 157.3 | NA | NA | NA | ||||||||||||||
| VAL | C:150 | C:165 | 15.0 | 0.097 | -148.0 | 157.2 | NA | NA | NA | ||||||||||||||
| VAL | D:150 | D:165 | 15.0 | 0.097 | -147.9 | 157.3 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9y5z0-f1 | 1 | Q9Y5Z0 | 100.0 | 0.0 | VAL | A:227 | A:227 | 14.0 | 0.09 | E | -145.6 | 138.8 | |