Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr21 42622749 . G A CCDS13668.1:NM_012105.4:c.1055tGg>tAg_NP_036237.2:p.352W>* Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6uj0 1 Q9Y5Z0 99.78 0.0 X-RAY
 2020-10-07 TRP A:352 A:290 31.0 0.122 G -63.1 -33.9 31.0 0.122 0.0 HOH
 6.993
 CH2
 O
TRP B:352 B:290 40.0 0.157 G -60.0 -35.0 NA NA NA
6uj1 1 Q9Y5Z0 99.78 0.0 X-RAY
 2020-10-07 TRP A:352 A:290 40.0 0.157 G -62.6 -41.3 40.0 0.157 0.0
TRP B:352 B:290 61.0 0.239 G -66.1 -43.2 NA NA NA
3zkm 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 TRP A:278 A:290 32.0 0.125 G -67.7 -40.9 32.0 0.125 0.0 DMS
HOH
 9.967
3.318
 N
N
 O
O
TRP B:278 B:290 34.0 0.133 G -62.2 -38.1 NA NA NA
3zkn 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 TRP A:278 A:290 31.0 0.122 G -60.6 -42.6 NA NA NA
TRP B:278 B:290 37.0 0.145 G -61.7 -44.4 37.0 0.145 0.0 DMS
HOH
 9.902
3.118
 N
N
 C2
O
3zkq 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 TRP A:278 A:290 67.0 0.263 G -54.2 -30.8 67.0 0.263 0.0 HOH
 3.335
 CH2
 O
3zks 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 TRP A:278 A:290 68.0 0.267 -138.3 -19.9 68.0 0.267 0.0 HOH
 8.588
 O
 O
4bel 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 TRP A:278 A:290 55.0 0.216 -80.8 -34.9 55.0 0.216 0.0 HOH
 3.602
 O
 O
TRP B:278 B:290 30.0 0.118 G -50.1 -39.9 NA NA NA
4bfb 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 TRP A:278 A:290 62.0 0.243 G -67.5 -11.1 62.0 0.243 0.0 HOH
 6.871
 N
 O
TRP B:278 B:290 60.0 0.235 G -66.7 -26.5 NA NA NA
6jsz 1 Q9Y5Z0 100.0 0.0 X-RAY
 2019-08-28 TRP A:278 A:290 113.0 0.443 360.0 -28.1 113.0 0.443 0.0 HOH
 3.317
 CZ2
 O
7d5b 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-03-31 TRP A:278 A:290 32.0 0.125 G -65.5 -35.6 32.0 0.125 0.0 HOH
 4.092
 CE3
 O
7d5u 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-03-31 TRP A:278 A:290 45.0 0.176 G -58.5 -31.0 45.0 0.176 0.0 HOH
 6.188
 CH2
 O
7n4n 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-10-06 TRP A:278 A:290 112.0 0.439 360.0 -44.5 112.0 0.439 0.0 HOH
 2.351
 HE1
 O
3zkg 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 TRP A:278 A:290 33.0 0.129 G -58.3 -37.5 33.0 0.129 0.0 HOH
 6.239
 O
 O
TRP B:278 B:290 31.0 0.122 G -51.2 -28.7 NA NA NA
3zki 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 TRP A:278 A:290 37.0 0.145 G -51.1 -38.6 37.0 0.145 0.0 HOH
 6.056
 O
 O
TRP B:278 B:290 39.0 0.153 G -52.7 -49.6 NA NA NA
3zkx 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 TRP A:278 A:290 38.0 0.149 G -53.2 -29.9 38.0 0.149 0.0 HOH
 4.091
 CE3
 O
3zl7 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 TRP A:278 A:290 52.0 0.204 G -56.7 -27.0 52.0 0.204 0.0 HOH
 8.486
 N
 O
3zlq 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-01 TRP A:278 A:290 58.0 0.227 G -51.8 -38.1 58.0 0.227 0.0 HOH
 3.321
 N
 O
TRP B:278 B:290 63.0 0.247 G -69.7 -27.1 63.0 0.247 0.0 HOH
 2.805
 N
 O
2ewy 1 Q9Y5Z0 100.0 0.0 X-RAY
 2006-11-07 TRP A:275 A:290 34.0 0.133 G -73.8 -44.4 34.0 0.133 0.0 HOH
 9.499
 CZ2
 O
TRP B:275 B:290 36.0 0.141 G -73.8 -44.4 NA NA NA
TRP C:275 C:290 35.0 0.137 G -73.8 -44.5 NA NA NA
TRP D:275 D:290 35.0 0.137 G -73.8 -44.4 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9y5z0-f1 1 Q9Y5Z0 100.0 0.0 TRP A:352 A:352 45.0 0.176 G -62.1 -32.5