Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr21 42629248 . G A CCDS13668.1:NM_012105.4:c.1298tGt>tAt_NP_036237.2:p.433C>Y Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6uj0 1 Q9Y5Z0 99.78 0.0 X-RAY
 2020-10-07 CYS A:433 A:371 34.0 0.252 G -68.7 -14.9 34.0 0.252 0.0 HOH
 2.947
 O
 O
CYS B:433 B:371 40.0 0.296 G -69.9 -18.0 NA NA NA
6uj1 1 Q9Y5Z0 99.78 0.0 X-RAY
 2020-10-07 CYS A:433 A:371 45.0 0.333 T -78.6 -3.9 45.0 0.333 0.0
CYS B:433 B:371 39.0 0.289 G -78.1 -11.2 NA NA NA
3zkm 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 CYS A:359 A:371 44.0 0.326 T -72.8 -8.5 44.0 0.326 0.0 HOH
 3.051
 N
 O
CYS B:359 B:371 45.0 0.333 T -75.8 -12.8 NA NA NA
3zkn 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 CYS A:359 A:371 45.0 0.333 T -71.9 -9.3 NA NA NA
CYS B:359 B:371 47.0 0.348 T -69.0 -16.9 47.0 0.348 0.0 HOH
 4.338
 SG
 O
3zkq 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 CYS A:359 A:371 42.0 0.311 T -66.3 -16.1 42.0 0.311 0.0 HOH
 3.309
 N
 O
3zks 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 CYS A:359 A:371 51.0 0.378 T -68.9 -22.3 51.0 0.378 0.0 HOH
 2.828
 N
 O
4bel 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 CYS A:359 A:371 42.0 0.311 T -75.5 -9.2 42.0 0.311 0.0 HOH
 3.926
 SG
 O
CYS B:359 B:371 43.0 0.319 T -62.7 -16.9 NA NA NA
4bfb 1 Q9Y5Z0 100.0 0.0 X-RAY
 2013-05-29 CYS A:359 A:371 43.0 0.319 T -71.9 -14.3 43.0 0.319 0.0 HOH
 3.503
 N
 O
CYS B:359 B:371 41.0 0.304 T -65.3 -27.3 NA NA NA
6jsz 1 Q9Y5Z0 100.0 0.0 X-RAY
 2019-08-28 CYS A:359 A:371 39.0 0.289 T -67.8 -22.7 39.0 0.289 0.0 HOH
 3.017
 N
 O
7d5b 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-03-31 CYS A:359 A:371 41.0 0.304 T -71.4 -12.3 41.0 0.304 0.0 HOH
 2.785
 O
 O
7d5u 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-03-31 CYS A:359 A:371 44.0 0.326 T -77.2 -10.0 44.0 0.326 0.0 HOH
 4.340
 SG
 O
7n4n 1 Q9Y5Z0 100.0 0.0 X-RAY
 2021-10-06 CYS A:359 A:371 42.0 0.311 T -69.1 -13.7 42.0 0.311 0.0 HOH
 2.344
 H
 O
3zkg 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 CYS A:359 A:371 34.0 0.252 T -84.6 -4.3 34.0 0.252 0.0 HOH
 3.545
 O
 O
CYS B:359 B:371 43.0 0.319 T -66.9 -13.3 NA NA NA
3zki 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 CYS A:359 A:371 25.0 0.185 T -85.7 8.4 25.0 0.185 0.0 HOH
 3.467
 O
 O
CYS B:359 B:371 40.0 0.296 T -75.3 -2.8 NA NA NA
3zkx 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 CYS A:359 A:371 42.0 0.311 T -71.5 -18.9 42.0 0.311 0.0 HOH
 2.725
 O
 O
3zl7 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-29 CYS A:359 A:371 41.0 0.304 T -78.1 -12.1 41.0 0.304 0.0 HOH
 9.323
 CB
 O
3zlq 1 Q9Y5Z0 99.74 0.0 X-RAY
 2013-05-01 CYS A:359 A:371 42.0 0.311 T -71.6 -2.1 42.0 0.311 0.0 HOH
 4.697
 SG
 O
CYS B:359 B:371 45.0 0.333 T -65.8 -7.4 45.0 0.333 0.0
2ewy 1 Q9Y5Z0 100.0 0.0 X-RAY
 2006-11-07 CYS A:356 A:371 47.0 0.348 T -56.3 -12.4 47.0 0.348 0.0 HOH
 3.735
 O
 O
CYS B:356 B:371 49.0 0.363 T -56.4 -12.3 NA NA NA
CYS C:356 C:371 48.0 0.356 T -56.3 -12.4 NA NA NA
CYS D:356 D:371 48.0 0.356 T -56.4 -12.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9y5z0-f1 1 Q9Y5Z0 100.0 0.0 CYS A:433 A:433 39.0 0.289 T -83.9 -8.8