Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr21 44188397 . A C CCDS13690.1:NM_002606.2:c.1456Atg>Ctg_NP_002597.1:p.486M>L Homo sapiens phosphodiesterase 9A (PDE9A), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4qge 1 K7AGW3 84.65 0.0 X-RAY
 2014-12-10 MET A:426 A:426 81.0 0.438 H -53.9 -32.4 81.0 0.438 0.0 HOH
 3.174
 SD
 O
MET B:426 B:426 70.0 0.378 H -68.0 -34.6 70.0 0.378 0.0 HOH
 2.735
 O
 O
4y86 1 O76083 84.65 0.0 X-RAY
 2015-09-16 MET A:426 A:426 77.0 0.416 H -48.6 -46.9 77.0 0.416 0.0 49D
HOH
 7.904
3.589
 N
CE
 CL
O
MET B:426 B:426 75.0 0.405 H -59.4 -40.5 75.0 0.405 0.0 HOH
 3.287
 SD
 O
4y87 1 O76083 84.65 0.0 X-RAY
 2015-09-16 MET A:426 A:426 80.0 0.432 H -29.3 -37.9 80.0 0.432 0.0
MET B:426 B:426 77.0 0.416 H -54.4 -52.3 77.0 0.416 0.0
4y8c 1 O76083 84.65 0.0 X-RAY
 2015-09-16 MET A:426 A:426 83.0 0.449 H -52.8 -41.9 83.0 0.449 0.0 49D
 7.882
 N
 CL
MET B:426 B:426 81.0 0.438 H -56.2 -39.9 81.0 0.438 0.0 49D
 7.939
 N
 CL
3qi3 1 O76083 84.49 0.0 X-RAY
 2011-04-27 MET A:426 A:426 79.0 0.427 H -65.7 -38.3 79.0 0.427 0.0 HOH
 6.092
 C
 O
MET B:426 B:426 76.0 0.411 H -60.7 -36.1 NA NA NA
3qi4 1 O76083 84.49 0.0 X-RAY
 2011-04-27 MET A:426 A:426 74.0 0.4 H -58.0 -44.1 74.0 0.4 0.0 HOH
 8.212
 CB
 O
MET B:426 B:426 75.0 0.405 H -60.1 -39.7 75.0 0.405 0.0
2yy2 1 O76083 100.0 0.0 X-RAY
 2007-10-30 MET A:253 A:426 79.0 0.427 H -55.5 -39.1 79.0 0.427 0.0 HOH
 6.617
 CB
 O
MET B:253 B:426 74.0 0.4 H -57.6 -40.3 74.0 0.4 0.0 HOH
 7.739
 CB
 O
2hd1 1 Q53Y40 100.0 0.0 X-RAY
 2006-06-27 MET A:246 A:426 75.0 0.405 H -60.2 -38.2 75.0 0.405 0.0 HOH
 3.056
 SD
 O
MET B:246 B:426 76.0 0.411 H -60.5 -40.3 NA NA NA
3k3e 1 O76083 100.0 0.0 X-RAY
 2010-02-16 MET A:246 A:426 76.0 0.411 H -52.2 -35.5 76.0 0.411 0.0
MET B:246 B:426 80.0 0.432 H -65.1 -29.9 80.0 0.432 0.0
3k3h 1 O76083 100.0 0.0 X-RAY
 2010-02-16 MET A:246 A:426 80.0 0.432 H -63.9 -33.7 80.0 0.432 0.0
MET B:246 B:426 85.0 0.459 H -60.6 -38.2 85.0 0.459 0.0
4gh6 1 O76083 100.0 0.0 X-RAY
 2012-10-03 MET A:246 A:426 72.0 0.389 H -52.7 -39.5 72.0 0.389 0.0
MET B:246 B:426 73.0 0.395 H -58.3 -43.8 73.0 0.395 0.0
3n3z 1 O76083 99.69 0.0 X-RAY
 2011-04-13 MET A:246 A:426 77.0 0.416 H -51.4 -43.3 77.0 0.416 0.0 HOH
 5.994
 CE
 O
MET B:246 B:426 78.0 0.422 H -52.0 -45.0 78.0 0.422 0.0 HOH
 9.974
 CG
 O
3dy8 1 O76083 100.0 0.0 X-RAY
 2008-09-16 MET A:249 A:426 76.0 0.411 H -61.2 -42.7 76.0 0.411 0.0 HOH
 2.512
 O
 O
MET B:249 B:426 77.0 0.416 H -59.7 -45.3 NA NA NA
3dyl 1 O76083 100.0 0.0 X-RAY
 2008-09-16 MET A:249 A:426 72.0 0.389 H -58.1 -45.8 72.0 0.389 0.0 HOH
 5.772
 N
 O
MET B:249 B:426 75.0 0.405 H -60.4 -41.3 NA NA NA
3dyn 1 O76083 100.0 0.0 X-RAY
 2008-09-16 MET A:249 A:426 72.0 0.389 H -57.7 -43.5 72.0 0.389 0.0 HOH
 2.490
 O
 O
MET B:249 B:426 73.0 0.395 H -62.0 -42.1 NA NA NA
3dyq 1 O76083 100.0 0.0 X-RAY
 2008-09-16 MET A:249 A:426 77.0 0.416 H -55.8 -46.8 77.0 0.416 0.0 HOH
 4.605
 O
 O
MET B:249 B:426 75.0 0.405 H -58.1 -44.9 75.0 0.405 0.0 HOH
 6.032
 C
 O
3dys 1 O76083 100.0 0.0 X-RAY
 2008-09-16 MET A:249 A:426 76.0 0.411 H -63.0 -48.8 76.0 0.411 0.0 HOH
 2.785
 O
 O
MET B:249 B:426 79.0 0.427 H -58.2 -46.7 79.0 0.427 0.0 HOH
 2.662
 O
 O
3jsi 1 O76083 100.0 0.0 X-RAY
 2009-12-01 MET A:249 A:426 75.0 0.405 H -64.6 -40.5 75.0 0.405 0.0
MET B:249 B:426 73.0 0.395 H -65.4 -40.5 NA NA NA
3jsw 1 O76083 100.0 0.0 X-RAY
 2009-12-01 MET A:249 A:426 73.0 0.395 H -47.2 -48.3 73.0 0.395 0.0 HOH
 3.140
 SD
 O
MET B:249 B:426 69.0 0.373 H -54.7 -42.8 69.0 0.373 0.0 HOH
 3.193
 SD
 O
4e90 1 O76083 100.0 0.0 X-RAY
 2013-02-27 MET A:249 A:426 78.0 0.422 H -62.3 -41.3 78.0 0.422 0.0 HOH
 3.361
 CE
 O
MET B:249 B:426 77.0 0.416 H -62.1 -42.7 NA NA NA
4g2j 1 O76083 100.0 0.0 X-RAY
 2013-05-29 MET A:249 A:426 77.0 0.416 H -61.4 -41.1 77.0 0.416 0.0 HOH
 3.067
 SD
 O
MET B:249 B:426 76.0 0.411 H -61.9 -41.0 NA NA NA
4g2l 1 O76083 100.0 0.0 X-RAY
 2013-05-29 MET A:249 A:426 85.0 0.459 H -52.5 -49.7 85.0 0.459 0.0
MET B:249 B:426 78.0 0.422 H -55.8 -48.2 NA NA NA
6a3n 1 O76083 100.0 0.0 X-RAY
 2019-04-10 MET A:242 A:426 86.0 0.465 H -55.8 -35.7 86.0 0.465 0.0 HOH
 4.632
 O
 O
MET B:242 B:426 71.0 0.384 H -47.8 -40.7 71.0 0.384 0.0 HOH
 4.247
 CE
 O
6lzz 1 O76083 100.0 0.0 X-RAY
 2021-02-24 MET A:242 A:426 82.0 0.443 H -56.2 -35.2 82.0 0.443 0.0 HOH
 2.969
 SD
 O
MET B:242 B:426 81.0 0.438 H -56.9 -44.0 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o76083-f1 1 O76083 100.0 0.0 MET A:486 A:486 82.0 0.443 H -58.7 -40.5