Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr22 19950317 . A C CCDS13770.1:NM_000754.3:c.268Atg>Ctg_NP_000745.1:p.90M>L Homo sapiens catechol-O-methyltransferase (COMT), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4pyi 1 P21964 100.0 3e-165 X-RAY
 2014-06-11 MET A:40 NA:NA DO NA DO DO DO NA NA NA
4pyj 1 P21964 100.0 3e-165 X-RAY
 2014-06-11 MET A:40 NA:NA DO NA DO DO DO NA NA NA
4pyk 1 P21964 100.0 3e-165 X-RAY
 2014-06-11 MET A:40 A:90 49.0 0.265 H -77.7 -40.3 49.0 0.265 0.0 HOH
 9.731
 CE
 O
5lsa 1 P21964 100.0 3e-165 X-RAY
 2016-09-07 MET A:40 A:90 44.0 0.238 -79.5 41.4 44.0 0.238 0.0 MG
CL
SAM
DNC
HOH
 4.326
9.670
3.426
3.909
2.743
 O
C
O
CB
O
 MG
CL
CE
C1
O
6i3c 1 P21964 99.1 4e-164 X-RAY
 2019-09-18 MET A:51 A:40 46.0 0.249 -81.1 42.8 46.0 0.249 0.0 MG
SAM
DNC
HOH
 4.394
3.342
3.972
2.850
 O
O
CB
O
 MG
CE
C1
O
6i3d 1 P21964 99.1 4e-164 X-RAY
 2019-09-18 MET A:51 A:40 46.0 0.249 -82.1 40.3 46.0 0.249 0.0 MG
HOH
 4.255
3.055
 O
N
 MG
O
MET B:51 B:40 44.0 0.238 -84.1 41.1 NA NA NA
4xuc 1 P21964 99.54 1e-161 X-RAY
 2015-04-15 MET A:43 A:90 41.0 0.222 -84.6 36.2 41.0 0.222 0.0 43G
MG
SAM
MES
HOH
 4.116
4.297
3.327
7.644
2.830
 O
O
O
N
O
 O
MG
CE
C2
O
4xud 1 P21964 99.54 1e-161 X-RAY
 2015-04-15 MET A:43 A:90 47.0 0.254 -85.2 31.2 47.0 0.254 0.0 43H
MG
SAM
MES
HOH
 4.046
4.143
3.270
8.004
2.671
 O
O
O
N
O
 O
MG
CE
C2
O
4xue 1 P21964 100.0 1e-159 X-RAY
 2015-04-15 MET A:40 B:90 43.0 0.232 -86.4 37.6 43.0 0.232 0.0 43J
MG
SAM
HOH
 3.625
4.382
3.211
2.765
 SD
O
O
O
 C12
MG
CE
O
MET B:40 A:90 46.0 0.249 -83.1 34.6 NA NA NA
3a7e 1 P21964 100.0 1e-159 X-RAY
 2010-09-15 MET A:42 A:40 50.0 0.27 -75.4 39.1 50.0 0.27 0.0 MG
SAM
DNC
HOH
 4.301
3.260
3.853
3.028
 O
SD
SD
N
 MG
SD
O3
O
3bwm 1 P21964 100.0 2e-159 X-RAY
 2008-06-03 MET A:39 A:40 38.0 0.205 -87.3 36.4 38.0 0.205 0.0 MG
SAM
DNC
HOH
 4.120
3.350
3.934
2.576
 O
O
SD
O
 MG
CE
O3
O
3bwy 1 Q6ICE6 99.53 5e-159 X-RAY
 2008-06-03 MET A:39 A:40 43.0 0.232 -86.7 39.4 43.0 0.232 0.0 MG
SAM
DNC
HOH
 4.296
3.440
3.952
2.797
 O
O
CB
O
 MG
CE
C1
O
3nwe 1 P22734 82.03 6e-135 X-RAY
 2011-08-03 MET A:40 A:40 83.0 0.449 -84.8 44.7 83.0 0.449 0.0 MG
CL
CL
SO4
662
HOH
 4.312
4.483
9.400
9.241
2.290
2.250
 O
O
HA
HE2
HE3
H
 MG
CL
CL
O3
H14B
O
3oe4 1 P22734 82.03 6e-135 X-RAY
 2011-03-16 MET A:40 A:40 101.0 0.546 -78.5 41.8 101.0 0.546 0.0 MG
HOH
 4.287
2.759
 O
O
 MG
O
3oe5 1 P22734 82.03 6e-135 X-RAY
 2011-03-16 MET A:40 A:40 99.0 0.535 -79.0 43.3 99.0 0.535 0.0 MG
HOH
 4.292
2.736
 O
O
 MG
O
3ozr 1 P22734 82.03 6e-135 X-RAY
 2011-03-16 MET A:40 A:40 96.0 0.519 -86.8 42.9 96.0 0.519 0.0 MG
CL
OZR
HOH
 4.300
4.455
3.571
2.721
 O
O
SD
O
 MG
CL
C12
O
3ozs 1 P22734 82.03 6e-135 X-RAY
 2011-03-16 MET A:40 A:40 99.0 0.535 -77.3 42.6 99.0 0.535 0.0 MG
HOH
 4.279
2.712
 O
O
 MG
O
3ozt 1 P22734 82.03 6e-135 X-RAY
 2011-03-16 MET A:40 A:40 102.0 0.551 -79.1 39.4 102.0 0.551 0.0 MG
HOH
 4.315
2.745
 O
O
 MG
O
3r6t 1 P22734 82.03 6e-135 X-RAY
 2012-02-01 MET A:40 A:83 98.0 0.53 -82.2 42.5 98.0 0.53 0.0 MG
CL
CL
NHE
HOH
 4.327
4.448
9.786
7.595
2.842
 O
O
C
N
O
 MG
CL
CL
C3'
O
3u81 1 P22734 82.03 6e-135 X-RAY
 2012-02-01 MET A:40 A:40 80.0 0.432 G -82.0 -1.3 80.0 0.432 0.0 SAH
HOH
 5.342
2.194
 O
H
 HB2
O
4pym 1 P22734 82.03 6e-135 X-RAY
 2014-06-11 MET A:40 A:83 78.0 0.422 G -75.7 -7.4 78.0 0.422 0.0 SO4
HOH
 6.442
2.265
 O
H
 O4
O
4pyn 1 P22734 82.03 6e-135 X-RAY
 2014-06-11 MET A:40 A:83 79.0 0.427 G -78.1 -6.4 79.0 0.427 0.0 SAH
K
HOH
 5.368
6.346
2.387
 O
HE2
H
 HB2
K
O
4pyo 1 P22734 82.03 6e-135 X-RAY
 2014-06-11 MET A:40 A:83 64.0 0.346 S -101.9 33.9 64.0 0.346 0.0 SAH
HOH
 6.820
5.588
 O
CB
 OXT
O
MET B:40 B:83 71.0 0.384 -76.0 28.0 NA NA NA
4pyq 1 P22734 82.03 6e-135 X-RAY
 2014-06-11 MET A:40 A:83 61.0 0.33 S -87.6 131.0 61.0 0.33 0.0 HOH
 2.743
 H
 O
MET B:40 B:83 87.0 0.47 S -103.4 124.8 87.0 0.47 0.0 CL
HOH
 9.870
3.680
 O
O
 CL
O
5lqj 1 P22734 82.03 6e-135 X-RAY
 2016-09-28 MET A:40 A:40 104.0 0.562 T -66.4 -45.0 104.0 0.562 0.0 HOH
 7.655
 C
 O
MET B:40 B:40 17.0 0.092 -139.1 155.2 NA NA NA
MET C:40 C:40 99.0 0.535 T -67.0 -27.4 NA NA NA
MET D:40 D:40 26.0 0.141 -72.9 136.5 NA NA NA
5lqk 1 P22734 82.03 6e-135 X-RAY
 2016-08-31 MET A:40 A:40 81.0 0.438 -79.7 42.1 81.0 0.438 0.0 MG
CL
CL
72M
NHE
HOH
 4.526
4.496
9.863
3.304
3.919
2.860
 O
O
C
CE
CE
O
 MG
CL
CL
C32
C3'
O
5lqn 1 P22734 82.03 6e-135 X-RAY
 2016-10-05 MET A:40 A:40 69.0 0.373 S -65.5 -41.4 69.0 0.373 0.0 72O
HOH
 8.857
3.150
 CE
CE
 C10
O
5lr6 1 P22734 82.03 6e-135 X-RAY
 2016-08-31 MET A:40 A:40 86.0 0.465 -82.9 360.0 86.0 0.465 0.0 731
NHE
HOH
 3.686
7.944
2.856
 CG
CE
N
 C17
O3
O
MET B:40 NA:NA DO NA DO DO DO NA NA NA
MET C:40 NA:NA DO NA DO DO DO NA NA NA
MET D:40 D:40 106.0 0.573 T -76.9 -39.2 NA NA NA
5p8w 1 P22734 82.03 6e-135 X-RAY
 2016-09-07 MET A:40 A:40 40.0 0.216 -85.3 132.7 40.0 0.216 0.0 DTT
NA
HOH
 3.531
6.639
2.684
 CA
O
O
 O2
NA
O
MET B:40 B:40 84.0 0.454 -64.5 120.7 84.0 0.454 0.0 DTT
NA
HOH
 3.162
4.878
3.181
 O
N
CE
 C4
NA
O
MET C:40 C:40 93.0 0.503 -87.4 137.0 71.0 0.384 0.119 B:P22734:0.119
 NA
DTT
HOH
 8.052
7.131
3.809
 CE
O
SD
 NA
C4
O
5p8x 1 P22734 82.03 6e-135 X-RAY
 2017-08-30 MET A:40 A:40 100.0 0.541 -82.9 42.3 100.0 0.541 0.0 MG
CL
CL
NHE
HOH
 4.305
4.384
9.803
7.541
2.821
 O
O
C
N
O
 MG
CL
CL
C5'
O
5p8y 1 P22734 82.03 6e-135 X-RAY
 2017-08-30 MET A:40 A:40 100.0 0.541 -79.1 40.6 100.0 0.541 0.0 MG
CL
CL
NHE
D1D
763
NHE
HOH
 4.379
4.342
9.713
7.814
7.224
3.505
8.067
2.847
 O
O
C
N
N
SD
SD
O
 MG
CL
CL
C6'
C1
C16
O1
O
5p8z 1 P22734 82.03 6e-135 X-RAY
 2017-08-30 MET A:40 A:40 101.0 0.546 -80.8 42.2 101.0 0.546 0.0 MG
CL
CL
766
NHE
D1D
HOH
 4.334
4.378
9.764
3.525
7.745
7.254
2.862
 O
O
C
SD
N
N
O
 MG
CL
CL
C22
C6'
C4
O
5p90 1 P22734 82.03 6e-135 X-RAY
 2017-08-30 MET A:40 A:40 100.0 0.541 -80.8 43.5 100.0 0.541 0.0 MG
CL
CL
D1D
NHE
HOH
 4.333
4.338
9.812
7.302
7.471
2.847
 O
O
C
N
N
O
 MG
CL
CL
C4
C3'
O
5p91 1 P22734 82.03 6e-135 X-RAY
 2017-08-30 MET A:40 A:40 101.0 0.546 -80.8 41.9 101.0 0.546 0.0 MG
CL
CL
HOH
 4.330
4.372
9.768
2.817
 O
O
C
O
 MG
CL
CL
O
5p92 1 P22734 82.03 6e-135 X-RAY
 2017-08-30 MET A:40 A:40 104.0 0.562 -82.4 41.1 104.0 0.562 0.0 MG
CL
CL
76G
D1D
NHE
HOH
 4.297
4.359
9.727
3.517
7.351
7.614
2.826
 O
O
C
SD
N
N
O
 MG
CL
CL
C22
C4
C5'
O
5p93 1 P22734 82.03 6e-135 X-RAY
 2017-08-30 MET A:40 A:40 98.0 0.53 -82.4 42.2 98.0 0.53 0.0 MG
CL
CL
HOH
 4.320
4.423
9.653
2.850
 O
O
C
O
 MG
CL
CL
O
5p94 1 P22734 82.03 6e-135 X-RAY
 2017-08-30 MET A:40 A:40 96.0 0.519 -80.8 40.9 96.0 0.519 0.0 MG
CL
CL
76T
HOH
 4.315
4.372
9.773
3.470
2.709
 O
O
C
SD
O
 MG
CL
CL
N11
O
5p9n 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 103.0 0.557 -82.0 40.1 103.0 0.557 0.0 MG
CL
CL
NHE
D1D
HOH
 4.288
4.371
9.784
7.299
7.357
2.796
 O
O
C
N
N
O
 MG
CL
CL
C2'
C1
O
5p9o 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 72.0 0.389 -82.3 38.1 72.0 0.389 0.0 7JF
SAH
CL
DTD
NHE
NHE
MG
HOH
 3.641
3.505
9.762
7.327
7.449
7.571
4.228
2.805
 SD
O
C
N
N
N
O
O
 C16
CB
CL
C1
C3'
C2'
MG
O
5p9p 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 72.0 0.389 -82.7 41.1 72.0 0.389 0.0 MG
CL
SAH
7JG
HOH
 4.209
9.741
3.523
3.662
2.813
 O
C
O
SD
O
 MG
CL
CB
C19
O
5p9q 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 72.0 0.389 -76.4 37.6 72.0 0.389 0.0 MG
CL
SAH
7JH
D1D
HOH
 4.197
9.785
3.532
3.677
7.326
2.704
 O
C
O
SD
N
O
 MG
CL
CB
C10
C4
O
5p9r 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 84.0 0.454 -84.1 43.5 84.0 0.454 0.0 MG
SAH
7JJ
HOH
 4.462
3.548
3.562
2.901
 O
O
SD
O
 MG
CB
C19
O
MET B:40 B:40 86.0 0.465 -86.0 43.2 NA NA NA
5p9s 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 76.0 0.411 -90.6 45.2 76.0 0.411 0.0 SAH
MG
7JK
HOH
 3.500
4.377
3.655
2.846
 O
O
CB
O
 CB
MG
C13
O
5p9t 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 70.0 0.378 -80.7 41.6 70.0 0.378 0.0 MG
CL
7JD
SAH
D1D
NHE
HOH
 4.232
9.740
3.632
3.467
7.438
7.675
2.785
 O
C
SD
O
N
N
O
 MG
CL
C18
CB
C4
C5'
O
5p9u 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 81.0 0.438 -84.6 33.5 81.0 0.438 0.0 MG
SAH
7JL
HOH
 4.238
3.329
3.526
2.793
 O
O
SD
O
 MG
CB
C12
O
5p9v 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 73.0 0.395 -81.5 38.0 73.0 0.395 0.0 MG
CL
SAH
D1D
7JM
HOH
 4.228
9.809
3.466
7.267
3.716
2.796
 O
C
O
N
SD
O
 MG
CL
CB
C4
C11
O
5p9x 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 100.0 0.541 -79.3 37.6 100.0 0.541 0.0 MG
CL
CL
HOH
 4.253
4.472
9.801
2.864
 O
O
C
O
 MG
CL
CL
O
5p9y 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 100.0 0.541 -83.2 37.1 100.0 0.541 0.0 MG
7JP
CL
CL
D1D
NHE
HOH
 4.292
3.496
4.445
9.749
7.374
7.682
2.778
 O
SD
O
C
N
N
O
 MG
C11
CL
CL
C1
C6'
O
5p9z 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 52.0 0.281 -79.1 41.2 52.0 0.281 0.0 MG
CL
SAH
7JQ
D1D
CL
HOH
 4.230
9.748
3.475
3.541
7.371
7.189
2.801
 O
C
O
SD
N
SD
O
 MG
CL
CB
C3
C4
CL
O
5pa0 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 SME A:40 A:40 NA NA NA NA NA NA NA NA SAH
7JR
CL
CXS
SO4
SO4
MG
HOH
 2.526
2.984
9.509
5.634
9.417
5.232
4.316
2.249
 HE1
HB3
HA
HB2
N
OE
O
H
 H3'
C3
CL
H61
O1
O1
MG
O
5pa2 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 70.0 0.378 -82.5 40.1 70.0 0.378 0.0 MG
CL
SAH
7JU
D1D
HOH
 4.251
9.702
3.462
3.670
7.287
2.803
 O
C
O
SD
N
O
 MG
CL
CB
C9
C4
O
5pa3 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 71.0 0.384 -79.8 39.3 71.0 0.384 0.0 SAH
7JV
CL
D1D
MG
HOH
 3.435
3.634
9.761
7.216
4.178
2.696
 O
SD
C
N
O
O
 CB
C12
CL
C4
MG
O
5pa4 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 72.0 0.389 -86.3 33.0 72.0 0.389 0.0 MG
SAH
7JD
HOH
 4.145
3.518
3.687
2.659
 O
O
O
O
 MG
CB
O12
O
5pa5 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 72.0 0.389 -76.4 37.6 72.0 0.389 0.0 MG
CL
SAH
7JH
D1D
HOH
 4.197
9.785
3.532
3.677
7.326
2.704
 O
C
O
SD
N
O
 MG
CL
CB
C10
C4
O
5pa6 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 50.0 0.27 -84.0 40.2 50.0 0.27 0.0 SAH
7JW
CL
NHE
MG
HOH
 3.426
3.549
9.651
7.763
4.279
2.821
 O
SD
C
N
O
O
 CB
N7
CL
C5'
MG
O
5pa7 1 P22734 82.03 6e-135 X-RAY
 2017-11-22 MET A:40 A:40 81.0 0.438 -78.6 35.8 81.0 0.438 0.0 SAH
MG
7JX
HOH
 3.700
4.327
3.826
2.767
 CE
O
CB
O
 SD
MG
C5
O
MET B:40 NA:NA DO NA DO DO DO NA NA NA
5k09 1 P22734 82.03 7e-135 X-RAY
 2016-09-07 MET A:39 A:40 22.0 0.119 -78.9 -177.8 22.0 0.119 0.0 6PQ
K
HOH
 9.371
5.832
4.533
 C
O
O
 C11
K
O
MET B:39 B:40 23.0 0.124 -87.5 -171.0 NA NA NA
MET C:39 C:40 28.0 0.151 -77.6 -168.1 NA NA NA
MET D:39 D:40 24.0 0.13 -79.7 -173.5 NA NA NA
MET E:39 E:40 28.0 0.151 -83.8 -168.9 NA NA NA
MET F:39 F:40 25.0 0.135 -82.9 -167.9 NA NA NA
MET G:39 G:40 31.0 0.168 -120.3 -176.3 NA NA NA
MET H:39 H:40 27.0 0.146 -88.4 -164.3 NA NA NA
MET I:39 I:40 26.0 0.141 -84.1 -166.9 NA NA NA
MET J:39 J:40 27.0 0.146 -89.0 -175.6 NA NA NA
MET K:39 K:40 30.0 0.162 -94.5 179.1 NA NA NA
MET L:39 L:40 31.0 0.168 -120.5 172.4 NA NA NA
MET M:39 M:40 23.0 0.124 -89.1 163.1 NA NA NA
MET N:39 N:40 21.0 0.114 -91.7 144.2 NA NA NA
MET O:39 O:40 26.0 0.141 -89.7 -176.6 NA NA NA
MET P:39 P:40 25.0 0.135 -86.4 -175.5 NA NA NA
MET Q:39 Q:40 29.0 0.157 -90.9 -163.8 NA NA NA
MET R:39 R:40 27.0 0.146 -94.6 -178.6 NA NA NA
MET S:39 S:40 25.0 0.135 -90.9 -173.3 NA NA NA
MET T:39 T:40 28.0 0.151 -82.2 -167.8 NA NA NA
MET U:39 U:40 28.0 0.151 -94.6 -166.5 NA NA NA
MET V:39 V:40 29.0 0.157 -90.5 176.8 NA NA NA
MET W:39 W:40 31.0 0.168 -90.0 -170.9 NA NA NA
MET X:39 X:40 26.0 0.141 -81.5 176.6 NA NA NA
5k0b 1 P22734 81.65 8e-135 X-RAY
 2016-09-07 MET A:39 A:40 99.0 0.535 -42.0 119.4 99.0 0.535 0.0 6PS
PO4
HOH
 3.734
6.480
2.778
 CE
SD
N
 C14
O1
O
MET B:39 B:40 95.0 0.514 -50.1 128.5 NA NA NA
MET C:39 C:40 73.0 0.395 -69.8 135.9 NA NA NA
MET D:39 D:40 73.0 0.395 -65.4 135.2 NA NA NA
MET E:39 E:40 117.0 0.632 -53.9 66.0 NA NA NA
MET F:39 F:40 102.0 0.551 -47.5 117.9 NA NA NA
MET G:39 G:40 97.0 0.524 -51.8 113.3 NA NA NA
MET H:39 H:40 69.0 0.373 -37.0 121.5 NA NA NA
4p7f 1 O88587 81.19 1e-134 X-RAY
 2014-06-11 MET A:40 A:83 86.0 0.465 S -91.4 124.5 86.0 0.465 0.0 HOH
 2.080
 H
 O
5k0f 1 P22734 82.41 1e-134 X-RAY
 2016-09-07 MET A:39 A:40 114.0 0.616 -53.2 111.7 114.0 0.616 0.0 NHE
6P1
NA
HOH
 4.200
3.967
6.047
2.746
 CE
CE
CB
O
 C6'
C16
NA
O
MET B:39 B:40 114.0 0.616 -56.8 118.3 NA NA NA
5k0g 1 P22734 82.41 1e-134 X-RAY
 2016-09-07 MET A:39 A:40 114.0 0.616 -52.8 109.4 114.0 0.616 0.0 NHE
6PM
NA
HOH
 4.048
3.627
6.083
2.829
 CE
CE
C
O
 C5'
C16
NA
O
MET B:39 B:40 114.0 0.616 -57.3 114.6 NA NA NA
5k0j 1 P22734 82.41 1e-134 X-RAY
 2016-09-07 MET A:39 A:40 120.0 0.649 -53.6 109.6 120.0 0.649 0.0 NHE
6P2
NA
HOH
 3.912
3.791
5.468
2.916
 CE
CE
CB
N
 C6'
C21
NA
O
MET B:39 B:40 116.0 0.627 S -53.9 110.2 NA NA NA
5k0n 1 P22734 81.94 4e-134 X-RAY
 2016-09-07 MET A:39 A:40 89.0 0.481 T -59.8 159.3 89.0 0.481 0.0 MG
NHE
6P0
HOH
 4.980
3.985
3.758
2.827
 CG
CE
SD
N
 MG
C2'
C20
O
MET B:39 B:40 91.0 0.492 T -73.2 162.9 NA NA NA
MET C:39 C:40 88.0 0.476 S -79.1 167.9 NA NA NA
MET D:39 D:40 88.0 0.476 S -59.6 155.8 NA NA NA
5k0l 1 P22734 81.94 4e-134 X-RAY
 2016-09-07 MET A:39 A:40 88.0 0.476 T -60.8 158.0 88.0 0.476 0.0 MG
6P2
NHE
HOH
 5.165
3.893
3.885
2.737
 C
SD
CE
N
 MG
C18
C6'
O
MET B:39 B:40 84.0 0.454 S -64.4 158.2 NA NA NA
MET C:39 C:40 92.0 0.497 S -62.4 154.3 NA NA NA
MET D:39 D:40 82.0 0.443 T -61.1 155.2 NA NA NA
5k0c 1 P22734 82.33 5e-134 X-RAY
 2016-09-07 MET A:39 A:40 113.0 0.611 -50.4 119.7 113.0 0.611 0.0 NHE
EDO
6OZ
NA
HOH
 8.470
9.444
4.211
6.185
2.800
 SD
CE
CE
CB
N
 O3
C1
C04
NA
O
MET B:39 B:40 109.0 0.589 -54.2 121.5 NA NA NA
5k0e 1 P22734 82.33 5e-134 X-RAY
 2016-09-07 MET A:39 A:40 29.0 0.157 -80.9 115.7 29.0 0.157 0.0 NHE
CL
6OZ
HOH
 9.071
3.333
9.443
7.568
 N
CE
SD
CE
 O2
CL
C20
O
6aw5 1 ? 81.0 5e-134 X-RAY
 2018-09-12 MET A:40 A:40 76.0 0.411 S -92.6 113.8 76.0 0.411 0.0 HOH
 2.881
 O
 O
6aw6 1 ? 81.0 5e-134 X-RAY
 2018-09-12 MET A:40 A:40 60.0 0.324 S -85.0 117.9 60.0 0.324 0.0 HOH
 2.951
 N
 O
6aw9 1 ? 81.0 5e-134 X-RAY
 2018-09-12 MET A:40 A:40 62.0 0.335 -90.5 49.2 62.0 0.335 0.0 CA
SAH
HOH
 4.555
3.389
5.130
 O
O
C
 CA
CB
O
MET B:40 B:40 70.0 0.378 -86.7 39.2 NA NA NA
MET C:40 C:40 46.0 0.249 -90.0 48.4 NA NA NA
6aw4 1 ? 80.54 2e-133 X-RAY
 2018-09-12 MET A:40 A:40 81.0 0.438 -93.2 116.4 81.0 0.438 0.0 TRS
HOH
 6.683
2.847
 N
O
 C2
O
6aw7 1 ? 80.54 2e-133 X-RAY
 2018-09-12 MET A:40 A:40 70.0 0.378 -74.9 27.9 70.0 0.378 0.0 CA
SAH
HOH
 4.617
3.490
2.805
 O
CE
O
 CA
SD
O
MET B:40 B:40 56.0 0.303 -87.3 41.8 NA NA NA
6aw8 1 ? 80.54 2e-133 X-RAY
 2018-09-12 MET A:40 A:40 70.0 0.378 -80.2 36.9 70.0 0.378 0.0 CA
SAH
HOH
 4.607
3.578
2.893
 O
CE
O
 CA
SD
O
MET B:40 B:40 72.0 0.389 -83.6 44.1 NA NA NA
MET C:40 C:40 43.0 0.232 -85.1 36.0 NA NA NA
5k05 1 P22734 82.24 2e-133 X-RAY
 2016-09-07 MET A:38 A:40 74.0 0.4 T -54.8 -4.4 74.0 0.4 0.0 6P5
SO4
HOH
 9.617
9.361
6.483
 O
CG
O
 C11
O2
O
MET B:38 B:40 59.0 0.319 T -91.8 -18.8 NA NA NA
1h1d 1 P22734 81.11 2e-133 X-RAY
 2003-07-17 MET A:40 A:40 37.0 0.2 -77.6 43.4 37.0 0.2 0.0 MG
SAM
BIA
HOH
 4.582
3.212
4.093
2.959
 O
O
SD
O
 MG
CE
N14
O
1jr4 1 P22734 81.11 2e-133 X-RAY
 2002-08-10 MET A:40 A:40 91.0 0.492 -80.9 58.4 91.0 0.492 0.0 MG
CL4
HOH
 4.603
3.561
2.565
 O
SD
O
 MG
C1
O
1vid 1 P22734 81.11 2e-133 X-RAY
 1996-07-11 MET A:40 A:40 35.0 0.189 -76.7 42.7 35.0 0.189 0.0 MG
SAM
DNC
HOH
 4.492
3.275
4.102
2.731
 O
SD
SD
N
 MG
SD
N1
O
2cl5 1 P22734 81.11 2e-133 X-RAY
 2006-06-28 MET A:40 A:40 36.0 0.195 -80.5 34.8 36.0 0.195 0.0 MG
SAM
BIE
BU3
HOH
 4.363
3.397
3.551
6.833
2.778
 O
O
SD
SD
O
 MG
CE
O4
C4
O
MET B:40 B:40 36.0 0.195 -84.9 38.7 NA NA NA
3hvh 1 P22734 81.11 2e-133 X-RAY
 2009-10-13 MET A:40 A:83 72.0 0.389 -81.1 44.6 72.0 0.389 0.0 542
CXS
MG
CL
SO4
HOH
 3.487
6.923
4.352
9.773
9.246
2.795
 SD
N
O
C
N
O
 N17
O3
MG
CL
O2
O
3hvi 1 P22734 81.11 2e-133 X-RAY
 2009-10-13 MET A:40 A:83 77.0 0.416 -81.9 49.9 77.0 0.416 0.0 MG
CL
619
HOH
 4.301
9.977
3.428
2.809
 O
C
SD
O
 MG
CL
N17
O
3hvj 1 P22734 81.11 2e-133 X-RAY
 2009-10-13 MET A:40 A:83 73.0 0.395 -82.8 50.9 73.0 0.395 0.0 MG
CL
BTB
HOH
 4.299
9.871
8.174
2.682
 O
C
N
O
 MG
CL
O4
O
MET B:40 B:83 89.0 0.481 -77.8 47.9 NA NA NA
3hvk 1 P22734 81.11 2e-133 X-RAY
 2009-10-13 MET A:40 A:83 92.0 0.497 -81.6 42.2 92.0 0.497 0.0 MG
CL
CL
NHE
719
HOH
 4.357
4.450
9.815
7.362
3.546
2.829
 O
O
C
N
SD
O
 MG
CL
CL
C2'
C14
O
3nw9 1 P22734 81.11 2e-133 X-RAY
 2011-03-16 MET A:40 A:40 91.0 0.492 -82.3 47.2 91.0 0.492 0.0 MG
CL
CL
CL
NHE
637
HOH
 4.351
4.437
9.799
7.287
7.351
3.606
2.828
 O
O
C
SD
N
SD
O
 MG
CL
CL
CL
C2'
C18
O
3nwb 1 P22734 81.11 2e-133 X-RAY
 2011-08-03 MET A:40 A:40 74.0 0.4 -82.9 44.2 74.0 0.4 0.0 MG
CL
CL
659
NHE
SO4
HOH
 4.295
4.485
9.452
2.888
6.071
9.491
2.290
 O
O
HA
HE1
HB3
HE2
H
 MG
CL
CL
F6
H3'2
O1
O
3s68 1 P22734 81.11 2e-133 X-RAY
 2012-02-01 MET A:40 A:40 35.0 0.189 -83.5 40.2 35.0 0.189 0.0 MG
SO4
CL
TCW
SAM
HOH
 4.396
9.309
9.664
3.083
2.386
2.354
 O
HE2
HA
HB2
O
H
 MG
O4
CL
C1
HE3
O
4p7g 1 P22734 81.11 2e-133 X-RAY
 2014-06-18 MET A:40 A:83 75.0 0.405 S -48.7 -70.3 75.0 0.405 0.0
MET B:40 B:83 64.0 0.346 S -49.6 -68.7 NA NA NA
MET C:40 C:83 71.0 0.384 S -50.4 -69.2 NA NA NA
MET D:40 D:83 83.0 0.449 S -39.8 -70.1 NA NA NA
4p7j 1 P22734 81.11 2e-133 X-RAY
 2014-06-18 MET A:40 A:83 77.0 0.416 S -100.2 117.5 77.0 0.416 0.0 HOH
 2.924
 O
 O
4p7k 1 P22734 81.11 2e-133 X-RAY
 2014-06-18 MET A:40 A:83 80.0 0.432 G -80.4 -4.2 80.0 0.432 0.0 SFG
K
HOH
 5.436
6.398
2.230
 O
HE3
H
 HB2
K
O
4pyl 1 P22734 81.11 2e-133 X-RAY
 2014-06-18 MET A:40 A:83 38.0 0.205 -80.2 44.0 38.0 0.205 0.0 MG
SFG
TCW
HOH
 4.438
3.249
3.697
2.727
 O
O
SD
O
 MG
CB
O10
O
5lqc 1 P22734 81.11 2e-133 X-RAY
 2016-08-31 MET A:40 A:40 73.0 0.395 -86.3 49.4 73.0 0.395 0.0 542
MG
HOH
 3.421
4.327
2.864
 SD
O
O
 N17
MG
O
5lqr 1 P22734 81.11 2e-133 X-RAY
 2016-10-05 MET A:40 A:40 94.0 0.508 -82.2 42.8 94.0 0.508 0.0 MG
CL
CL
NHE
72W
HOH
 4.334
4.391
9.777
7.860
3.458
2.837
 O
O
C
N
SD
O
 MG
CL
CL
C5'
N26
O
5lqu 1 P22734 81.11 2e-133 X-RAY
 2016-10-05 MET A:40 A:40 76.0 0.411 -83.5 46.9 76.0 0.411 0.0 619
MG
CL
BTB
HOH
 3.536
4.228
9.832
8.173
2.705
 SD
O
C
N
O
 N17
MG
CL
O4
O
MET B:40 B:40 92.0 0.497 -79.5 47.9 NA NA NA
5p95 1 P22734 81.11 2e-133 X-RAY
 2017-08-30 MET A:40 A:40 80.0 0.432 -82.5 42.0 80.0 0.432 0.0 MG
CL
CL
CL
77G
D1D
NHE
HOH
 4.335
4.325
9.795
9.735
3.592
7.389
7.109
2.865
 O
O
C
CE
CE
N
N
O
 MG
CL
CL
CL
C32
C1
C3'
O
5p96 1 P22734 81.11 2e-133 X-RAY
 2017-08-30 MET A:40 A:40 86.0 0.465 -79.0 40.9 86.0 0.465 0.0 MG
77H
D1D
NHE
CL
CL
HOH
 4.331
3.648
7.382
7.373
4.342
9.806
2.828
 O
SD
N
N
O
C
O
 MG
C11
C1
C3'
CL
CL
O
5p97 1 P22734 81.11 2e-133 X-RAY
 2017-08-30 MET A:40 A:40 98.0 0.53 -80.5 43.2 98.0 0.53 0.0 MG
CL
CL
HOH
 4.333
9.782
4.403
2.665
 O
C
O
O
 MG
CL
CL
O
5p98 1 P22734 81.11 2e-133 X-RAY
 2017-08-30 MET A:40 A:40 77.0 0.416 -80.9 41.6 77.0 0.416 0.0 MG
CL
CL
CL
D1D
NHE
77L
HOH
 4.360
4.317
9.793
7.372
7.340
7.274
3.408
2.867
 O
O
C
CE
N
N
CE
O
 MG
CL
CL
CL
C4
C3'
O21
O
5p99 1 P22734 81.11 2e-133 X-RAY
 2017-08-30 MET A:40 A:40 75.0 0.405 -83.3 40.9 75.0 0.405 0.0 MG
CL
77M
CL
HOH
 4.361
4.377
3.526
9.805
2.864
 O
O
SD
C
O
 MG
CL
C16
CL
O
5p9a 1 P22734 81.11 2e-133 X-RAY
 2017-08-30 MET A:40 A:40 78.0 0.422 -77.8 36.6 78.0 0.422 0.0 MG
77N
D1D
K
HOH
 4.283
3.550
6.996
4.326
2.709
 O
SD
N
O
O
 MG
C9
O2
K
O
5p9b 1 P22734 81.11 2e-133 X-RAY
 2017-08-30 MET A:40 A:40 75.0 0.405 -83.8 42.2 75.0 0.405 0.0 MG
CL
CL
77P
NHE
HOH
 4.320
4.320
9.787
3.548
7.306
2.843
 O
O
C
SD
N
O
 MG
CL
CL
C14
C3'
O
5p9c 1 P22734 81.11 2e-133 X-RAY
 2017-08-30 MET A:40 A:40 80.0 0.432 -69.6 39.9 80.0 0.432 0.0 MG
77Q
SO4
K
D1D
HOH
 4.386
3.620
8.192
4.382
7.149
2.838
 O
CE
SD
O
N
O
 MG
C31
O1
K
C1
O
5p9d 1 P22734 81.11 2e-133 X-RAY
 2017-08-30 MET A:40 A:40 81.0 0.438 -74.4 41.3 81.0 0.438 0.0 MG
77R
K
D1D
HOH
 4.368
3.633
4.305
7.262
2.825
 O
SD
O
N
O
 MG
C4
K
C4
O
5p9e 1 P22734 81.11 2e-133 X-RAY
 2017-08-30 MET A:40 A:40 79.0 0.427 -82.3 44.2 79.0 0.427 0.0 MG
CL
CL
77S
D1D
HOH
 4.335
9.852
4.312
3.449
7.277
2.773
 O
C
O
SD
N
O
 MG
CL
CL
C16
C1
O
5p9w 1 P22734 81.11 2e-133 X-RAY
 2017-11-22 MET A:40 A:40 83.0 0.449 -81.6 43.4 83.0 0.449 0.0 MG
CL
CL
7JN
SO4
D1D
NHE
HOH
 4.327
9.827
4.328
3.718
8.388
7.166
7.336
2.848
 O
C
O
SD
SD
N
N
O
 MG
CL
CL
C15
O1
C4
C6'
O
5pa1 1 P22734 81.11 2e-133 X-RAY
 2017-11-22 MET A:40 A:40 42.0 0.227 -81.0 39.6 42.0 0.227 0.0 MG
CL
SO4
D1D
NHE
SAH
7JS
HOH
 4.176
9.841
6.565
7.478
7.299
3.458
3.773
2.767
 O
C
SD
N
N
O
SD
O
 MG
CL
O3
O3
C5'
CB
C16
O
2zlb 1 P22734 81.11 3e-133 X-RAY
 2008-10-07 MET A:42 A:40 73.0 0.395 S -123.2 -144.8 73.0 0.395 0.0 HOH
 2.602
 SD
 O
2zth 1 P22734 81.11 3e-133 X-RAY
 2009-01-13 MET A:42 NA:NA DO NA DO DO DO NA NA NA
2zvj 1 P22734 81.11 3e-133 X-RAY
 2009-01-06 MET A:42 A:40 61.0 0.33 -99.5 34.3 61.0 0.33 0.0 MG
SAM
KOM
HOH
 4.305
3.514
3.615
2.165
 O
SD
O
SD
 MG
CE
O10
O
3a7d 1 P22734 81.11 3e-133 X-RAY
 2010-09-15 MET A:42 A:40 100.0 0.541 -85.7 40.9 100.0 0.541 0.0 MG
SO4
SO4
FBN
HOH
 4.350
3.501
9.338
3.030
2.906
 O
O
C
CE
N
 MG
O1
O4
N35
O
6gy1 1 P22734 81.11 3e-133 X-RAY
 2018-10-10 MET A:42 A:40 41.0 0.222 -85.8 39.0 41.0 0.222 0.0 MG
SAH
FGQ
DMS
HOH
 4.339
3.414
3.638
7.226
2.792
 O
O
SD
SD
O
 MG
CB
C15
O
O
6lfe 1 P22734 81.11 3e-133 X-RAY
 2020-03-04 MET A:42 A:40 37.0 0.2 -84.7 38.8 37.0 0.2 0.0 SAM
EAO
MG
IPA
PEG
HOH
 3.325
3.900
4.343
9.239
4.327
2.820
 O
SD
O
N
CE
O
 CE
N02
MG
O2
O1
O
5k01 1 P22734 81.78 1e-132 X-RAY
 2016-09-07 MET A:38 A:40 53.0 0.286 -70.0 150.5 53.0 0.286 0.0 HOH
 2.376
 O
 O
5k03 1 P22734 81.78 1e-132 X-RAY
 2016-09-07 MET A:38 A:40 51.0 0.276 -80.7 150.6 51.0 0.276 0.0 HOH
 2.754
 O
 O
4p58 1 O88587 81.6 2e-131 X-RAY
 2014-06-25 MET A:37 NA:NA DO NA DO DO DO NA NA NA
5fhq 1 P22734 81.22 9e-131 X-RAY
 2016-02-03 MET A:38 A:40 39.0 0.211 -86.1 34.9 39.0 0.211 0.0 SAM
DNC
MG
HOH
 2.380
3.206
4.331
2.307
 O
HB2
O
H
 HE3
C2
MG
O
5lqa 1 P22734 81.22 9e-131 X-RAY
 2016-10-05 MET A:38 A:40 78.0 0.422 -84.4 46.2 78.0 0.422 0.0 NHE
619
MG
CL
CL
HOH
 7.667
3.502
4.368
4.402
9.851
2.830
 N
SD
O
O
C
O
 C5'
N17
MG
CL
CL
O
5fhr 1 P22734 80.75 2e-129 X-RAY
 2016-02-03 MET A:38 A:83 39.0 0.211 -82.2 34.2 39.0 0.211 0.0 DNC
MG
SAM
BR
HOH
 4.105
4.325
3.154
9.053
2.858
 O
O
O
CE
O
 O1
MG
CE
BR
O
MET B:38 B:83 43.0 0.232 -79.8 34.0 43.0 0.232 0.0 DNC
MG
SAM
HOH
 4.083
4.339
3.130
2.856
 O
O
O
O
 O1
MG
CE
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p21964-f1 1 P21964 100.0 0.0 MET A:90 A:90 81.0 0.438 -79.2 35.9