Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr22 | 30051597 | . | T | A | CCDS13861.1:NM_000268.3:c.531taT>taA_NP_000259.1:p.177Y>* | Homo sapiens neurofibromin 2 (NF2), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6cds | 1 | P35240 | 99.71 | 0.0 |
X-RAY |
2018-07-18 | TYR | A:177 | A:177 | 115.0 | 0.5 | H | -112.1 | -28.7 | 115.0 | 0.5 | 0.0 |
HOH |
3.474 |
O |
O |
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| TYR | B:177 | B:177 | 21.0 | 0.091 | -70.3 | 63.7 | NA | NA | NA | ||||||||||||||
| 7lwh | 1 | P35240 | 99.41 | 0.0 |
X-RAY |
2021-08-11 | TYR | A:177 | A:177 | 113.0 | 0.491 | S | -130.2 | 155.0 | 39.0 | 0.17 | 0.321 |
B:O95835:0.322 |
HOH |
2.544 |
O |
O |
|
| 1isn | 1 | P46662 | 99.38 | 0.0 |
X-RAY |
2002-04-03 | TYR | A:160 | A:177 | 210.0 | 0.913 | T | -22.0 | -43.3 | 210.0 | 0.913 | 0.0 | ||||||
| 4zrj | 1 | P35240 | 100.0 | 0.0 |
X-RAY |
2015-06-17 | TYR | A:177 | A:177 | 109.0 | 0.474 | S | -124.8 | 154.1 | 9.0 | 0.039 | 0.435 |
B:P35240:0.435 |
HOH |
2.651 |
OH |
O |
|
| 4zri | 1 | P35240 | 100.0 | 0.0 |
X-RAY |
2015-06-17 | TYR | A:181 | A:177 | 106.0 | 0.461 | S | -127.7 | 158.1 | 28.0 | 0.122 | 0.339 |
C:Q9NRM7:0.339 |
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| TYR | B:181 | B:177 | 114.0 | 0.496 | S | -122.2 | 169.8 | NA | NA | NA | |||||||||||||
| 4zrk | 1 | P46662 | 99.38 | 0.0 |
X-RAY |
2015-06-17 | TYR | A:181 | A:177 | 111.0 | 0.483 | S | -131.6 | 148.1 | 37.0 | 0.161 | 0.322 |
E:O95835:0.322 |
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| TYR | B:181 | B:177 | 117.0 | 0.509 | S | -130.8 | 148.9 | NA | NA | NA | |||||||||||||
| TYR | C:181 | C:177 | 115.0 | 0.5 | S | -132.8 | 149.3 | NA | NA | NA | |||||||||||||
| TYR | D:181 | D:177 | 113.0 | 0.491 | S | -135.0 | 147.2 | NA | NA | NA | |||||||||||||
| 1h4r | 1 | P35240 | 100.0 | 0.0 |
X-RAY |
2002-01-16 | TYR | A:178 | A:177 | 109.0 | 0.474 | S | -133.0 | 169.1 | 103.0 | 0.448 | 0.026 |
B:P35240:0.026 |
SO4 HOH |
5.519 2.445 |
OH OH |
O2 O |
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| TYR | B:178 | B:177 | 70.0 | 0.304 | -111.3 | 142.0 | 53.0 | 0.23 | 0.074 |
A:P35240:0.074 |
HOH |
2.567 |
O |
O |
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| 4p7i | 1 | P46662 | 99.36 | 0.0 |
X-RAY |
2014-04-09 | TYR | A:181 | A:177 | 121.0 | 0.526 | T | -113.9 | 104.5 | 121.0 | 0.526 | 0.0 | ||||||
| TYR | B:181 | B:177 | 122.0 | 0.53 | S | -143.9 | 130.8 | NA | NA | NA | |||||||||||||
| 3u8z | 1 | P35240 | 100.0 | 0.0 |
X-RAY |
2011-11-02 | TYR | A:165 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| TYR | B:165 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| TYR | C:165 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| TYR | D:165 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3wa0 | 1 | P46662 | 99.32 | 0.0 |
X-RAY |
2014-05-28 | TYR | A:164 | A:177 | 91.0 | 0.396 | S | -133.3 | 162.4 | 91.0 | 0.396 | 0.0 |
HOH |
2.348 |
OH |
O |
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| TYR | B:164 | B:177 | 84.0 | 0.365 | S | -124.0 | 162.9 | NA | NA | NA | |||||||||||||
| TYR | C:164 | C:177 | 89.0 | 0.387 | S | -134.5 | 162.9 | NA | NA | NA | |||||||||||||
| TYR | D:164 | D:177 | 85.0 | 0.37 | S | -131.5 | 165.8 | NA | NA | NA | |||||||||||||
| TYR | E:164 | E:177 | 80.0 | 0.348 | S | -114.8 | 174.6 | NA | NA | NA | |||||||||||||
| TYR | F:164 | F:177 | 75.0 | 0.326 | S | -138.6 | 169.9 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p35240-f1 | 1 | P35240 | 100.0 | 0.0 | TYR | A:177 | A:177 | 9.0 | 0.039 | B | -121.7 | 148.7 | |