Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr22 | 30054241 | . | C | A | CCDS13861.1:NM_000268.3:c.663taC>taA_NP_000259.1:p.221Y>* | Homo sapiens neurofibromin 2 (NF2), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6cds | 1 | P35240 | 99.71 | 0.0 |
X-RAY |
2018-07-18 | TYR | A:221 | A:221 | 37.0 | 0.161 | E | -94.5 | 142.4 | 37.0 | 0.161 | 0.0 |
PO4 HOH |
6.942 3.051 |
OH N |
O3 O |
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| TYR | B:221 | B:221 | 40.0 | 0.174 | E | -94.0 | 142.2 | NA | NA | NA | |||||||||||||
| 7lwh | 1 | P35240 | 99.41 | 0.0 |
X-RAY |
2021-08-11 | TYR | A:221 | A:221 | 41.0 | 0.178 | E | -98.8 | 140.9 | 41.0 | 0.178 | 0.0 |
IMD HOH |
6.777 2.713 |
OH O |
C2 O |
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| 1isn | 1 | P46662 | 99.38 | 0.0 |
X-RAY |
2002-04-03 | TYR | A:204 | A:221 | 41.0 | 0.178 | E | -95.8 | 138.9 | 41.0 | 0.178 | 0.0 | ||||||
| 4zrj | 1 | P35240 | 100.0 | 0.0 |
X-RAY |
2015-06-17 | TYR | A:221 | A:221 | 42.0 | 0.183 | E | -100.1 | 142.1 | 42.0 | 0.183 | 0.0 |
GOL GOL HOH |
3.854 3.650 2.868 |
OH CD2 O |
O3 O1 O |
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| 4zri | 1 | P35240 | 100.0 | 0.0 |
X-RAY |
2015-06-17 | TYR | A:225 | A:221 | 41.0 | 0.178 | E | -79.9 | 147.5 | 41.0 | 0.178 | 0.0 |
HOH |
4.618 |
CB |
O |
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| TYR | B:225 | B:221 | 39.0 | 0.17 | E | -93.5 | 145.7 | NA | NA | NA | |||||||||||||
| 4zrk | 1 | P46662 | 99.38 | 0.0 |
X-RAY |
2015-06-17 | TYR | A:225 | A:221 | 42.0 | 0.183 | E | -102.7 | 138.2 | 42.0 | 0.183 | 0.0 |
HOH |
4.230 |
O |
O |
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| TYR | B:225 | B:221 | 41.0 | 0.178 | E | -103.0 | 135.1 | NA | NA | NA | |||||||||||||
| TYR | C:225 | C:221 | 41.0 | 0.178 | E | -102.9 | 137.6 | NA | NA | NA | |||||||||||||
| TYR | D:225 | D:221 | 42.0 | 0.183 | E | -102.3 | 138.3 | NA | NA | NA | |||||||||||||
| 1h4r | 1 | P35240 | 100.0 | 0.0 |
X-RAY |
2002-01-16 | TYR | A:222 | A:221 | 40.0 | 0.174 | E | -103.2 | 142.8 | 40.0 | 0.174 | 0.0 |
SO4 HOH |
6.568 2.817 |
OH N |
O2 O |
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| TYR | B:222 | B:221 | 41.0 | 0.178 | E | -99.8 | 141.0 | 41.0 | 0.178 | 0.0 |
HOH |
2.723 |
O |
O |
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| 4p7i | 1 | P46662 | 99.36 | 0.0 |
X-RAY |
2014-04-09 | TYR | A:225 | A:221 | 40.0 | 0.174 | E | -97.4 | 139.1 | 40.0 | 0.174 | 0.0 |
HOH |
3.568 |
CE1 |
O |
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| TYR | B:225 | B:221 | 49.0 | 0.213 | E | -98.0 | 136.6 | NA | NA | NA | |||||||||||||
| 3u8z | 1 | P35240 | 100.0 | 0.0 |
X-RAY |
2011-11-02 | TYR | A:209 | A:221 | 39.0 | 0.17 | E | -102.8 | 139.0 | 39.0 | 0.17 | 0.0 |
HOH |
2.926 |
N |
O |
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| TYR | B:209 | B:221 | 41.0 | 0.178 | E | -102.9 | 138.8 | NA | NA | NA | |||||||||||||
| TYR | C:209 | C:221 | 40.0 | 0.174 | E | -102.5 | 138.4 | 40.0 | 0.174 | 0.0 |
HOH |
2.671 |
N |
O |
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| TYR | D:209 | D:221 | 43.0 | 0.187 | E | -102.8 | 137.6 | NA | NA | NA | |||||||||||||
| 3wa0 | 1 | P46662 | 99.32 | 0.0 |
X-RAY |
2014-05-28 | TYR | A:208 | A:221 | 45.0 | 0.196 | E | -101.5 | 136.5 | 45.0 | 0.196 | 0.0 |
HOH |
3.162 |
O |
O |
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| TYR | B:208 | B:221 | 45.0 | 0.196 | E | -100.7 | 141.1 | NA | NA | NA | |||||||||||||
| TYR | C:208 | C:221 | 40.0 | 0.174 | E | -101.7 | 144.8 | NA | NA | NA | |||||||||||||
| TYR | D:208 | D:221 | 41.0 | 0.178 | E | -93.4 | 135.7 | NA | NA | NA | |||||||||||||
| TYR | E:208 | E:221 | 42.0 | 0.183 | E | -99.7 | 144.5 | NA | NA | NA | |||||||||||||
| TYR | F:208 | F:221 | 44.0 | 0.191 | E | -106.0 | 141.7 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p35240-f1 | 1 | P35240 | 100.0 | 0.0 | TYR | A:221 | A:221 | 47.0 | 0.204 | E | -95.2 | 137.2 | |