Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr22 37627343 . T A CCDS13945.1:NM_002872.4:c.376Atc>Ttc_NP_002863.1:p.126I>F Homo sapiens ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (RAC2), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1ds6 1 P15153 100.0 2e-143 X-RAY
 2000-07-12 ILE A:126 A:126 66.0 0.377 H -61.5 -44.7 66.0 0.377 0.0 HOH
 2.693
 O
 O
1i4d 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 ILE C:126 D:126 57.0 0.326 H -68.0 -42.1 57.0 0.326 0.0 HOH
 3.153
 CD1
 O
1i4l 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 ILE C:126 D:126 46.0 0.263 H -56.8 -35.3 46.0 0.263 0.0 HOH
 7.730
 CG2
 O
6tgc 3 P63000 92.19 3e-133 EM
 2020-07-29 ILE C:126 C:126 53.0 0.303 H -44.5 -42.7 53.0 0.303 0.0
ILE F:126 F:126 53.0 0.303 H -44.4 -42.7 53.0 0.303 0.0
5fi0 2 P63000 92.19 4e-133 X-RAY
 2016-04-20 ILE B:129 B:126 45.0 0.257 H -53.9 -40.3 45.0 0.257 0.0
ILE D:129 D:126 45.0 0.257 H -54.4 -40.6 NA NA NA
ILE F:129 F:126 52.0 0.297 H -54.2 -39.4 NA NA NA
ILE H:129 H:126 56.0 0.32 H -53.5 -39.6 NA NA NA
1i4t 2 P63000 91.67 5e-132 X-RAY
 2001-05-16 ILE C:126 D:126 46.0 0.263 H -75.6 -16.9 46.0 0.263 0.0 HOH
 2.456
 O
 O
1e96 1 P15154 91.62 5e-131 X-RAY
 2000-11-17 ILE A:126 A:126 44.0 0.251 H -52.1 -50.1 44.0 0.251 0.0 HOH
 2.782
 O
 O
1hh4 1 P15154 91.62 8e-131 X-RAY
 2001-08-28 ILE A:126 A:126 33.0 0.189 H -73.9 25.0 33.0 0.189 0.0
ILE B:126 B:126 69.0 0.394 H -82.0 30.4 NA NA NA
2w2t 1 P15153 99.44 2e-130 X-RAY
 2009-05-05 ILE A:132 A:126 71.0 0.406 H -54.6 -39.4 71.0 0.406 0.0 HOH
 2.638
 O
 O
2w2x 1 P15153 99.44 2e-130 X-RAY
 2009-05-05 ILE A:132 A:126 79.0 0.451 H -57.9 -27.2 79.0 0.451 0.0
ILE B:132 B:126 82.0 0.469 H -58.7 -25.6 NA NA NA
2w2v 1 P15153 99.44 9e-130 X-RAY
 2009-05-05 ILE A:133 A:126 72.0 0.411 H -56.9 -38.1 72.0 0.411 0.0 HOH
 3.324
 CD1
 O
ILE B:133 B:126 78.0 0.446 H -53.0 -38.2 NA NA NA
ILE C:133 C:126 134.0 0.766 -92.9 360.0 NA NA NA
ILE D:133 D:126 67.0 0.383 H -58.7 -37.7 NA NA NA
2vrw 1 P63000 93.48 1e-129 X-RAY
 2008-06-17 ILE A:126 A:126 67.0 0.383 H -60.2 -37.1 67.0 0.383 0.0 HOH
 2.621
 O
 O
2h7v 1 P63000 92.93 2e-128 X-RAY
 2006-09-19 ILE A:130 A:126 50.0 0.286 H -67.8 -37.3 50.0 0.286 0.0
ILE B:130 B:126 59.0 0.337 H -71.6 -47.1 NA NA NA
2p2l 1 P63000 92.93 2e-128 X-RAY
 2007-05-01 ILE A:130 A:126 68.0 0.389 H -63.7 -38.8 68.0 0.389 0.0 ZN
HOH
 7.796
2.818
 O
O
 ZN
O
ILE B:130 B:126 27.0 0.154 H -67.0 -39.9 27.0 0.154 0.0 HOH
 2.865
 O
 O
ILE C:130 C:126 49.0 0.28 H -63.3 -47.8 49.0 0.28 0.0 HOH
 3.439
 CG2
 O
1g4u 2 P63000 92.93 3e-128 X-RAY
 2001-01-24 ILE B:126 R:126 60.0 0.343 H -61.5 -45.0 60.0 0.343 0.0 HOH
 2.388
 O
 O
1mh1 1 P63000 92.9 3e-127 X-RAY
 1998-01-21 ILE A:128 A:126 57.0 0.326 H -60.3 -56.4 57.0 0.326 0.0 HOH
 3.031
 O
 O
2yin 2 P63000 95.48 7e-127 X-RAY
 2011-05-25 ILE C:145 C:126 66.0 0.377 H -58.9 -41.9 NA NA NA
ILE D:145 D:126 58.0 0.331 H -64.1 -40.5 58.0 0.331 0.0 HOH
 8.346
 CD1
 O
2fju 1 P63000 95.48 1e-126 X-RAY
 2006-11-21 ILE A:126 A:126 68.0 0.389 H -62.1 -48.6 68.0 0.389 0.0 HOH
 3.312
 CD1
 O
5qqd 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ILE A:127 A:126 67.0 0.383 H -55.2 -43.5 67.0 0.383 0.0 EDO
HOH
 8.690
2.803
 CD1
O
 O1
O
5qqe 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ILE A:127 A:126 68.0 0.389 H -55.2 -47.7 68.0 0.389 0.0 EDO
N5S
HOH
 8.522
9.764
2.700
 CD1
N
O
 O2
F
O
5qqf 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ILE A:127 A:126 66.0 0.377 H -55.2 -46.1 66.0 0.377 0.0 EDO
HOH
 8.153
2.505
 CD1
O
 O1
O
5qqg 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ILE A:127 A:126 68.0 0.389 H -53.3 -50.0 68.0 0.389 0.0 EDO
HOH
 8.315
2.688
 CD1
O
 O1
O
5qqh 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ILE A:127 A:126 66.0 0.377 H -59.4 -50.6 66.0 0.377 0.0 EDO
N67
HOH
 8.500
9.722
2.713
 CD1
N
O
 O2
O1
O
5qqi 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ILE A:127 A:126 68.0 0.389 H -57.7 -41.9 68.0 0.389 0.0 EDO
N6D
HOH
 8.399
9.705
2.670
 CD1
N
O
 O1
C
O
5qqj 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ILE A:127 A:126 67.0 0.383 H -58.1 -48.5 67.0 0.383 0.0 EDO
N6J
HOH
 8.313
8.372
2.800
 CD1
N
O
 O1
C12
O
5qqk 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ILE A:127 A:126 69.0 0.394 H -54.5 -49.2 69.0 0.394 0.0 EDO
N6V
HOH
 7.814
8.463
2.509
 CD1
N
O
 O1
C
O
5qql 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ILE A:127 A:126 67.0 0.383 H -56.8 -46.0 67.0 0.383 0.0 EDO
HOH
 8.241
2.628
 CD1
O
 O1
O
5qqm 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ILE A:127 A:126 66.0 0.377 H -59.8 -48.6 66.0 0.377 0.0 EDO
HOH
 8.150
2.720
 CD1
O
 O2
O
5qqn 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ILE A:127 A:126 71.0 0.406 H -53.8 -54.6 71.0 0.406 0.0 EDO
N5D
HOH
 8.229
8.495
2.628
 CD1
N
O
 O2
C9
O
5qu9 1 P63000 95.48 1e-126 X-RAY
 2020-01-29 ILE A:127 A:126 70.0 0.4 H -57.5 -42.5 70.0 0.4 0.0 EDO
HOH
 7.474
2.817
 CD1
O
 O1
O
1foe 2 P63000 95.48 1e-126 X-RAY
 2001-01-17 ILE B:126 B:126 54.0 0.309 H -60.3 -34.5 54.0 0.309 0.0
ILE D:126 D:126 55.0 0.314 H -60.2 -34.3 NA NA NA
ILE F:126 F:126 55.0 0.314 H -59.4 -34.3 NA NA NA
ILE H:126 H:126 54.0 0.309 H -60.8 -33.6 NA NA NA
2nz8 1 P63000 95.48 1e-126 X-RAY
 2007-04-10 ILE A:126 A:126 46.0 0.263 H -58.1 -43.8 46.0 0.263 0.0 HOH
 2.786
 O
 O
3bji 2 P63000 95.48 1e-126 X-RAY
 2008-07-15 ILE C:126 C:126 67.0 0.383 H -43.4 -55.4 NA NA NA
ILE D:126 NA:NA DO NA DO DO DO NA NA NA
5o33 1 P63000 95.48 1e-126 X-RAY
 2017-05-31 ILE A:126 A:126 71.0 0.406 H -61.5 -44.6 71.0 0.406 0.0 EDO
HOH
 7.443
2.812
 CD1
O
 HO1
O
3su8 1 P63000 95.48 1e-126 X-RAY
 2011-09-28 ILE A:126 A:126 71.0 0.406 H -65.6 -40.2 71.0 0.406 0.0
3sua 1 P63000 95.48 1e-126 X-RAY
 2011-09-07 ILE A:126 A:126 68.0 0.389 H -62.9 -23.4 68.0 0.389 0.0
ILE B:126 B:126 68.0 0.389 H -63.0 -22.9 NA NA NA
ILE C:126 C:126 69.0 0.394 H -63.0 -23.3 NA NA NA
6x1g 2 P63000 95.48 2e-126 X-RAY
 2020-11-25 ILE C:126 B:126 56.0 0.32 H -57.7 -42.6 56.0 0.32 0.0 HOH
 7.448
 CD1
 O
ILE D:126 D:126 54.0 0.309 H -58.1 -42.1 NA NA NA
6tm1 2 P60763 88.54 2e-126 X-RAY
 2020-01-22 ILE B:126 A:126 54.0 NA H -66.4 -16.2 54.0 NA NA
3b13 2 P63000 94.92 4e-126 X-RAY
 2012-03-14 ILE B:133 B:126 41.0 0.234 H -55.3 -35.4 41.0 0.234 0.0
ILE D:133 D:126 49.0 0.28 H -62.2 -38.0 49.0 0.28 0.0
7dpa 2 P63000 94.92 5e-126 EM
 2021-08-04 ILE B:133 B:126 46.0 0.263 H -61.2 -41.1 46.0 0.263 0.0
ILE E:133 E:126 46.0 0.263 H -61.2 -41.0 46.0 0.263 0.0
5n6o 1 P63000 95.45 2e-125 X-RAY
 2017-12-27 ILE A:125 A:126 67.0 0.383 H -69.0 -42.2 67.0 0.383 0.0 HOH
 7.144
 CG1
 O
ILE B:125 B:126 49.0 0.28 H -68.3 -38.1 NA NA NA
3th5 1 P63000 95.45 2e-125 X-RAY
 2012-07-18 ILE A:153 A:126 76.0 0.434 H -52.9 -49.7 76.0 0.434 0.0
ILE B:153 B:126 75.0 0.429 H -64.0 -51.3 NA NA NA
2g0n 1 P60763 93.79 2e-125 X-RAY
 2006-05-30 ILE A:127 A:126 63.0 0.36 H -59.5 -42.5 63.0 0.36 0.0 HOH
 2.728
 O
 O
ILE B:127 B:126 55.0 0.314 H -60.5 -43.8 NA NA NA
2ov2 1 P60763 93.79 2e-125 X-RAY
 2007-03-13 ILE A:127 A:126 49.0 0.28 H -58.1 -47.7 49.0 0.28 0.0 HOH
 2.923
 O
 O
ILE B:127 F:126 73.0 0.417 H -54.8 -49.5 NA NA NA
ILE C:127 B:126 42.0 0.24 H -58.4 -40.0 NA NA NA
ILE D:127 C:126 75.0 0.429 H -54.2 -46.8 NA NA NA
ILE E:127 G:126 76.0 0.434 H -61.0 -38.7 NA NA NA
ILE F:127 D:126 45.0 0.257 H -52.3 -43.0 NA NA NA
ILE G:127 E:126 74.0 0.423 H -64.5 -45.2 NA NA NA
ILE H:127 H:126 85.0 0.486 H -63.7 -49.5 NA NA NA
2qme 1 P60763 93.79 2e-125 X-RAY
 2007-08-28 ILE A:127 A:126 56.0 0.32 H -56.1 -43.4 56.0 0.32 0.0 HOH
 2.846
 O
 O
6bc1 1 P63000 95.45 3e-125 X-RAY
 2017-12-13 ILE A:126 A:126 50.0 0.286 H -68.1 -39.0 50.0 0.286 0.0 HOH
 3.139
 N
 O
ILE C:126 B:126 52.0 0.297 H -63.8 -34.9 NA NA NA
2ic5 1 P60763 93.79 3e-125 X-RAY
 2006-10-10 ILE A:127 A:126 61.0 0.349 H -58.9 -44.4 61.0 0.349 0.0 HOH
 2.729
 O
 O
ILE B:127 B:126 57.0 0.326 H -60.1 -44.1 NA NA NA
3ryt 2 P63000 94.92 3e-125 X-RAY
 2012-01-18 ILE C:129 C:126 62.0 0.354 H -60.4 -33.0 62.0 0.354 0.0
4yon 2 P63000 94.92 4e-125 X-RAY
 2015-07-01 ILE B:128 B:126 70.0 0.4 H -60.5 -44.3 70.0 0.4 0.0 HOH
 2.786
 O
 O
2c2h 1 P60763 88.02 6e-125 X-RAY
 2005-10-13 ILE A:126 A:126 67.0 0.383 H -60.2 -46.7 67.0 0.383 0.0 GDP
HOH
 9.641
3.467
 CD1
CG2
 O1B
O
ILE B:126 B:126 66.0 0.377 H -65.7 -37.5 NA NA NA
1he1 2 P15154 95.43 9e-125 X-RAY
 2001-01-02 ILE C:126 C:126 55.0 0.314 H -59.9 -45.7 55.0 0.314 0.0 HOH
 2.886
 O
 O
ILE D:126 D:126 66.0 0.377 H -60.2 -43.5 NA NA NA
3sbd 1 P63000 94.89 9e-125 X-RAY
 2012-07-18 ILE A:136 A:126 69.0 0.394 H -68.2 -54.8 69.0 0.394 0.0 HOH
 6.666
 CD1
 O
ILE B:136 B:126 65.0 0.371 H -62.4 -45.4 NA NA NA
3sbe 1 P63000 94.89 9e-125 X-RAY
 2012-07-18 ILE A:136 A:126 54.0 0.309 H -65.7 -40.7 54.0 0.309 0.0 HOH
 6.157
 CD1
 O
7ajk 1 P63000 94.89 2e-124 X-RAY
 2020-11-18 ILE A:129 BBB:126 51.0 0.291 H -83.5 -26.2 51.0 0.291 0.0
4gzm 1 P63000 94.89 2e-124 X-RAY
 2012-12-12 ILE A:153 A:126 57.0 0.326 H -57.5 -42.7 57.0 0.326 0.0
ILE B:153 B:126 57.0 0.326 H -58.1 -42.1 NA NA NA
1ryf 1 P63000 86.0 2e-124 X-RAY
 2004-01-27 ILE A:147 A:145 58.0 0.331 H -60.7 -44.6 58.0 0.331 0.0 HOH
 2.631
 O
 O
ILE B:147 B:145 59.0 0.337 H -62.7 -38.5 NA NA NA
1ryh 1 P63000 86.0 2e-124 X-RAY
 2004-01-27 ILE A:147 A:145 54.0 0.309 H -54.1 -48.2 54.0 0.309 0.0 HOH
 2.906
 O
 O
ILE B:147 B:145 57.0 0.326 H -59.1 -44.1 NA NA NA
4gzl 1 P63000 94.89 4e-124 X-RAY
 2012-12-12 ILE A:153 A:126 63.0 0.36 H -66.0 -36.2 63.0 0.36 0.0 HOH
 2.557
 O
 O
ILE B:153 B:126 70.0 0.4 H -59.2 -43.4 NA NA NA
6agp 1 P63000 92.82 1e-123 NMR
 2019-03-20 ILE A:126 A:126 65.0 0.371 H -61.5 -45.6 65.0 0.371 0.0
2wkq 1 O49003,P63000 92.7 2e-122 X-RAY
 2009-08-18 ILE A:278 A:669 72.0 0.411 H -62.3 -40.7 72.0 0.411 0.0 HOH
 2.916
 O
 O
2wkr 1 O49003,P63000 92.7 2e-122 X-RAY
 2009-08-18 ILE A:278 A:669 73.0 0.417 H -59.0 -41.6 73.0 0.417 0.0 HOH
 2.766
 O
 O
2wkp 1 O49003,P63000 92.7 3e-122 X-RAY
 2009-08-18 ILE A:278 A:669 67.0 0.383 H -63.1 -39.0 67.0 0.383 0.0 HOH
 2.833
 O
 O
5hzh 1 P63000,O49003 86.71 3e-88 X-RAY
 2016-12-21 ILE A:278 A:275 69.0 0.394 H -65.0 -36.5 69.0 0.394 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p15153-f1 1 P15153 100.0 7e-144 ILE A:126 A:126 42.0 0.24 H -62.5 -43.6
af-p63000-f1 1 P63000 92.19 1e-133 ILE A:126 A:126 44.0 0.251 H -62.9 -43.1
af-p60763-f1 1 P60763 88.54 1e-126 ILE A:126 A:126 63.0 0.36 H -61.6 -44.9