Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr22 37627423 . G A CCDS13945.1:NM_002872.4:c.296cCa>cTa_NP_002863.1:p.99P>L Homo sapiens ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (RAC2), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1ds6 1 P15153 100.0 2e-143 X-RAY
 2000-07-12 PRO A:99 A:99 58.0 0.4 H -59.6 -40.7 7.0 0.048 0.352 B:P52566:0.352
 HOH
 3.188
 O
 O
1i4d 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 PRO C:99 D:99 61.0 0.421 H -58.8 -37.8 61.0 0.421 0.0 HOH
 6.458
 C
 O
1i4l 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 PRO C:99 D:99 59.0 0.407 H -71.4 -57.5 59.0 0.407 0.0 HOH
 6.696
 C
 O
6tgc 3 P63000 92.19 3e-133 EM
 2020-07-29 PRO C:99 C:99 48.0 0.331 H -54.1 -53.9 48.0 0.331 0.0
PRO F:99 F:99 47.0 0.324 H -54.1 -53.9 47.0 0.324 0.0
5fi0 2 P63000 92.19 4e-133 X-RAY
 2016-04-20 PRO B:102 B:99 59.0 0.407 H -60.6 -32.4 59.0 0.407 0.0
PRO D:102 D:99 56.0 0.386 H -60.7 -33.8 NA NA NA
PRO F:102 F:99 59.0 0.407 H -61.0 -33.1 NA NA NA
PRO H:102 H:99 61.0 0.421 H -60.8 -33.3 NA NA NA
1i4t 2 P63000 91.67 5e-132 X-RAY
 2001-05-16 PRO C:99 D:99 60.0 0.414 H -62.7 -42.4 60.0 0.414 0.0 HOH
 9.973
 N
 O
1e96 1 P15154 91.62 5e-131 X-RAY
 2000-11-17 PRO A:99 A:99 56.0 0.386 H -52.8 -39.9 56.0 0.386 0.0 HOH
 3.693
 CB
 O
1hh4 1 P15154 91.62 8e-131 X-RAY
 2001-08-28 PRO A:99 A:99 52.0 0.359 H -66.0 -37.5 5.0 0.034 0.325 C:P52565:0.324
 HOH
 5.848
 O
 O
PRO B:99 B:99 51.0 0.352 H -70.2 -39.2 NA NA NA
2w2t 1 P15153 99.44 2e-130 X-RAY
 2009-05-05 PRO A:105 A:99 58.0 0.4 H -52.6 -39.4 58.0 0.4 0.0 HOH
 3.426
 O
 O
2w2x 1 P15153 99.44 2e-130 X-RAY
 2009-05-05 PRO A:105 A:99 54.0 0.372 H -63.7 -53.1 54.0 0.372 0.0 HOH
 8.989
 N
 O
PRO B:105 B:99 55.0 0.379 H -63.5 -51.2 NA NA NA
2w2v 1 P15153 99.44 9e-130 X-RAY
 2009-05-05 PRO A:106 A:99 57.0 0.393 H -59.4 -46.4 57.0 0.393 0.0 HOH
 2.797
 O
 O
PRO B:106 B:99 59.0 0.407 H -60.1 -49.1 NA NA NA
PRO C:106 C:99 57.0 0.393 H -59.8 -44.3 NA NA NA
PRO D:106 D:99 59.0 0.407 H -58.3 -46.1 NA NA NA
2vrw 1 P63000 93.48 1e-129 X-RAY
 2008-06-17 PRO A:99 A:99 55.0 0.379 H -60.9 -37.0 55.0 0.379 0.0 HOH
 2.804
 O
 O
2h7v 1 P63000 92.93 2e-128 X-RAY
 2006-09-19 PRO A:103 A:99 53.0 0.366 H -59.9 -34.3 53.0 0.366 0.0 HOH
 7.215
 O
 O
PRO B:103 B:99 59.0 0.407 H -62.3 -32.4 NA NA NA
2p2l 1 P63000 92.93 2e-128 X-RAY
 2007-05-01 PRO A:103 A:99 34.0 0.234 H -49.9 -40.7 34.0 0.234 0.0 ZN
HOH
 5.890
2.689
 O
O
 ZN
O
PRO B:103 B:99 35.0 0.241 H -53.7 -37.9 35.0 0.241 0.0 ZN
HOH
 5.832
2.693
 O
O
 ZN
O
PRO C:103 C:99 34.0 0.234 H -51.5 -40.1 34.0 0.234 0.0 ZN
HOH
 5.824
2.708
 O
O
 ZN
O
1g4u 2 P63000 92.93 3e-128 X-RAY
 2001-01-24 PRO B:99 R:99 63.0 0.434 H -59.9 -36.4 63.0 0.434 0.0 HOH
 2.982
 O
 O
1mh1 1 P63000 92.9 3e-127 X-RAY
 1998-01-21 PRO A:101 A:99 40.0 0.276 H -58.9 -39.2 40.0 0.276 0.0 HOH
 2.776
 O
 O
2yin 2 P63000 95.48 7e-127 X-RAY
 2011-05-25 PRO C:118 C:99 58.0 0.4 H -49.5 -47.3 NA NA NA
PRO D:118 D:99 56.0 0.386 H -50.5 -46.8 56.0 0.386 0.0 HOH
 3.069
 O
 O
2fju 1 P63000 95.48 1e-126 X-RAY
 2006-11-21 PRO A:99 A:99 60.0 0.414 H -60.6 -41.1 60.0 0.414 0.0 HOH
 3.622
 CG
 O
5qqd 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:100 A:99 58.0 0.4 H -54.5 -50.0 58.0 0.4 0.0 HOH
 3.282
 CG
 O
5qqe 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:100 A:99 57.0 0.393 H -51.9 -55.7 57.0 0.393 0.0 HOH
 3.322
 CB
 O
5qqf 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:100 A:99 56.0 0.386 H -50.2 -56.6 56.0 0.386 0.0 HOH
 3.621
 O
 O
5qqg 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:100 A:99 57.0 0.393 H -49.9 -51.5 57.0 0.393 0.0 HOH
 3.668
 CA
 O
5qqh 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:100 A:99 58.0 0.4 H -52.7 -46.7 58.0 0.4 0.0 HOH
 3.567
 CB
 O
5qqi 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:100 A:99 58.0 0.4 H -56.7 -51.7 58.0 0.4 0.0 HOH
 3.720
 CG
 O
5qqj 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:100 A:99 58.0 0.4 H -50.8 -47.5 58.0 0.4 0.0 HOH
 3.244
 CG
 O
5qqk 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:100 A:99 60.0 0.414 H -52.7 -52.8 60.0 0.414 0.0 HOH
 3.301
 C
 O
5qql 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:100 A:99 59.0 0.407 H -55.3 -48.8 59.0 0.407 0.0 HOH
 3.194
 C
 O
5qqm 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:100 A:99 60.0 0.414 H -58.4 -47.0 60.0 0.414 0.0 HOH
 3.511
 CB
 O
5qqn 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:100 A:99 57.0 0.393 H -52.1 -54.6 57.0 0.393 0.0 HOH
 3.676
 CG
 O
5qu9 1 P63000 95.48 1e-126 X-RAY
 2020-01-29 PRO A:100 A:99 62.0 0.428 H -55.6 -43.0 62.0 0.428 0.0 HOH
 3.740
 CG
 O
1foe 2 P63000 95.48 1e-126 X-RAY
 2001-01-17 PRO B:99 B:99 58.0 0.4 H -54.7 -37.1 58.0 0.4 0.0 HOH
 6.098
 O
 O
PRO D:99 D:99 58.0 0.4 H -55.9 -37.0 NA NA NA
PRO F:99 F:99 60.0 0.414 H -53.6 -38.5 NA NA NA
PRO H:99 H:99 60.0 0.414 H -54.3 -39.2 NA NA NA
2nz8 1 P63000 95.48 1e-126 X-RAY
 2007-04-10 PRO A:99 A:99 58.0 0.4 H -53.5 -46.1 58.0 0.4 0.0 HOH
 2.669
 O
 O
3bji 2 P63000 95.48 1e-126 X-RAY
 2008-07-15 PRO C:99 C:99 57.0 0.393 H -59.6 -45.6 NA NA NA
PRO D:99 D:99 62.0 0.428 H -51.2 -39.4 62.0 0.428 0.0 HOH
 8.987
 O
 O
5o33 1 P63000 95.48 1e-126 X-RAY
 2017-05-31 PRO A:99 A:99 58.0 0.4 H -59.3 -41.2 58.0 0.4 0.0 HOH
 3.580
 CG
 O
3su8 1 P63000 95.48 1e-126 X-RAY
 2011-09-28 PRO A:99 A:99 63.0 0.434 H -69.3 -25.3 63.0 0.434 0.0
3sua 1 P63000 95.48 1e-126 X-RAY
 2011-09-07 PRO A:99 A:99 60.0 0.414 H -58.6 -49.3 60.0 0.414 0.0
PRO B:99 B:99 59.0 0.407 H -59.2 -49.0 NA NA NA
PRO C:99 C:99 60.0 0.414 H -58.4 -49.5 NA NA NA
6x1g 2 P63000 95.48 2e-126 X-RAY
 2020-11-25 PRO C:99 B:99 60.0 0.414 H -60.8 -35.6 60.0 0.414 0.0 HOH
 2.481
 O
 O
PRO D:99 D:99 60.0 0.414 H -60.8 -37.7 NA NA NA
6tm1 2 P60763 88.54 2e-126 X-RAY
 2020-01-22 PRO B:99 A:99 77.0 0.531 H -58.2 -20.0 77.0 0.531 0.0
3b13 2 P63000 94.92 4e-126 X-RAY
 2012-03-14 PRO B:106 B:99 55.0 0.379 H -54.5 -48.7 55.0 0.379 0.0
PRO D:106 D:99 56.0 0.386 H -58.6 -44.5 56.0 0.386 0.0
7dpa 2 P63000 94.92 5e-126 EM
 2021-08-04 PRO B:106 B:99 40.0 0.276 H -63.8 -52.0 40.0 0.276 0.0
PRO E:106 E:99 44.0 0.303 H -63.9 -52.0 44.0 0.303 0.0
5n6o 1 P63000 95.45 2e-125 X-RAY
 2017-12-27 PRO A:98 A:99 57.0 0.393 H -57.0 -43.9 57.0 0.393 0.0
PRO B:98 B:99 61.0 0.421 H -61.0 -45.1 NA NA NA
3th5 1 P63000 95.45 2e-125 X-RAY
 2012-07-18 PRO A:126 A:99 34.0 0.234 H -66.5 -44.9 34.0 0.234 0.0
PRO B:126 B:99 35.0 0.241 H -61.1 -49.1 NA NA NA
2g0n 1 P60763 93.79 2e-125 X-RAY
 2006-05-30 PRO A:100 A:99 60.0 0.414 H -56.8 -42.0 60.0 0.414 0.0 HOH
 2.652
 O
 O
PRO B:100 B:99 62.0 0.428 H -58.0 -40.6 NA NA NA
2ov2 1 P60763 93.79 2e-125 X-RAY
 2007-03-13 PRO A:100 A:99 59.0 0.407 H -56.6 -41.8 59.0 0.407 0.0 HOH
 2.600
 O
 O
PRO B:100 F:99 58.0 0.4 H -58.0 -44.8 NA NA NA
PRO C:100 B:99 59.0 0.407 H -55.8 -44.2 NA NA NA
PRO D:100 C:99 62.0 0.428 H -54.2 -41.0 NA NA NA
PRO E:100 G:99 57.0 0.393 H -60.5 -40.9 NA NA NA
PRO F:100 D:99 60.0 0.414 H -53.6 -48.7 NA NA NA
PRO G:100 E:99 57.0 0.393 H -55.1 -41.8 NA NA NA
PRO H:100 H:99 56.0 0.386 H -64.7 -37.1 NA NA NA
2qme 1 P60763 93.79 2e-125 X-RAY
 2007-08-28 PRO A:100 A:99 60.0 0.414 H -62.0 -34.4 60.0 0.414 0.0 HOH
 2.587
 O
 O
6bc1 1 P63000 95.45 3e-125 X-RAY
 2017-12-13 PRO A:99 A:99 32.0 0.221 H -57.0 -32.9 32.0 0.221 0.0 HOH
 2.778
 HG3
 O
PRO C:99 B:99 31.0 0.214 H -55.4 -30.9 NA NA NA
2ic5 1 P60763 93.79 3e-125 X-RAY
 2006-10-10 PRO A:100 A:99 59.0 0.407 H -55.8 -38.8 59.0 0.407 0.0 HOH
 2.667
 O
 O
PRO B:100 B:99 62.0 0.428 H -54.8 -39.9 NA NA NA
3ryt 2 P63000 94.92 3e-125 X-RAY
 2012-01-18 PRO C:102 C:99 64.0 0.441 H -59.4 -51.9 64.0 0.441 0.0
4yon 2 P63000 94.92 4e-125 X-RAY
 2015-07-01 PRO B:101 B:99 60.0 0.414 H -55.4 -42.9 60.0 0.414 0.0 HOH
 2.551
 O
 O
2c2h 1 P60763 88.02 6e-125 X-RAY
 2005-10-13 PRO A:99 A:99 59.0 0.407 H -57.6 -33.3 59.0 0.407 0.0 GDP
GDP
CA
CA
MG
HOH
 3.039
8.170
7.069
8.109
9.865
3.948
 O
O
O
O
O
CG
 N1
O3B
CA
CA
MG
O
PRO B:99 B:99 58.0 0.4 H -55.2 -40.5 NA NA NA
1he1 2 P15154 95.43 9e-125 X-RAY
 2001-01-02 PRO C:99 C:99 58.0 0.4 H -58.5 -46.9 58.0 0.4 0.0 NI
HOH
 8.708
2.968
 O
O
 NI
O
PRO D:99 D:99 60.0 0.414 H -59.1 -41.5 NA NA NA
3sbd 1 P63000 94.89 9e-125 X-RAY
 2012-07-18 PRO A:109 A:99 59.0 0.407 H -62.5 -40.4 59.0 0.407 0.0 HOH
 2.767
 O
 O
PRO B:109 B:99 62.0 0.428 H -59.8 -38.6 NA NA NA
3sbe 1 P63000 94.89 9e-125 X-RAY
 2012-07-18 PRO A:109 A:99 60.0 0.414 H -64.3 -52.9 60.0 0.414 0.0 HOH
 3.506
 O
 O
7ajk 1 P63000 94.89 2e-124 X-RAY
 2020-11-18 PRO A:102 BBB:99 60.0 0.414 H -48.8 -48.4 60.0 0.414 0.0
4gzm 1 P63000 94.89 2e-124 X-RAY
 2012-12-12 PRO A:126 A:99 57.0 0.393 H -63.3 -59.4 57.0 0.393 0.0
PRO B:126 B:99 60.0 0.414 H -63.3 -59.4 NA NA NA
1ryf 1 P63000 86.0 2e-124 X-RAY
 2004-01-27 PRO A:120 A:118 57.0 0.393 H -60.6 -39.1 57.0 0.393 0.0 HOH
 4.041
 CG
 O
PRO B:120 B:118 57.0 0.393 H -58.1 -43.0 NA NA NA
1ryh 1 P63000 86.0 2e-124 X-RAY
 2004-01-27 PRO A:120 A:118 40.0 0.276 H -60.3 -37.1 40.0 0.276 0.0 HOH
 3.335
 CB
 O
PRO B:120 B:118 58.0 0.4 H -60.3 -42.7 NA NA NA
4gzl 1 P63000 94.89 4e-124 X-RAY
 2012-12-12 PRO A:126 A:99 62.0 0.428 H -64.0 -39.9 62.0 0.428 0.0 HOH
 3.646
 CG
 O
PRO B:126 B:99 62.0 0.428 H -64.7 -36.1 NA NA NA
6agp 1 P63000 92.82 1e-123 NMR
 2019-03-20 PRO A:99 A:99 60.0 0.414 H -56.3 -42.9 60.0 0.414 0.0
2wkq 1 O49003,P63000 92.7 2e-122 X-RAY
 2009-08-18 PRO A:251 A:642 59.0 0.407 H -60.5 -39.6 59.0 0.407 0.0 HOH
 2.831
 O
 O
2wkr 1 O49003,P63000 92.7 2e-122 X-RAY
 2009-08-18 PRO A:251 A:642 50.0 0.345 H -60.2 -42.9 50.0 0.345 0.0 HOH
 2.870
 O
 O
2wkp 1 O49003,P63000 92.7 3e-122 X-RAY
 2009-08-18 PRO A:251 A:642 58.0 0.4 H -61.8 -38.9 58.0 0.4 0.0 HOH
 2.633
 O
 O
5hzh 1 P63000,O49003 86.71 3e-88 X-RAY
 2016-12-21 PRO A:251 A:248 61.0 0.421 H -65.4 -30.9 61.0 0.421 0.0 HOH
 4.585
 CG
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p15153-f1 1 P15153 100.0 7e-144 PRO A:99 A:99 61.0 0.421 H -53.8 -44.1
af-p63000-f1 1 P63000 92.19 1e-133 PRO A:99 A:99 58.0 0.4 H -54.5 -44.7
af-p60763-f1 1 P60763 88.54 1e-126 PRO A:99 A:99 59.0 0.407 H -54.4 -44.5