Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr22 37628897 . C A CCDS13945.1:NM_002872.4:c.169Gac>Tac_NP_002863.1:p.57D>Y Homo sapiens ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (RAC2), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1ds6 1 P15153 100.0 2e-143 X-RAY
 2000-07-12 ASP A:57 A:57 12.0 0.08 -89.9 167.5 4.0 0.027 0.053 B:P52566:0.053
 MG
GDP
HOH
 4.209
5.148
2.684
 OD2
OD1
OD1
 MG
O2B
O
1i4d 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 ASP C:57 D:57 19.0 0.127 -92.5 159.4 7.0 0.047 0.08 A:P53365:0.08
 MG
GDP
HOH
 4.138
4.986
2.513
 OD2
OD2
OD2
 MG
O3B
O
1i4l 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 ASP C:57 D:57 18.0 0.12 -85.2 169.9 9.0 0.06 0.06 A:P53365:0.06
 MG
GDP
HOH
 4.387
4.955
3.564
 OD2
OD2
O
 MG
O2B
O
6tgc 3 P63000 92.19 3e-133 EM
 2020-07-29 ASP C:57 C:57 23.0 0.153 -90.1 113.6 5.0 0.033 0.12 A:Q92608:0.12
ASP F:57 F:57 22.0 0.147 -90.2 113.6 6.0 0.04 0.107 D:Q92608:0.107
5fi0 2 P63000 92.19 4e-133 X-RAY
 2016-04-20 ASP B:60 B:57 20.0 0.133 E -91.3 151.2 3.0 0.02 0.113 A:Q8TCU6:0.113
ASP D:60 D:57 20.0 0.133 E -91.0 150.6 NA NA NA
ASP F:60 F:57 19.0 0.127 -90.0 149.4 NA NA NA
ASP H:60 H:57 22.0 0.147 -90.6 150.5 NA NA NA
1i4t 2 P63000 91.67 5e-132 X-RAY
 2001-05-16 ASP C:57 D:57 24.0 0.16 E -94.5 152.8 10.0 0.067 0.093 A:P53365:0.093
 MG
GNP
HOH
 3.873
5.287
2.801
 OD2
OD1
OD2
 MG
O2B
O
1e96 1 P15154 91.62 5e-131 X-RAY
 2000-11-17 ASP A:57 A:57 0.0 0.0 E -87.8 123.7 0.0 0.0 0.0 GTP
MG
HOH
 4.975
3.692
2.461
 OD2
OD2
OD1
 O2B
MG
O
1hh4 1 P15154 91.62 8e-131 X-RAY
 2001-08-28 ASP A:57 A:57 9.0 0.06 E -108.8 140.7 2.0 0.013 0.047 C:P52565:0.047
 GDP
MG
HOH
 4.901
2.737
4.490
 OD2
OD2
OD2
 O2B
MG
O
ASP B:57 B:57 12.0 0.08 E -107.0 142.0 NA NA NA
2w2t 1 P15153 99.44 2e-130 X-RAY
 2009-05-05 ASP A:63 A:57 12.0 0.08 -76.6 165.9 12.0 0.08 0.0 MG
GDP
HOH
 3.869
4.749
2.460
 OD2
OD1
OD1
 MG
O1B
O
2w2x 1 P15153 99.44 2e-130 X-RAY
 2009-05-05 ASP A:63 A:57 1.0 0.007 E -90.9 128.7 1.0 0.007 0.0 GSP
MG
HOH
 4.721
3.416
4.331
 OD1
OD1
O
 O2B
MG
O
ASP B:63 B:57 0.0 0.0 E -86.0 128.6 NA NA NA
2w2v 1 P15153 99.44 9e-130 X-RAY
 2009-05-05 ASP A:64 A:57 11.0 0.073 -86.8 158.3 11.0 0.073 0.0 GTP
HOH
 3.191
2.478
 OD2
OD1
 O2G
O
ASP B:64 B:57 10.0 0.067 -81.0 166.5 NA NA NA
ASP C:64 C:57 12.0 0.08 -84.3 165.2 NA NA NA
ASP D:64 D:57 9.0 0.06 -85.9 165.7 NA NA NA
2vrw 1 P63000 93.48 1e-129 X-RAY
 2008-06-17 ASP A:57 A:57 15.0 0.1 -91.5 156.2 1.0 0.007 0.093 B:P27870:0.093
 HOH
 2.680
 OD2
 O
2h7v 1 P63000 92.93 2e-128 X-RAY
 2006-09-19 ASP A:61 A:57 12.0 0.08 -83.3 158.9 1.0 0.007 0.073 C:Q05608:0.073
 MG
GDP
HOH
 4.581
5.136
2.754
 OD2
OD1
N
 MG
O3B
O
ASP B:61 B:57 13.0 0.087 -82.4 156.2 NA NA NA
2p2l 1 P63000 92.93 2e-128 X-RAY
 2007-05-01 ASP A:61 A:57 6.0 0.04 -83.9 161.7 6.0 0.04 0.0 ZN
GDP
HOH
 3.973
4.782
2.588
 OD2
OD1
OD1
 ZN
O3B
O
ASP B:61 B:57 5.0 0.033 -79.7 160.4 5.0 0.033 0.0 ZN
GDP
HOH
 3.948
4.844
2.557
 OD2
OD1
O
 ZN
O3B
O
ASP C:61 C:57 4.0 0.027 -84.0 163.7 4.0 0.027 0.0 ZN
GDP
HOH
 4.033
4.872
2.661
 OD2
OD1
O
 ZN
O3B
O
1g4u 2 P63000 92.93 3e-128 X-RAY
 2001-01-24 ASP B:57 R:57 2.0 0.013 E -81.6 134.5 2.0 0.013 0.0 MG
GDP
AF3
HOH
 4.240
4.895
5.809
2.613
 OD1
OD1
OD1
OD1
 MG
O2B
F1
O
1mh1 1 P63000 92.9 3e-127 X-RAY
 1998-01-21 ASP A:59 A:57 0.0 0.0 -75.1 149.2 0.0 0.0 0.0 MG
GNP
HOH
 4.053
4.894
2.665
 OD2
OD1
OD1
 MG
O2B
O
2yin 2 P63000 95.48 7e-127 X-RAY
 2011-05-25 ASP C:76 C:57 15.0 0.1 E -92.2 98.3 NA NA NA
ASP D:76 D:57 15.0 0.1 E -91.6 96.8 7.0 0.047 0.053 B:Q92608:0.053
 HOH
 6.512
 OD1
 O
2fju 1 P63000 95.48 1e-126 X-RAY
 2006-11-21 ASP A:57 A:57 2.0 0.013 E -87.4 140.5 0.0 0.0 0.013 B:Q00722:0.013
 MG
GSP
HOH
 4.606
4.770
2.680
 OD2
OD1
OD2
 MG
O2B
O
5qqd 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ASP A:58 A:57 17.0 0.113 -81.4 161.1 0.0 0.0 0.113 B:O60229:0.113
 HOH
 2.678
 OD2
 O
5qqe 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ASP A:58 A:57 16.0 0.107 -81.6 158.8 0.0 0.0 0.107 B:O60229:0.107
 HOH
 2.474
 OD2
 O
5qqf 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ASP A:58 A:57 16.0 0.107 -80.9 159.5 0.0 0.0 0.107 B:O60229:0.107
 HOH
 2.596
 OD2
 O
5qqg 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ASP A:58 A:57 16.0 0.107 -74.9 159.8 0.0 0.0 0.107 B:O60229:0.107
 HOH
 2.570
 OD2
 O
5qqh 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ASP A:58 A:57 16.0 0.107 -81.5 160.6 0.0 0.0 0.107 B:O60229:0.107
 N67
HOH
 9.932
2.578
 OD1
OD2
 C10
O
5qqi 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ASP A:58 A:57 17.0 0.113 -81.5 162.3 0.0 0.0 0.113 B:O60229:0.113
 HOH
 2.705
 OD2
 O
5qqj 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ASP A:58 A:57 17.0 0.113 -80.8 159.8 0.0 0.0 0.113 B:O60229:0.113
 HOH
 2.663
 OD2
 O
5qqk 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ASP A:58 A:57 16.0 0.107 -74.0 153.4 0.0 0.0 0.107 B:O60229:0.107
 N6V
HOH
 9.943
2.519
 OD1
OD2
 C15
O
5qql 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ASP A:58 A:57 17.0 0.113 -76.0 159.9 0.0 0.0 0.113 B:O60229:0.113
 HOH
 2.618
 OD2
 O
5qqm 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ASP A:58 A:57 17.0 0.113 -83.7 159.4 0.0 0.0 0.113 B:O60229:0.113
 HOH
 2.620
 OD2
 O
5qqn 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 ASP A:58 A:57 18.0 0.12 -79.2 162.2 0.0 0.0 0.12 B:O60229:0.12
 HOH
 2.648
 OD2
 O
5qu9 1 P63000 95.48 1e-126 X-RAY
 2020-01-29 ASP A:58 A:57 18.0 0.12 -83.2 159.7 0.0 0.0 0.12 B:O60229:0.12
 HOH
 2.773
 OD2
 O
1foe 2 P63000 95.48 1e-126 X-RAY
 2001-01-17 ASP B:57 B:57 19.0 0.127 -84.8 168.7 2.0 0.013 0.114 A:Q60610:0.113
 SO4
HOH
 5.078
8.059
 OD1
CB
 O1
O
ASP D:57 D:57 19.0 0.127 -79.7 169.6 NA NA NA
ASP F:57 F:57 20.0 0.133 -84.7 169.0 NA NA NA
ASP H:57 H:57 19.0 0.127 -83.3 168.6 NA NA NA
2nz8 1 P63000 95.48 1e-126 X-RAY
 2007-04-10 ASP A:57 A:57 17.0 0.113 -82.9 161.3 1.0 0.007 0.106 B:O75962:0.107
 HOH
 2.771
 OD2
 O
3bji 2 P63000 95.48 1e-126 X-RAY
 2008-07-15 ASP C:57 C:57 16.0 0.107 -86.5 156.3 NA NA NA
ASP D:57 D:57 17.0 0.113 -78.0 158.0 1.0 0.007 0.106 A:P15498:0.107
 HOH
 9.074
 N
 O
5o33 1 P63000 95.48 1e-126 X-RAY
 2017-05-31 ASP A:57 A:57 19.0 0.127 -80.1 160.9 1.0 0.007 0.12 B:P97924:0.12
 GDP
EDO
HOH
 4.965
7.080
2.831
 OD2
O
N
 O1B
HO2
O
3su8 1 P63000 95.48 1e-126 X-RAY
 2011-09-28 ASP A:57 A:57 1.0 0.007 E -91.6 133.1 1.0 0.007 0.0 MG
GNP
 3.671
4.417
 OD2
OD1
 MG
O2B
3sua 1 P63000 95.48 1e-126 X-RAY
 2011-09-07 ASP A:57 A:57 0.0 0.0 -84.4 157.2 0.0 0.0 0.0 MG
GNP
 4.377
4.279
 OD2
OD2
 MG
O2G
ASP B:57 B:57 0.0 0.0 -84.6 156.7 NA NA NA
ASP C:57 C:57 0.0 0.0 -84.1 156.8 NA NA NA
6x1g 2 P63000 95.48 2e-126 X-RAY
 2020-11-25 ASP C:57 B:57 25.0 0.167 E -65.3 151.8 3.0 0.02 0.147 A:B3CVM3:0.147
 HOH
 2.642
 OD2
 O
ASP D:57 D:57 25.0 0.167 E -67.6 151.8 NA NA NA
6tm1 2 P60763 88.54 2e-126 X-RAY
 2020-01-22 ASP B:57 A:57 30.0 0.2 E -88.3 138.8 7.0 0.047 0.153 A:Q96BY6:0.153
3b13 2 P63000 94.92 4e-126 X-RAY
 2012-03-14 ASP B:64 B:57 23.0 0.153 E -91.3 109.5 10.0 0.067 0.086 A:Q92608:0.087
ASP D:64 D:57 21.0 0.14 E -97.8 108.9 7.0 0.047 0.093 C:Q92608:0.093
7dpa 2 P63000 94.92 5e-126 EM
 2021-08-04 ASP B:64 B:57 24.0 0.16 E -86.7 109.1 17.0 0.113 0.047 A:Q9H7D0:0.047
ASP E:64 E:57 23.0 0.153 E -86.8 109.2 16.0 0.107 0.046 D:Q9H7D0:0.047
5n6o 1 P63000 95.45 2e-125 X-RAY
 2017-12-27 ASP A:56 A:57 11.0 0.073 -88.4 151.2 11.0 0.073 0.0 GDP
MG
HOH
 4.695
3.593
2.847
 OD2
OD2
OD2
 O2B
MG
O
ASP B:56 B:57 11.0 0.073 E -91.0 147.6 NA NA NA
3th5 1 P63000 95.45 2e-125 X-RAY
 2012-07-18 ASP A:84 A:57 0.0 0.0 E -93.6 122.2 0.0 0.0 0.0 GNP
MG
HOH
 5.019
3.971
2.692
 OD1
OD2
OD1
 O2B
MG
O
ASP B:84 B:57 0.0 0.0 E -87.8 127.4 NA NA NA
2g0n 1 P60763 93.79 2e-125 X-RAY
 2006-05-30 ASP A:58 A:57 5.0 0.033 -83.2 151.2 5.0 0.033 0.0 MG
CL
GDP
HOH
 3.798
6.252
4.868
2.535
 OD2
OD1
OD1
OD1
 MG
CL
O1B
O
ASP B:58 B:57 6.0 0.04 -81.7 149.1 NA NA NA
2ov2 1 P60763 93.79 2e-125 X-RAY
 2007-03-13 ASP A:58 A:57 0.0 0.0 E -98.2 106.1 0.0 0.0 0.0 MG
GCP
HOH
 4.156
4.697
2.529
 OD1
OD1
OD1
 MG
O2B
O
ASP B:58 F:57 0.0 0.0 E -94.1 104.7 NA NA NA
ASP C:58 B:57 0.0 0.0 E -96.5 111.7 NA NA NA
ASP D:58 C:57 0.0 0.0 E -95.0 110.3 NA NA NA
ASP E:58 G:57 0.0 0.0 E -97.2 109.8 NA NA NA
ASP F:58 D:57 0.0 0.0 E -101.2 106.0 NA NA NA
ASP G:58 E:57 0.0 0.0 E -95.5 106.5 NA NA NA
ASP H:58 H:57 0.0 0.0 E -99.4 110.3 NA NA NA
2qme 1 P60763 93.79 2e-125 X-RAY
 2007-08-28 ASP A:58 A:57 0.0 0.0 E -93.7 130.1 0.0 0.0 0.0 MG
GCP
HOH
 4.107
4.823
2.578
 OD2
OD1
OD1
 MG
O2B
O
6bc1 1 P63000 95.45 3e-125 X-RAY
 2017-12-13 ASP A:57 A:57 0.0 0.0 E -77.1 142.9 0.0 0.0 0.0 GSP
MG
HOH
 4.659
3.532
2.724
 OD2
OD2
OD1
 O2B
MG
O
ASP C:57 B:57 0.0 0.0 E -79.2 145.9 NA NA NA
2ic5 1 P60763 93.79 3e-125 X-RAY
 2006-10-10 ASP A:58 A:57 6.0 0.04 -78.3 151.4 6.0 0.04 0.0 MG
GNP
HOH
 3.969
4.811
2.614
 OD2
OD1
OD1
 MG
O2B
O
ASP B:58 B:57 6.0 0.04 -83.1 147.9 NA NA NA
3ryt 2 P63000 94.92 3e-125 X-RAY
 2012-01-18 ASP C:60 C:57 1.0 0.007 E -65.3 124.3 1.0 0.007 0.0 MG
GNP
 2.875
4.925
 OD1
OD2
 MG
O2B
4yon 2 P63000 94.92 4e-125 X-RAY
 2015-07-01 ASP B:59 B:57 18.0 0.12 -82.6 157.0 1.0 0.007 0.113 A:Q8TCU6:0.113
 HOH
 2.748
 O
 O
2c2h 1 P60763 88.02 6e-125 X-RAY
 2005-10-13 ASP A:57 A:57 23.0 0.153 -85.9 153.1 23.0 0.153 0.0 GDP
MG
HOH
 4.796
3.999
2.330
 OD1
OD2
OD2
 O1B
MG
O
ASP B:57 B:57 25.0 0.167 E -88.3 142.5 NA NA NA
1he1 2 P15154 95.43 9e-125 X-RAY
 2001-01-02 ASP C:57 C:57 0.0 0.0 E -98.2 130.6 0.0 0.0 0.0 GDP
AF3
MG
HOH
 4.803
5.358
4.045
2.595
 OD1
OD1
OD2
OD1
 O2B
F3
MG
O
ASP D:57 D:57 0.0 0.0 E -97.0 135.1 NA NA NA
3sbd 1 P63000 94.89 9e-125 X-RAY
 2012-07-18 ASP A:67 A:57 0.0 0.0 E -94.3 113.9 0.0 0.0 0.0 GNP
MG
HOH
 4.770
3.969
2.651
 OD1
OD2
OD1
 O2B
MG
O
ASP B:67 B:57 0.0 0.0 E -91.7 111.0 NA NA NA
3sbe 1 P63000 94.89 9e-125 X-RAY
 2012-07-18 ASP A:67 A:57 0.0 0.0 E -95.1 110.6 0.0 0.0 0.0 GNP
MG
HOH
 4.466
3.163
4.778
 OD1
OD1
O
 O2B
MG
O
7ajk 1 P63000 94.89 2e-124 X-RAY
 2020-11-18 ASP A:60 BBB:57 2.0 0.013 E -79.1 128.5 2.0 0.013 0.0 MG
GNP
HOH
 3.093
4.668
2.717
 OD2
OD2
OD1
 MG
O1B
O
4gzm 1 P63000 94.89 2e-124 X-RAY
 2012-12-12 ASP A:84 A:57 0.0 0.0 E -67.2 135.3 0.0 0.0 0.0 GSP
MG
 4.471
3.346
 OD1
OD1
 O3G
MG
ASP B:84 B:57 1.0 0.007 E -67.3 135.3 NA NA NA
1ryf 1 P63000 86.0 2e-124 X-RAY
 2004-01-27 ASP A:59 A:57 18.0 0.12 E -108.8 106.9 18.0 0.12 0.0 MG
GDP
HOH
 4.002
4.861
2.600
 OD2
OD1
OD1
 MG
O2B
O
ASP B:59 B:57 19.0 0.127 E -105.5 126.1 NA NA NA
1ryh 1 P63000 86.0 2e-124 X-RAY
 2004-01-27 ASP A:59 A:57 25.0 0.167 -96.0 147.4 25.0 0.167 0.0 MG
GNP
HOH
 4.023
4.904
2.637
 OD2
OD1
OD2
 MG
O2B
O
ASP B:59 B:57 20.0 0.133 -97.8 148.8 NA NA NA
4gzl 1 P63000 94.89 4e-124 X-RAY
 2012-12-12 ASP A:84 A:57 0.0 0.0 E -92.1 113.3 0.0 0.0 0.0 GNP
MG
HOH
 4.566
4.203
2.639
 OD1
OD1
OD1
 O2B
MG
O
ASP B:84 B:57 0.0 0.0 E -98.5 112.1 NA NA NA
6agp 1 P63000 92.82 1e-123 NMR
 2019-03-20 ASP A:57 A:57 54.0 0.36 -88.1 170.0 54.0 0.36 0.0 GDP
MG
 5.140
4.309
 OD1
OD2
 O2B
MG
2wkq 1 O49003,P63000 92.7 2e-122 X-RAY
 2009-08-18 ASP A:209 A:600 1.0 0.007 E -92.1 140.1 1.0 0.007 0.0 GTP
MG
HOH
 4.823
4.019
2.622
 OD1
OD2
OD1
 O1B
MG
O
2wkr 1 O49003,P63000 92.7 2e-122 X-RAY
 2009-08-18 ASP A:209 A:600 1.0 0.007 E -84.6 138.3 1.0 0.007 0.0 GTP
MG
HOH
 4.849
3.926
2.531
 OD1
OD2
OD1
 O1B
MG
O
2wkp 1 O49003,P63000 92.7 3e-122 X-RAY
 2009-08-18 ASP A:209 A:600 0.0 0.0 E -90.8 139.7 0.0 0.0 0.0 GTP
MG
CA
HOH
 4.801
4.038
8.167
2.572
 OD1
OD2
OD2
OD1
 O1B
MG
CA
O
5hzh 1 P63000,O49003 86.71 3e-88 X-RAY
 2016-12-21 ASP A:209 A:206 0.0 0.0 E -82.5 129.9 0.0 0.0 0.0 GTP
MG
HOH
 4.783
3.698
2.260
 OD2
OD2
OD1
 O1B
MG
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p15153-f1 1 P15153 100.0 7e-144 ASP A:57 A:57 0.0 0.0 E -83.8 137.1
af-p63000-f1 1 P63000 92.19 1e-133 ASP A:57 A:57 0.0 0.0 E -83.1 138.1
af-p60763-f1 1 P60763 88.54 1e-126 ASP A:57 A:57 0.0 0.0 E -82.7 137.4