Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr22 37628899 . C A CCDS13945.1:NM_002872.4:c.167tGg>tTg_NP_002863.1:p.56W>L Homo sapiens ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (RAC2), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1ds6 1 P15153 100.0 2e-143 X-RAY
 2000-07-12 TRP A:56 A:56 78.0 0.306 E -130.0 121.1 60.0 0.235 0.071 B:P52566:0.071
 MG
GDP
HOH
 9.627
9.943
4.300
 C
O
C
 MG
O2B
O
1i4d 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 TRP C:56 D:56 89.0 0.349 E -100.0 123.2 18.0 0.071 0.278 A:P53365:0.278
 MG
GDP
HOH
 9.275
9.879
3.102
 C
O
CH2
 MG
O2B
O
1i4l 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 TRP C:56 D:56 89.0 0.349 E -107.7 118.9 19.0 0.075 0.274 A:P53365:0.275
 MG
GDP
HOH
 9.717
9.770
6.408
 C
O
C
 MG
O1B
O
6tgc 3 P63000 92.19 3e-133 EM
 2020-07-29 TRP C:56 C:56 96.0 0.376 E -87.8 85.7 8.0 0.031 0.345 A:Q92608:0.345
TRP F:56 F:56 100.0 0.392 E -87.7 85.7 14.0 0.055 0.337 D:Q92608:0.337
5fi0 2 P63000 92.19 4e-133 X-RAY
 2016-04-20 TRP B:59 B:56 85.0 0.333 E -124.4 119.1 10.0 0.039 0.294 A:Q8TCU6:0.294
TRP D:59 D:56 84.0 0.329 E -124.6 119.8 NA NA NA
TRP F:59 F:56 76.0 0.298 E -124.2 122.5 NA NA NA
TRP H:59 H:56 83.0 0.325 E -126.2 120.7 NA NA NA
1i4t 2 P63000 91.67 5e-132 X-RAY
 2001-05-16 TRP C:56 D:56 88.0 0.345 E -103.4 125.0 22.0 0.086 0.259 A:P53365:0.259
 MG
GNP
HOH
 9.069
9.876
2.735
 O
O
NE1
 MG
O2B
O
1e96 1 P15154 91.62 5e-131 X-RAY
 2000-11-17 TRP A:56 A:56 79.0 0.31 E -98.4 111.6 79.0 0.31 0.0 GTP
MG
HOH
 9.730
8.856
6.946
 O
O
O
 O2B
MG
O
1hh4 1 P15154 91.62 8e-131 X-RAY
 2001-08-28 TRP A:56 A:56 88.0 0.345 E -120.2 128.1 40.0 0.157 0.188 C:P52565:0.188
 GDP
MG
HOH
 9.954
7.820
2.910
 O
O
CE2
 O2B
MG
O
TRP B:56 B:56 68.0 0.267 E -120.6 125.2 NA NA NA
2w2t 1 P15153 99.44 2e-130 X-RAY
 2009-05-05 TRP A:62 A:56 83.0 0.325 E -107.3 114.5 83.0 0.325 0.0 MG
GDP
HOH
 9.242
9.647
3.022
 C
O
CE3
 MG
O1B
O
2w2x 1 P15153 99.44 2e-130 X-RAY
 2009-05-05 TRP A:62 A:56 71.0 0.278 E -113.4 113.9 23.0 0.09 0.188 D:P16885:0.188
 GSP
MG
HOH
 9.274
8.251
3.468
 O
O
NE1
 O2B
MG
O
TRP B:62 B:56 67.0 0.263 E -115.2 112.0 NA NA NA
2w2v 1 P15153 99.44 9e-130 X-RAY
 2009-05-05 TRP A:63 A:56 82.0 0.322 E -106.9 117.5 82.0 0.322 0.0 GTP
HOH
 8.385
2.942
 C
NE1
 O2G
O
TRP B:63 B:56 18.0 NA E -105.1 117.3 NA NA NA
TRP C:63 C:56 86.0 0.337 E -109.7 118.9 NA NA NA
TRP D:63 D:56 92.0 0.361 E -104.7 121.0 NA NA NA
2vrw 1 P63000 93.48 1e-129 X-RAY
 2008-06-17 TRP A:56 A:56 77.0 0.302 E -123.8 127.0 7.0 0.027 0.275 B:P27870:0.275
 HOH
 2.893
 NE1
 O
2h7v 1 P63000 92.93 2e-128 X-RAY
 2006-09-19 TRP A:60 A:56 83.0 0.325 E -115.6 111.2 21.0 0.082 0.243 C:Q05608:0.243
 MG
HOH
 9.956
3.704
 C
C
 MG
O
TRP B:60 B:56 82.0 0.322 E -117.7 119.3 NA NA NA
2p2l 1 P63000 92.93 2e-128 X-RAY
 2007-05-01 TRP A:60 A:56 48.0 0.188 E -122.1 122.4 47.0 0.184 0.004 B:P63000:0.004
 ZN
GDP
HOH
 9.362
9.777
3.072
 C
O
NE1
 ZN
O3B
O
TRP B:60 B:56 40.0 0.157 E -122.7 118.6 39.0 0.153 0.004 C:P63000:0.004
 ZN
GDP
HOH
 9.318
9.806
2.930
 C
O
NE1
 ZN
O3B
O
TRP C:60 C:56 44.0 0.173 E -123.2 125.4 44.0 0.173 0.0 ZN
GDP
HOH
 9.325
9.799
3.383
 C
O
NE1
 ZN
O3B
O
1g4u 2 P63000 92.93 3e-128 X-RAY
 2001-01-24 TRP B:56 R:56 81.0 0.318 E -116.9 108.3 81.0 0.318 0.0 MG
GDP
HOH
 9.208
9.840
3.192
 C
O
CE3
 MG
O2B
O
1mh1 1 P63000 92.9 3e-127 X-RAY
 1998-01-21 TRP A:58 A:56 79.0 0.31 E -109.2 107.1 79.0 0.31 0.0 MG
GNP
HOH
 9.309
9.844
2.799
 C
O
NE1
 MG
O2B
O
2yin 2 P63000 95.48 7e-127 X-RAY
 2011-05-25 TRP C:75 C:56 83.0 0.325 E -91.8 117.5 NA NA NA
TRP D:75 D:56 77.0 0.302 E -90.3 117.9 6.0 0.024 0.278 B:Q92608:0.278
 HOH
 8.532
 NE1
 O
2fju 1 P63000 95.48 1e-126 X-RAY
 2006-11-21 TRP A:56 A:56 75.0 0.294 E -96.7 113.4 32.0 0.125 0.169 B:Q00722:0.169
 GSP
HOH
 9.531
3.075
 O
CH2
 O2B
O
5qqd 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 TRP A:57 A:56 73.0 0.286 E -109.4 133.6 17.0 0.067 0.219 B:O60229:0.22
 HOH
 3.108
 NE1
 O
5qqe 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 TRP A:57 A:56 73.0 0.286 E -111.1 130.6 16.0 0.063 0.223 B:O60229:0.224
 HOH
 3.336
 CZ3
 O
5qqf 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 TRP A:57 A:56 76.0 0.298 E -116.9 129.0 16.0 0.063 0.235 B:O60229:0.235
 HOH
 3.419
 CZ3
 O
5qqg 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 TRP A:57 A:56 77.0 0.302 E -117.7 122.3 18.0 0.071 0.231 B:O60229:0.231
 HOH
 3.266
 NE1
 O
5qqh 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 TRP A:57 A:56 75.0 0.294 E -116.3 129.1 17.0 0.067 0.227 B:O60229:0.227
 HOH
 3.518
 CZ3
 O
5qqi 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 TRP A:57 A:56 74.0 0.29 E -116.8 126.4 17.0 0.067 0.223 B:O60229:0.224
 HOH
 3.269
 NE1
 O
5qqj 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 TRP A:57 A:56 74.0 0.29 E -112.6 127.3 15.0 0.059 0.231 B:O60229:0.231
 HOH
 3.618
 CZ3
 O
5qqk 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 TRP A:57 A:56 76.0 0.298 E -116.3 122.7 17.0 0.067 0.231 B:O60229:0.231
 HOH
 3.306
 CZ3
 O
5qql 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 TRP A:57 A:56 80.0 0.314 E -116.8 125.5 17.0 0.067 0.247 B:O60229:0.247
 HOH
 3.406
 CZ3
 O
5qqm 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 TRP A:57 A:56 77.0 0.302 E -115.6 131.3 18.0 0.071 0.231 B:O60229:0.231
 HOH
 3.630
 CZ3
 O
5qqn 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 TRP A:57 A:56 73.0 0.286 E -115.7 127.5 16.0 0.063 0.223 B:O60229:0.224
 HOH
 3.430
 CZ3
 O
5qu9 1 P63000 95.48 1e-126 X-RAY
 2020-01-29 TRP A:57 A:56 76.0 0.298 E -115.5 130.3 20.0 0.078 0.22 B:O60229:0.22
 HOH
 3.125
 NE1
 O
1foe 2 P63000 95.48 1e-126 X-RAY
 2001-01-17 TRP B:56 B:56 82.0 0.322 E -118.6 125.5 1.0 0.004 0.318 A:Q60610:0.318
 SO4
HOH
 9.894
4.262
 O
CH2
 O1
O
TRP D:56 D:56 79.0 0.31 E -119.6 121.2 NA NA NA
TRP F:56 F:56 81.0 0.318 E -119.3 124.4 NA NA NA
TRP H:56 H:56 81.0 0.318 E -119.2 125.7 NA NA NA
2nz8 1 P63000 95.48 1e-126 X-RAY
 2007-04-10 TRP A:56 A:56 76.0 0.298 E -122.8 127.1 15.0 0.059 0.239 B:O75962:0.239
 HOH
 3.090
 NE1
 O
3bji 2 P63000 95.48 1e-126 X-RAY
 2008-07-15 TRP C:56 C:56 82.0 0.322 E -118.4 119.5 NA NA NA
TRP D:56 D:56 74.0 0.29 E -127.9 120.1 11.0 0.043 0.247 A:P15498:0.247
 HOH
 3.993
 CZ2
 O
5o33 1 P63000 95.48 1e-126 X-RAY
 2017-05-31 TRP A:56 A:56 76.0 0.298 E -117.3 126.8 20.0 0.078 0.22 B:P97924:0.22
 EDO
HOH
 8.166
3.193
 CA
NE1
 HO2
O
3su8 1 P63000 95.48 1e-126 X-RAY
 2011-09-28 TRP A:56 A:56 70.0 0.275 E -125.1 112.4 31.0 0.122 0.153 B:O43157:0.153
 MG
GNP
 9.117
9.166
 C
O
 MG
O2G
3sua 1 P63000 95.48 1e-126 X-RAY
 2011-09-07 TRP A:56 A:56 64.0 0.251 E -135.8 111.0 30.0 0.118 0.133 D:O43157:0.133
 MG
GNP
 9.810
8.608
 O
O
 MG
O2G
TRP B:56 B:56 64.0 0.251 E -135.2 110.9 NA NA NA
TRP C:56 C:56 64.0 0.251 E -135.7 110.9 NA NA NA
6x1g 2 P63000 95.48 2e-126 X-RAY
 2020-11-25 TRP C:56 B:56 89.0 0.349 E -117.5 115.2 35.0 0.137 0.212 A:B3CVM3:0.212
 HOH
 3.037
 NE1
 O
TRP D:56 D:56 94.0 0.369 E -114.9 112.8 NA NA NA
6tm1 2 P60763 88.54 2e-126 X-RAY
 2020-01-22 TRP B:56 A:56 81.0 0.318 E -100.1 127.8 4.0 0.016 0.302 A:Q96BY6:0.302
3b13 2 P63000 94.92 4e-126 X-RAY
 2012-03-14 TRP B:63 B:56 88.0 0.345 E -88.8 118.3 6.0 0.024 0.321 A:Q92608:0.322
TRP D:63 D:56 94.0 0.369 E -94.3 116.9 6.0 0.024 0.345 C:Q92608:0.345
7dpa 2 P63000 94.92 5e-126 EM
 2021-08-04 TRP B:63 B:56 66.0 0.259 E -58.9 110.9 21.0 0.082 0.177 A:Q9H7D0:0.176
TRP E:63 E:56 65.0 0.255 E -58.8 110.9 20.0 0.078 0.177 D:Q9H7D0:0.176
5n6o 1 P63000 95.45 2e-125 X-RAY
 2017-12-27 TRP A:55 A:56 86.0 0.337 E -112.7 119.3 86.0 0.337 0.0 GDP
MG
HOH
 9.639
9.246
6.880
 O
C
C
 O2B
MG
O
TRP B:55 B:56 88.0 0.345 E -93.0 121.1 NA NA NA
3th5 1 P63000 95.45 2e-125 X-RAY
 2012-07-18 TRP A:83 A:56 69.0 0.271 E -109.0 115.1 69.0 0.271 0.0 GNP
MG
HOH
 9.790
9.269
7.233
 O
C
O
 O2B
MG
O
TRP B:83 B:56 65.0 0.255 E -111.2 114.2 NA NA NA
2g0n 1 P60763 93.79 2e-125 X-RAY
 2006-05-30 TRP A:57 A:56 70.0 0.275 E -109.1 115.8 70.0 0.275 0.0 MG
GDP
HOH
 9.165
9.721
3.177
 C
O
NE1
 MG
O1B
O
TRP B:57 B:56 67.0 0.263 E -98.8 114.4 NA NA NA
2ov2 1 P60763 93.79 2e-125 X-RAY
 2007-03-13 TRP A:57 A:56 66.0 0.259 E -109.8 106.7 52.0 0.204 0.055 I:O96013:0.055
 MG
GCP
HOH
 9.062
9.533
3.014
 C
O
NE1
 MG
O2B
O
TRP B:57 F:56 69.0 0.271 E -108.2 103.7 NA NA NA
TRP C:57 B:56 68.0 0.267 E -109.2 107.5 NA NA NA
TRP D:57 C:56 64.0 0.251 E -114.4 107.8 NA NA NA
TRP E:57 G:56 66.0 0.259 E -108.8 102.9 NA NA NA
TRP F:57 D:56 70.0 0.275 E -103.6 111.2 NA NA NA
TRP G:57 E:56 68.0 0.267 E -105.5 105.8 NA NA NA
TRP H:57 H:56 67.0 0.263 E -104.7 107.5 NA NA NA
2qme 1 P60763 93.79 2e-125 X-RAY
 2007-08-28 TRP A:57 A:56 58.0 0.227 E -112.2 111.5 54.0 0.212 0.015 B:Q13153:0.016
 MG
GCP
HOH
 8.985
9.580
7.083
 O
O
O
 MG
O2B
O
6bc1 1 P63000 95.45 3e-125 X-RAY
 2017-12-13 TRP A:56 A:56 55.0 0.216 E -128.3 103.6 33.0 0.129 0.087 B:Q8N1W1:0.086
 GSP
MG
HOH
 9.469
8.902
3.420
 O
C
HZ2
 HOG3
MG
O
TRP C:56 B:56 57.0 0.224 E -127.5 103.1 NA NA NA
2ic5 1 P60763 93.79 3e-125 X-RAY
 2006-10-10 TRP A:57 A:56 69.0 0.271 E -108.9 113.0 69.0 0.271 0.0 MG
GNP
HOH
 9.203
9.761
3.132
 C
O
NE1
 MG
O2B
O
TRP B:57 B:56 66.0 0.259 E -96.1 114.4 NA NA NA
3ryt 2 P63000 94.92 3e-125 X-RAY
 2012-01-18 TRP C:59 C:56 82.0 0.322 E -114.9 86.9 60.0 0.235 0.087 A:P70206:0.086
 MG
GNP
 7.639
9.576
 O
O
 MG
O1G
4yon 2 P63000 94.92 4e-125 X-RAY
 2015-07-01 TRP B:58 B:56 82.0 0.322 E -123.0 115.8 6.0 0.024 0.298 A:Q8TCU6:0.298
 HOH
 3.423
 CH2
 O
2c2h 1 P60763 88.02 6e-125 X-RAY
 2005-10-13 TRP A:56 A:56 88.0 0.345 E -113.0 123.4 88.0 0.345 0.0 GDP
MG
HOH
 9.714
9.101
2.908
 O
C
NE1
 O1B
MG
O
TRP B:56 B:56 81.0 0.318 E -113.2 124.1 NA NA NA
1he1 2 P15154 95.43 9e-125 X-RAY
 2001-01-02 TRP C:56 C:56 55.0 0.216 E -113.7 118.3 39.0 0.153 0.063 A:Q51451:0.063
 GDP
AF3
MG
HOH
 9.474
9.814
8.898
2.926
 O
O
C
NE1
 O2B
F2
MG
O
TRP D:56 D:56 52.0 0.204 E -111.1 119.0 NA NA NA
3sbd 1 P63000 94.89 9e-125 X-RAY
 2012-07-18 TRP A:66 A:56 67.0 0.263 E -99.8 112.2 67.0 0.263 0.0 GNP
MG
HOH
 9.588
9.072
3.426
 O
O
CH2
 O2B
MG
O
TRP B:66 B:56 69.0 0.271 E -104.1 109.0 NA NA NA
3sbe 1 P63000 94.89 9e-125 X-RAY
 2012-07-18 TRP A:66 A:56 68.0 0.267 E -110.6 113.2 68.0 0.267 0.0 GNP
MG
HOH
 9.428
8.200
7.510
 O
O
O
 O2B
MG
O
7ajk 1 P63000 94.89 2e-124 X-RAY
 2020-11-18 TRP A:59 BBB:56 91.0 0.357 E -111.9 100.2 17.0 0.067 0.29 B:Q9NUQ9:0.29
 MG
GNP
HOH
 8.505
9.851
7.376
 C
O
O
 MG
O1B
O
4gzm 1 P63000 94.89 2e-124 X-RAY
 2012-12-12 TRP A:83 A:56 65.0 0.255 E -110.5 93.7 65.0 0.255 0.0 GSP
MG
 9.268
8.509
 O
O
 O3G
MG
TRP B:83 B:56 68.0 0.267 E -110.6 93.8 NA NA NA
1ryf 1 P63000 86.0 2e-124 X-RAY
 2004-01-27 TRP A:58 A:56 92.0 0.361 E -110.9 123.5 92.0 0.361 0.0 MG
GDP
HOH
 9.214
9.729
4.297
 C
O
CE3
 MG
O2B
O
TRP B:58 B:56 90.0 0.353 E -105.0 125.3 NA NA NA
1ryh 1 P63000 86.0 2e-124 X-RAY
 2004-01-27 TRP A:58 A:56 90.0 0.353 E -109.2 123.9 90.0 0.353 0.0 MG
GNP
HOH
 9.295
9.860
3.444
 C
O
CE3
 MG
O2B
O
TRP B:58 B:56 85.0 0.333 E -111.6 124.5 NA NA NA
4gzl 1 P63000 94.89 4e-124 X-RAY
 2012-12-12 TRP A:83 A:56 69.0 0.271 E -106.8 108.5 69.0 0.271 0.0 GNP
MG
HOH
 9.454
9.146
4.256
 O
C
CH2
 O2B
MG
O
TRP B:83 B:56 68.0 0.267 E -98.9 112.0 NA NA NA
6agp 1 P63000 92.82 1e-123 NMR
 2019-03-20 TRP A:56 A:56 96.0 0.376 E -129.4 123.1 96.0 0.376 0.0 MG
 9.664
 C
 MG
2wkq 1 O49003,P63000 92.7 2e-122 X-RAY
 2009-08-18 TRP A:208 A:599 1.0 0.004 E -96.0 112.9 1.0 0.004 0.0 GTP
MG
HOH
 9.718
9.115
3.349
 O
C
CD1
 O1B
MG
O
2wkr 1 O49003,P63000 92.7 2e-122 X-RAY
 2009-08-18 TRP A:208 A:599 0.0 0.0 E -96.7 105.7 0.0 0.0 0.0 GTP
MG
HOH
 9.638
9.056
3.328
 O
O
CD1
 O1B
MG
O
2wkp 1 O49003,P63000 92.7 3e-122 X-RAY
 2009-08-18 TRP A:208 A:599 0.0 0.0 E -99.0 114.0 0.0 0.0 0.0 GTP
MG
HOH
 9.713
9.179
3.335
 O
C
CD1
 O1B
MG
O
5hzh 1 P63000,O49003 86.71 3e-88 X-RAY
 2016-12-21 TRP A:208 A:205 71.0 0.278 E -108.8 104.6 71.0 0.278 0.0 GTP
MG
HOH
 9.210
9.016
6.800
 O
C
O
 O3G
MG
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p15153-f1 1 P15153 100.0 7e-144 TRP A:56 A:56 62.0 0.243 E -99.2 107.1
af-p63000-f1 1 P63000 92.19 1e-133 TRP A:56 A:56 61.0 0.239 E -98.9 106.8
af-p60763-f1 1 P60763 88.54 1e-126 TRP A:56 A:56 62.0 0.243 E -97.8 106.9