Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr22 37637633 . G A CCDS13945.1:NM_002872.4:c.101cCc>cTc_NP_002863.1:p.34P>L Homo sapiens ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (RAC2), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1ds6 1 P15153 100.0 2e-143 X-RAY
 2000-07-12 PRO A:34 A:34 28.0 0.193 -68.4 157.2 21.0 0.145 0.048 B:P52566:0.048
 MG
GDP
HOH
 4.069
4.708
2.802
 O
O
O
 MG
O2A
O
1i4d 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 PRO C:34 D:34 28.0 0.193 -48.2 178.4 25.0 0.172 0.021 B:P53365:0.021
 MG
GDP
HOH
 7.426
6.583
2.816
 CG
CD
CB
 MG
O2A
O
1i4l 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 PRO C:34 D:34 56.0 0.386 -53.5 143.7 55.0 0.379 0.007 B:P53365:0.007
 MG
GDP
HOH
 7.912
8.832
9.601
 O
CD
C
 MG
O2A
O
6tgc 3 P63000 92.19 3e-133 EM
 2020-07-29 PRO C:34 C:34 70.0 0.483 -55.4 165.9 5.0 0.034 0.449 A:Q92608:0.448
PRO F:34 F:34 73.0 0.503 -55.4 165.9 7.0 0.048 0.455 D:Q92608:0.455
5fi0 2 P63000 92.19 4e-133 X-RAY
 2016-04-20 PRO B:37 B:34 41.0 0.283 -63.2 152.7 33.0 0.228 0.055 A:Q8TCU6:0.055
PRO D:37 D:34 44.0 0.303 -64.2 153.4 NA NA NA
PRO F:37 F:34 47.0 0.324 -61.6 153.9 NA NA NA
PRO H:37 H:34 44.0 0.303 -63.1 153.3 NA NA NA
1i4t 2 P63000 91.67 5e-132 X-RAY
 2001-05-16 PRO C:34 D:34 46.0 0.317 -73.9 141.9 46.0 0.317 0.0 MG
GNP
HOH
 8.146
8.773
4.262
 O
CD
CB
 MG
O2A
O
1e96 1 P15154 91.62 5e-131 X-RAY
 2000-11-17 PRO A:34 A:34 50.0 0.345 -58.4 125.3 50.0 0.345 0.0 GTP
MG
HOH
 3.526
4.965
4.013
 CA
C
CB
 O3G
MG
O
1hh4 1 P15154 91.62 8e-131 X-RAY
 2001-08-28 PRO A:34 A:34 69.0 0.476 -71.8 154.6 56.0 0.386 0.09 C:P52565:0.09
 GDP
MG
HOH
 4.918
5.149
3.376
 O
O
O
 O2A
MG
O
PRO B:34 B:34 68.0 0.469 -71.1 149.3 NA NA NA
2w2t 1 P15153 99.44 2e-130 X-RAY
 2009-05-05 PRO A:40 A:34 59.0 0.407 -61.1 137.6 59.0 0.407 0.0 MG
GDP
HOH
 5.644
6.238
2.860
 O
O
O
 MG
O2A
O
2w2x 1 P15153 99.44 2e-130 X-RAY
 2009-05-05 PRO A:40 A:34 59.0 0.407 -44.4 139.9 59.0 0.407 0.0 GSP
MG
HOH
 3.590
5.309
4.310
 C
C
C
 O2G
MG
O
PRO B:40 B:34 63.0 0.434 -45.7 139.8 NA NA NA
2w2v 1 P15153 99.44 9e-130 X-RAY
 2009-05-05 PRO A:41 A:34 65.0 0.448 -61.0 135.7 65.0 0.448 0.0 GTP
HOH
 4.648
2.650
 O
O
 O1G
O
PRO B:41 B:34 65.0 0.448 -61.3 135.1 NA NA NA
PRO C:41 C:34 65.0 0.448 -60.0 135.7 NA NA NA
PRO D:41 D:34 52.0 0.359 -54.9 137.0 NA NA NA
2vrw 1 P63000 93.48 1e-129 X-RAY
 2008-06-17 PRO A:34 A:34 43.0 0.297 -61.9 146.5 34.0 0.234 0.063 B:P27870:0.062
 HOH
 3.010
 O
 O
2h7v 1 P63000 92.93 2e-128 X-RAY
 2006-09-19 PRO A:38 A:34 33.0 0.228 -50.7 158.6 28.0 0.193 0.035 C:Q05608:0.034
 MG
GDP
HOH
 3.936
4.468
8.979
 O
O
CG
 MG
O2A
O
PRO B:38 B:34 38.0 0.262 -66.5 166.8 NA NA NA
2p2l 1 P63000 92.93 2e-128 X-RAY
 2007-05-01 PRO A:38 A:34 63.0 0.434 -54.2 139.8 16.0 0.11 0.324 C:P63000:0.324
 ZN
ZN
GDP
HOH
 4.010
7.967
4.635
2.687
 O
CB
O
O
 ZN
ZN
O2A
O
PRO B:38 B:34 63.0 0.434 -59.6 143.0 15.0 0.103 0.331 A:P63000:0.331
 ZN
ZN
GDP
HOH
 7.801
4.046
4.746
2.699
 CB
O
O
O
 ZN
ZN
O2A
O
PRO C:38 C:34 62.0 0.428 -60.9 146.1 15.0 0.103 0.325 B:P63000:0.324
 ZN
ZN
GDP
HOH
 7.852
4.035
4.644
2.716
 CB
O
O
O
 ZN
ZN
O2A
O
1g4u 2 P63000 92.93 3e-128 X-RAY
 2001-01-24 PRO B:34 R:34 82.0 0.566 -59.4 135.9 11.0 0.076 0.49 A:P74873:0.49
 MG
GDP
AF3
HOH
 4.900
6.497
4.994
3.353
 C
CA
C
CA
 MG
O2A
F1
O
1mh1 1 P63000 92.9 3e-127 X-RAY
 1998-01-21 PRO A:36 A:34 103.0 0.71 -59.4 150.2 103.0 0.71 0.0 MG
GNP
HOH
 4.482
3.554
3.533
 C
CB
CA
 MG
O3G
O
2yin 2 P63000 95.48 7e-127 X-RAY
 2011-05-25 PRO C:53 C:34 84.0 0.579 -75.6 157.0 NA NA NA
PRO D:53 D:34 86.0 0.593 -73.3 157.0 13.0 0.09 0.503 B:Q92608:0.503
 HOH
 4.327
 O
 O
2fju 1 P63000 95.48 1e-126 X-RAY
 2006-11-21 PRO A:34 A:34 59.0 0.407 -45.2 142.2 59.0 0.407 0.0 MG
GSP
HOH
 4.305
3.832
4.131
 C
CA
CB
 MG
S1G
O
5qqd 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:35 A:34 39.0 0.269 -57.8 145.1 31.0 0.214 0.055 B:O60229:0.055
 HOH
 2.756
 O
 O
5qqe 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:35 A:34 39.0 0.269 -62.8 144.8 29.0 0.2 0.069 B:O60229:0.069
 HOH
 2.756
 O
 O
5qqf 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:35 A:34 40.0 0.276 -60.9 147.3 30.0 0.207 0.069 B:O60229:0.069
 N5V
HOH
 9.926
2.747
 O
O
 S
O
5qqg 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:35 A:34 39.0 0.269 -66.0 146.3 30.0 0.207 0.062 B:O60229:0.062
 HOH
 2.521
 O
 O
5qqh 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:35 A:34 38.0 0.262 -58.9 145.5 29.0 0.2 0.062 B:O60229:0.062
 HOH
 2.851
 O
 O
5qqi 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:35 A:34 40.0 0.276 -57.9 146.1 31.0 0.214 0.062 B:O60229:0.062
 N6D
HOH
 9.503
2.723
 O
O
 C11
O
5qqj 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:35 A:34 39.0 0.269 -55.5 144.9 30.0 0.207 0.062 B:O60229:0.062
 N6J
HOH
 9.960
2.767
 O
O
 C
O
5qqk 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:35 A:34 36.0 0.248 -62.1 146.8 28.0 0.193 0.055 B:O60229:0.055
 HOH
 2.606
 O
 O
5qql 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:35 A:34 39.0 0.269 -61.4 149.6 31.0 0.214 0.055 B:O60229:0.055
 N71
HOH
 9.301
2.778
 N
O
 C9
O
5qqm 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:35 A:34 39.0 0.269 -59.0 144.1 31.0 0.214 0.055 B:O60229:0.055
 N74
HOH
 9.786
2.865
 N
O
 C12
O
5qqn 1 P63000 95.48 1e-126 X-RAY
 2019-12-18 PRO A:35 A:34 40.0 0.276 -58.8 146.4 31.0 0.214 0.062 B:O60229:0.062
 HOH
 2.782
 O
 O
5qu9 1 P63000 95.48 1e-126 X-RAY
 2020-01-29 PRO A:35 A:34 40.0 0.276 -64.1 151.8 30.0 0.207 0.069 B:O60229:0.069
 HOH
 2.822
 O
 O
1foe 2 P63000 95.48 1e-126 X-RAY
 2001-01-17 PRO B:34 B:34 43.0 0.297 -49.8 152.5 36.0 0.248 0.049 A:Q60610:0.048
 SO4
HOH
 6.890
7.648
 O
CB
 O1
O
PRO D:34 D:34 45.0 0.31 -50.0 151.8 NA NA NA
PRO F:34 F:34 45.0 0.31 -49.6 151.3 NA NA NA
PRO H:34 H:34 45.0 0.31 -50.9 151.3 NA NA NA
2nz8 1 P63000 95.48 1e-126 X-RAY
 2007-04-10 PRO A:34 A:34 54.0 0.372 -60.5 148.4 45.0 0.31 0.062 B:O75962:0.062
 HOH
 2.821
 O
 O
3bji 2 P63000 95.48 1e-126 X-RAY
 2008-07-15 PRO C:34 C:34 56.0 0.386 -67.0 139.7 NA NA NA
PRO D:34 D:34 47.0 0.324 -58.7 151.1 38.0 0.262 0.062 A:P15498:0.062
 HOH
 9.184
 CG
 O
5o33 1 P63000 95.48 1e-126 X-RAY
 2017-05-31 PRO A:34 A:34 39.0 0.269 -65.2 150.8 31.0 0.214 0.055 B:P97924:0.055
 GDP
EDO
HOH
 5.049
6.320
2.797
 O
CB
O
 O2A
C1
O
3su8 1 P63000 95.48 1e-126 X-RAY
 2011-09-28 PRO A:34 A:34 65.0 0.448 -67.2 114.8 65.0 0.448 0.0 MG
GNP
 4.722
3.583
 C
CB
 MG
O3G
3sua 1 P63000 95.48 1e-126 X-RAY
 2011-09-07 PRO A:34 A:34 58.0 0.4 -72.8 115.7 58.0 0.4 0.0 MG
GNP
 3.984
3.418
 C
CA
 MG
O3G
PRO B:34 B:34 57.0 0.393 -72.7 116.0 NA NA NA
PRO C:34 C:34 59.0 0.407 -72.5 115.2 NA NA NA
6x1g 2 P63000 95.48 2e-126 X-RAY
 2020-11-25 PRO C:34 B:34 57.0 0.393 -68.8 169.8 9.0 0.062 0.331 A:B3CVM3:0.331
 HOH
 2.818
 O
 O
PRO D:34 D:34 57.0 0.393 -69.4 165.8 NA NA NA
6tm1 2 P60763 88.54 2e-126 X-RAY
 2020-01-22 PRO B:34 A:34 98.0 0.676 -80.6 153.4 40.0 0.276 0.4 A:Q96BY6:0.4
3b13 2 P63000 94.92 4e-126 X-RAY
 2012-03-14 PRO B:41 B:34 76.0 0.524 -73.1 160.3 4.0 0.028 0.496 A:Q92608:0.497
PRO D:41 D:34 77.0 0.531 -73.3 165.1 2.0 0.014 0.517 C:Q92608:0.517
7dpa 2 P63000 94.92 5e-126 EM
 2021-08-04 PRO B:41 B:34 88.0 0.607 -65.4 146.8 9.0 0.062 0.545 A:Q9H7D0:0.545
PRO E:41 E:34 88.0 0.607 -65.3 146.8 7.0 0.048 0.559 D:Q9H7D0:0.559
5n6o 1 P63000 95.45 2e-125 X-RAY
 2017-12-27 PRO A:33 A:34 46.0 0.317 -55.3 141.0 46.0 0.317 0.0 GDP
MG
HOH
 6.079
5.411
2.757
 O
O
O
 O2A
MG
O
PRO B:33 B:34 37.0 0.255 -62.8 144.4 NA NA NA
3th5 1 P63000 95.45 2e-125 X-RAY
 2012-07-18 PRO A:61 A:34 59.0 0.407 -57.0 132.5 59.0 0.407 0.0 GNP
MG
HOH
 3.779
4.681
4.055
 CA
C
CA
 O3G
MG
O
PRO B:61 NA:NA DO NA DO DO DO NA NA NA
2g0n 1 P60763 93.79 2e-125 X-RAY
 2006-05-30 PRO A:35 A:34 49.0 0.338 -46.9 131.9 49.0 0.338 0.0 MG
CL
GDP
HOH
 4.282
8.212
5.740
2.834
 O
O
O
O
 MG
CL
O2A
O
PRO B:35 B:34 48.0 0.331 -47.7 133.5 NA NA NA
2ov2 1 P60763 93.79 2e-125 X-RAY
 2007-03-13 PRO A:35 A:34 69.0 0.476 -53.7 144.9 69.0 0.476 0.0 MG
GCP
HOH
 4.686
3.489
2.460
 C
CB
O
 MG
O3G
O
PRO B:35 F:34 64.0 0.441 -56.8 153.8 NA NA NA
PRO C:35 B:34 65.0 0.448 -57.7 148.9 NA NA NA
PRO D:35 C:34 66.0 0.455 -53.4 143.4 NA NA NA
PRO E:35 G:34 64.0 0.441 -49.5 148.0 NA NA NA
PRO F:35 D:34 66.0 0.455 -53.2 143.6 NA NA NA
PRO G:35 E:34 66.0 0.455 -54.8 152.5 NA NA NA
PRO H:35 H:34 69.0 0.476 -52.8 146.8 NA NA NA
2qme 1 P60763 93.79 2e-125 X-RAY
 2007-08-28 PRO A:35 A:34 72.0 0.497 -56.1 139.9 72.0 0.497 0.0 MG
GCP
HOH
 4.661
3.284
2.752
 C
CB
O
 MG
O3G
O
6bc1 1 P63000 95.45 3e-125 X-RAY
 2017-12-13 PRO A:34 A:34 68.0 0.469 -52.7 141.2 68.0 0.469 0.0 GSP
MG
HOH
 2.804
4.032
3.336
 HA
HA
HA
 HOG2
MG
O
PRO C:34 B:34 62.0 0.428 -57.0 129.8 NA NA NA
2ic5 1 P60763 93.79 3e-125 X-RAY
 2006-10-10 PRO A:35 A:34 99.0 0.683 -69.2 360.0 99.0 0.683 0.0 MG
GNP
HOH
 4.975
5.726
3.375
 O
O
O
 MG
O1G
O
PRO B:35 B:34 16.0 0.11 -49.3 131.0 NA NA NA
3ryt 2 P63000 94.92 3e-125 X-RAY
 2012-01-18 PRO C:37 C:34 75.0 0.517 -43.1 133.7 75.0 0.517 0.0 MG
GNP
 5.709
3.528
 C
CA
 MG
O2G
4yon 2 P63000 94.92 4e-125 X-RAY
 2015-07-01 PRO B:36 B:34 55.0 0.379 -59.5 155.7 47.0 0.324 0.055 A:Q8TCU6:0.055
 HOH
 2.721
 O
 O
2c2h 1 P60763 88.02 6e-125 X-RAY
 2005-10-13 PRO A:34 NA:NA DO NA DO DO DO NA NA NA
PRO B:34 NA:NA DO NA DO DO DO NA NA NA
1he1 2 P15154 95.43 9e-125 X-RAY
 2001-01-02 PRO C:34 C:34 83.0 0.572 -55.5 141.8 10.0 0.069 0.503 A:Q51451:0.503
 GDP
AF3
MG
HOH
 6.296
4.434
4.942
2.708
 CA
C
C
O
 O2A
F3
MG
O
PRO D:34 D:34 80.0 0.552 -59.4 138.3 NA NA NA
3sbd 1 P63000 94.89 9e-125 X-RAY
 2012-07-18 PRO A:44 A:34 56.0 0.386 -57.9 131.5 56.0 0.386 0.0 GNP
MG
HOH
 3.727
4.733
4.133
 CA
C
CB
 O3G
MG
O
PRO B:44 B:34 58.0 0.4 -56.0 127.0 NA NA NA
3sbe 1 P63000 94.89 9e-125 X-RAY
 2012-07-18 PRO A:44 A:34 58.0 0.4 -60.8 133.3 58.0 0.4 0.0 GNP
MG
HOH
 3.909
5.087
3.789
 CA
C
CA
 O3G
MG
O
7ajk 1 P63000 94.89 2e-124 X-RAY
 2020-11-18 PRO A:37 BBB:34 71.0 0.49 -58.3 142.3 59.0 0.407 0.083 B:Q9NUQ9:0.083
 MG
GNP
HOH
 4.997
3.786
3.332
 C
CA
CB
 MG
O3G
O
4gzm 1 P63000 94.89 2e-124 X-RAY
 2012-12-12 PRO A:61 A:34 85.0 0.586 -63.8 136.7 85.0 0.586 0.0 GSP
MG
 3.641
5.094
 CA
C
 S1G
MG
PRO B:61 B:34 85.0 0.586 -63.5 136.5 NA NA NA
1ryf 1 P63000 86.0 2e-124 X-RAY
 2004-01-27 PRO A:36 A:34 60.0 0.414 -60.3 161.9 60.0 0.414 0.0 MG
GDP
HOH
 7.679
9.451
3.096
 O
O
O
 MG
O2B
O
PRO B:36 B:34 60.0 0.414 -53.6 147.8 NA NA NA
1ryh 1 P63000 86.0 2e-124 X-RAY
 2004-01-27 PRO A:36 A:34 83.0 0.572 -64.1 141.4 83.0 0.572 0.0 MG
GNP
HOH
 8.605
9.288
4.180
 C
C
O
 MG
O2G
O
PRO B:36 B:34 60.0 0.414 -49.0 145.6 NA NA NA
4gzl 1 P63000 94.89 4e-124 X-RAY
 2012-12-12 PRO A:61 A:34 58.0 0.4 -49.8 129.2 58.0 0.4 0.0 GNP
MG
HOH
 3.465
4.666
3.950
 CA
C
CB
 O3G
MG
O
PRO B:61 B:34 61.0 0.421 -59.0 131.5 NA NA NA
6agp 1 P63000 92.82 1e-123 NMR
 2019-03-20 PRO A:34 A:34 81.0 0.559 T -65.9 -16.0 81.0 0.559 0.0
2wkq 1 O49003,P63000 92.7 2e-122 X-RAY
 2009-08-18 PRO A:186 A:577 82.0 0.566 -60.2 142.9 82.0 0.566 0.0 GTP
MG
HOH
 3.589
4.760
2.618
 CA
C
O
 O2G
MG
O
2wkr 1 O49003,P63000 92.7 2e-122 X-RAY
 2009-08-18 PRO A:186 A:577 73.0 0.503 -55.5 146.6 73.0 0.503 0.0 GTP
MG
HOH
 3.545
4.644
3.481
 CA
C
O
 O2G
MG
O
2wkp 1 O49003,P63000 92.7 3e-122 X-RAY
 2009-08-18 PRO A:186 A:577 74.0 0.51 -58.2 143.6 74.0 0.51 0.0 GTP
MG
HOH
 3.719
4.705
2.705
 CA
C
O
 O2G
MG
O
5hzh 1 P63000,O49003 97.92 1e-25 X-RAY
 2016-12-21 PRO A:37 A:34 78.0 0.538 -57.1 110.7 78.0 0.538 0.0 GTP
MG
HOH
 3.517
4.553
4.234
 CA
C
CA
 O1G
MG
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p15153-f1 1 P15153 100.0 7e-144 PRO A:34 A:34 62.0 0.428 -61.1 117.9
af-p63000-f1 1 P63000 92.19 1e-133 PRO A:34 A:34 61.0 0.421 -61.7 118.1
af-p60763-f1 1 P60763 88.54 1e-126 PRO A:34 A:34 62.0 0.428 -61.8 116.9