Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10191533 . A C CCDS2597.1:NM_000551.3:c.526Agg>Cgg_NP_000542.1:p.176R>R Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
2015-03-04 ARG A:196 A:176 113.0 0.502 G -65.8 -8.0 113.0 0.502 0.0
7q2j 3 P40337 94.25 1e-118 X-RAY
2021-11-24 ARG C:160 C:176 127.0 0.564 G -79.9 -14.5 127.0 0.564 0.0
4b9k 3 P40337 95.32 3e-118 X-RAY
2012-10-24 ARG C:134 C:176 177.0 0.787 G -61.6 -22.9 177.0 0.787 0.0 HOH
3.230
N
O
ARG F:134 F:176 63.0 NA G -65.8 -18.2 NA NA NA
ARG I:134 I:176 115.0 0.511 G -64.2 -18.9 NA NA NA
ARG L:134 L:176 129.0 0.573 G -70.2 -12.3 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
2002-07-03 ARG C:125 C:176 115.0 0.511 G -69.9 1.5 115.0 0.511 0.0 HOH
9.049
N
O
3ztd 3 P40337 99.38 4e-117 X-RAY
2012-07-25 ARG C:125 C:176 78.0 NA T -37.9 -41.2 78.0 NA NA
ARG F:125 F:176 73.0 NA G -69.7 -10.2 NA NA NA
ARG I:125 I:176 63.0 NA T -56.9 -65.5 NA NA NA
ARG L:125 L:176 105.0 0.467 G -60.1 -39.2 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
2012-10-24 ARG C:125 C:176 92.0 NA G -67.8 -13.8 92.0 NA NA HOH
8.703
O
O
ARG F:125 F:176 87.0 NA G -60.4 -12.6 NA NA NA
ARG I:125 I:176 77.0 NA G -63.9 -14.0 NA NA NA
ARG L:125 L:176 111.0 NA G -60.3 -9.9 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
2013-11-27 ARG C:125 C:176 72.0 NA G -72.0 -8.3 72.0 NA NA HOH
4.030
CA
O
ARG F:125 F:176 134.0 0.596 G -71.7 -9.0 NA NA NA
ARG I:125 I:176 130.0 0.578 G -66.2 -24.3 NA NA NA
ARG L:125 L:176 119.0 0.529 G -77.8 1.2 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
2013-11-27 ARG C:125 C:176 71.0 NA G -71.6 -2.8 71.0 NA NA
ARG F:125 F:176 166.0 0.738 G -74.5 -6.6 NA NA NA
ARG I:125 I:176 124.0 0.551 G -66.7 -20.8 NA NA NA
ARG L:125 L:176 140.0 0.622 G -72.5 -10.5 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:125 C:176 150.0 0.667 G -70.5 -26.9 150.0 0.667 0.0 HOH
4.941
NH2
O
ARG F:125 F:176 139.0 0.618 G -67.1 -15.1 NA NA NA
ARG I:125 I:176 134.0 0.596 G -68.5 -26.5 NA NA NA
ARG L:125 L:176 118.0 0.524 G -68.9 -18.7 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:125 C:176 152.0 0.676 G -74.9 -18.3 152.0 0.676 0.0 HOH
3.685
NH2
O
ARG F:125 F:176 137.0 0.609 G -66.3 -17.6 NA NA NA
ARG I:125 I:176 117.0 0.52 G -70.5 -19.1 NA NA NA
ARG L:125 L:176 109.0 0.484 G -63.5 -22.2 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:125 C:176 165.0 0.733 G -66.4 -24.2 165.0 0.733 0.0
ARG F:125 F:176 139.0 0.618 G -65.0 -21.1 NA NA NA
ARG I:125 I:176 120.0 0.533 G -71.9 -22.5 NA NA NA
ARG L:125 L:176 128.0 0.569 T -69.2 -31.5 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:125 C:176 91.0 NA G -65.4 -19.1 91.0 NA NA HOH
7.749
C
O
ARG F:125 F:176 63.0 NA G -59.7 -18.9 NA NA NA
ARG I:125 I:176 130.0 0.578 G -70.8 -17.1 NA NA NA
ARG L:125 NA:NA DO NA DO DO DO NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:125 C:176 159.0 0.707 T -69.0 -19.5 159.0 0.707 0.0
ARG F:125 F:176 143.0 0.636 G -68.2 -27.5 NA NA NA
ARG I:125 I:176 136.0 0.604 G -70.1 -30.4 NA NA NA
ARG L:125 L:176 142.0 0.631 G -73.0 -16.9 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:125 C:176 136.0 0.604 G -72.2 -26.5 136.0 0.604 0.0 HOH
8.336
NH1
O
ARG F:125 F:176 131.0 0.582 G -62.0 -25.9 NA NA NA
ARG I:125 I:176 123.0 0.547 G -67.7 -24.0 NA NA NA
ARG L:125 L:176 107.0 0.476 G -57.2 -30.9 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:125 C:176 152.0 0.676 T -75.9 -23.7 152.0 0.676 0.0 HOH
8.859
NH2
O
ARG F:125 F:176 133.0 0.591 G -62.6 -22.3 NA NA NA
ARG I:125 I:176 110.0 0.489 G -71.5 -23.2 NA NA NA
ARG L:125 L:176 102.0 0.453 G -64.7 -19.7 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:125 C:176 139.0 0.618 G -67.2 -23.1 139.0 0.618 0.0 HOH
2.734
N
O
ARG F:125 F:176 136.0 0.604 G -71.6 -13.2 NA NA NA
ARG I:125 I:176 156.0 0.693 G -68.4 -11.2 NA NA NA
ARG L:125 L:176 129.0 0.573 G -67.3 -20.1 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:125 C:176 163.0 0.724 G -66.6 -23.7 163.0 0.724 0.0
ARG F:125 F:176 144.0 0.64 G -63.9 -24.7 NA NA NA
ARG I:125 I:176 140.0 0.622 G -69.2 -29.4 NA NA NA
ARG L:125 L:176 127.0 0.564 G -61.3 -24.9 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:125 C:176 98.0 NA G -71.4 -13.4 98.0 NA NA
ARG F:125 F:176 134.0 0.596 G -68.6 -19.2 NA NA NA
ARG I:125 I:176 149.0 0.662 G -69.8 -12.9 NA NA NA
ARG L:125 L:176 152.0 0.676 G -65.1 -25.1 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
2016-11-09 ARG C:125 C:176 201.0 0.893 G -67.8 -21.1 201.0 0.893 0.0 HOH
7.804
O
O
ARG F:125 F:176 68.0 NA G -67.9 -6.9 NA NA NA
ARG I:125 I:176 131.0 0.582 T -75.3 -33.9 NA NA NA
ARG L:125 L:176 107.0 0.476 G -61.9 -24.6 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:125 C:176 200.0 0.889 G -68.4 -21.2 200.0 0.889 0.0 HOH
6.983
O
O
ARG F:125 F:176 62.0 NA G -61.1 -22.8 NA NA NA
ARG I:125 I:176 122.0 0.542 T -72.0 -21.3 NA NA NA
ARG L:125 L:176 101.0 0.449 G -64.4 -19.7 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:125 C:176 206.0 0.916 G -69.3 -23.9 206.0 0.916 0.0 HOH
6.924
O
O
ARG F:125 F:176 64.0 NA G -60.0 -20.2 NA NA NA
ARG I:125 I:176 123.0 0.547 G -71.6 -19.6 NA NA NA
ARG L:125 L:176 105.0 0.467 G -69.4 -19.2 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:125 C:176 206.0 0.916 G -69.5 -23.4 206.0 0.916 0.0 HOH
4.092
O
O
ARG F:125 F:176 66.0 NA G -65.5 -17.1 NA NA NA
ARG I:125 I:176 118.0 0.524 G -72.5 -21.5 NA NA NA
ARG L:125 L:176 105.0 0.467 T -63.6 -21.9 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:125 C:176 170.0 0.756 T -62.2 -28.8 170.0 0.756 0.0 HOH
3.434
O
O
ARG F:125 F:176 94.0 0.418 T -49.2 -41.8 NA NA NA
ARG I:125 I:176 114.0 0.507 T -67.0 -33.2 NA NA NA
ARG L:125 L:176 132.0 0.587 G -66.8 -31.2 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:125 C:176 200.0 0.889 G -82.0 -15.8 200.0 0.889 0.0
ARG F:125 F:176 67.0 NA G -60.3 -20.1 NA NA NA
ARG I:125 I:176 122.0 0.542 G -75.3 -15.8 NA NA NA
ARG L:125 L:176 113.0 0.502 G -70.9 -21.8 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:125 C:176 157.0 0.698 G -74.5 -18.7 157.0 0.698 0.0 HOH
2.906
N
O
ARG F:125 F:176 170.0 0.756 G -63.7 -25.0 NA NA NA
ARG I:125 I:176 70.0 NA G -63.2 -24.5 NA NA NA
ARG L:125 L:176 137.0 0.609 G -67.8 -16.2 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:125 C:176 207.0 0.92 G -69.3 -20.4 207.0 0.92 0.0 HOH
7.699
O
O
ARG F:125 F:176 69.0 NA G -56.3 -29.4 NA NA NA
ARG I:125 I:176 106.0 0.471 G -72.1 -7.6 NA NA NA
ARG L:125 L:176 100.0 0.444 G -67.5 -14.9 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:125 C:176 207.0 0.92 G -72.7 -18.7 207.0 0.92 0.0 HOH
3.427
O
O
ARG F:125 F:176 66.0 NA G -63.1 -20.6 NA NA NA
ARG I:125 I:176 105.0 0.467 G -77.1 -2.6 NA NA NA
ARG L:125 L:176 103.0 0.458 G -74.4 -5.8 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
2017-03-08 ARG D:125 D:176 119.0 0.529 G -87.2 7.1 119.0 0.529 0.0 HOH
8.338
C
O
ARG H:125 H:176 142.0 0.631 G -87.4 7.6 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
2018-08-01 ARG A:125 V:176 140.0 0.622 G -80.7 -0.6 140.0 0.622 0.0 HOH
8.766
H
O
6gfy 3 P40337 99.38 4e-117 X-RAY
2018-07-11 ARG C:125 C:176 203.0 0.902 G -72.9 -26.7 203.0 0.902 0.0 HOH
9.890
N
O
ARG F:125 F:176 71.0 NA G -65.2 -15.1 NA NA NA
ARG I:125 I:176 131.0 0.582 T -71.0 -23.8 NA NA NA
ARG L:125 L:176 114.0 0.507 G -55.7 -33.7 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
2018-07-11 ARG C:125 C:176 201.0 0.893 G -59.9 -29.8 201.0 0.893 0.0 HOH
6.698
C
O
ARG F:125 F:176 62.0 NA G -63.0 -23.5 NA NA NA
ARG I:125 I:176 123.0 0.547 G -69.1 -23.1 NA NA NA
ARG L:125 L:176 100.0 0.444 G -56.5 -21.0 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
2018-08-08 ARG C:125 C:176 65.0 NA G -74.5 -13.1 65.0 NA NA HOH
9.491
O
O
ARG F:125 F:176 126.0 0.56 G -75.7 -8.7 NA NA NA
ARG L:125 L:176 69.0 NA G -72.6 -15.1 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
2018-08-08 ARG I:125 I:176 130.0 0.578 G -73.3 -17.0 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
2018-08-22 ARG C:125 C:176 77.0 NA G -68.7 -12.2 77.0 NA NA
ARG F:125 F:176 154.0 0.684 G -72.3 -5.2 NA NA NA
ARG I:125 I:176 73.0 NA G -72.6 -16.3 NA NA NA
ARG L:125 L:176 119.0 0.529 G -72.0 -6.4 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
2018-08-08 ARG C:125 C:176 86.0 NA G -74.7 -1.1 86.0 NA NA
ARG F:125 F:176 130.0 0.578 G -72.4 -4.8 NA NA NA
ARG I:125 I:176 128.0 0.569 G -77.4 -0.3 NA NA NA
ARG L:125 L:176 104.0 0.462 G -75.9 -3.5 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
2019-06-12 ARG B:125 B:176 121.0 0.538 G -81.3 7.3 121.0 0.538 0.0 EPE
HOH
8.669
2.652
NH1
O
O3S
O
ARG F:125 F:176 126.0 0.56 G -81.0 7.2 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
2019-06-12 ARG B:125 B:176 122.0 0.542 G -77.2 1.0 122.0 0.542 0.0 HOH
6.496
NH2
O
ARG F:125 F:176 122.0 0.542 G -72.5 5.7 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
2019-12-04 ARG D:125 D:176 130.0 0.578 G -96.6 24.6 130.0 0.578 0.0
ARG H:125 H:176 129.0 0.573 G -96.6 24.9 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
2021-10-06 ARG D:125 L:176 113.0 0.502 G -79.3 1.9 113.0 0.502 0.0 HOH
2.921
NH2
O
7jtp 3 P40337 99.38 4e-117 X-RAY
2021-10-06 ARG C:125 L:176 133.0 0.591 T -81.7 5.7 133.0 0.591 0.0 HOH
4.051
O
O
3zrc 3 P40337 98.77 4e-117 X-RAY
2012-03-07 ARG C:126 C:176 102.0 NA S -113.0 -5.1 102.0 NA NA HOH
9.839
O
O
ARG F:126 F:176 78.0 NA G -67.1 -1.6 NA NA NA
ARG I:126 I:176 72.0 NA S -66.5 -52.0 NA NA NA
ARG L:126 L:176 129.0 0.573 T -80.3 -9.2 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
2012-03-07 ARG C:126 C:176 102.0 NA G -54.1 -46.9 102.0 NA NA HOH
9.747
O
O
ARG F:126 F:176 90.0 NA G -65.9 -19.3 NA NA NA
ARG I:126 I:176 129.0 0.573 G -65.5 -37.9 NA NA NA
ARG L:126 L:176 114.0 0.507 G -59.0 -18.8 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
2012-07-25 ARG C:126 C:176 93.0 NA G -46.7 -29.4 93.0 NA NA
ARG F:126 F:176 150.0 0.667 G -65.0 -27.5 NA NA NA
ARG I:126 I:176 118.0 0.524 G -76.0 -36.0 NA NA NA
ARG L:126 L:176 104.0 0.462 G -53.6 -19.5 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
2012-07-25 ARG C:126 C:176 94.0 NA T -53.0 -41.7 94.0 NA NA HOH
2.559
O
O
ARG F:126 F:176 70.0 NA G -62.9 -20.6 NA NA NA
ARG I:126 I:176 77.0 NA G -59.5 -44.4 NA NA NA
ARG L:126 L:176 113.0 0.502 G -63.5 -21.9 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
2012-11-14 ARG D:126 V:176 126.0 0.56 G -81.1 3.4 126.0 0.56 0.0 HOH
2.806
O
O
4awj 3 P40337 98.77 4e-117 X-RAY
2012-11-14 ARG C:126 C:176 94.0 NA T -76.4 -24.8 94.0 NA NA
ARG F:126 F:176 73.0 NA G -74.5 -7.8 NA NA NA
ARG I:126 I:176 89.0 NA T -74.6 -31.9 NA NA NA
ARG L:126 L:176 117.0 0.52 G -73.2 -9.1 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
2018-08-08 ARG D:126 V:176 105.0 0.467 G -78.5 5.2 105.0 0.467 0.0 HOH
2.924
O
O
1lm8 3 P40337 100.0 6e-117 X-RAY
2002-06-12 ARG C:123 V:176 98.0 0.436 G -64.7 -6.7 98.0 0.436 0.0 HOH
2.817
O
O
1vcb 3 P40337 100.0 6e-117 X-RAY
1999-04-21 ARG C:123 C:176 91.0 0.404 G -63.5 -8.2 91.0 0.404 0.0 HOH
4.057
NE
O
ARG F:123 F:176 90.0 0.4 G -63.4 -8.9 NA NA NA
ARG I:123 I:176 88.0 0.391 G -65.6 -8.7 NA NA NA
ARG L:123 L:176 89.0 0.396 G -65.6 -7.3 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
2017-06-07 ARG B:123 V:176 148.0 0.658 S -127.3 -28.9 148.0 0.658 0.0
6gfx 3 P40337 100.0 6e-117 X-RAY
2018-07-11 ARG C:123 C:176 102.0 0.453 G -78.5 -1.3 102.0 0.453 0.0 HOH
2.961
N
O
6i7q 4 P40337 100.0 6e-117 X-RAY
2019-11-27 ARG D:123 V:176 128.0 0.569 G -82.7 -1.0 128.0 0.569 0.0 HOH
2.040
H
O
6i7r 4 P40337 100.0 6e-117 X-RAY
2019-11-27 ARG D:123 V:176 133.0 0.591 G -74.2 -8.9 133.0 0.591 0.0 HOH
1.828
HH12
O
6r7f 9 P40337 100.0 6e-117 EM
2019-08-28 ARG I:123 V:176 173.0 0.769 T -64.1 -30.3 173.0 0.769 0.0
7khh 3 P40337 100.0 6e-116 X-RAY
2021-02-24 ARG C:138 C:176 118.0 0.524 G -73.8 2.6 118.0 0.524 0.0 HOH
2.936
O
O
7cjb 1 P40337 100.0 8e-116 X-RAY
2021-07-14 ARG A:126 A:176 127.0 0.564 G -81.4 -3.1 127.0 0.564 0.0
ARG E:126 E:176 178.0 0.791 G -80.5 -4.4 NA NA NA
ARG I:126 I:176 190.0 0.844 G -82.3 -2.2 NA NA NA
ARG M:126 M:176 141.0 0.627 G -82.3 -1.9 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
2020-08-05 ARG A:118 AAA:176 175.0 0.778 G -69.1 -13.9 175.0 0.778 0.0 EDO
HOH
2.973
2.889
O
N
O1
O
7pi4 1 P40337 100.0 4e-113 X-RAY
2021-09-29 ARG A:118 AAA:176 118.0 0.524 G -79.0 -10.7 118.0 0.524 0.0 HOH
3.239
NH2
O
6fmi 3 P40337 99.34 1e-109 X-RAY
2018-04-11 ARG C:125 C:176 123.0 0.547 G -63.6 -20.9 123.0 0.547 0.0 HOH
3.452
CD
O
ARG F:125 F:176 130.0 0.578 T -62.9 -31.7 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
2018-04-11 ARG C:125 C:176 207.0 0.92 T -63.4 -36.4 207.0 0.92 0.0 HOH
2.727
NH1
O
ARG F:125 F:176 63.0 NA G -57.0 -31.0 NA NA NA
ARG I:125 I:176 111.0 0.493 T -73.9 -20.4 NA NA NA
ARG L:125 L:176 108.0 0.48 G -73.7 -19.8 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
2018-04-11 ARG C:125 C:176 162.0 0.72 G -68.9 -12.7 162.0 0.72 0.0 HOH
4.794
NH1
O
ARG F:125 F:176 178.0 0.791 G -68.6 -16.9 NA NA NA
ARG I:125 I:176 143.0 0.636 T -71.6 -23.0 NA NA NA
ARG L:125 L:176 139.0 0.618 G -68.3 -24.6 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
2019-06-12 ARG B:116 B:176 145.0 0.644 T -75.4 -5.9 145.0 0.644 0.0 HOH
7.314
C
O
ARG F:116 F:176 139.0 0.618 T -75.4 -6.8 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
2019-08-28 ARG L:117 V:176 171.0 0.76 T -68.0 -29.7 171.0 0.76 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 ARG A:176 A:176 166.0 0.738 G -74.3 2.6