Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 105464863 . C A CCDS2948.1:NM_170662.3:c.743cGg>cTg_NP_733762.2:p.248R>L Homo sapiens Cbl proto-oncogene B, E3 ubiquitin protein ligase (CBLB), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3zni 1 Q13191 99.49 0.0 X-RAY
 2013-07-10 ARG A:215 A:248 122.0 0.542 H -70.6 -43.3 122.0 0.542 0.0 HOH
 3.615
 N
 O
ARG E:215 E:248 135.0 0.6 H -70.9 -40.6 NA NA NA
ARG I:215 I:248 44.0 NA H -63.4 -44.0 NA NA NA
ARG M:215 M:248 157.0 0.698 H -67.0 -42.2 NA NA NA
3vgo 1 Q13191 100.0 0.0 X-RAY
 2011-12-14 ARG A:216 A:248 163.0 0.724 H -64.5 -42.6 163.0 0.724 0.0
ARG B:216 B:248 203.0 0.902 H -65.3 -49.9 NA NA NA
ARG C:216 C:248 59.0 NA H -58.5 -54.5 NA NA NA
4a4c 1 P22681 85.6 0.0 X-RAY
 2012-01-25 ARG A:212 A:256 141.0 0.627 H -61.5 -28.1 141.0 0.627 0.0
2y1m 1 P22681 85.6 0.0 X-RAY
 2012-01-18 ARG A:210 A:256 81.0 0.36 H -69.3 -27.0 81.0 0.36 0.0 HOH
 7.528
 N
 O
ARG B:210 B:256 54.0 0.24 H -68.4 -38.6 NA NA NA
ARG C:210 C:256 86.0 0.382 H -62.1 -38.5 NA NA NA
ARG D:210 D:256 52.0 0.231 H -58.8 -39.8 NA NA NA
ARG E:210 E:256 51.0 0.227 H -60.0 -34.5 NA NA NA
ARG F:210 F:256 51.0 0.227 H -71.2 -38.2 NA NA NA
2y1n 1 P22681 85.6 0.0 X-RAY
 2012-01-18 ARG A:210 A:256 129.0 0.573 H -65.1 -49.2 NA NA NA
ARG C:210 C:256 100.0 0.444 H -64.3 -44.1 100.0 0.444 0.0 HOH
 3.398
 NE
 O
4a4b 1 P22681 85.35 0.0 X-RAY
 2012-01-25 ARG A:212 A:256 153.0 0.68 H -60.6 -42.2 153.0 0.68 0.0
5o76 1 P22681 85.35 0.0 X-RAY
 2017-11-01 ARG A:212 A:256 138.0 0.613 H -69.7 -44.0 138.0 0.613 0.0 HOH
 2.844
 NH1
 O
ARG C:212 C:256 154.0 0.684 H -73.7 -39.9 NA NA NA
5j3x 1 P22681 85.35 0.0 X-RAY
 2016-09-21 ARG A:212 A:256 53.0 0.236 H -73.0 -22.2 53.0 0.236 0.0
ARG B:212 B:256 54.0 0.24 H -64.6 -29.5 NA NA NA
ARG C:212 C:256 50.0 0.222 H -68.1 -30.7 NA NA NA
ARG D:212 D:256 45.0 NA H -70.5 -26.4 NA NA NA
ARG E:212 E:256 60.0 0.267 H -67.8 -33.6 NA NA NA
ARG F:212 F:256 43.0 0.191 H -65.8 -36.4 NA NA NA
1fbv 1 P22681 85.57 0.0 X-RAY
 2000-08-30 ARG A:210 A:256 24.0 0.107 H -69.6 -48.5 24.0 0.107 0.0 SO4
 2.891
 N
 O1
5hkx 1 P22681 85.35 0.0 X-RAY
 2017-01-18 ARG A:213 A:256 35.0 0.156 H -65.9 -37.4 35.0 0.156 0.0 HOH
 3.075
 O
 O
3pfv 1 Q13191 99.68 0.0 X-RAY
 2010-12-08 ARG A:212 A:248 151.0 0.671 H -75.2 -33.9 151.0 0.671 0.0 HOH
 3.484
 N
 O
ARG B:212 B:248 129.0 0.573 H -71.8 -37.2 NA NA NA
5axi 1 Q3TTA7 100.0 0.0 X-RAY
 2016-03-02 ARG A:212 A:248 132.0 0.587 H -59.7 -48.0 132.0 0.587 0.0 HOH
 2.959
 O
 O
ARG B:212 B:248 175.0 0.778 H -59.7 -44.9 NA NA NA
ARG C:212 C:248 156.0 0.693 H -74.0 -45.4 NA NA NA
6xar 1 P22681 83.28 0.0 X-RAY
 2021-03-03 ARG A:234 A:256 161.0 0.716 H -71.1 -44.1 161.0 0.716 0.0 HOH
 3.480
 N
 O
ARG B:234 B:256 148.0 0.658 H -73.0 -51.5 NA NA NA
6o02 1 P22681 83.06 0.0 X-RAY
 2020-08-19 ARG A:212 A:256 133.0 0.591 H -52.5 -53.7 133.0 0.591 0.0
6o03 1 P22681 82.74 0.0 X-RAY
 2020-08-19 ARG A:212 B:256 177.0 0.787 H -65.7 -39.5 177.0 0.787 0.0
ARG C:212 A:256 198.0 0.88 H -59.7 -46.8 NA NA NA
5hkw 1 P22681 82.95 0.0 X-RAY
 2017-01-18 ARG A:213 A:256 141.0 0.627 H -71.5 -34.3 141.0 0.627 0.0 HOH
 5.609
 N
 O
ARG B:213 B:256 151.0 0.671 H -62.4 -38.5 NA NA NA
ARG C:213 C:256 153.0 0.68 H -63.0 -39.5 NA NA NA
5hky 1 P22681 82.95 0.0 X-RAY
 2017-01-18 ARG A:213 A:256 82.0 NA H -67.1 -39.8 82.0 NA NA HOH
 3.027
 O
 O
5hkz 1 P22681 82.95 0.0 X-RAY
 2017-01-18 ARG A:213 A:256 110.0 NA H -66.7 -39.4 110.0 NA NA HOH
 3.141
 O
 O
5hl0 1 P22681 82.95 0.0 X-RAY
 2017-01-18 ARG A:213 A:256 86.0 NA H -61.3 -43.1 86.0 NA NA HOH
 3.503
 N
 O
4gpl 2 P22681 82.95 0.0 X-RAY
 2013-09-18 ARG B:214 B:256 186.0 0.827 H -58.8 -42.9 186.0 0.827 0.0 HOH
 3.089
 N
 O
1yvh 1 P22681 82.95 0.0 X-RAY
 2005-03-08 ARG A:234 A:256 190.0 0.844 H -69.3 -37.7 190.0 0.844 0.0 HOH
 2.942
 O
 O
3bum 2 P22681 82.95 0.0 X-RAY
 2008-02-26 ARG B:234 B:256 191.0 0.849 H -72.4 -39.4 NA NA NA
3bun 2 P22681 82.95 0.0 X-RAY
 2008-02-26 ARG B:234 B:256 178.0 0.791 H -67.9 -41.8 NA NA NA
3buo 2 P22681 82.95 0.0 X-RAY
 2008-02-26 ARG B:234 B:256 183.0 0.813 H -66.7 -31.5 183.0 0.813 0.0 HOH
 3.023
 NH2
 O
ARG D:234 D:256 186.0 0.827 H -66.5 -30.2 NA NA NA
3buw 2 P22681 82.95 0.0 X-RAY
 2008-02-26 ARG B:234 B:256 158.0 0.702 H -67.0 -38.8 NA NA NA
ARG D:234 D:256 160.0 0.711 H -67.4 -41.1 NA NA NA
3bux 2 P22681 82.95 0.0 X-RAY
 2008-02-26 ARG B:234 B:256 165.0 0.733 H -66.4 -41.5 NA NA NA
ARG D:234 D:256 170.0 0.756 H -66.9 -39.2 NA NA NA
3ob1 2 P22681 82.95 0.0 X-RAY
 2010-08-18 ARG B:234 B:256 166.0 0.738 H -67.9 -38.5 166.0 0.738 0.0 HOH
 3.636
 N
 O
3ob2 2 P22681 82.95 0.0 X-RAY
 2010-08-18 ARG B:234 B:256 161.0 0.716 H -57.5 -41.0 161.0 0.716 0.0 HOH
 2.767
 CD
 O
3plf 2 P22681 82.95 0.0 X-RAY
 2010-12-01 ARG B:234 B:256 160.0 0.711 H -65.2 -43.2 160.0 0.711 0.0 HOH
 2.997
 O
 O
ARG D:234 D:256 157.0 0.698 H -65.6 -40.3 NA NA NA
2cbl 1 P22681 82.95 0.0 X-RAY
 1999-05-18 ARG A:210 A:256 183.0 0.813 H -71.4 -40.3 183.0 0.813 0.0 HOH
 2.662
 NE
 O
1b47 1 P22681 82.89 0.0 X-RAY
 1999-04-27 ARG A:210 A:256 159.0 0.707 H -73.1 -30.3 159.0 0.707 0.0 HOH
 2.798
 NH2
 O
ARG B:210 B:256 181.0 0.804 H -71.9 -31.3 174.0 0.773 0.031 C:P22681:0.031
 HOH
 3.255
 CG
 O
ARG C:210 C:256 159.0 0.707 H -66.3 -44.8 159.0 0.707 0.0 HOH
 2.809
 CG
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q13191-f1 1 Q13191 100.0 0.0 ARG A:248 A:248 96.0 0.427 H -67.8 -48.4