Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 114014555 . G A CCDS2980.1:NM_173799.3:c.225tgG>tgA_NP_776160.2:p.75W>* Homo sapiens T-cell immunoreceptor with Ig and ITIM domains (TIGIT), mRNA.
pdb_id: 
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label_comp_id: 
auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3q0h 1 Q495A1 100.0 1e-82 X-RAY
 2011-02-16 TRP A:55 A:75 81.0 0.318 E -74.6 132.4 81.0 0.318 0.0 HOH
 3.071
 N
 O
TRP B:55 B:75 71.0 0.278 E -70.8 129.4 NA NA NA
3rq3 1 Q495A1 100.0 2e-82 X-RAY
 2011-06-01 TRP A:54 A:75 87.0 0.341 E -87.8 133.3 79.0 0.31 0.031 B:Q495A1:0.031
 HOH
 2.913
 N
 O
TRP B:54 B:75 81.0 0.318 E -90.6 140.4 73.0 0.286 0.032 A:Q495A1:0.031
 HOH
 2.717
 N
 O
3udw 1 Q495A1 98.18 1e-75 X-RAY
 2012-03-14 TRP A:57 A:75 78.0 0.306 E -92.0 144.0 76.0 0.298 0.008 C:P15151:0.008
TRP B:57 B:75 81.0 0.318 E -90.6 139.3 77.0 0.302 0.016 D:P15151:0.016
3ucr 1 Q495A1 97.27 1e-74 X-RAY
 2012-03-14 TRP A:57 A:68 61.0 0.239 E -75.7 140.0 61.0 0.239 0.0 CL
CL
HOH
 9.158
6.006
6.759
 CZ2
O
CH2
 CL
CL
O
TRP B:57 B:68 69.0 0.271 E -78.3 140.7 NA NA NA
TRP C:57 C:68 64.0 0.251 E -84.2 153.5 64.0 0.251 0.0 CL
HOH
 9.291
7.928
 CZ2
NE1
 CL
O
TRP D:57 D:68 82.0 0.322 -61.1 145.2 NA NA NA
5v52 1 Q495A1 99.07 1e-74 X-RAY
 2017-05-24 TRP A:54 A:75 84.0 0.329 E -85.3 156.3 79.0 0.31 0.019 D:Q92692:0.02
TRP B:54 B:75 84.0 0.329 E -85.2 156.0 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q495a1-f1 1 Q495A1 100.0 0.0 TRP A:75 A:75 81.0 0.318 E -84.5 132.7