Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 3192647 . G A CCDS2562.1:NM_016302.3:c.1231Cct>Tct_NP_057386.2:p.411P>S Homo sapiens cereblon (CRBN), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6bn7 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 PRO B:432 B:411 18.0 0.124 S -75.2 150.2 18.0 0.124 0.0
6bn8 2 Q96SW2 97.06 0.0 X-RAY
 2018-06-06 PRO B:432 B:411 15.0 0.103 S -74.2 145.9 15.0 0.103 0.0
6bn9 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 PRO B:432 B:411 20.0 0.138 S -76.6 154.7 20.0 0.138 0.0
6bnb 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 PRO B:432 B:411 29.0 0.2 S -63.8 128.5 29.0 0.2 0.0
6boy 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 PRO B:432 B:411 19.0 0.131 S -75.8 155.4 19.0 0.131 0.0
5hxb 3 Q96SW2 99.75 0.0 X-RAY
 2016-06-29 PRO C:375 Z:411 10.0 0.069 26.8 110.7 10.0 0.069 0.0
PRO E:375 C:411 10.0 0.069 26.1 110.9 NA NA NA
5v3o 2 Q96SW2 99.75 0.0 X-RAY
 2017-05-03 PRO B:375 C:411 13.0 0.09 S -78.6 156.5 13.0 0.09 0.0
6uml 2 Q96SW2 99.75 0.0 X-RAY
 2020-04-15 PRO B:375 C:411 38.0 0.262 S 38.8 53.8 38.0 0.262 0.0
6xk9 3 Q96SW2 99.75 0.0 X-RAY
 2020-12-02 PRO C:375 Z:411 11.0 0.076 S -67.5 154.6 11.0 0.076 0.0
PRO F:375 C:411 12.0 0.083 S -67.2 154.7 NA NA NA
5fqd 2 Q96SW2 99.02 0.0 X-RAY
 2016-02-24 PRO B:395 B:411 13.0 0.09 S -66.7 154.8 13.0 0.09 0.0 HOH
 3.454
 CB
 O
PRO E:395 E:411 14.0 0.097 S -69.8 154.5 NA NA NA
6h0f 2 Q96SW2 99.02 0.0 X-RAY
 2018-11-07 PRO B:395 B:411 34.0 0.234 S -64.4 -25.4 34.0 0.234 0.0
PRO E:395 E:411 36.0 0.248 S -64.2 -25.6 NA NA NA
PRO H:395 H:411 37.0 0.255 S -64.2 -25.4 NA NA NA
PRO K:395 K:411 37.0 0.255 S -64.3 -25.4 NA NA NA
6h0g 2 Q96SW2 99.02 0.0 X-RAY
 2018-11-07 PRO B:395 B:411 20.0 0.138 S -74.0 150.0 20.0 0.138 0.0
PRO E:395 E:411 20.0 0.138 S -74.1 150.0 NA NA NA
7lps 2 Q96SW2 100.0 0.0 X-RAY
 2021-06-02 PRO B:365 B:411 25.0 0.172 S -73.6 150.2 25.0 0.172 0.0
PRO E:365 E:411 24.0 0.166 S -73.9 150.4 NA NA NA
PRO H:365 H:411 23.0 0.159 S -73.4 150.4 NA NA NA
PRO K:365 K:411 24.0 0.166 S -73.6 150.1 NA NA NA
4tz4 2 Q96SW2 100.0 0.0 X-RAY
 2014-08-06 PRO B:364 C:411 20.0 0.138 33.7 107.2 20.0 0.138 0.0
4ci1 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 PRO B:437 B:413 10.0 0.069 S -70.7 152.0 10.0 0.069 0.0
4ci2 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 PRO B:437 B:413 10.0 0.069 S -75.1 151.7 10.0 0.069 0.0 HOH
 9.992
 CG
 O
4ci3 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 PRO B:437 B:413 10.0 0.069 S -70.6 150.6 10.0 0.069 0.0
7bqu 1 Q96SW2 96.43 3e-76 X-RAY
 2020-08-26 PRO A:99 A:411 30.0 0.207 S -82.0 -177.0 30.0 0.207 0.0 HOH
 3.302
 CB
 O
7bqv 1 Q96SW2 99.08 6e-76 X-RAY
 2020-08-26 PRO A:94 A:411 28.0 0.193 S -80.1 157.9 28.0 0.193 0.0 HOH
 8.836
 CD
 O
3wx1 1 Q8C7D2 97.25 2e-74 X-RAY
 2014-08-06 PRO A:95 A:414 21.0 0.145 S -71.7 158.1 21.0 0.145 0.0 SO4
SO4
HOH
 7.329
9.661
4.650
 CB
CB
N
 O4
O4
O
PRO B:95 B:414 25.0 0.172 S -75.2 159.6 NA NA NA
3wx2 1 Q8C7D2 97.25 2e-74 X-RAY
 2014-08-06 PRO A:95 A:414 20.0 0.138 S -71.8 154.7 20.0 0.138 0.0 SO4
SO4
HOH
 7.680
9.596
4.669
 CB
CB
N
 O4
O4
O
PRO B:95 B:414 25.0 0.172 S -75.9 156.9 NA NA NA
5yiz 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 PRO A:95 A:414 26.0 0.179 S -70.3 165.1 26.0 0.179 0.0 SO4
SO4
HOH
 7.233
9.443
4.315
 CB
CB
CB
 O2
O1
O
PRO B:95 D:414 25.0 0.172 S -70.9 165.0 NA NA NA
PRO C:95 G:414 26.0 0.179 S -70.5 163.1 NA NA NA
PRO D:95 J:414 26.0 0.179 S -70.8 162.0 NA NA NA
PRO E:95 M:414 24.0 0.166 S -72.0 162.8 NA NA NA
PRO F:95 P:414 26.0 0.179 S -69.8 161.4 NA NA NA
PRO G:95 S:414 24.0 0.166 S -69.3 161.5 NA NA NA
PRO H:95 V:414 25.0 0.172 S -71.7 163.3 NA NA NA
PRO I:95 Y:414 25.0 0.172 S -73.7 159.5 NA NA NA
PRO J:95 b:414 24.0 0.166 S -71.1 159.6 NA NA NA
PRO K:95 e:414 25.0 0.172 S -70.7 161.5 NA NA NA
PRO L:95 h:414 27.0 0.186 S -71.6 160.6 NA NA NA
PRO M:95 k:414 25.0 0.172 S -72.0 161.7 NA NA NA
PRO N:95 n:414 27.0 0.186 S -72.1 160.5 NA NA NA
PRO O:95 q:414 25.0 0.172 S -71.4 158.9 NA NA NA
PRO P:95 t:414 26.0 0.179 S -70.8 163.8 NA NA NA
5yj0 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 PRO A:95 A:414 26.0 0.179 S -68.5 164.4 26.0 0.179 0.0 SO4
SO4
HOH
 7.203
9.463
4.259
 CB
CB
CB
 O2
O1
O
PRO B:95 D:414 25.0 0.172 S -71.0 166.3 NA NA NA
PRO C:95 G:414 24.0 0.166 S -70.8 164.4 NA NA NA
PRO D:95 J:414 24.0 0.166 S -72.2 163.8 NA NA NA
PRO E:95 M:414 26.0 0.179 S -71.1 162.2 NA NA NA
PRO F:95 P:414 25.0 0.172 S -67.0 161.9 NA NA NA
PRO G:95 S:414 24.0 0.166 S -67.2 163.4 NA NA NA
PRO H:95 V:414 24.0 0.166 S -69.8 163.9 NA NA NA
PRO I:95 Y:414 25.0 0.172 S -70.3 159.6 NA NA NA
PRO J:95 b:414 25.0 0.172 S -67.4 160.5 NA NA NA
PRO K:95 e:414 26.0 0.179 S -73.3 160.4 NA NA NA
PRO L:95 h:414 26.0 0.179 S -71.0 162.2 NA NA NA
PRO M:95 k:414 24.0 0.166 S -69.8 160.7 NA NA NA
PRO N:95 n:414 26.0 0.179 S -70.4 161.6 NA NA NA
PRO O:95 q:414 26.0 0.179 S -66.8 163.1 NA NA NA
PRO P:95 t:414 25.0 0.172 S -70.5 165.0 NA NA NA
5yj1 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 PRO A:95 A:414 27.0 0.186 S -73.7 162.5 27.0 0.186 0.0 SO4
SO4
HOH
 7.206
9.419
4.286
 CB
CB
CB
 O2
O1
O
PRO B:95 D:414 25.0 0.172 S -71.7 161.3 NA NA NA
PRO C:95 G:414 25.0 0.172 S -71.6 160.4 NA NA NA
PRO D:95 J:414 25.0 0.172 S -72.8 164.4 NA NA NA
PRO E:95 M:414 25.0 0.172 S -72.1 160.2 NA NA NA
PRO F:95 P:414 25.0 0.172 S -72.9 156.7 NA NA NA
PRO G:95 S:414 25.0 0.172 S -72.0 159.0 NA NA NA
PRO H:95 V:414 25.0 0.172 S -71.7 165.5 NA NA NA
PRO I:95 Y:414 25.0 0.172 S -72.7 157.4 NA NA NA
PRO J:95 b:414 26.0 0.179 S -75.7 157.2 NA NA NA
PRO K:95 e:414 26.0 0.179 S -73.6 161.6 NA NA NA
PRO L:95 h:414 26.0 0.179 S -73.9 163.7 NA NA NA
PRO M:95 k:414 26.0 0.179 S -70.8 160.2 NA NA NA
PRO N:95 n:414 26.0 0.179 S -73.0 164.6 NA NA NA
PRO O:95 q:414 26.0 0.179 S -74.0 157.9 NA NA NA
PRO P:95 t:414 25.0 0.172 S -73.3 158.5 NA NA NA
4tzu 1 Q8C7D2 97.22 9e-74 X-RAY
 2014-08-06 PRO A:93 A:413 27.0 0.186 S -37.3 149.6 4.0 0.028 0.158 B:Q8C7D2:0.159
 SO4
SO4
SO4
HOH
 9.641
3.444
7.366
3.872
 CB
CA
CB
CA
 O2
O2
O2
O
PRO B:93 B:413 26.0 0.179 S -45.1 152.5 7.0 0.048 0.131 D:Q8C7D2:0.131
 SO4
SO4
SO4
HOH
 9.601
3.549
7.654
4.056
 CB
CA
CB
CA
 O4
O4
O4
O
PRO C:93 C:413 24.0 0.166 S -39.5 146.4 NA NA NA
PRO D:93 D:413 24.0 0.166 S -41.0 148.1 4.0 0.028 0.138 A:Q8C7D2:0.138
 SO4
SO4
SO4
HOH
 3.377
9.157
7.313
4.039
 CA
CB
CB
CB
 O3
O3
O3
O
4tzc 1 Q8C7D2 97.2 4e-73 X-RAY
 2014-08-06 PRO A:94 C:413 25.0 0.172 S -39.6 149.8 NA NA NA
PRO B:94 A:413 26.0 0.179 S -46.0 152.1 26.0 0.179 0.0 SO4
HOH
 3.306
4.017
 CA
CB
 O1
O
PRO C:94 B:413 24.0 0.166 S -43.4 149.9 NA NA NA
PRO D:94 D:413 25.0 0.172 -48.3 152.1 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q96sw2-f1 1 Q96SW2 100.0 0.0 PRO A:411 A:411 4.0 0.028 S -67.4 156.3