Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 3194170 . C A CCDS2562.1:NM_016302.3:c.1118cGg>cTg_NP_057386.2:p.373R>L Homo sapiens cereblon (CRBN), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6bn7 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 ARG B:394 B:373 221.0 0.982 E -104.8 153.6 221.0 0.982 0.0 RN3
 7.349
 O
 C25
6bn8 2 Q96SW2 97.06 0.0 X-RAY
 2018-06-06 ARG B:394 B:373 221.0 0.982 E -79.0 158.7 221.0 0.982 0.0
6bn9 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 ARG B:394 B:373 222.0 0.987 E -79.7 154.7 222.0 0.987 0.0
6bnb 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 ARG B:394 B:373 220.0 0.978 E -140.5 154.8 189.0 0.84 0.138 C:O60885:0.138
6boy 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 ARG B:394 B:373 222.0 0.987 E -100.6 152.2 222.0 0.987 0.0 RN6
 9.425
 O
 C26
5hxb 3 Q96SW2 99.75 0.0 X-RAY
 2016-06-29 ARG C:337 Z:373 221.0 0.982 E -120.5 155.2 221.0 0.982 0.0 85C
 9.677
 O
 C7
ARG E:337 C:373 212.0 0.942 E -118.1 153.9 NA NA NA
5v3o 2 Q96SW2 99.75 0.0 X-RAY
 2017-05-03 ARG B:337 C:373 223.0 0.991 E -116.0 151.2 223.0 0.991 0.0 8W7
 9.053
 O
 O4
6uml 2 Q96SW2 99.75 0.0 X-RAY
 2020-04-15 ARG B:337 C:373 214.0 0.951 E -110.7 140.7 214.0 0.951 0.0 Y70
 9.538
 O
 C14
6xk9 3 Q96SW2 99.75 0.0 X-RAY
 2020-12-02 ARG C:337 Z:373 78.0 NA -118.1 159.1 78.0 NA NA V4M
 9.909
 O
 C10
ARG F:337 C:373 219.0 0.973 -117.4 159.4 NA NA NA
5fqd 2 Q96SW2 99.02 0.0 X-RAY
 2016-02-24 ARG B:357 B:373 224.0 0.996 E -117.9 159.3 145.0 0.644 0.352 C:P48729:0.351
 LVY
HOH
 9.828
2.613
 O
O
 C2
O
ARG E:357 E:373 225.0 1.0 E -117.7 160.5 NA NA NA
6h0f 2 Q96SW2 99.02 0.0 X-RAY
 2018-11-07 ARG B:357 B:373 219.0 0.973 E -96.6 160.8 153.0 0.68 0.293 C:Q13422:0.293
 Y70
HOH
 8.993
7.472
 O
O
 H141
O
ARG E:357 E:373 220.0 0.978 E -97.7 160.6 NA NA NA
ARG H:357 H:373 218.0 0.969 E -97.1 160.2 NA NA NA
ARG K:357 K:373 220.0 0.978 E -97.1 160.1 NA NA NA
6h0g 2 Q96SW2 99.02 0.0 X-RAY
 2018-11-07 ARG B:357 B:373 224.0 0.996 E -123.8 152.2 224.0 0.996 0.0 Y70
 8.502
 O
 N10
ARG E:357 E:373 220.0 0.978 E -122.7 161.4 NA NA NA
7lps 2 Q96SW2 100.0 0.0 X-RAY
 2021-06-02 ARG B:327 B:373 221.0 0.982 E -121.0 154.8 217.0 0.964 0.018 C:Q9UKS7:0.018
 RN9
 9.577
 O
 O
ARG E:327 E:373 219.0 0.973 E -120.4 156.0 NA NA NA
ARG H:327 H:373 220.0 0.978 E -120.7 155.1 NA NA NA
ARG K:327 K:373 221.0 0.982 E -120.5 155.7 NA NA NA
4tz4 2 Q96SW2 100.0 0.0 X-RAY
 2014-08-06 ARG B:326 C:373 215.0 0.956 E -111.3 139.5 215.0 0.956 0.0 LVY
HOH
 9.384
7.420
 O
C
 C2
O
4ci1 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 ARG B:399 B:375 213.0 0.947 E -99.3 155.3 213.0 0.947 0.0 EF2
HOH
 9.938
3.611
 O
NH1
 C07
O
4ci2 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 ARG B:399 B:375 209.0 0.929 E -97.7 153.8 209.0 0.929 0.0 LVY
 9.712
 O
 N17
4ci3 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 ARG B:399 B:375 213.0 0.947 E -101.1 158.0 213.0 0.947 0.0 Y70
 9.895
 O
 C14
7bqu 1 Q96SW2 96.43 3e-76 X-RAY
 2020-08-26 ARG A:61 A:373 226.0 1.0 E -120.6 158.4 226.0 1.0 0.0 EF2
HOH
 9.741
2.672
 O
O
 C07
O
7bqv 1 Q96SW2 99.08 6e-76 X-RAY
 2020-08-26 ARG A:56 A:373 211.0 0.938 E -86.7 144.3 161.0 0.716 0.222 B:Q9UJQ4:0.222
 F4U
SO4
HOH
 9.775
8.155
2.550
 O
NH2
O
 CB
O4
O
3wx1 1 Q8C7D2 97.25 2e-74 X-RAY
 2014-08-06 ARG A:57 A:376 212.0 0.942 E -113.2 162.5 212.0 0.942 0.0 HOH
 2.507
 O
 O
ARG B:57 B:376 221.0 0.982 E -109.2 165.9 NA NA NA
3wx2 1 Q8C7D2 97.25 2e-74 X-RAY
 2014-08-06 ARG A:57 A:376 208.0 0.924 E -121.0 159.4 208.0 0.924 0.0 HOH
 2.541
 O
 O
ARG B:57 B:376 218.0 0.969 E -107.6 165.9 NA NA NA
5yiz 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 ARG A:57 A:376 207.0 0.92 E -130.9 159.7 207.0 0.92 0.0 EF2
HOH
 9.510
2.316
 O
O
 C07
O
ARG B:57 D:376 222.0 0.987 E -128.2 159.3 NA NA NA
ARG C:57 G:376 194.0 0.862 E -131.0 160.1 NA NA NA
ARG D:57 J:376 220.0 0.978 E -116.7 159.6 NA NA NA
ARG E:57 M:376 207.0 0.92 E -115.3 161.2 NA NA NA
ARG F:57 P:376 218.0 0.969 E -114.3 163.1 NA NA NA
ARG G:57 S:376 212.0 0.942 E -105.4 164.3 NA NA NA
ARG H:57 V:376 220.0 0.978 E -116.1 154.4 NA NA NA
ARG I:57 Y:376 205.0 0.911 E -115.6 162.5 NA NA NA
ARG J:57 b:376 218.0 0.969 E -107.1 160.7 NA NA NA
ARG K:57 e:376 215.0 0.956 E -111.6 164.9 NA NA NA
ARG L:57 h:376 219.0 0.973 E -120.3 156.8 NA NA NA
ARG M:57 k:376 215.0 0.956 E -113.1 159.9 NA NA NA
ARG N:57 n:376 219.0 0.973 E -117.5 158.1 NA NA NA
ARG O:57 q:376 218.0 0.969 E -105.6 163.1 NA NA NA
ARG P:57 t:376 212.0 0.942 E -124.5 160.3 NA NA NA
5yj0 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 ARG A:57 A:376 205.0 0.911 E -126.4 157.0 205.0 0.911 0.0 EF2
HOH
 9.608
2.474
 O
O
 C07
O
ARG B:57 D:376 221.0 0.982 E -130.9 154.7 NA NA NA
ARG C:57 G:376 197.0 0.876 E -129.6 159.7 NA NA NA
ARG D:57 J:376 219.0 0.973 E -117.5 161.0 NA NA NA
ARG E:57 M:376 209.0 0.929 E -111.0 160.7 NA NA NA
ARG F:57 P:376 216.0 0.96 E -116.0 159.5 NA NA NA
ARG G:57 S:376 213.0 0.947 E -104.2 165.4 NA NA NA
ARG H:57 V:376 225.0 1.0 E -115.0 158.8 NA NA NA
ARG I:57 Y:376 206.0 0.916 E -117.9 159.9 NA NA NA
ARG J:57 b:376 221.0 0.982 E -109.9 161.9 NA NA NA
ARG K:57 e:376 214.0 0.951 E -113.9 164.1 NA NA NA
ARG L:57 h:376 220.0 0.978 E -119.7 159.2 NA NA NA
ARG M:57 k:376 218.0 0.969 E -111.6 161.2 NA NA NA
ARG N:57 n:376 222.0 0.987 E -118.2 157.0 NA NA NA
ARG O:57 q:376 221.0 0.982 E -106.9 162.0 NA NA NA
ARG P:57 t:376 213.0 0.947 E -131.8 159.5 NA NA NA
5yj1 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 ARG A:57 A:376 207.0 0.92 E -104.2 164.3 207.0 0.92 0.0 6EL
HOH
 9.755
3.752
 O
O
 CG
O
ARG B:57 D:376 223.0 0.991 E -116.3 159.9 NA NA NA
ARG C:57 G:376 201.0 0.893 E -99.7 159.0 NA NA NA
ARG D:57 J:376 220.0 0.978 E -111.7 162.5 NA NA NA
ARG E:57 M:376 203.0 0.902 E -103.5 164.7 NA NA NA
ARG F:57 P:376 213.0 0.947 E -116.2 159.2 NA NA NA
ARG G:57 S:376 208.0 0.924 E -108.3 161.2 NA NA NA
ARG H:57 V:376 223.0 0.991 E -104.1 164.0 NA NA NA
ARG I:57 Y:376 211.0 0.938 E -104.2 164.1 NA NA NA
ARG J:57 b:376 222.0 0.987 E -104.9 162.0 NA NA NA
ARG K:57 e:376 213.0 0.947 E -105.9 167.2 NA NA NA
ARG L:57 h:376 218.0 0.969 E -117.5 161.6 NA NA NA
ARG M:57 k:376 209.0 0.929 E -102.5 165.1 NA NA NA
ARG N:57 n:376 223.0 0.991 E -113.4 159.4 NA NA NA
ARG O:57 q:376 217.0 0.964 E -106.2 157.0 NA NA NA
ARG P:57 t:376 219.0 0.973 E -106.5 163.5 NA NA NA
4tzu 1 Q8C7D2 97.22 9e-74 X-RAY
 2014-08-06 ARG A:55 A:375 212.0 0.942 E -117.3 151.4 212.0 0.942 0.0 Y70
HOH
 9.668
3.616
 O
NH1
 C14
O
ARG B:55 B:375 214.0 0.951 E -110.6 158.7 214.0 0.951 0.0 Y70
HOH
 9.622
2.816
 O
N
 C14
O
ARG C:55 C:375 218.0 0.969 E -114.8 156.6 NA NA NA
ARG D:55 D:375 206.0 0.916 E -113.2 155.6 206.0 0.916 0.0 Y70
HOH
 9.604
2.566
 O
O
 C14
O
4tzc 1 Q8C7D2 97.2 4e-73 X-RAY
 2014-08-06 ARG A:56 C:375 212.0 0.942 E -115.3 156.9 NA NA NA
ARG B:56 A:375 210.0 0.933 E -118.3 156.8 210.0 0.933 0.0 EF2
HOH
 9.632
2.607
 O
O
 C07
O
ARG C:56 B:375 211.0 0.938 E -134.3 156.7 NA NA NA
ARG D:56 D:375 217.0 0.964 E -114.4 159.4 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q96sw2-f1 1 Q96SW2 100.0 0.0 ARG A:373 A:373 225.0 1.0 E -96.5 153.4