Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10183719 . T A CCDS2597.1:NM_000551.3:c.188cTg>cAg_NP_000542.1:p.63L>Q Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
2015-03-04 LEU A:83 A:63 9.0 0.053 S -87.2 101.6 9.0 0.053 0.0
7q2j 3 P40337 94.25 1e-118 X-RAY
2021-11-24 LEU C:47 C:63 15.0 0.088 S -98.3 88.3 15.0 0.088 0.0 HOH
8.419
CD2
O
4b9k 3 P40337 95.32 3e-118 X-RAY
2012-10-24 LEU C:21 C:63 49.0 0.288 -86.7 93.8 49.0 0.288 0.0 HOH
2.619
O
O
LEU F:21 F:63 35.0 0.206 -84.9 92.9 NA NA NA
LEU I:21 I:63 13.0 0.076 -85.9 91.8 NA NA NA
LEU L:21 L:63 21.0 0.124 -89.3 101.4 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
2002-07-03 LEU C:12 C:63 10.0 0.059 S -97.6 109.6 10.0 0.059 0.0 HOH
2.803
N
O
3ztd 3 P40337 99.38 4e-117 X-RAY
2012-07-25 LEU C:12 C:63 95.0 0.559 360.0 73.7 95.0 0.559 0.0
LEU F:12 F:63 95.0 0.559 360.0 69.7 NA NA NA
LEU I:12 I:63 91.0 0.535 360.0 75.4 NA NA NA
LEU L:12 L:63 96.0 0.565 360.0 71.0 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
2012-10-24 LEU C:12 C:63 57.0 0.335 -125.2 62.7 57.0 0.335 0.0 HOH
6.571
C
O
LEU F:12 F:63 96.0 0.565 360.0 78.1 NA NA NA
LEU I:12 I:63 34.0 0.2 -107.0 85.0 NA NA NA
LEU L:12 L:63 42.0 0.247 55.3 72.2 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
2013-11-27 LEU C:12 C:63 40.0 0.235 -116.9 100.3 40.0 0.235 0.0 HOH
6.761
O
O
LEU F:12 F:63 90.0 0.529 360.0 92.0 NA NA NA
LEU I:12 I:63 34.0 0.2 -82.5 93.0 NA NA NA
LEU L:12 L:63 38.0 0.224 -82.6 95.0 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
2013-11-27 LEU C:12 C:63 56.0 0.329 -83.3 100.6 56.0 0.329 0.0 HOH
6.841
O
O
LEU F:12 F:63 94.0 0.553 360.0 90.6 NA NA NA
LEU I:12 I:63 35.0 0.206 -80.1 93.9 NA NA NA
LEU L:12 L:63 42.0 0.247 66.5 80.4 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:12 C:63 35.0 0.206 -76.4 100.4 35.0 0.206 0.0 HOH
6.522
O
O
LEU F:12 F:63 39.0 0.229 -90.7 101.4 NA NA NA
LEU I:12 I:63 43.0 0.253 -76.5 94.2 NA NA NA
LEU L:12 L:63 41.0 0.241 -76.4 98.9 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:12 C:63 39.0 0.229 -80.8 103.3 39.0 0.229 0.0 HOH
5.884
O
O
LEU F:12 F:63 38.0 0.224 -82.8 106.5 NA NA NA
LEU I:12 I:63 42.0 0.247 -80.5 93.3 NA NA NA
LEU L:12 L:63 41.0 0.241 -74.7 99.3 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:12 C:63 37.0 0.218 -84.4 95.9 37.0 0.218 0.0 HOH
6.486
O
O
LEU F:12 F:63 28.0 0.165 -93.4 103.3 NA NA NA
LEU I:12 I:63 43.0 0.253 -77.0 94.8 NA NA NA
LEU L:12 L:63 42.0 0.247 -75.7 95.0 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:12 C:63 42.0 0.247 -89.8 100.4 42.0 0.247 0.0 HOH
2.736
O
O
LEU F:12 F:63 40.0 0.235 -90.9 109.9 NA NA NA
LEU I:12 I:63 31.0 0.182 -79.6 86.0 NA NA NA
LEU L:12 L:63 40.0 0.235 46.7 73.8 NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:12 C:63 36.0 0.212 -83.1 95.8 36.0 0.212 0.0 HOH
6.865
O
O
LEU F:12 F:63 25.0 0.147 -101.7 99.0 NA NA NA
LEU I:12 I:63 46.0 0.271 -77.9 99.1 NA NA NA
LEU L:12 L:63 46.0 0.271 -77.9 102.1 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:12 C:63 39.0 0.229 -74.8 107.8 39.0 0.229 0.0 HOH
5.724
O
O
LEU F:12 F:63 33.0 0.194 -75.2 111.6 NA NA NA
LEU I:12 I:63 40.0 0.235 -75.0 97.2 NA NA NA
LEU L:12 L:63 44.0 0.259 -76.3 101.0 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:12 C:63 41.0 0.241 -70.1 105.3 41.0 0.241 0.0 HOH
6.210
O
O
LEU F:12 F:63 44.0 0.259 -62.2 102.9 NA NA NA
LEU I:12 I:63 47.0 0.276 -74.3 102.5 NA NA NA
LEU L:12 L:63 47.0 0.276 -70.3 116.1 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:12 C:63 37.0 0.218 -70.2 96.7 37.0 0.218 0.0 HOH
4.168
CB
O
LEU F:12 F:63 37.0 0.218 -80.8 94.4 NA NA NA
LEU I:12 I:63 37.0 0.218 -90.5 93.6 NA NA NA
LEU L:12 L:63 46.0 0.271 -75.9 111.6 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:12 C:63 39.0 0.229 -79.7 95.3 39.0 0.229 0.0 HOH
7.013
O
O
LEU F:12 F:63 33.0 0.194 -78.5 100.0 NA NA NA
LEU I:12 I:63 38.0 0.224 -81.6 93.8 NA NA NA
LEU L:12 L:63 43.0 0.253 -70.3 107.1 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:12 C:63 39.0 0.229 -77.4 94.3 39.0 0.229 0.0 HOH
9.740
O
O
LEU F:12 F:63 38.0 0.224 -86.5 94.8 NA NA NA
LEU I:12 I:63 37.0 0.218 -83.3 93.0 NA NA NA
LEU L:12 L:63 46.0 0.271 -74.0 110.2 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
2016-11-09 LEU C:12 C:63 44.0 0.259 -84.6 112.7 44.0 0.259 0.0 HOH
2.841
O
O
LEU F:12 F:63 45.0 0.265 -86.2 111.7 NA NA NA
LEU I:12 I:63 43.0 0.253 -79.2 96.6 NA NA NA
LEU L:12 L:63 45.0 0.265 -82.8 103.3 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:12 C:63 42.0 0.247 -78.6 105.8 42.0 0.247 0.0 HOH
2.705
O
O
LEU F:12 F:63 41.0 0.241 -93.4 103.5 NA NA NA
LEU I:12 I:63 40.0 0.235 -83.4 96.1 NA NA NA
LEU L:12 L:63 40.0 0.235 -78.3 102.4 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:12 C:63 42.0 0.247 -77.1 109.9 42.0 0.247 0.0 HOH
2.732
O
O
LEU F:12 F:63 39.0 0.229 -79.3 102.0 NA NA NA
LEU I:12 I:63 40.0 0.235 -80.0 98.3 NA NA NA
LEU L:12 L:63 40.0 0.235 -77.6 98.5 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:12 C:63 43.0 0.253 -78.9 111.6 43.0 0.253 0.0 HOH
2.754
O
O
LEU F:12 F:63 43.0 0.253 -83.2 103.7 NA NA NA
LEU I:12 I:63 39.0 0.229 -80.4 99.4 NA NA NA
LEU L:12 L:63 40.0 0.235 -75.7 104.3 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:12 C:63 36.0 0.212 -75.4 96.2 36.0 0.212 0.0 HOH
4.464
CD2
O
LEU F:12 F:63 31.0 0.182 -88.1 87.7 NA NA NA
LEU I:12 I:63 43.0 0.253 -91.6 91.5 NA NA NA
LEU L:12 L:63 38.0 0.224 -71.1 98.1 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:12 C:63 44.0 0.259 -82.4 102.5 44.0 0.259 0.0 HOH
7.007
O
O
LEU F:12 F:63 44.0 0.259 -83.9 96.7 NA NA NA
LEU I:12 I:63 48.0 0.282 -80.0 97.1 NA NA NA
LEU L:12 L:63 47.0 0.276 -80.4 101.9 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:12 C:63 46.0 0.271 -79.2 110.2 46.0 0.271 0.0 HOH
2.649
O
O
LEU F:12 F:63 45.0 0.265 -83.3 107.9 NA NA NA
LEU I:12 I:63 44.0 0.259 -80.9 103.5 NA NA NA
LEU L:12 L:63 42.0 0.247 -79.0 101.5 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:12 C:63 45.0 0.265 -76.5 108.5 45.0 0.265 0.0 HOH
2.684
O
O
LEU F:12 F:63 40.0 0.235 -77.0 97.0 NA NA NA
LEU I:12 I:63 42.0 0.247 -73.6 102.2 NA NA NA
LEU L:12 L:63 41.0 0.241 -72.4 101.1 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:12 C:63 46.0 0.271 -77.4 106.3 46.0 0.271 0.0 HOH
2.655
O
O
LEU F:12 F:63 46.0 0.271 -72.5 94.6 NA NA NA
LEU I:12 I:63 43.0 0.253 -78.0 92.7 NA NA NA
LEU L:12 L:63 42.0 0.247 -80.3 97.8 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
2017-03-08 LEU D:12 D:63 9.0 0.053 S -79.8 107.3 9.0 0.053 0.0
LEU H:12 H:63 9.0 0.053 S -79.2 107.3 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
2018-08-01 LEU A:12 V:63 8.0 0.047 S -90.3 104.3 8.0 0.047 0.0 HOH
2.083
H
O
6gfy 3 P40337 99.38 4e-117 X-RAY
2018-07-11 LEU C:12 C:63 48.0 0.282 -74.5 107.5 48.0 0.282 0.0 HOH
7.133
O
O
LEU F:12 F:63 46.0 0.271 -80.8 103.5 NA NA NA
LEU I:12 I:63 46.0 0.271 -73.5 97.5 NA NA NA
LEU L:12 L:63 48.0 0.282 -78.9 102.0 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
2018-07-11 LEU C:12 C:63 43.0 0.253 -82.2 107.5 43.0 0.253 0.0 HOH
2.688
O
O
LEU F:12 F:63 42.0 0.247 -81.8 103.4 NA NA NA
LEU I:12 I:63 39.0 0.229 -75.2 96.7 NA NA NA
LEU L:12 L:63 41.0 0.241 -79.5 102.0 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
2018-08-08 LEU C:12 C:63 40.0 0.235 -84.5 99.5 40.0 0.235 0.0 HOH
2.688
O
O
LEU F:12 F:63 88.0 0.518 360.0 98.3 NA NA NA
LEU L:12 L:63 38.0 0.224 -87.7 96.9 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
2018-08-08 LEU I:12 I:63 39.0 0.229 -87.1 95.5 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
2018-08-22 LEU C:12 C:63 97.0 0.571 360.0 81.6 97.0 0.571 0.0 HOH
7.425
CD1
O
LEU F:12 F:63 97.0 0.571 360.0 84.9 NA NA NA
LEU I:12 I:63 37.0 0.218 -93.2 84.7 NA NA NA
LEU L:12 L:63 37.0 0.218 73.6 76.5 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
2018-08-08 LEU C:12 C:63 62.0 0.365 -106.6 95.8 62.0 0.365 0.0 HOH
9.789
O
O
LEU F:12 F:63 81.0 0.476 360.0 91.1 NA NA NA
LEU I:12 I:63 46.0 0.271 -89.6 91.2 NA NA NA
LEU L:12 L:63 39.0 0.229 56.2 79.6 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
2019-06-12 LEU B:12 B:63 21.0 0.124 S -90.1 111.5 21.0 0.124 0.0 HOH
2.646
O
O
LEU F:12 F:63 9.0 0.053 S -94.9 97.1 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
2019-06-12 LEU B:12 B:63 12.0 0.071 S -88.4 98.1 12.0 0.071 0.0 HOH
2.632
O
O
LEU F:12 F:63 22.0 0.129 S -89.0 97.5 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
2019-12-04 LEU D:12 D:63 11.0 0.065 S -83.2 104.5 11.0 0.065 0.0
LEU H:12 H:63 10.0 0.059 S -83.0 104.7 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
2021-10-06 LEU D:12 L:63 32.0 0.188 -63.9 118.8 32.0 0.188 0.0 HOH
3.552
CA
O
7jtp 3 P40337 99.38 4e-117 X-RAY
2021-10-06 LEU C:12 L:63 46.0 0.271 -85.1 111.7 46.0 0.271 0.0 HOH
5.747
N
O
3zrc 3 P40337 98.77 4e-117 X-RAY
2012-03-07 LEU C:13 C:63 104.0 0.612 360.0 75.3 104.0 0.612 0.0
LEU F:13 F:63 110.0 0.647 360.0 58.7 NA NA NA
LEU I:13 I:63 50.0 0.294 -91.6 96.0 NA NA NA
LEU L:13 L:63 57.0 0.335 85.5 69.7 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
2012-03-07 LEU C:13 C:63 95.0 0.559 360.0 79.2 95.0 0.559 0.0
LEU F:13 F:63 78.0 0.459 360.0 67.9 NA NA NA
LEU I:13 I:63 38.0 0.224 -98.8 90.2 NA NA NA
LEU L:13 L:63 59.0 0.347 117.9 50.6 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
2012-07-25 LEU C:13 C:63 101.0 0.594 360.0 89.7 101.0 0.594 0.0
LEU F:13 F:63 108.0 0.635 360.0 67.0 NA NA NA
LEU I:13 I:63 51.0 0.3 -104.3 97.0 NA NA NA
LEU L:13 L:63 50.0 0.294 55.9 71.2 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
2012-07-25 LEU C:13 C:63 48.0 0.282 -93.6 93.2 48.0 0.282 0.0 HOH
6.741
O
O
LEU F:13 F:63 85.0 0.5 360.0 57.0 NA NA NA
LEU I:13 I:63 49.0 0.288 -106.4 90.5 NA NA NA
LEU L:13 L:63 54.0 0.318 52.0 57.1 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
2012-11-14 LEU D:13 V:63 8.0 0.047 S -90.0 108.4 8.0 0.047 0.0 HOH
2.671
O
O
4awj 3 P40337 98.77 4e-117 X-RAY
2012-11-14 LEU C:13 C:63 56.0 0.329 -124.2 74.9 56.0 0.329 0.0 HOH
7.462
O
O
LEU F:13 F:63 90.0 0.529 360.0 78.5 NA NA NA
LEU I:13 I:63 46.0 0.271 -82.9 101.9 NA NA NA
LEU L:13 L:63 20.0 0.118 62.3 76.5 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
2018-08-08 LEU D:13 V:63 10.0 0.059 S -101.1 107.1 10.0 0.059 0.0 F4K
HOH
7.752
2.824
CD1
O
C12
O
1lm8 3 P40337 100.0 6e-117 X-RAY
2002-06-12 LEU C:10 V:63 9.0 0.053 S -88.3 101.0 9.0 0.053 0.0 HOH
2.646
O
O
1vcb 3 P40337 100.0 6e-117 X-RAY
1999-04-21 LEU C:10 C:63 93.0 0.547 360.0 72.9 93.0 0.547 0.0 HOH
2.930
N
O
LEU F:10 F:63 92.0 0.541 360.0 72.9 NA NA NA
LEU I:10 I:63 91.0 0.535 360.0 73.9 NA NA NA
LEU L:10 L:63 90.0 0.529 360.0 73.1 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
2017-06-07 LEU B:10 NA:NA DO NA DO DO DO NA NA NA
6gfx 3 P40337 100.0 6e-117 X-RAY
2018-07-11 LEU C:10 C:63 7.0 0.041 S -98.3 107.2 7.0 0.041 0.0 HOH
2.567
O
O
6i7q 4 P40337 100.0 6e-117 X-RAY
2019-11-27 LEU D:10 V:63 7.0 0.041 S -88.0 90.4 7.0 0.041 0.0 HOH
2.201
H
O
6i7r 4 P40337 100.0 6e-117 X-RAY
2019-11-27 LEU D:10 V:63 7.0 0.041 S -101.2 97.7 7.0 0.041 0.0 HOH
2.126
H
O
6r7f 9 P40337 100.0 6e-117 EM
2019-08-28 LEU I:10 V:63 8.0 0.047 S -89.9 103.7 8.0 0.047 0.0
7khh 3 P40337 100.0 6e-116 X-RAY
2021-02-24 LEU C:25 C:63 8.0 0.047 S -95.4 98.2 8.0 0.047 0.0 HOH
2.554
O
O
7cjb 1 P40337 100.0 8e-116 X-RAY
2021-07-14 LEU A:13 A:63 7.0 0.041 S -89.9 102.8 7.0 0.041 0.0
LEU E:13 E:63 11.0 0.065 S -91.5 103.9 NA NA NA
LEU I:13 I:63 8.0 0.047 S -89.8 102.9 NA NA NA
LEU M:13 M:63 6.0 0.035 S -90.7 103.4 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
2020-08-05 LEU A:5 AAA:63 7.0 0.041 S -94.2 102.6 7.0 0.041 0.0 EDO
HOH
6.553
2.712
O
O
C1
O
7pi4 1 P40337 100.0 4e-113 X-RAY
2021-09-29 LEU A:5 AAA:63 6.0 0.035 S -97.0 94.7 6.0 0.035 0.0 HOH
2.407
O
O
6fmi 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LEU C:12 C:63 43.0 0.253 -75.7 115.3 43.0 0.253 0.0 HOH
3.507
CD1
O
LEU F:12 F:63 35.0 0.206 -128.4 97.4 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LEU C:12 C:63 44.0 0.259 -76.7 105.7 44.0 0.259 0.0 HOH
2.929
O
O
LEU F:12 F:63 48.0 0.282 -74.9 111.5 NA NA NA
LEU I:12 I:63 45.0 0.265 -77.1 99.9 NA NA NA
LEU L:12 L:63 42.0 0.247 -75.1 99.1 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LEU C:12 C:63 42.0 0.247 -81.0 105.2 42.0 0.247 0.0 HOH
6.995
O
O
LEU F:12 F:63 38.0 0.224 -76.9 97.5 NA NA NA
LEU I:12 I:63 42.0 0.247 -74.6 91.4 NA NA NA
LEU L:12 L:63 40.0 0.235 -73.0 101.4 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
2019-06-12 LEU B:3 B:63 8.0 0.047 S -97.8 99.5 8.0 0.047 0.0 HOH
2.127
H
O
LEU F:3 F:63 7.0 0.041 S -93.0 98.3 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
2019-08-28 LEU L:4 V:63 148.0 0.871 S -68.0 123.3 148.0 0.871 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 LEU A:63 A:63 6.0 0.035 S -98.2 107.1